Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.

PubWeight™: 1.90‹?› | Rank: Top 3%

🔗 View Article (PMID 8620493)

Published in Cancer Res on April 15, 1996

Authors

D Gallahan1, C Jhappan, G Robinson, L Hennighausen, R Sharp, E Kordon, R Callahan, G Merlino, G H Smith

Author Affiliations

1: Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Articles citing this

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med (2007) 3.05

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10

Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse. Breast Cancer Res Treat (2011) 1.96

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer (2009) 1.85

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81

Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol (2006) 1.80

Neoplastic transformation by Notch requires nuclear localization. Mol Cell Biol (2000) 1.64

Mouse models of breast cancer metastasis. Breast Cancer Res (2006) 1.62

Strategies for the discovery and development of therapies for metastatic breast cancer. Nat Rev Drug Discov (2012) 1.61

Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol (2002) 1.59

Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol (2004) 1.59

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. J Clin Invest (2015) 1.58

Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55

Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50

RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini. Mol Cell Biol (2006) 1.49

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol (2013) 1.30

Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene (2009) 1.29

Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer (2009) 1.25

Is there a role for Notch signalling in human breast cancer? Breast Cancer Res (2003) 1.21

Gamma secretase inhibitors of Notch signaling. Onco Targets Ther (2013) 1.21

The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res (2009) 1.19

The notch ligand JAGGED1 as a target for anti-tumor therapy. Front Oncol (2014) 1.11

Notch activation stimulates migration of breast cancer cells and promotes tumor growth. Breast Cancer Res (2013) 1.08

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis. Oncogene (2008) 1.03

NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro. Breast Cancer Res (2012) 1.02

Common integration sites for MMTV in viral induced mouse mammary tumors. J Mammary Gland Biol Neoplasia (2008) 1.02

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01

The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. PLoS One (2013) 1.01

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis. Mol Oncol (2009) 1.01

Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Mol Cancer (2015) 0.98

A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer. Breast Cancer Res (2014) 0.97

Notch signaling as a therapeutic target for breast cancer treatment? Breast Cancer Res (2011) 0.97

Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. Breast Cancer Res (2014) 0.93

Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Mol Cell Biol (2001) 0.91

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget (2013) 0.91

Shared signaling pathways in normal and breast cancer stem cells. J Carcinog (2011) 0.91

Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells. Oncogenesis (2013) 0.91

Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland. J Cell Physiol (2011) 0.90

Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor. Oncogene (2011) 0.89

Activation of the Notch-regulated transcription factor CBF1/RBP-Jkappa through the 13SE1A oncoprotein. Genes Dev (2001) 0.88

Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat (2015) 0.84

The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. Dig Dis Sci (2008) 0.84

The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84

γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Breast Cancer Res (2012) 0.83

Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation. Mol Cell Biol (2007) 0.83

Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer. Breast Cancer Res Treat (2016) 0.80

Mammary development and breast cancer: the role of stem cells. Curr Mol Med (2011) 0.80

Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern? Circ Res (2010) 0.79

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression. Oncotarget (2015) 0.77

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance. Stem Cells Int (2016) 0.76

Original Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development. Exp Biol Med (Maywood) (2016) 0.75

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One (2011) 0.75

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer. Oncotarget (2017) 0.75

Articles by these authors

The Families and Genera of the Bacteria: Preliminary Report of the Committee of the Society of American Bacteriologists on Characterization and Classification of Bacterial Types. J Bacteriol (1917) 10.16

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet (1999) 8.17

Naturally occurring antibodies devoid of light chains. Nature (1993) 7.35

Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71

Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell (1984) 5.61

Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev (1997) 5.57

The Families and Genera of the Bacteria: Final Report of the Committee of the Society of American Bacteriologists on Characterization and Classification of Bacterial Types. J Bacteriol (1920) 5.56

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene (2000) 4.90

Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89

An entire functional mammary gland may comprise the progeny from a single cell. Development (1998) 4.77

PRODUCTION OF PULMONARY INFARCTS BY THE INSUFFLATION OF ACID. J Exp Med (1920) 4.54

EFFECT OF INTRABRONCHIAL INSUFFLATION OF ACID. J Exp Med (1920) 4.17

Informed consent: recall by patients tested postoperatively. Ann Thorac Surg (1976) 4.13

TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell (1990) 3.86

Competency development in public health leadership. Am J Public Health (2000) 3.84

Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. Science (1984) 3.63

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res (2001) 3.45

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut (2001) 3.40

Cannabis use and risk of lung cancer: a case-control study. Eur Respir J (2008) 3.29

In vivo gene expression profile analysis of human breast cancer progression. Cancer Res (1999) 3.19

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet (1992) 3.11

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol (1999) 3.04

The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice. Nucleic Acids Res (1991) 2.93

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer. Proc Natl Acad Sci U S A (1987) 2.89

Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res (2001) 2.85

Guidelines for the diagnosis and management of migraine in clinical practice. Canadian Headache Society. CMAJ (1997) 2.83

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci U S A (1995) 2.79

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med (1999) 2.74

Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc Natl Acad Sci U S A (1975) 2.71

Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol (1989) 2.69

Detection of baboon type C viral sequences in various primate tissues by molecular hybridization. J Virol (1974) 2.69

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas. Proc Natl Acad Sci U S A (1986) 2.66

Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene. EMBO J (1986) 2.62

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev (1992) 2.59

Nucleic acid homology of murine type-C viral genes. J Virol (1974) 2.51

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J Virol (1987) 2.51

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development (1995) 2.50

Morphological and cytochemical studies on lymphocytic choriomeningitis virus. J Virol (1968) 2.46

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J Virol (1992) 2.29

Major pol gene progenitors in the evolution of oncoviruses. Science (1984) 2.28

The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev (1998) 2.25

Neonatal sunburn and melanoma in mice. Nature (2001) 2.25

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl Acad Sci U S A (1987) 2.23

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci U S A (1994) 2.20

Distribution of intracisternal A-particles in a variety of normal and neoplastic mouse tissues. Int J Cancer (1971) 2.19

Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia. Science (1987) 2.17

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A (1997) 2.12

Learning preferences and learning styles: a study of Wessex general practice registrars. Br J Gen Pract (2001) 2.11

Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development (2000) 2.10

Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma. J Natl Cancer Inst (1989) 2.09

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res (1993) 2.09

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J (1997) 2.08

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J (1998) 2.07

Interaction of protein with DNA in vitro. Methods Enzymol (1987) 2.07

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol (2001) 2.05

Use of enzyme-labeled antibody for electron microscope localization of lymphocytic choriomeningitis virus antigens in infected cell cultures. J Natl Cancer Inst (1969) 2.01

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity (1997) 2.01

High-affinity binding site for a specific nuclear protein in the human IgM gene. Nature (1985) 2.00

Two distinct endogenous type C viruses isolated from the asian rodent Mus cervicolor: conservation of virogene sequences in related rodent species. J Virol (1977) 1.98

Placental failure in mice lacking the homeobox gene Dlx3. Proc Natl Acad Sci U S A (1999) 1.96

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.92

A new class of endogenous human retroviral genomes. Science (1985) 1.89

Transgenic factor VIII: the milky way and beyond. Nat Biotechnol (1997) 1.88

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol Endocrinol (1996) 1.86

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J (1993) 1.86

Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation. J Biol Chem (1991) 1.84

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science (1996) 1.82

Nucleic acid homology of murine xenotropic type C viruses. J Virol (1975) 1.82

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene (1997) 1.81

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc Natl Acad Sci U S A (1997) 1.80

Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J Virol (1995) 1.79

Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene. J Virol (1988) 1.78

Fatal D.D.T. Poisoning. Br Med J (1945) 1.78

Effect of the depth and width of the urethral plate on tubularized incised plate urethroplasty. J Urol (2000) 1.77

Detection and cloning of human DNA sequences related to the mouse mammary tumor virus genome. Proc Natl Acad Sci U S A (1982) 1.74

MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene (2000) 1.74

Exploring the scope for advocacy by paediatricians. Arch Dis Child (1999) 1.74

Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc Natl Acad Sci U S A (1996) 1.73

The future for practice nurses. Br J Gen Pract (1990) 1.70

Surgical experience in the management of spontaneous pneumothorax, 1972-82. Thorax (1983) 1.69

Three division-competent, structurally-distinct cell populations contribute to murine mammary epithelial renewal. Tissue Cell (1997) 1.68

Malignant melanoma: modern black plague and genetic black box. Genes Dev (1998) 1.67

A freshwater anaerobe coupling acetate oxidation to tetrachloroethylene dehalogenation. Appl Environ Microbiol (1996) 1.66

Renal cysts in transgenic mice expressing transforming growth factor-alpha. J Lab Clin Med (1994) 1.66

Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol (2001) 1.66

Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J Neuroendocrinol (1996) 1.62

Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth Differ (1995) 1.62