Published in EMBO J on November 03, 1997
Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med (1999) 2.12
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther (2007) 1.38
Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J (2001) 1.17
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J (1998) 1.12
Regulation of RelA (p65) function by the large subunit of replication factor C. Mol Cell Biol (2003) 1.02
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med (1997) 0.98
Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia. Arch Biochem Biophys (2011) 0.92
Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells. World J Gastroenterol (2004) 0.90
Alpha fetoprotein antagonizes apoptosis induced by paclitaxel in hepatoma cells in vitro. Sci Rep (2016) 0.81
Fanconi anemia D2 protein is an apoptotic target mediated by caspases. J Cell Biochem (2011) 0.78
Gonocyte development in rats: proliferation, distribution and death revisited. Histochem Cell Biol (2012) 0.77
Cancer cell cycles. Science (1996) 21.29
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med (1995) 10.91
Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell (1995) 9.53
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell (1997) 5.95
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem (1994) 5.51
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature (1996) 4.92
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev (1995) 4.54
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med (1996) 3.16
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet (1996) 3.08
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science (1997) 3.07
Characterization of the five replication factor C genes of Saccharomyces cerevisiae. Mol Cell Biol (1995) 2.69
Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med (1996) 2.42
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J (1996) 2.22
Smart machines at the DNA replication fork. Cell (1994) 2.22
The cell-death machine. Curr Biol (1996) 2.18
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem (1996) 2.07
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97
Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Proc Natl Acad Sci U S A (1996) 1.89
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J Biol Chem (1996) 1.74
Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.74
Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. J Biol Chem (1997) 1.65
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J (1996) 1.58
Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities. J Biol Chem (1997) 1.55
CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C. Mol Cell Biol (1994) 1.51
PITSLRE protein kinase activity is associated with apoptosis. Mol Cell Biol (1995) 1.51
Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. J Biol Chem (1995) 1.37
cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A (1993) 1.32
The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae. Genetics (1996) 1.20
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J Biol Chem (1997) 1.17
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells. EMBO J (1996) 1.14
In vitro reconstitution of human replication factor C from its five subunits. Proc Natl Acad Sci U S A (1996) 1.04
Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases. J Biol Chem (1997) 1.03
Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Proc Natl Acad Sci U S A (1993) 1.02
Cloning of the murine cDNA encoding VDJP, a protein homologous to the large subunit of replication factor C and bacterial DNA ligases. Gene (1995) 0.81
Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease. Biochem Biophys Res Commun (1997) 0.79
Antisense oligonucleotides to differentiation-specific element binding protein (DSEB) mRNA inhibit adipocyte differentiation. Biochem Biophys Res Commun (1996) 0.79
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature (1995) 9.03
Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature (2001) 7.90
The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976) (1984) 6.42
Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. Nature (1994) 5.68
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell (1996) 5.38
Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sci U S A (1983) 5.21
DNA synthesis in vitro dependent upon phiX174 replicative form I DNA. Proc Natl Acad Sci U S A (1976) 5.20
In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site. Proc Natl Acad Sci U S A (1985) 5.16
Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc Natl Acad Sci U S A (1987) 4.79
Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev (1999) 4.73
Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex. Proc Natl Acad Sci U S A (1982) 4.72
Binding and unwinding--how T antigen engages the SV40 origin of DNA replication. Cell (1990) 4.65
ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (1989) 4.64
Role of DNA gyrase in phiX replicative-form replication in vitro. Proc Natl Acad Sci U S A (1977) 4.39
Splitting the chromosome: cutting the ties that bind sister chromatids. Science (2000) 4.20
Purification and properties of bacteriophage T4-induced RNA ligase. Proc Natl Acad Sci U S A (1972) 4.18
First clinical isolate of vancomycin-intermediate Staphylococcus aureus in a French hospital. Lancet (1998) 4.08
RNA-dependent DNA polymerase activity of RNA tumor viruses. I. Directing influence of DNA in the reaction. J Virol (1972) 4.06
RNA helicase A mediates association of CBP with RNA polymerase II. Cell (1997) 4.00
Replication of simian virus 40 origin-containing DNA in vitro with purified proteins. Proc Natl Acad Sci U S A (1987) 3.97
Localized melting and structural changes in the SV40 origin of replication induced by T-antigen. EMBO J (1988) 3.96
Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1986) 3.85
Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol (1989) 3.73
Mechanism of action of ribonuclease H isolated from avian myeloblastosis virus and Escherichia coli. Proc Natl Acad Sci U S A (1973) 3.71
The enzymatic repair of DNA. I. Formation of circular lambda-DNA. Proc Natl Acad Sci U S A (1967) 3.67
Complete enzymatic synthesis of DNA containing the SV40 origin of replication. J Biol Chem (1988) 3.61
Isolation and characterization of the protein coded by gene A of bacteriophage phiX174 DNA. Proc Natl Acad Sci U S A (1976) 3.56
Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro. Proc Natl Acad Sci U S A (1981) 3.55
Conversion of phiX174 viral DNA to double-stranded form by purified Escherichia coli proteins. Proc Natl Acad Sci U S A (1974) 3.52
Complications associated with pedicle screws. J Bone Joint Surg Am (1999) 3.41
Deoxyribonucleic acid plymerase II. of Escherichia coli. I. The purification and characterization of the enzyme. J Biol Chem (1972) 3.31
Conversion of phiX174 and fd single-stranded DNA to replicative forms in extracts of Escherichia coli. Proc Natl Acad Sci U S A (1972) 3.27
Isolation and characterization of an endonuclease from Escherichia coli specific for ribonucleic acid in ribonucleic acid-deoxyribonucleic acid hybrid structures. J Biol Chem (1973) 3.13
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature (1995) 3.11
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature (2001) 3.04
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A (1994) 3.03
Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell (2001) 2.99
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication. Proc Natl Acad Sci U S A (1993) 2.95
The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J Biol Chem (1990) 2.94
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase. Genes Dev (2000) 2.94
Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin. Cell (2000) 2.94
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity. Proc Natl Acad Sci U S A (1999) 2.93
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science (1994) 2.92
Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol (2001) 2.84
The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity. J Biol Chem (1988) 2.80
Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin. Proc Natl Acad Sci U S A (1993) 2.74
Complementation of the temperature-sensitive defect in H5ts125 adenovirus DNA replication in vitro. Proc Natl Acad Sci U S A (1979) 2.70
Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta. J Biol Chem (1991) 2.70
Interaction of Escherichia coli dnaB and dnaC(D) gene products in vitro. Proc Natl Acad Sci U S A (1975) 2.68
The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. X. Bacteriophage T3-induced S-adenosylmethionine cleavage. J Biol Chem (1966) 2.67
Replication of adenovirus DNA-protein complex with purified proteins. Proc Natl Acad Sci U S A (1981) 2.66
Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: role of both proteins in the initiation of adenovirus DNA replication. Proc Natl Acad Sci U S A (1982) 2.65
Mechanism of mRNA capping by vaccinia virus guanylyltransferase: characterization of an enzyme--guanylate intermediate. Proc Natl Acad Sci U S A (1981) 2.65
Synthesis of DNA by DNA polymerase epsilon in vitro. J Biol Chem (1991) 2.60
Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins. Proc Natl Acad Sci U S A (1983) 2.58
Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases alpha and delta. Proc Natl Acad Sci U S A (1989) 2.56
Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19. Nat Cell Biol (2001) 2.55
ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication. Proc Natl Acad Sci U S A (1988) 2.51
Mechanism of elongation of primed DNA by DNA polymerase delta, proliferating cell nuclear antigen, and activator 1. Proc Natl Acad Sci U S A (1990) 2.49
ATP-dependent formation of a specialized nucleoprotein structure by simian virus 40 (SV40) large tumor antigen at the SV40 replication origin. Proc Natl Acad Sci U S A (1987) 2.49
Serological evidence for virus related to simian T-lymphotropic retrovirus III in residents of west Africa. Lancet (1986) 2.48
Acute thoracolumbar burst fractures in the absence of neurologic deficit. A comparison between operative and nonoperative treatment. Clin Orthop Relat Res (1984) 2.47
Studies on ribonucleic acid ligase. Characterization of an adenosine triphosphate-inorganic pyrophosphate exchange reaction and demonstration of an enzyme-adenylate complex with T4 bacteriophage-induced enzyme. J Biol Chem (1974) 2.44
Adenovirus DNA replication in vitro: purification of the terminal protein in a functional form. Proc Natl Acad Sci U S A (1981) 2.43
Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases alpha and delta. Proc Natl Acad Sci U S A (1989) 2.38
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc Natl Acad Sci U S A (1999) 2.37
The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini. J Biol Chem (1966) 2.36
Unwinding of duplex DNA from the SV40 origin of replication by T antigen. Science (1987) 2.35
A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction. J Biol Chem (1992) 2.33
Efficacy of hepatitis B vaccine in prevention of early HBsAg carrier state in children. Controlled trial in an endemic area (Senegal). Lancet (1981) 2.31
Enzymatic breakage of deoxyribonucleic acid. II. Purification and properties of endonuclease IV from T4 phage-infected Escherichia coli. J Biol Chem (1969) 2.30
Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A (2001) 2.26
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol (1991) 2.26
Molecular characterization of integrons in Acinetobacter baumannii: description of a hybrid class 2 integron. Antimicrob Agents Chemother (2000) 2.25
Heterogeneous bullous pemphigoid antibodies: detection and characterization by immunoblotting when absent by indirect immunofluorescence. J Invest Dermatol (1989) 2.25
Purification and characterization of human DNA damage checkpoint Rad complexes. Proc Natl Acad Sci U S A (2001) 2.24
RNA-dependent DNA polymerase activity of RNA tumor viruses. II. Directing influence of RNA in the reaction. J Virol (1972) 2.23
The surgical and medical perioperative complications of anterior spinal fusion surgery in the thoracic and lumbar spine in adults. A review of 1223 procedures. Spine (Phila Pa 1976) (1995) 2.22
Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites. Mol Cell Biol (1985) 2.19
Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication. Proc Natl Acad Sci U S A (1986) 2.16
Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. Proc Natl Acad Sci U S A (2001) 2.14
Role of ATP in DNA synthesis in Escherichia coli. J Mol Biol (1972) 2.13
Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med (1999) 2.12
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J Biol Chem (2001) 2.11
Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases. Genes Cells (1996) 2.09
Characteristics of reactions catalyzed by purified guanylyltransferase from vaccinia virus. J Biol Chem (1978) 2.08
Involvement of escherichia coli dnaZ gene product in DNA elongation in vitro. Proc Natl Acad Sci U S A (1976) 2.07
Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli. J Biol Chem (1969) 2.07
DNA sequences required for the in vitro replication of adenovirus DNA. Proc Natl Acad Sci U S A (1984) 2.07
Purification and properties of vaccinia virus DNA-dependent RNA polymerase. J Biol Chem (1980) 2.05
Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe. J Biol Chem (2000) 2.04
The role of deoxyribonucleic acid in ribonucleic acid synthesis. XIV. A study of the initiation of ribonucleic acid synthesis. J Biol Chem (1967) 2.03
Spinal instability as defined by the three-column spine concept in acute spinal trauma. Clin Orthop Relat Res (1984) 2.02
Association of DNA-dependent and -independent ribonucleoside triphosphatase activities with dnaB gene product of Escherichia coli. Proc Natl Acad Sci U S A (1974) 2.00
Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme. EMBO J (1999) 2.00
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A (1997) 1.99
Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur Heart J (2000) 1.98
Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem (1993) 1.97