Published in J Virol on December 13, 2006
Papillomavirus E6 proteins. Virology (2008) 1.70
Oncogenic activities of human papillomaviruses. Virus Res (2009) 1.60
The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J Virol (2007) 1.40
Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway. Mol Cell (2010) 1.34
Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53. Structure (2012) 1.30
Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol (2012) 1.28
Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses. Virology (2012) 1.23
Papillomavirus E6 oncoproteins. Virology (2013) 1.21
Cellular binding partners of the human papillomavirus E6 protein. Arch Virol (2008) 1.21
HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage. PLoS Pathog (2012) 1.16
Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J Virol (2011) 1.12
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog (2011) 1.10
The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. J Virol (2009) 1.00
Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes. Virology (2008) 1.00
The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog (2013) 0.94
NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol (2009) 0.93
HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. Virology (2013) 0.89
The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. Wiley Interdiscip Rev Syst Biol Med (2010) 0.88
Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance. J Virol (2013) 0.87
HPV E6 proteins target Ubc9, the SUMO conjugating enzyme. Virus Res (2011) 0.87
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses (2015) 0.84
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction. PLoS One (2008) 0.81
Point-of-care test for cervical cancer in LMICs. Oncotarget (2016) 0.80
Human papillomavirus E6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53. J Virol (2007) 0.79
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait? Pathogens (2016) 0.78
Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC). PLoS One (2014) 0.77
A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor. PLoS Pathog (2016) 0.77
Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. Oncotarget (2017) 0.75
Sterile α Motif Domain Containing 9 Is a Novel Cellular Interacting Partner to Low-Risk Type Human Papillomavirus E6 Proteins. PLoS One (2016) 0.75
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. Anal Biochem (1979) 22.03
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell (1993) 12.41
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature (1995) 5.89
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J (1991) 5.39
Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system. Proc Natl Acad Sci U S A (1989) 5.23
Rules for making human tumor cells. N Engl J Med (2002) 4.84
Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science (2004) 4.67
Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics (1982) 4.66
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
Human papillomavirus immortalization and transformation functions. Virus Res (2002) 3.58
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A (1997) 3.37
Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol (2001) 3.37
Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol Cell Biol (1993) 2.91
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A (1997) 2.87
Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression. J Cell Biol (1991) 2.79
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol (2000) 2.79
The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene (2001) 2.77
RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. J Cell Sci (2003) 2.21
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene (2000) 2.20
Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J Invest Dermatol (2000) 2.08
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol (2000) 1.97
Rapid induction of senescence in human cervical carcinoma cells. Proc Natl Acad Sci U S A (2000) 1.93
The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol (2003) 1.91
Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J Virol (2000) 1.71
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. Oncogene (2002) 1.71
Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif. Oncogene (1998) 1.69
The EGF receptor - an essential regulator of multiple epidermal functions. Eur J Dermatol (2000) 1.67
The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene (2005) 1.40
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol (2004) 1.35
Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem (2002) 1.29
Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27
Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein. Virology (2006) 1.22
Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. J Biol Chem (1999) 1.17
Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein. Virology (2002) 1.12
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. Virology (2003) 1.11
Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein. Virology (2000) 1.09
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. J Biol Chem (2003) 1.03
Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6. J Med Virol (2006) 1.01
Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6. J Gen Virol (2005) 0.98
The E7 oncoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF). J Virol (1999) 0.98
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. Mol Endocrinol (2003) 0.97
Cytoskeletal protein tyrosine phosphatase PTPH1 reduces T cell antigen receptor signaling. Eur J Immunol (2000) 0.94
E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia. Br J Cancer (2002) 0.84
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63
Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. Cell (2004) 3.12
Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages. J Biol Chem (2004) 1.80
DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol Cell (2008) 1.70
Histone H3 as a novel substrate for MAP kinase phosphatase-1. Am J Physiol Cell Physiol (2008) 1.68
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. PLoS One (2013) 1.43
Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation. J Immunol (2006) 1.34
Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities. J Biol Chem (2005) 1.33
Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. Mol Cell (2009) 1.27
Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption. J Neurosci (2003) 1.27
Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis. Mol Cell Biol (2007) 1.27
Apolipoprotein A-I tryptophan substitution leads to resistance to myeloperoxidase-mediated loss of function. Arterioscler Thromb Vasc Biol (2008) 1.23
Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. Clin Exp Metastasis (2004) 1.22
Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein. Virology (2006) 1.22
Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science (2013) 1.22
Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene (2002) 1.17
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. Virology (2003) 1.11
High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem (2012) 1.09
Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production. PLoS One (2008) 1.08
Quantitative dynamics of site-specific protein phosphorylation determined using liquid chromatography electrospray ionization mass spectrometry. Anal Chem (2002) 1.08
Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent with iron hypothesis in atherosclerosis. Physiol Genomics (2003) 1.07
Abnormalities in nitric oxide and its derivatives in lung cancer. Am J Respir Crit Care Med (2005) 1.07
Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Pflugers Arch (2005) 1.03
Site-specific quantitation of protein nitration using liquid chromatography/tandem mass spectrometry. Anal Chem (2003) 0.99
The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. J Biol Chem (2007) 0.97
Proteomic analysis of oxidative stress-resistant cells: a specific role for aldose reductase overexpression in cytoprotection. Mol Cell Proteomics (2003) 0.97
Peptide interactions stabilize and restructure human papillomavirus type 16 E6 to interact with p53. J Virol (2012) 0.96
Control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex. J Lipid Res (2008) 0.96
Dual role of peroxiredoxin I in macrophage-derived foam cells. J Biol Chem (2006) 0.94
Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling. J Biol Chem (2008) 0.92
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS. J Biol Chem (2011) 0.92
Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem (2005) 0.91
Proteomic analysis of resistance mediated by Rcm 2.0 and Rcm 5.1, two loci controlling resistance to bacterial canker of tomato. Mol Plant Microbe Interact (2004) 0.91
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity. J Biol Chem (2003) 0.90
Concealment of epitope by reduction and alkylation in prion protein. Biochem Biophys Res Commun (2005) 0.89
Transformation by bovine papillomavirus type 1 E6 requires paxillin. J Virol (2008) 0.89
Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. PLoS One (2013) 0.88
Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance. J Virol (2013) 0.87
Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal (2012) 0.86
Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6. Protein Expr Purif (2011) 0.86
Proteomic and transcriptomic analyses of macrophages with an increased resistance to oxidized low density lipoprotein (oxLDL)-induced cytotoxicity generated by chronic exposure to oxLDL. Mol Cell Proteomics (2005) 0.85
A quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring. PLoS One (2012) 0.85
Intregrated analysis of the human cardiac transcriptome, proteome and phosphoproteome. Proteomics (2004) 0.85
Protein sequencing with tandem mass spectrometry. Methods Mol Biol (2009) 0.84
The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase. Glia (2004) 0.84
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. Nucleic Acids Res (2008) 0.83
Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria. Am J Physiol Heart Circ Physiol (2013) 0.82
Suprabasal overexpression of beta-1 integrin is induced by bovine papillomavirus type 1. Virology (2006) 0.81
Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L. Protein J (2006) 0.81
Effects of calorie restriction on the zebrafish liver proteome. Comp Biochem Physiol Part D Genomics Proteomics (2008) 0.80
Human papillomavirus E6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53. J Virol (2007) 0.79
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics (2009) 0.79
Role of tyrosine phosphorylation in the regulation of cleavage secretion of angiotensin-converting enzyme. J Biol Chem (2004) 0.78
Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site. Proteomics (2011) 0.75
Toward broader inclusion of liquid chromatography-mass spectrometry in the clinical laboratory. Clin Chem (2004) 0.75
Correction: Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS One (2016) 0.75
AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling. PLoS One (2010) 0.75
Deposition of stearate-oleate rich seed fat in Mangifera indica is mediated by a FatA type acyl-ACP thioesterase. Phytochemistry (2010) 0.75