Published in EMBO J on May 01, 1997
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J (1997) 2.28
The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. J Cell Biol (1997) 1.80
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48
Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell (1999) 1.25
Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J (2003) 1.21
Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol (2010) 1.11
Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules. Mol Cell Biol (1998) 1.10
Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Mol Biol Cell (2007) 1.08
Strong precursor-pore interactions constrain models for mitochondrial protein import. Biophys J (1998) 1.08
The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation. J Cell Biol (1999) 0.98
Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol (2011) 0.97
Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes. Front Genet (2015) 0.95
Reconstitution of the protein insertion machinery of the mitochondrial inner membrane. EMBO J (1997) 0.93
Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix. Int J Biochem Cell Biol (2009) 0.83
The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Int J Mol Sci (2009) 0.83
Mitochondrial membrane complex that contains proteins necessary for tRNA import in Trypanosoma brucei. J Biol Chem (2012) 0.80
Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50. Sci Adv (2017) 0.75
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Molecular chaperones in cellular protein folding. Nature (1996) 14.00
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J Biol Chem (1982) 12.07
Common principles of protein translocation across membranes. Science (1996) 7.00
Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells. Cell (1989) 6.38
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell (1995) 3.46
The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science (1994) 3.26
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome. J Cell Biol (1993) 2.65
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28
SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth. Proc Natl Acad Sci U S A (1987) 2.10
Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell (1996) 2.02
Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum. Mol Biol Cell (1993) 1.94
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. EMBO J (1996) 1.93
Mas37p, a novel receptor subunit for protein import into mitochondria. J Cell Biol (1995) 1.89
Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A (1994) 1.87
Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol (1993) 1.73
MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J Cell Biol (1993) 1.72
Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A (1992) 1.67
The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system. Cell (1995) 1.63
A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J (1994) 1.60
Partner proteins determine multiple functions of Hsp70. Trends Cell Biol (1995) 1.55
Dynamic interaction of the protein translocation systems in the inner and outer membranes of yeast mitochondria. EMBO J (1995) 1.54
A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation. Proc Natl Acad Sci U S A (1994) 1.51
Disruption of the outer membrane restores protein import to trypsin-treated yeast mitochondria. EMBO J (1987) 1.46
Import of cytochrome b2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci (1993) 1.45
The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol Cell Biol (1993) 1.43
The requirement of matrix ATP for the import of precursor proteins into the mitochondrial matrix and intermembrane space. Eur J Biochem (1994) 1.40
Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci (1996) 1.40
SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol Biol Cell (1994) 1.36
Protein import into yeast mitochondria: the inner membrane import site protein ISP45 is the MPI1 gene product. EMBO J (1993) 1.31
Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J (1996) 1.28
Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes. Mol Cell Biol (1994) 1.27
Role of ATP in the intramitochondrial sorting of cytochrome c1 and the adenine nucleotide translocator. EMBO J (1992) 1.24
Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett (1993) 1.22
The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria. EMBO J (1996) 1.21
Mitochondrial receptor complex from Neurospora crassa and Saccharomyces cerevisiae. Methods Enzymol (1995) 1.16
Post-translational protein translocation: not all hsc70s are created equal. Trends Biochem Sci (1996) 1.12
A matrix ATP requirement for presequence translocation across the inner membrane of mitochondria. J Biol Chem (1993) 1.11
The mitochondrial protein import machinery. Role of ATP in dissociation of the Hsp70.Mim44 complex. J Biol Chem (1995) 1.07
Mas6p can be cross-linked to an arrested precursor and interacts with other proteins during mitochondrial protein import. J Biol Chem (1993) 1.06
Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats. FEBS Lett (1996) 1.01
Functional and physical interactions of components of the yeast mitochondrial inner-membrane import machinery (MIM). Eur J Biochem (1995) 1.01
The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site. FEBS Lett (1994) 0.98
The sorting signal of cytochrome b2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70. EMBO J (1995) 0.97
The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. J Mol Biol (1996) 0.95
Nucleotide sequence of the origin of replication of the Escherichia coli K-12 chromosome. Proc Natl Acad Sci U S A (1979) 5.31
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12
Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature (1998) 3.77
Mitochondrial preprotein translocase. Annu Rev Cell Dev Biol (1997) 3.68
Mitochondrial protein import. Biochim Biophys Acta (1989) 3.66
The preprotein translocase of the mitochondrial inner membrane: function and evolution. J Mol Biol (1999) 3.57
A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol (2001) 3.06
Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature (1997) 2.88
Origin of replication, oriC, of the Escherichia coli K12 chromosome: genetic mapping and minichromosome replication. Cold Spring Harb Symp Quant Biol (1979) 2.85
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors. Cell (1987) 2.61
Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol (2001) 2.46
Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa. One gene codes for both the cytosolic and mitochondrial forms. J Biol Chem (1988) 2.43
Transport of F1-ATPase subunit beta into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett (1986) 2.33
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44. EMBO J (1997) 2.28
Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem (2000) 2.26
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol (2000) 2.21
Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J (1985) 2.19
MOM19, an import receptor for mitochondrial precursor proteins. Cell (1989) 2.18
Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences. J Biol Chem (1991) 2.17
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J (1992) 2.16
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J (2000) 2.08
Assaying protein import into mitochondria. Methods Cell Biol (2001) 2.04
Distinct steps in the import of ADP/ATP carrier into mitochondria. J Biol Chem (1987) 2.02
Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein. EMBO J (1984) 1.97
Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell (1992) 1.96
A mitochondrial import receptor for the ADP/ATP carrier. Cell (1990) 1.95
How do polypeptides cross the mitochondrial membranes? Cell (1990) 1.91
The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell (1999) 1.91
Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature (1990) 1.90
Mini-chromosomes: plasmids which carry the E. coli replication origin. Mol Gen Genet (1978) 1.90
Origin of replication, oriC, of the Escherichia coli K12 chromosome: nucleotide sequence. Cold Spring Harb Symp Quant Biol (1979) 1.89
Analysis of mitochondrial protein import using translocation intermediates and specific antibodies. Methods Cell Biol (1991) 1.81
A dynamic model of the mitochondrial protein import machinery. Cell (1992) 1.74
Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol (1993) 1.73
Import of ADP/ATP carrier into mitochondria: two receptors act in parallel. J Cell Biol (1990) 1.72
Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol (1998) 1.71
The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore. Cell (1993) 1.67
Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem (1997) 1.66
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J Cell Biol (2001) 1.65
Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep (2000) 1.64
Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett (1990) 1.60
The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J (2001) 1.60
Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates. Nature (1992) 1.56
Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature (1999) 1.56
Partner proteins determine multiple functions of Hsp70. Trends Cell Biol (1995) 1.55
Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53
Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem (1999) 1.52
Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site. J Cell Biol (1988) 1.52
Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J (1996) 1.51
Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem (1999) 1.50
Diagnostic tools to identify black aspergilli. Stud Mycol (2007) 1.49
Targeting of the master receptor MOM19 to mitochondria. Science (1991) 1.48
Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations. Anal Biochem (2000) 1.48
Site-directed mutagenesis of the Escherichia coli chromosome near oriC: identification and characterization of asnC, a regulatory element in E. coli asparagine metabolism. Nucleic Acids Res (1985) 1.45
Maintenance and incompatibility of plasmids carrying the replication origin of the Escherichia coli chromosome: evidence for a control region of replication between oriC and asnA. Nucleic Acids Res (1983) 1.44
The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol Cell Biol (1993) 1.43
Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria. J Biol Chem (1994) 1.42
Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci (1996) 1.40
Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence. Mol Biol Cell (2000) 1.39
Mitochondrial protein import. Bypass of proteinaceous surface receptors can occur with low specificity and efficiency. J Biol Chem (1989) 1.36
Insertion of MOM22 into the mitochondrial outer membrane strictly depends on surface receptors. FEBS Lett (1993) 1.35
The Tom and Tim machine. Curr Biol (1997) 1.34
Mechanisms of protein translocation into mitochondria. Biochim Biophys Acta (1999) 1.33
The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences. Mol Cell Biol (1997) 1.33
Dissection of promoter sequences involved in transcriptional activation of the Escherichia coli replication origin. Nucleic Acids Res (1986) 1.31
Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix. FEBS Lett (1990) 1.31
Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space. FEBS Lett (1991) 1.30
Cyclophilin 20 is involved in mitochondrial protein folding in cooperation with molecular chaperones Hsp70 and Hsp60. Mol Cell Biol (1995) 1.29
Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J (1996) 1.28
Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes. Mol Cell Biol (1994) 1.27
Efficient isolation of the linear DNA killer plasmid of Kluyveromyces lactis: evidence for location and expression in the cytoplasm and characterization of their terminally bound proteins. Nucleic Acids Res (1986) 1.27