Published in Development on June 01, 1997
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J (1997) 3.35
Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev (2002) 3.12
GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U S A (2004) 3.08
Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev (1999) 2.95
Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol (1998) 2.17
Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Natl Acad Sci U S A (2004) 2.07
Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol Cell Biol (1999) 1.95
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev (2001) 1.94
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4. Mol Cell Biol (1999) 1.91
Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol (2010) 1.82
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A (2006) 1.73
Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol (2008) 1.39
Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A (2003) 1.37
Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc Natl Acad Sci U S A (2002) 1.36
GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. EMBO J (2003) 1.34
Redundancy and evolution of GATA factor requirements in development of the myocardium. Dev Biol (2007) 1.31
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development. EMBO J (2006) 1.25
Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol (2009) 1.23
Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes. Dev Biol (2007) 1.19
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells. J Biol Chem (2010) 1.16
Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biol (2009) 1.13
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12
Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4. Mol Cell Biol (2005) 1.09
Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J Exp Med (1998) 1.08
Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells. Nucleic Acids Res (2010) 1.07
Mobilized bone marrow progenitor cells serve as donors of cytoprotective genes for cardiac repair. J Mol Cell Cardiol (2007) 1.02
Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network. Mol Ther (2011) 0.97
Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Cell Signal (2011) 0.96
Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2. PLoS One (2010) 0.96
GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4. Cytotherapy (2011) 0.95
Directed differentiation of size-controlled embryoid bodies towards endothelial and cardiac lineages in RGD-modified poly(ethylene glycol) hydrogels. Adv Healthc Mater (2012) 0.90
Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors. Stem Cells Dev (2013) 0.89
Transduction of Wnt11 promotes mesenchymal stem cell transdifferentiation into cardiac phenotypes. Stem Cells Dev (2011) 0.89
Xenopus: An emerging model for studying congenital heart disease. Birth Defects Res A Clin Mol Teratol (2011) 0.89
Dissociation of cardiogenic and postnatal myocardial activities of GATA4. Mol Cell Biol (2012) 0.88
Silencing of FABP3 promotes apoptosis and induces mitochondrion impairment in embryonic carcinoma cells. J Bioenerg Biomembr (2012) 0.88
BMP induction of cardiogenesis in P19 cells requires prior cell-cell interaction(s). Dev Dyn (2006) 0.87
Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proc Natl Acad Sci U S A (2014) 0.86
Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro. Nucleic Acids Res (2011) 0.85
Cardiac repair by embryonic stem-derived cells. Handb Exp Pharmacol (2006) 0.85
Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. Am J Pathol (1999) 0.84
Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J (2011) 0.84
Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue. Stem Cell Rev (2009) 0.83
Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate. Cell Death Dis (2014) 0.81
Induction of Pax3 gene expression impedes cardiac differentiation. Sci Rep (2013) 0.81
Embryonic stem cells overexpressing Pitx2c engraft in infarcted myocardium and improve cardiac function. Int Heart J (2009) 0.80
Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors. Mol Cell Biochem (2011) 0.79
Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. Mech Dev (2014) 0.78
A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects. PLoS One (2013) 0.78
Transcription factors GATA-4 and GATA-6: molecular characterization, expression patterns and possible functions during goose (Anser cygnoides) follicle development. J Reprod Dev (2014) 0.78
Adrenomedullin upregulates M2-muscarinic receptors in cardiomyocytes from P19 cell line. Br J Pharmacol (2003) 0.77
Activation of GATA4 gene expression at the early stage of cardiac specification. Front Chem (2014) 0.76
NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans. Cardiovasc Res (2014) 0.76
Repairing hearts with AKT. Proc Natl Acad Sci U S A (2015) 0.75
Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS One (2017) 0.75
Constitutive Expression of GATA4 Dramatically Increases the Cardiogenic Potential of D3 Mouse Embryonic Stem Cells. Open Biotechnol J (2016) 0.75
Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells. Cell Dev Biol (2015) 0.75
Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum. Stem Cell Res Ther (2016) 0.75
Genetic programme of cardiogenesis: implications for therapeutic application. Neth Heart J (2004) 0.75
Comparative Analysis of Nkx2-5/GATA4/TBX5 Expression in Chicken, Quail and Chicken-quail Hybrids during the Early Stage of Cardiac Development in Embryos. Asian-Australas J Anim Sci (2013) 0.75
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5. PLoS One (2015) 0.75
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell (2001) 5.77
The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4. Am J Hum Genet (1985) 4.01
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J (1997) 3.35
GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J (2000) 2.79
Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature (1985) 2.41
Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature (1994) 2.24
A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol (1994) 2.15
GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol (1998) 2.00
Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol Cell Biol (1999) 1.95
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev (2001) 1.94
Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A (2000) 1.93
GATA transcription factors and cardiac development. Semin Cell Dev Biol (1999) 1.81
The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol (1996) 1.67
Methylated blocked 5' terminal sequences of sea urchin embryo messenger RNA classes containing and lacking poly(A). Cell (1976) 1.65
Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol Cell Biol (1989) 1.65
Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J (1993) 1.63
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter. Development (1998) 1.60
Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators. Mol Cell Biol (2000) 1.59
Messenger RNA in early sea-urchin embryos: cytoplasmic particles. Science (1965) 1.49
Molecular classes of heterogeneous nuclear RNA in sea urchin embryos. J Mol Biol (1975) 1.39
Sea urchin metallothionein sequence: key to an evolutionary diversity. Proc Natl Acad Sci U S A (1985) 1.37
Co-existence of non-histone messenger RNA species lacking and containing polyadenylic acid in sea urchin embryos. J Mol Biol (1974) 1.35
Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol (1995) 1.30
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells. Mol Cell Biol (1994) 1.30
Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors. Proc Natl Acad Sci U S A (1984) 1.26
The gene for rat atrial natriuretic factor. J Biol Chem (1985) 1.25
Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development (1999) 1.21
Properties of sea urchin embryo messenger RNA containing and lacking poly(A). Cell (1975) 1.21
Heterogeneous ribonucleoprotein particles in the cytoplasm of sea urchin embryos. J Mol Biol (1968) 1.19
Expression of atrial natriuretic factor gene in heart ventricular tissue. Peptides (1987) 1.17
Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor. Mol Endocrinol (1992) 1.17
Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. Mol Cell Biol (2001) 1.14
Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues. Mol Endocrinol (1991) 1.11
Structure of the rat pro-opiomelanocortin (POMC) gene. FEBS Lett (1985) 1.09
Regulation of heart development and function through combinatorial interactions of transcription factors. Ann Med (2001) 1.08
Combinatorial interactions regulating cardiac transcription. Dev Genet (1998) 1.08
Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J Exp Med (1998) 1.08
A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells. EMBO J (1993) 1.07
Structure, expression, and function of atrial natriuretic factor in extraatrial tissues. Endocr Rev (1989) 1.05
fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element. Mol Cell Biol (1993) 1.04
Functional analysis and chromosomal mapping of Gata5, a gene encoding a zinc finger DNA-binding protein. Mamm Genome (1999) 1.01
Cooperative activation by GATA-4 and YY1 of the cardiac B-type natriuretic peptide promoter. J Biol Chem (2001) 1.00
Evidence that the s-polysomes of early sea urchin embryos may be responsible for the synthesis of chromosomal histones. Biochem Biophys Res Commun (1969) 0.99
Metallothionein genes MTa and MTb expressed under distinct quantitative and tissue-specific regulation in sea urchin embryos. Mol Cell Biol (1987) 0.99
The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers. Mol Cell Biol (1998) 0.99
Distal cis-acting promoter sequences mediate glucocorticoid stimulation of cardiac atrial natriuretic factor gene transcription. J Biol Chem (1991) 0.98
Detection of C-type natriuretic peptide (CNP) transcript in the rat heart and immune organs. Endocrinology (1993) 0.97
Structure of an ectodermally expressed sea urchin metallothionein gene and characterization of its metal-responsive region. Mol Cell Biol (1989) 0.96
Developmental shifts in the synthesis of heterogeneous nuclear RNA classes in the sea urchin embryo. Nature (1976) 0.95
Developmental shifts in frequency distribution of polysomal mRNA and their posttranscriptional regulation in the sea urchin embryo. Proc Natl Acad Sci U S A (1980) 0.94
Messenger RNA in early sea-urchin embryos: size classes. Science (1965) 0.94
Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues. J Clin Endocrinol Metab (1994) 0.94
Developmental regulation, induction, and embryonic tissue specificity of sea urchin metallothionein gene expression. Dev Biol (1984) 0.94
Regulation of the ANF and BNP promoters by GATA factors: lessons learned for cardiac transcription. Can J Physiol Pharmacol (2001) 0.92
Accumulation of newly synthesized RNA templates in a unique class of polyribosomes during embryogenesis. Proc Natl Acad Sci U S A (1967) 0.91
Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids. J Cell Biochem (1987) 0.91
XhoI polymorphism at the human pronatriodilatin (hPND) gene locus. Nucleic Acids Res (1986) 0.89
Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. Genome (1989) 0.88
Differences in abundance of individual RNAs in normal and animalized sea urchin embryos. Dev Biol (1983) 0.88
Glucocorticoid repression of pro-opiomelanocortin gene transcription. J Steroid Biochem (1989) 0.87
Ribosomal ribonucleic acid of the sea urchin egg and its fate during embryogenesis. J Mol Biol (1967) 0.86
GATA4 mediates activation of the B-type natriuretic peptide gene expression in response to hemodynamic stress. Endocrinology (2001) 0.86
Primary carnitine deficiency: novel mutations and insights into the cardiac phenotype. Clin Genet (2013) 0.85
Lysophosphatidylethanolamine acyltransferase activity is elevated during cardiac cell differentiation. Biochim Biophys Acta (2000) 0.84
Cytoplasmic extraction: polyribosomes and heterogenous ribonucleoproteins without associated DNA. Science (1970) 0.84
Regulation of gene expression in the endocrine heart. Recent Prog Horm Res (1998) 0.84
Combinatorial regulation by promoter and intron 1 regions of the metallothionein SpMTA gene in the sea urchin embryo. Mol Cell Biol (1993) 0.83
Increased transcripts for B-type natriuretic peptide in spontaneously hypertensive rats. Quantitative polymerase chain reaction for atrial and brain natriuretic peptide transcripts. Hypertension (1992) 0.83
Developmental and tissue-specific regulation of beta-tubulin gene expression in the embryo of the sea urchin Strongylocentrotus purpuratus. Genes Dev (1987) 0.83
Histone synthesis. Assignment to a special class of polyribosomes in sea urchin embryos. Biochemistry (1971) 0.82
Ventricles as a major site of atrial natriuretic factor synthesis and release in cardiomyopathic hamsters with heart failure. Circ Res (1989) 0.82
mRNAs containing and lacking poly (A) function as separate and distinct classes during embryonic development. Prog Nucleic Acid Res Mol Biol (1976) 0.81
An altered series of ectodermal gene expressions accompanying the reversible suspension of differentiation in the zinc-animalized sea urchin embryo. Dev Biol (1986) 0.81
Primary differentiation and ectoderm-specific gene expression in the animalized sea urchin embryo. Dev Biol (1985) 0.81
Spatial patterns of metallothionein mRNA expression in the sea urchin embryo. Dev Biol (1986) 0.80
Coordinate and selective beta-tubulin gene expression associated with cilium formation in sea urchin embryos. Genes Dev (1987) 0.80
TaqI polymorphism at the 3' end of the human pronatriodilatin gene (hPND). Nucleic Acids Res (1986) 0.80
Exclusive cardiac dysfunction in familial primary carnitine deficiency cases: a genotype-phenotype correlation. Clin Genet (2007) 0.79
Regulatory elements of the pro-opiomelanocortin gene: pituitary specificity and glucocorticoid repression. Trends Endocrinol Metab (2008) 0.79
Effect of prolonged high salt diet on atrial natriuretic factor in rats. Proc Soc Exp Biol Med (1990) 0.78
Ventricular activation of the atrial natriuretic factor gene in acute myocardial infarction. N Engl J Med (1988) 0.78
Early and severe liver disease associated with homozygosity for an exon 7 mutation, G691R, in Wilson's disease. Clin Genet (2007) 0.78
Elevation in phosphatidylethanolamine is an early but not essential event for cardiac cell differentiation. Exp Cell Res (2000) 0.78
Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36. Genomics (1995) 0.78
Sea urchin embryo chromatin and nuclear ribonucleoproteins fractionated by anion exchange chromatography. Arch Biochem Biophys (1975) 0.78
Detection of C-type natriuretic peptide compared with brain and atrial natriuretic peptide transcripts in human heart by the polymerase chain reaction. Clin Investig (1993) 0.77
Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy. J Clin Invest (1989) 0.77
Localization of the Catf1 transcription factor gene to mouse chromosome 19. Mamm Genome (1995) 0.77
Synonymous nucleotide substitution rates of beta-tubulin and histone genes conform to high overall genomic rates in rodents but not in sea urchins. J Mol Evol (1988) 0.77
The subcellular distribution of protein kinase Calpha, -epsilon, and -zeta isoforms during cardiac cell differentiation. Arch Biochem Biophys (1999) 0.76
Mapping of the Gata6 gene to mouse chromosome 18. Mamm Genome (1996) 0.76
Atrial natriuretic factor in the impulse-conduction system of rat cardiac ventricles. Cell Tissue Res (1989) 0.76
The 5' terminal capping of heterogeneous nuclear RNA at different embryonic stages of the sea urchin. Nucleic Acids Res (1979) 0.75
S-adenosylmethionine pool size and turnover rate in sea urchin embryos determined from simultaneous measurements of amounts and specific activities. Dev Biol (1979) 0.75
Atrial natriuretic factor in the impulse conduction system of the heart. Trans Assoc Am Physicians (1988) 0.75
The mouse Gata4 transcription factor maps to chromosome 14. Mamm Genome (1995) 0.75
Evidence for atrial natriuretic peptide (ANP) synthesis and the presence of ANP-transducing receptors in the rat olfactory bulb. J Neurochem (1991) 0.75
Ribosomal RNA synthesis in pre- and post-gastrula-stage sea urchin embryos. Dev Biol (1979) 0.75