Published in Science on June 06, 1997
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun (2005) 6.31
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J (1997) 4.66
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell (2008) 3.64
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev (1999) 3.61
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J (1998) 3.03
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J Cell Biol (1998) 2.96
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol Cell Biol (1998) 2.92
Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48
Caspases and kinases in a death grip. Cell (2009) 2.47
Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells. J Virol (1998) 2.46
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol Cell Biol (1998) 1.87
Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell (1998) 1.87
Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. Proc Natl Acad Sci U S A (2001) 1.83
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med (1998) 1.74
Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J (1999) 1.71
Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J Cell Biol (1997) 1.60
Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol (2008) 1.57
Extranuclear apoptosis. The role of the cytoplasm in the execution phase. J Cell Biol (1999) 1.57
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A (1998) 1.56
Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Mol Cell Biol (2003) 1.49
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci U S A (1997) 1.48
Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol Cell Biol (1998) 1.40
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol Cell Biol (2000) 1.39
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell (2003) 1.37
Conformational switch and role of phosphorylation in PAK activation. Mol Cell Biol (2001) 1.37
Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc Natl Acad Sci U S A (1998) 1.36
p21-activated kinase 1 plays a critical role in cellular activation by Nef. Mol Cell Biol (2000) 1.35
Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. Proc Natl Acad Sci U S A (1998) 1.32
Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc Natl Acad Sci U S A (1998) 1.31
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Mol Cell Biol (2000) 1.31
pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A (2007) 1.28
Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. J Cell Biol (2000) 1.28
Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Mol Cell Biol (2000) 1.26
Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol Cell Biol (2003) 1.20
Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases. J Cell Biol (1997) 1.20
Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med (2001) 1.19
Lentivirus Nef specifically activates Pak2. J Virol (2000) 1.18
Negative control of the Myc protein by the stress-responsive kinase Pak2. Mol Cell Biol (2004) 1.14
Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J (2005) 1.14
Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4. Mol Cell Biol (2003) 1.13
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proc Natl Acad Sci U S A (2009) 1.13
Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. Proc Natl Acad Sci U S A (2006) 1.13
Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells. Br J Cancer (2002) 1.12
Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol Cell Biol (1999) 1.12
Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med (1998) 1.12
A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin. Proc Natl Acad Sci U S A (1998) 1.11
Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1. Proc Natl Acad Sci U S A (2001) 1.09
Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures. PLoS One (2008) 1.09
Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol Biol Cell (2009) 1.07
MST1 promotes apoptosis through phosphorylation of histone H2AX. J Biol Chem (2010) 1.07
Systematic identification of regulatory proteins critical for T-cell activation. J Biol (2003) 1.06
Antiapoptotic activity of the herpesvirus saimiri-encoded Bcl-2 homolog: stabilization of mitochondria and inhibition of caspase-3-like activity. J Virol (1998) 1.06
Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts. Int J Mol Sci (2008) 1.04
Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J Exp Med (2002) 1.04
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A (2000) 1.02
Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB. Mol Biol Cell (2004) 0.99
Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2. Mol Cell Biol (1999) 0.98
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J (1997) 0.98
Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. Prostate (2010) 0.97
Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK. Mol Cell Biol (2004) 0.95
Protection of epithelial cells by keratinocyte growth factor signaling. Proc Am Thorac Soc (2005) 0.95
Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J (1998) 0.92
Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein. Mol Cell Biol (2002) 0.91
Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells. Mol Cell Biol (2003) 0.90
The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology. Curr Trends Neurol (2011) 0.90
Inhibition of citrinin-induced apoptotic biochemical signaling in human hepatoma G2 cells by resveratrol. Int J Mol Sci (2009) 0.89
Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2. Biochem J (2000) 0.89
P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. Carcinogenesis (2010) 0.88
Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis. AAPS PharmSci (1999) 0.88
Huntingtin promotes cell survival by preventing Pak2 cleavage. J Cell Sci (2009) 0.87
Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome. Am J Pathol (2005) 0.86
Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells. Invest New Drugs (2007) 0.86
Roles of P21-activated kinases and associated proteins in epithelial wound healing. Int Rev Cell Mol Biol (2008) 0.85
Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Mol Cell Biol (2002) 0.85
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin. Cell Death Dis (2014) 0.85
A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure. Nat Commun (2015) 0.85
Multiple protein analysis of formalin-fixed and paraffin-embedded tissue samples with reverse phase protein arrays. Mol Cell Proteomics (2013) 0.84
Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase. Biochem J (2000) 0.83
Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex. J Virol (2005) 0.83
Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation. Cytotechnology (2000) 0.83
Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death. Neoplasia (2009) 0.82
Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol (2014) 0.82
Lycopene supplementation prevents reactive oxygen species mediated apoptosis in Sertoli cells of adult albino rats exposed to polychlorinated biphenyls. Interdiscip Toxicol (2013) 0.81
p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway. Mol Cell Biol (2015) 0.81
Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. Virus Res (2010) 0.80
Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34. Mamm Genome (2011) 0.80
Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. Ann Rheum Dis (1998) 0.79
Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells. Exp Hematol Oncol (2014) 0.79
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1. Mol Biol Cell (2013) 0.78
Group I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cells. PLoS One (2014) 0.78
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell (1994) 4.80
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
Regulation of receptor-mediated endocytosis by Rho and Rac. Nature (1996) 2.84
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol (2001) 2.45
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J Cell Biol (1997) 2.37
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem (1999) 2.36
A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35
Signal transduction and cytoskeletal activation in the neutrophil. Physiol Rev (1987) 2.34
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Biol (1997) 2.14
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J Biol Chem (2000) 2.12
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol (1998) 2.00
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol (1998) 1.99
p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem Sci (1999) 1.94
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J Biol Chem (1996) 1.74
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem (1992) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell (1996) 1.66
Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187. J Biol Chem (1980) 1.65
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
Biologically active lipids are regulators of Rac.GDI complexation. J Biol Chem (1993) 1.62
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. J Biol Chem (1994) 1.59
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes. J Cell Biol (1992) 1.52
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol (1991) 1.52
alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J Biol Chem (1999) 1.47
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J Biol Chem (2000) 1.47
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils. J Immunol (1991) 1.43
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A (1995) 1.38
Resolved phospholipase D activity is modulated by cytosolic factors other than Arf. J Biol Chem (1995) 1.37
Lateral segregation of neutrophil chemotactic receptors into actin- and fodrin-rich plasma membrane microdomains depleted in guanyl nucleotide regulatory proteins. J Cell Biol (1988) 1.28
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell (1993) 1.28
Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils. J Biol Chem (1998) 1.28
Human myosin-IXb is a mechanochemically active motor and a GAP for rho. J Cell Sci (1998) 1.27
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem (2000) 1.25
Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun (1998) 1.24
GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein. J Biol Chem (1993) 1.24
A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. J Biol Chem (1996) 1.23
Mechanisms of guanine nucleotide-mediated regulation of adenylate cyclase activity. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 1.22
Increased neutrophil respiratory burst in bcr-null mutants. Cell (1995) 1.19
Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells. J Biol Chem (1989) 1.16
De novo formation of focal complex-like structures in host cells by invading Streptococci. Mol Microbiol (2001) 1.15
Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain. J Biol Chem (1993) 1.15
p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I. Proc Natl Acad Sci U S A (1997) 1.15
p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J Immunol (1998) 1.14
Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42. J Biol Chem (1998) 1.14
Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi. J Biol Chem (1990) 1.14
Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol (1990) 1.13
Regulation of chemoattractant receptor interaction with transducing proteins by organizational control in the plasma membrane of human neutrophils. J Cell Biol (1989) 1.12
Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells. J Immunol (1998) 1.12
Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes. J Biol Chem (1981) 1.11
Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes. J Biol Chem (1994) 1.10
Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol (2001) 1.08
G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes. J Biol Chem (1995) 1.08
Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils. J Leukoc Biol (1999) 1.07
Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors. J Leukoc Biol (1995) 1.06
The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases. J Biol Chem (1996) 1.05
Regulation of ligand-receptor dynamics by guanine nucleotides. Real-time analysis of interconverting states for the neutrophil formyl peptide receptor. J Biol Chem (1987) 1.04
The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol Biol Cell (1997) 1.00
Interferon-gamma listericidal action is mediated by novel Rab5a functions at the phagosomal environment. J Biol Chem (2001) 0.99
Inhibition of the neutrophil oxidative response to a chemotactic peptide by inhibitors of arachidonic acid oxygenation. Biochem Biophys Res Commun (1979) 0.95
The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1. J Biol Chem (1996) 0.94
Regulation of NADPH oxidase activity by Rac GTPase activating protein(s). Mol Biol Cell (1993) 0.93
The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J (1992) 0.91
Stimulus-induced dissociation of alpha subunits of heterotrimeric GTP-binding proteins from the cytoskeleton of human neutrophils. Proc Natl Acad Sci U S A (1993) 0.91
Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes. Curr Top Microbiol Immunol (2005) 0.90
Rap1A antagonizes the ability of Ras and Ras-Gap to inhibit muscarinic K+ channels. J Biol Chem (1991) 0.89
Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein. Inhibition by pertussis toxin-catalyzed ADP ribosylation. J Biol Chem (1992) 0.89
The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity. J Biol Chem (1987) 0.88
Rho GTPases and leukocyte cytoskeletal regulation. Curr Opin Hematol (1997) 0.88
SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism. Biochem J (1994) 0.88
Expression and translocation of Rac2 in eosinophils during superoxide generation. Immunology (1999) 0.87
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes. J Biol Chem (1981) 0.86
Guanine nucleotide regulatory proteins as transducers of receptor-stimulated neutrophil activation. Int J Tissue React (1987) 0.86
Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells. J Leukoc Biol (1994) 0.85
Identification of rho as a substrate for botulinum toxin C3-catalyzed ADP-ribosylation. FEBS Lett (1989) 0.85
Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis. Cell Death Differ (2006) 0.84
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1. Structure (2000) 0.84
Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides. J Biol Chem (1994) 0.83
GTP binding proteins and signal transduction in the human neutrophil. Immunol Lett (1990) 0.83