Published in J Exp Med on December 20, 1999
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Caspase 3 activity is required for skeletal muscle differentiation. Proc Natl Acad Sci U S A (2002) 2.88
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A (2008) 2.52
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J (2004) 2.12
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11
Old, new and emerging functions of caspases. Cell Death Differ (2014) 2.01
Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. J Exp Med (2000) 1.79
Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A (2000) 1.68
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J Exp Med (2010) 1.52
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol Cell Biol (2000) 1.39
The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev (2010) 1.35
Death receptors couple to both cell proliferation and apoptosis. J Clin Invest (2002) 1.35
Loss of T cell responses following long-term cryopreservation. J Immunol Methods (2007) 1.23
Physiological functions of caspases beyond cell death. Am J Pathol (2006) 1.22
Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet (2010) 1.20
Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. Mol Cell Biol (2006) 1.19
Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J (2001) 1.17
Ripped to death. Trends Cell Biol (2011) 1.14
Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP. Mol Cell Biol (2001) 1.13
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity (2008) 1.12
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem (2007) 1.12
Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation. Proc Natl Acad Sci U S A (2001) 1.08
Caspase-3 protects stressed organs against cell death. Mol Cell Biol (2012) 1.03
The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis (2004) 1.01
Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates. J Immunol (2005) 1.01
c-FLIP protects mature T lymphocytes from TCR-mediated killing. J Immunol (2008) 0.99
Functions of caspase 8: the identified and the mysterious. Semin Immunol (2014) 0.99
Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion. Cell Death Differ (2010) 0.98
Pro- and anti-apoptotic CD95 signaling in T cells. Cell Commun Signal (2011) 0.98
Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol (2004) 0.97
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes. Retrovirology (2008) 0.96
PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem (2010) 0.96
Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway. Mol Cell Biol (2005) 0.96
The "fuzzy logic" of the death-inducing signaling complex in lymphocytes. J Clin Immunol (2003) 0.96
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives. J Cereb Blood Flow Metab (2011) 0.94
Acute cardiac allograft rejection by directly cytotoxic CD4 T cells: parallel requirements for Fas and perforin. Transplantation (2010) 0.92
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol (2005) 0.91
Caspases. Multifunctional proteases. J Exp Med (1999) 0.89
Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins. Proc Natl Acad Sci U S A (2004) 0.89
Caspases as therapeutic targets. J Cell Mol Med (2008) 0.89
Mitochondria-centric activation induced cell death of cytolytic T lymphocytes and its implications for cancer immunotherapy. Vaccine (2010) 0.89
T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med (2002) 0.88
Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor. Antimicrob Agents Chemother (2002) 0.88
Modulation of CD4+ T-cell activation by CD95 co-stimulation. Cell Death Differ (2010) 0.88
The role of CD95 and CD95 ligand in cancer. Cell Death Differ (2015) 0.88
T cell intrinsic roles of autophagy in promoting adaptive immunity. Curr Opin Immunol (2010) 0.87
Protease activity of procaspase-8 is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3. J Biol Chem (2012) 0.87
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity (2014) 0.86
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. J Immunol (2010) 0.85
Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway. J Immunol (2008) 0.85
Regional differences in the temporal expression of non-apoptotic caspase-3-positive bergmann glial cells in the developing rat cerebellum. Front Neuroanat (2009) 0.85
Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol (2004) 0.81
Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo. PLoS One (2010) 0.81
Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division? Clin Exp Immunol (2008) 0.80
Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP. Genes Cancer (2011) 0.79
Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B. J Immunol (2014) 0.79
Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro. PLoS One (2012) 0.79
Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development. J Hematol Oncol (2016) 0.78
Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2. Gene Ther Mol Biol (2009) 0.78
Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζ chain down-regulation via caspase-3 activation in oral cancer. Immunology (2015) 0.78
Protease signaling in animal and plant-regulated cell death. FEBS J (2015) 0.78
Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A (2004) 0.78
Kinetics of T lymphocyte apoptosis and the cellular immune response in SIVmac239-infected rhesus macaques. J Med Primatol (2008) 0.78
Apoptosis resistant bronchoalveolar lavage (BAL) fluid lymphocytes in sarcoidosis. Thorax (2002) 0.78
Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol (2012) 0.78
MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals. Genet Mol Biol (2009) 0.77
Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced disease. J Immunol (2009) 0.77
The regulation and role of c-FLIP in human Th cell differentiation. PLoS One (2014) 0.77
Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death. Hum Immunol (2011) 0.77
High rate of mutation reporter gene inactivation during human T cell proliferation. Immunogenetics (2006) 0.77
Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease. J Neural Transm (Vienna) (2006) 0.77
Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Virus Res (2008) 0.77
Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. PLoS One (2016) 0.76
KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development. Genes Immun (2015) 0.76
Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress. PLoS One (2015) 0.75
Fas-670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development. Biomed Rep (2015) 0.75
A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation. Genes Immun (2015) 0.75
Metacaspases versus caspases in development and cell fate regulation. Cell Death Differ (2017) 0.75
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Caspases: enemies within. Science (1998) 19.45
Biologic basis for interleukin-1 in disease. Blood (1996) 16.04
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem (1997) 9.97
IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (1992) 9.96
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93
Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A (1998) 6.69
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature (1998) 6.47
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell (1997) 5.95
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature (1997) 5.35
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature (1998) 4.97
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J (1997) 4.56
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
Bcl-2 family proteins. Oncogene (1998) 3.56
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J (1993) 3.30
Caspases: the proteases of the apoptotic pathway. Oncogene (1998) 3.11
Fas transduces activation signals in normal human T lymphocytes. J Exp Med (1993) 3.04
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J (1998) 2.82
The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J (1996) 2.71
Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem (1999) 2.65
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J (1997) 2.44
IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol (1997) 2.29
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells. EMBO J (1997) 1.82
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. J Biol Chem (1997) 1.82
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci U S A (1999) 1.52
Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proc Natl Acad Sci U S A (1998) 1.49
p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. Curr Biol (1998) 1.31
Transducing signals of life and death. Curr Opin Cell Biol (1997) 1.25
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes Cells (1996) 1.23
Regulation of apoptosis and T cell activation by Fas-specific mAb. Int Immunol (1994) 1.22
Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J Biol Chem (1997) 1.19
T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. EMBO J (1997) 1.18
Granzyme release and caspase activation in activated human T-lymphocytes. J Biol Chem (1998) 1.10
Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes. J Clin Invest (1978) 1.07
Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases. J Biol Chem (1997) 1.03
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med (1997) 0.98
Activation of caspase-3-like enzymes in non-apoptotic T cells. Eur J Immunol (1998) 0.98
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J (1997) 0.98
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proc Natl Acad Sci U S A (1999) 0.94
Molecular cloning and identification of murine caspase-8. J Mol Biol (1998) 0.86
Induction of poly(ADP-ribose) polymerase gene expression in lectin-stimulated human T lymphocytes is dependent on protein synthesis. Biochem Biophys Res Commun (1988) 0.82
The role of caspases in T cell development and the control of immune responses. Cell Mol Life Sci (1998) 0.80
Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature (2001) 7.90
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science (1994) 2.92
Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor. Nature (1992) 1.81
Direct evidence for thymic function in adult humans. J Exp Med (1999) 1.70
A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II. J Exp Med (1998) 1.39
Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. J Exp Med (1995) 1.30
Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. EMBO J (1996) 1.28
Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state. J Immunol (2001) 1.27
Longitudinal assessment of changes in HIV-specific effector activity in HIV-infected patients starting highly active antiretroviral therapy in primary infection. J Immunol (2003) 1.25
Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding. Science (1994) 1.24
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med (2012) 1.23
Human T cells respond to mouse mammary tumor virus-encoded superantigen: V beta restriction and conserved evolutionary features. J Exp Med (1993) 1.21
Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule. EMBO J (1989) 1.20
Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J (2001) 1.17
Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J (1994) 1.04
Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes. Immunity (1999) 1.04
Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J Endocrinol (2003) 1.02
Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule. J Virol (1996) 1.02
Understanding the mechanism of action of bacterial superantigens from a decade of research. Immunol Rev (1999) 1.02
The T cell receptor V beta repertoire in HIV-1 infection and disease. Semin Immunol (1993) 1.00
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. J Exp Med (1997) 0.98
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J (1997) 0.98
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J Exp Med (1995) 0.97
Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on bone marrow-derived cells. Blood (1996) 0.97
T cell receptor-major histocompatibility complex class II interaction is required for the T cell response to bacterial superantigens. J Exp Med (1994) 0.94
Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors. J Immunol (1998) 0.93
Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity. Virology (1995) 0.92
Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules. J Exp Med (1994) 0.91
Molecular analysis of the cytoplasmic domain of CD4: overlapping but noncompetitive requirement for lck association and down-regulation by Nef. J Immunol (1996) 0.87
Learning to remember: generation and maintenance of T-cell memory. DNA Cell Biol (2001) 0.86
T-cell receptor recognition of superantigens: another view. Res Immunol (1993) 0.85
Interactions between staphylococcal superantigens and MHC class II molecules. Semin Immunol (1993) 0.85
HLA-DR polymorphism affects the interaction with CD4. J Exp Med (1995) 0.84
Superantigen-mediated deletion of specific T cell receptor V beta subsets in the SCID-hu Thy/Liv mouse is induced by staphylococcal enterotoxin B, but not HIV-1. J Immunol (1997) 0.84
Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain. J Immunol (1997) 0.82
Conserved structural features between HLA-DO beta and -DR beta. Mol Immunol (1998) 0.81
Evidence that the murine AIDS defective virus does not encode a superantigen. J Virol (1996) 0.81
CD4-mediated enhancement or inhibition of T cell activation does not require the CD4:p56lck association. J Exp Med (1994) 0.81
Binding of soluble recombinant HIV envelope glycoprotein, rgp120, induces conformational changes in the cellular membrane-anchored CD4 molecule. Biochem Biophys Res Commun (1999) 0.81
Highly biased CDR3 usage in restricted sets of beta chain variable regions during viral superantigen 9 response. J Exp Med (1998) 0.80
Structural aspects of CD4 and CD8 involvement in the cellular immune response. Cold Spring Harb Symp Quant Biol (1992) 0.80
The role of caspases in T cell development and the control of immune responses. Cell Mol Life Sci (1998) 0.80
A mutation of F47 to A in staphylococcus enterotoxin A activates the T-cell receptor Vbeta repertoire in vivo. Infect Immun (1997) 0.79
The processing routes determined by negatively charged residues in DR1-restricted T cell determinants. J Immunol (1997) 0.79
Design and implementation of a randomized crossover study of valproic acid and antiretroviral therapy to reduce the HIV reservoir. HIV Clin Trials (2012) 0.79
Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM. Proc Natl Acad Sci U S A (1997) 0.79
lck-independent inhibition of T cell antigen response by the HIV gp120. J Immunol (1998) 0.79
An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line. J Biol Chem (1996) 0.78
Generation of thymocyte subpopulations in organ culture: correlated analysis of Lyt-2 phenotype and cell cycle status by flow microfluorometry. J Immunol (1983) 0.77
Quantitative relationship between MHC class II-superantigen complexes and the balance of T cell activation versus death. J Immunol (2001) 0.77
CD4 and CD8 recognition of class II and class I molecules of the major histocompatibility complex. Semin Immunol (1991) 0.77
Comparative analysis of the T cell receptor V beta repertoire in various lymphoid tissues from HIV-infected patients: evidence for an HIV-associated superantigen. Leukemia (1994) 0.77
Alternative proteolytic processing of mouse mammary tumor virus superantigens. J Virol (2000) 0.77
Combination therapy for HIV: towards long term control of disease progression. Expert Opin Investig Drugs (1998) 0.75
Study of the T cell receptor repertoire in viral immunodeficiency disease. Springer Semin Immunopathol (1996) 0.75
Early expression of human CD4 delays thymic differentiation in transgenic mice. Res Immunol (1994) 0.75
T-cell receptor V beta-specific expansions in children from HIV-infected mothers. AIDS (1996) 0.75
Function of the thymus in HIV-infected adults. JAMA (1999) 0.75
Pentosan polysulfate, a potent anti HIV and anti tumor agent, inhibits protein serine/threonine and tyrosine kinases. Mol Cell Biochem (1993) 0.75