Published in EMBO J on August 15, 1997
The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Go alpha in an identified population of migratory neurons. Dev Biol (2005) 0.90
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling. J Toxicol (2012) 0.90
Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes. Curr Mol Med (2009) 0.88
Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin. Curr Neuropharmacol (2006) 0.88
First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Mol Neurodegener (2010) 0.88
Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiol Aging (2013) 0.86
Molecular mechanisms of go signaling. Neurosignals (2009) 0.85
A TAG on to the neurogenic functions of APP. Cell Adh Migr (2008) 0.82
The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation. Cell Res (2014) 0.80
Late Simian virus 40 transcription factor is a target of the phosphoinositide 3-kinase/Akt pathway in anti-apoptotic Alzheimer's amyloid precursor protein signalling. Biochem J (2003) 0.80
G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis. Eukaryot Cell (2004) 0.80
Viruses and neurodegeneration. Virol J (2013) 0.79
Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development. Front Mol Neurosci (2016) 0.78
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem (1987) 59.79
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell (1994) 3.50
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. Nature (1992) 2.88
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A (1993) 2.62
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem (1994) 2.53
Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature (1992) 2.47
MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae. EMBO J (1994) 2.32
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature (1991) 1.87
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem (1995) 1.85
Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport (1994) 1.81
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature (1992) 1.81
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J Biol Chem (1995) 1.73
G0 is a major growth cone protein subject to regulation by GAP-43. Nature (1990) 1.72
Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science (1996) 1.56
G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem (1995) 1.50
Interaction between G-protein beta and gamma subunit types is selective. Proc Natl Acad Sci U S A (1992) 1.49
Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol (1995) 1.49
Specificity of G protein beta and gamma subunit interactions. J Biol Chem (1992) 1.46
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. J Biol Chem (1996) 1.46
Intraneuronal compartments of the amyloid precursor protein. J Neurosci (1993) 1.41
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res (1991) 1.41
Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide. Proc Natl Acad Sci U S A (1990) 1.34
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem (1996) 1.32
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem (1994) 1.21
Framing beta-amyloid. Nat Genet (1992) 1.21
Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J Biol Chem (1993) 1.20
Isoprenylation of C-terminal cysteine in a G-protein gamma subunit. J Biol Chem (1990) 1.15
Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits. EMBO J (1995) 1.15
Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. J Biol Chem (1995) 1.11
Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. J Biol Chem (1996) 1.10
Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J Biol Chem (1995) 1.09
Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits. J Biol Chem (1994) 1.07
Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene. Neurology (1992) 1.02
Activated mutants of the alpha subunit of G(o) promote an increased number of neurites per cell. J Neurosci (1994) 0.99
IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein. J Immunol (1993) 0.98
Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J (1996) 0.96
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (1993) 0.96
Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. J Biol Chem (1995) 0.92
Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. J Neurochem (1995) 0.91
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem (1994) 0.89
Subunit composition of G(o) proteins functionally coupling galanin receptors to voltage-gated calcium channels. EMBO J (1995) 0.85
Purification of four forms of the beta gamma subunit complex of G proteins containing different gamma subunits. J Biol Chem (1993) 0.83
In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor. J Biol Chem (1995) 0.82
A novel system that reports the G-proteins linked to a given receptor: a study of type 3 somatostatin receptor. FEBS Lett (1997) 0.81
Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J (1996) 0.81
Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product. J Biol Chem (1994) 0.80
Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system. J Biol Chem (1992) 0.79
Production, processing and partial purification of functional G protein beta gamma subunits in baculovirus-infected insect cells. Biochem J (1992) 0.78
Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases. Gerontology (1996) 0.77
Analysis of G protein gamma subunit heterogeneity using mass spectrometry. J Biol Chem (1994) 0.76
Distinct cellular expression of pertussis toxin-sensitive GTP-binding proteins in rat cerebellum. Neurosci Lett (1991) 0.76
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J Biol Chem (1980) 10.78
Multiple factors are required for the accurate transcription of purified genes by RNA polymerase III. J Biol Chem (1980) 10.63
Diversity of G proteins in signal transduction. Science (1991) 7.41
Nucleotide sequence of bacteriophage fd DNA. Nucleic Acids Res (1978) 7.25
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nat Genet (1994) 7.07
Studies on bacteriophage fd DNA. IV. The sequence of messenger RNA for the major coat protein gene. J Mol Biol (1977) 5.34
The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine (Baltimore) (1981) 5.29
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem (1996) 4.50
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem (1997) 4.12
Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery (2001) 3.49
Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem (1995) 3.45
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation (1999) 3.19
Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy. N Engl J Med (1990) 3.09
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09
Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem (1996) 3.05
Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem (1996) 2.95
Sequence of promoter for coat protein gene of bacteriophage fd. Nature (1976) 2.82
Control of fertilization-independent endosperm development by the MEDEA polycomb gene in Arabidopsis. Proc Natl Acad Sci U S A (1999) 2.76
Percutaneous transluminal catheter-based coil embolization of septal artery as a treatment for hypetrophic obstructive cardiomyopathy. Indian Heart J (2009) 2.76
Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem (1997) 2.73
Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A (1996) 2.68
A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev (2001) 2.59
Characterization of long terminal repeat sequences of HTLV-III. Science (1985) 2.56
Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. BJOG (2014) 2.56
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity (2000) 2.47
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A (2000) 2.45
neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group. J Clin Oncol (1998) 2.42
Functional organization of human supplementary motor cortex studied by electrical stimulation. J Neurosci (1991) 2.41
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol (2000) 2.40
Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett (1998) 2.40
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A (2001) 2.39
ACE inhibitors and pneumonia. Lancet (1998) 2.38
Natural history of the neck remnant of a cerebral aneurysm treated with the Guglielmi detachable coil system. J Neurosurg (2000) 2.38
Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology (1992) 2.35
Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem (1997) 2.34
Computed tomographic findings of brain and skull in myotonic dystrophy. J Neurol Neurosurg Psychiatry (1987) 2.33
Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med (1998) 2.31
Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci U S A (1992) 2.26
Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability. Neuron (1996) 2.23
Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci U S A (1998) 2.19
Primary hyperparathyroidism. Lancet (1997) 2.17
Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues. J Cell Sci (1999) 2.15
Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. Am J Med (1983) 2.14
Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J Biol Chem (1993) 2.14
Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free system. Cell (1986) 2.13
Adenoviral gene transfer of phospholamban in isolated rat cardiomyocytes. Rescue effects by concomitant gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circ Res (1997) 2.12
Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells (2000) 2.12
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o) Nature (1993) 2.08
Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J (1999) 2.08
With a pinch of salt. Clin Med (2010) 2.06
Changes in epidural pressure during walking in patients with lumbar spinal stenosis. Spine (Phila Pa 1976) (1995) 2.06
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci U S A (1994) 2.04
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut (2005) 2.03
Bone marrow and spleen: dissociation of immunologic properties by cortisone. Science (1970) 2.02
Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circulation (2000) 1.93
Mutations in the FIE and MEA genes that encode interacting polycomb proteins cause parent-of-origin effects on seed development by distinct mechanisms. Plant Cell (2000) 1.90
An efficient directional cloning system to construct cDNA libraries containing full-length inserts at high frequency. Gene (1989) 1.90
FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem Biophys Res Commun (2001) 1.90
Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol (2001) 1.87
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus. Antimicrob Agents Chemother (1987) 1.82
Expression of a kinase-defective Eph-like receptor in the normal human brain. Biochem Biophys Res Commun (1997) 1.79
Mass transport of proform of a KDEL-tailed cysteine proteinase (SH-EP) to protein storage vacuoles by endoplasmic reticulum-derived vesicle is involved in protein mobilization in germinating seeds. J Cell Biol (2000) 1.79
Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J Biol Chem (1999) 1.79
The G protein subunit gene families. Genomics (1999) 1.75
A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis. Gut (2006) 1.75
Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell (1991) 1.74
Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase. J Biol Chem (1983) 1.74
Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur J Immunol (1998) 1.73
FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron (1990) 1.72
Neuronal mechanisms of selectivity for object features revealed by blocking inhibition in inferotemporal cortex. Nat Neurosci (2000) 1.71
Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab (2001) 1.71
Isolation and characterization of proteinase from Candida albicans: substrate specificity. J Invest Dermatol (1984) 1.70
Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. Cancer Res (1992) 1.70
Expression of E-cadherin and beta-catenin in human non-small cell lung cancer and the clinical significance. Clin Cancer Res (2000) 1.69
Bipyridine: the most widely used ligand. A review of molecules comprising at least two 2,2'-bipyridine units. Chem Rev (2000) 1.67
Acute promyelocytic leukemia with marrow fibrosis at initial presentation: possible involvement of transforming growth factor-beta(1). Acta Haematol (2000) 1.66
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro. Antimicrob Agents Chemother (1986) 1.66
Molecular diagnosis of residual and recurrent thyroid cancer by amplification of thyroglobulin messenger ribonucleic acid in peripheral blood. J Clin Endocrinol Metab (1998) 1.65
Validity of the in-training examination for predicting American Board of Internal Medicine certifying examination scores. J Gen Intern Med (1992) 1.65
Developing a Canadian prescribing practices network. Network Development Committee of the Canadian Prescribing Practices Network Project. CMAJ (1996) 1.64
Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias. Am J Respir Crit Care Med (2000) 1.64
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem Biophys Res Commun (1993) 1.64
Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest Endosc (1990) 1.62
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol (2003) 1.61
Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth. Mol Cell Biol (1987) 1.61
Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group. Aging (Milano) (2000) 1.59