Published in Proc Natl Acad Sci U S A on April 20, 2004
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
Anthracycline cardiotoxicity: from bench to bedside. J Clin Oncol (2008) 2.04
Doxorubicin cardiomyopathy. Cardiology (2009) 1.99
The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. J Clin Invest (2007) 1.98
Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol (2006) 1.82
Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest (2006) 1.81
Role of the GATA family of transcription factors in endocrine development, function, and disease. Mol Endocrinol (2008) 1.81
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A (2006) 1.73
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem (2009) 1.52
Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Arch Immunol Ther Exp (Warsz) (2009) 1.41
GATA transcription factor required for immunity to bacterial and fungal pathogens. PLoS One (2006) 1.38
Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol (2006) 1.36
The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res (2010) 1.32
Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation (2011) 1.30
Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest (2011) 1.28
Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol Cell Biol (2005) 1.27
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development. EMBO J (2006) 1.25
Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure. J Mol Cell Cardiol (2010) 1.23
Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. Am J Physiol Heart Circ Physiol (2010) 1.23
Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J Virol (2007) 1.18
Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog Cardiovasc Dis (2010) 1.17
Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues. Circulation (2012) 1.14
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol (2013) 1.11
Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4. Mol Cell Biol (2005) 1.09
Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect. J Pharmacol Exp Ther (2010) 1.09
Mechanisms and management of doxorubicin cardiotoxicity. Herz (2011) 1.05
A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med (2011) 1.05
Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal (2013) 1.04
Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation. Mol Cell Biol (2008) 1.01
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A (2010) 0.99
Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy. PLoS One (2012) 0.99
Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins. Am J Physiol Heart Circ Physiol (2009) 0.98
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem (2009) 0.98
Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Cell Signal (2011) 0.96
Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev (2013) 0.96
Regulation of Bcl-xL expression in lung vascular smooth muscle. Am J Respir Cell Mol Biol (2007) 0.96
Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation. J Cardiovasc Pharmacol (2014) 0.96
20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin. Oncotarget (2014) 0.95
Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress. Oxid Med Cell Longev (2015) 0.95
GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos. BMC Dev Biol (2008) 0.94
Partial loss of GATA factor Pannier impairs adult heart function in Drosophila. Hum Mol Genet (2009) 0.93
Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem (2012) 0.92
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts. Am J Physiol Heart Circ Physiol (2012) 0.90
Dissociation of cardiogenic and postnatal myocardial activities of GATA4. Mol Cell Biol (2012) 0.88
Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system. J Physiol (2016) 0.87
Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies. Biochem Res Int (2012) 0.86
Cardiac side effects of anticancer treatments: new mechanistic insights. Curr Heart Fail Rep (2012) 0.86
Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proc Natl Acad Sci U S A (2014) 0.86
Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Dev Biol (2013) 0.85
Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol (2012) 0.85
Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart. Cardiovasc Res (2010) 0.85
The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Mol Cell Biol (2005) 0.85
MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Mediators Inflamm (2015) 0.85
GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling. Am J Physiol Heart Circ Physiol (2008) 0.84
Metabolic stress in the myocardium: adaptations of gene expression. J Mol Cell Cardiol (2012) 0.84
MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction. Oxid Med Cell Longev (2015) 0.83
Enhanced mesenchymal stem cell survival induced by GATA-4 overexpression is partially mediated by regulation of the miR-15 family. Int J Biochem Cell Biol (2013) 0.83
Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity. Pharmacogenomics (2013) 0.82
Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. J Cell Mol Med (2011) 0.82
Acetaminophen attenuates doxorubicin-induced cardiac fibrosis via osteopontin and GATA4 regulation: reduction of oxidant levels. J Cell Physiol (2013) 0.82
GATA4 reduction enhances 3',5'-cyclic adenosine 5'-monophosphate-stimulated steroidogenic acute regulatory protein messenger ribonucleic acid and progesterone production in luteinized porcine granulosa cells. Endocrinology (2008) 0.82
Epigenetic regulation of cardiac development and function by polycomb group and trithorax group proteins. Dev Dyn (2012) 0.82
Electrically conductive chitosan/carbon scaffolds for cardiac tissue engineering. Biomacromolecules (2014) 0.81
GATA4 and DcR1 methylation in glioblastomas. Diagn Pathol (2013) 0.81
Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate. Cell Death Dis (2014) 0.81
Ageing is a risk factor in imatinib mesylate cardiotoxicity. Eur J Heart Fail (2014) 0.80
Maintenance of adult cardiac function requires the chromatin factor Asxl2. J Mol Cell Cardiol (2012) 0.80
Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor. Mol Cell Pharmacol (2010) 0.79
Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. PLoS One (2013) 0.79
Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis. Am J Pathol (2009) 0.79
Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up. PLoS One (2014) 0.78
GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol (2013) 0.78
Cardiovascular Late Effects and Exercise Treatment in Breast Cancer: Current Evidence and Future Directions. Can J Cardiol (2016) 0.78
Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. Mech Dev (2014) 0.78
Exercise Prevention of Cardiovascular Disease in Breast Cancer Survivors. J Oncol (2015) 0.78
ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling. J Biol Chem (2010) 0.77
Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function. J Biol Chem (2015) 0.77
Silencing of hepcidin enforces the apoptosis in iron-induced human cardiomyocytes. J Occup Med Toxicol (2014) 0.77
GATA factors in endocrine neoplasia. Mol Cell Endocrinol (2015) 0.77
Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol (2009) 0.77
Heart failure in congenital heart disease: a confluence of acquired and congenital. Heart Fail Clin (2014) 0.77
Apoptosis in Anthracycline Cardiomyopathy. Curr Pediatr Rev (2011) 0.77
Pharmacogenetics in the management of breast cancer -- prospects for individualised treatment. Fam Cancer (2006) 0.76
Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death. Cell Stress Chaperones (2014) 0.76
Signaling Pathways in Cardiac Myocyte Apoptosis. Biomed Res Int (2016) 0.76
Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS One (2017) 0.75
Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep (2017) 0.75
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5. PLoS One (2015) 0.75
Cardiovascular disease following hematopoietic stem cell transplantation: Pathogenesis, detection, and the cardioprotective role of aerobic training. Crit Rev Oncol Hematol (2015) 0.75
Multifunctional protein: cardiac ankyrin repeat protein. J Zhejiang Univ Sci B (2016) 0.75
The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer (2002) 14.94
Doxorubicin-induced cardiomyopathy. N Engl J Med (1998) 9.08
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev (1997) 6.52
Apoptosis in the failing human heart. N Engl J Med (1997) 6.35
Apoptosis signaling. Annu Rev Biochem (2000) 6.18
Natriuretic peptides. N Engl J Med (1998) 6.04
Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell (2002) 5.31
Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene (2002) 4.80
Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer (2002) 4.76
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell (1999) 4.69
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet (1995) 4.39
Ways of dying: multiple pathways to apoptosis. Genes Dev (2003) 4.14
Female sex and drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer. N Engl J Med (1995) 4.03
A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest (2003) 3.96
Sizing up the heart: development redux in disease. Genes Dev (2003) 3.52
The GATA family (vertebrates and invertebrates). Curr Opin Genet Dev (2002) 3.39
The transcription factor GATA6 is essential for early extraembryonic development. Development (1999) 3.19
A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev (1997) 3.18
GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J (2000) 2.79
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A (1995) 2.78
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood (1999) 2.62
Echocardiographic assessment of cardiac function in conscious and anesthetized mice. Am J Physiol (1999) 2.56
cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation (1997) 2.54
Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol (2001) 2.38
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development (1997) 2.07
Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol Cell Biol (1999) 1.95
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev (2001) 1.94
Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A (2000) 1.93
Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol (1997) 1.75
GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Am J Med Genet (1999) 1.59
Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro. Proc Natl Acad Sci U S A (1990) 1.59
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci U S A (1997) 1.56
A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes. J Biol Chem (1997) 1.54
Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol (2003) 1.45
Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol (2000) 1.31
Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells. Mol Cell Biol (1994) 1.30
Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development (2002) 1.22
Pressure overload increases GATA4 binding activity via endothelin-1. Circulation (2001) 1.21
Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. Mol Cell Biol (2001) 1.14
Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury. Biochem Biophys Res Commun (2003) 1.07
Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance. Circulation (2002) 1.04
GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1. Blood (2000) 1.02
Calcineurin-GATA4 pathway is involved in beta-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes. J Biol Chem (2001) 1.00
The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers. Mol Cell Biol (1998) 0.99
Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid. Dev Biol (2000) 0.97
Regulation of the ANF and BNP promoters by GATA factors: lessons learned for cardiac transcription. Can J Physiol Pharmacol (2001) 0.92
Mitochondria-assisted cell suicide: a license to kill. J Mol Cell Cardiol (2003) 0.92
GATA4 mediates activation of the B-type natriuretic peptide gene expression in response to hemodynamic stress. Endocrinology (2001) 0.86
Protecting the myocardium from ischemic injury: a critical role for alpha(1)-adrenoreceptors? Chest (2001) 0.85
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell (2008) 4.70
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development (2005) 2.92
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature (2009) 2.74
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Multiple roles for Sox2 in the developing and adult mouse trachea. Development (2009) 2.62
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest (2005) 2.50
Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab (2003) 2.42
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell (2003) 2.28
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res (2006) 2.08
Fgf8 is required for anterior heart field development. Development (2006) 2.03
T regulatory lymphocytes prevent angiotensin II-induced hypertension and vascular injury. Hypertension (2011) 2.03
COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development (2005) 2.00
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J (2006) 1.99
Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci (2008) 1.97
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A (2004) 1.93
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development (2005) 1.82
Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci (2004) 1.80
Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol (2007) 1.77
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A (2006) 1.76
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev (2010) 1.75
Concurrent partnerships, nonmonogamous partners, and substance use among women in the United States. Am J Public Health (2010) 1.75
Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.75
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A (2012) 1.72
A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot. Hum Mutat (2006) 1.64
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity (2004) 1.63
Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol (2003) 1.62
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem (2003) 1.58
Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. J Biol Chem (2002) 1.57
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem (2005) 1.56
Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension (2009) 1.54
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. J Mol Med (Berl) (2011) 1.51
Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol (2005) 1.50
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Deficiency of T-regulatory cells exaggerates angiotensin II-induced microvascular injury by enhancing immune responses. J Hypertens (2016) 1.43
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A (2008) 1.39
Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem (2005) 1.38
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res (2009) 1.38
Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36
Rare copy number variants contribute to congenital left-sided heart disease. PLoS Genet (2012) 1.35
T regulatory lymphocytes prevent aldosterone-induced vascular injury. Hypertension (2011) 1.35
Msx2 and necdin combined activities are required for smooth muscle differentiation in mesoangioblast stem cells. Circ Res (2004) 1.33
Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation (2003) 1.33
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell (2010) 1.33
Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes. J Biol Chem (2004) 1.32
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol (2006) 1.28
SUMO-1 modification activated GATA4-dependent cardiogenic gene activity. J Biol Chem (2004) 1.28
Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res (2009) 1.28
Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest (2011) 1.28
Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension (2011) 1.26
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development. EMBO J (2006) 1.25
Sex ratio, poverty, and concurrent partnerships among men and women in the United States: a multilevel analysis. Ann Epidemiol (2013) 1.24
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development (2011) 1.24
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development (2002) 1.22
Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci U S A (2006) 1.21
Prox1 maintains muscle structure and growth in the developing heart. Development (2008) 1.21
Hydroxyurea therapy for sickle cell disease in community-based practices: a survey of Florida and North Carolina hematologists/oncologists. Am J Hematol (2005) 1.21
Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts. Mol Cell Biol (2006) 1.20
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol (2007) 1.18
Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. Circ Res (2009) 1.17
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development (2008) 1.16
Targeted expression of IGF-1 transgene to skeletal muscle accelerates muscle and motor neuron regeneration. FASEB J (2002) 1.14
Immune regulation and vascular inflammation in genetic hypertension. Am J Physiol Heart Circ Physiol (2009) 1.14
Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature (2009) 1.13
GATA5 interacts with GATA4 and GATA6 in outflow tract development. Dev Biol (2011) 1.11
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology (2009) 1.10
Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension (2003) 1.09
Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4. Mol Cell Biol (2005) 1.09
GATA factors and transcriptional regulation of cardiac natriuretic peptide genes. Regul Pept (2005) 1.09
Sumoylation and regulation of cardiac gene expression. Circ Res (2010) 1.08
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor. J Biol Chem (2001) 1.08
GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. J Biol Chem (2003) 1.07
LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.06
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development (2002) 1.05
Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Ann N Y Acad Sci (2007) 1.04
T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proc Natl Acad Sci U S A (2009) 1.04
SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. Nucleic Acids Res (2009) 1.03
New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone. J Mol Med (Berl) (2008) 1.03
Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation. Mol Cell Biol (2008) 1.01
The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Circ Res (2010) 1.00
Cross-talk between aldosterone and angiotensin signaling in vascular smooth muscle cells. Steroids (2011) 1.00
Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation. Dev Biol (2011) 0.99
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A (2010) 0.99
MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting. PLoS Genet (2013) 0.98
GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. Endocrinology (2008) 0.98