Transgenic factor VIII: the milky way and beyond.

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Published in Nat Biotechnol on October 01, 1997

Authors

L Hennighausen

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Interaction of protein with DNA in vitro. Methods Enzymol (1987) 2.07

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Conserved region of the rat alpha-lactalbumin promoter is a target site for protein binding in vitro. Biochem J (1988) 0.85

Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells. J Immunol (2001) 0.84

Understanding mammary gland development through the imbalanced expression of growth regulators. Dev Dyn (1996) 0.84

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice. Prog Growth Factor Res (1995) 0.84

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Assignment of the murine tumor susceptibility gene 101 (tsg101) and a processed tsg101 pseudogene (tsg101-ps1) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization. Cytogenet Cell Genet (1999) 0.83

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Functional human CD4 protein produced in milk of transgenic mice. Mol Biol Med (1989) 0.82