Published in FEBS Lett on October 13, 1997
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell (1996) 8.25
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature (1996) 7.90
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature (1991) 5.90
Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell (1981) 5.81
Viral subversion of the immune system. Annu Rev Immunol (2000) 5.76
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol (1986) 4.30
The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell (1990) 4.18
Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50
Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell (1990) 3.44
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J (2001) 3.42
Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A (1983) 3.42
Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. Proc Natl Acad Sci U S A (1979) 3.29
Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc Natl Acad Sci U S A (1996) 3.17
The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol (1987) 3.09
Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity (1999) 3.01
Molecular cloning of a human histocompatibility antigen cDNA fragment. Proc Natl Acad Sci U S A (1980) 2.99
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity (1996) 2.93
The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity (1997) 2.93
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature (1987) 2.72
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell (1993) 2.43
Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J Immunol (1993) 2.40
The WD-40 repeat. FEBS Lett (1992) 2.37
Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J (1996) 2.26
Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J (2000) 2.24
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol (1995) 2.24
The alpha chain of the T cell antigen receptor is degraded in the cytosol. Immunity (1997) 2.20
Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol (1998) 2.16
HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Int Immunol (1990) 2.12
Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association. Eur J Immunol (1988) 2.03
Peptide selection by MHC class I molecules. Nature (1991) 2.01
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. EMBO J (1997) 1.98
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell (1993) 1.96
Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc Natl Acad Sci U S A (1979) 1.94
Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens. J Immunol (1981) 1.91
How MHC class II molecules reach the endocytic pathway. EMBO J (1995) 1.80
Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (1996) 1.76
Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest (1998) 1.76
A proteolytic system that compensates for loss of proteasome function. Nature (1998) 1.76
The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol (1999) 1.74
Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med (1994) 1.73
Peptide translocation by variants of the transporter associated with antigen processing. Science (1993) 1.71
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell (2001) 1.69
Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp Med (1994) 1.69
An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Hum Immunol (1986) 1.67
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc Natl Acad Sci U S A (2001) 1.60
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J Biol Chem (1993) 1.58
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol (1999) 1.58
Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. J Exp Med (1995) 1.57
Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature (1982) 1.56
Proteases involved in MHC class II antigen presentation. Immunol Rev (1999) 1.54
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol (2001) 1.52
The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. J Exp Med (1997) 1.51
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. Chem Biol (1998) 1.51
Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses. Eur J Immunol (1991) 1.51
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med (2000) 1.49
Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity (1998) 1.46
Purification, cDNA-cloning and expression of human diacylglycerol kinase. FEBS Lett (1990) 1.45
In vitro translation and assembly of a complete T cell receptor-CD3 complex. J Exp Med (1997) 1.45
Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: evolutionary aspects. Immunogenetics (1987) 1.41
Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. J Exp Med (1980) 1.39
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J Biol Chem (2000) 1.38
Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J Exp Med (1995) 1.38
Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37
The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proc Natl Acad Sci U S A (1999) 1.35
N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. J Exp Med (1990) 1.34
Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med (1994) 1.32
Proteolysis in MHC class II antigen presentation: who's in charge? Immunity (2000) 1.32
Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses. Eur J Immunol (1992) 1.30
Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. Mol Immunol (1998) 1.29
Altered natural killer cell repertoire in Tap-1 mutant mice. Proc Natl Acad Sci U S A (1994) 1.28
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med (1997) 1.25
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem (1993) 1.25
Intracellular transport of MHC class II molecules. Immunol Today (1992) 1.24
Intracellular targeting of the proteasome. Trends Cell Biol (2000) 1.24
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J (2001) 1.24
Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. J Exp Med (1998) 1.24
Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment. J Cell Biol (1995) 1.24
The eS-Sence of -SH in the ER. Cell (1998) 1.22
Peptide-induced stabilization and intracellular localization of empty HLA class I complexes. J Exp Med (1992) 1.22
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Mol Cell Neurosci (2008) 1.22
Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. J Virol (2001) 1.21
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon. Biochem J (1993) 1.20
An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting. Immunogenetics (1986) 1.19
Gene conversion-like mechanisms may generate polymorphism in human class I genes. EMBO J (1986) 1.17
HLA-restricted recognition of viral antigens in HLA transgenic mice. Nature (1987) 1.16
Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.15
Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein. J Virol (2001) 1.15
Characterization of a G-protein beta-subunit gene from the nematode Caenorhabditis elegans. J Mol Biol (1990) 1.11
Substrate specificity of allelic variants of the TAP peptide transporter. Immunity (1994) 1.10
Definition of four HLA-A2 subtypes by CML typing and biochemical analysis. Immunogenetics (1983) 1.08
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol (1995) 1.07
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proc Natl Acad Sci U S A (2000) 1.07
Virus subversion of immunity: a structural perspective. Curr Opin Immunol (2001) 1.06
Biosynthesis of murine immunoglobulin D: heterogeneity of glycosylation. Eur J Immunol (1982) 1.06
Viruses use stealth technology to escape from the host immune system. Mol Med Today (1997) 1.05
The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions. Eur J Immunol (1993) 1.02