Published in J Biol Chem on February 10, 1983
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen. Biochem J (1986) 2.50
Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase. Proc Natl Acad Sci U S A (1984) 1.96
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell (1999) 1.91
Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A (1986) 1.63
Ca2+-dependent and -independent release of neurotransmitters from PC12 cells: a role for protein kinase C activation? J Cell Biol (1984) 1.46
Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling. Biochem J (1987) 1.39
Evidence that nitric oxide is an endogenous antiangiogenic mediator. Br J Pharmacol (1994) 1.39
Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets. Biochem J (1985) 1.35
Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. J Cell Biol (1992) 1.34
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase. Proc Natl Acad Sci U S A (1985) 1.33
Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation. Biochem J (1984) 1.27
Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation. Proc Natl Acad Sci U S A (1984) 1.27
Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity. EMBO J (1986) 1.26
Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts. EMBO J (1985) 1.16
A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J (1987) 1.14
Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets. Biochem J (1984) 1.13
Signal transduction in human platelets and inflammatory mediator release induced by genetically cloned hemolysin-positive and -negative Escherichia coli strains. Infect Immun (1990) 1.05
Factors affecting dense and alpha-granule secretion from electropermeabilized human platelets: Ca(2+)-independent actions of phorbol ester and GTP gamma S. Cell Regul (1990) 1.02
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. J Cell Biol (1987) 1.01
Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids. Proc Natl Acad Sci U S A (1992) 1.00
Properties and distribution of the protein inhibitor (Mr 17,000) of protein kinase C. Biochem J (1987) 0.99
Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells. Biochem J (1987) 0.96
Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J (1991) 0.95
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation. Biochem J (1992) 0.95
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Characterization of bovine aortic protein kinase C with histone and platelet protein P47 as substrates. Biochem J (1988) 0.91
Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets. Biochem J (1984) 0.91
Activation of protein kinase in the bovine corpus luteum by phospholipid and Ca2+. Biochem J (1983) 0.87
Activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid. Proc Natl Acad Sci U S A (1983) 0.87
Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein. Biochem J (1990) 0.86
Modulation of human platelet protein kinase C by endotoxic lipid A. J Clin Invest (1988) 0.86
Reciprocal transmembranous receptor-cytoskeleton interactions in concanavalin A-activated platelets. J Cell Biol (1985) 0.85
Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family? J Biomed Sci (2010) 0.85
Developmental studies of phospholipid-sensitive Ca2+-dependent protein kinase and its substrates and of phosphoprotein phosphatases in rat brain. Proc Natl Acad Sci U S A (1984) 0.83
Translocation-independent activation of protein kinase C by platelet-activating factor, thrombin and prostacyclin. Lack of correlation with polyphosphoinositide hydrolysis in rabbit platelets. Biochem J (1990) 0.82
Induction of inflammatory mediator release (serotonin and 12-hydroxyeicosatetraenoic acid) from human platelets by Pseudomonas aeruginosa glycolipid. Infect Immun (1992) 0.80
Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C. Biochem J (1996) 0.80
Chemical cross-linking of pleckstrin in human platelets: evidence for oligomerization of the protein and its dissociation by protein kinase C. Biochem J (1996) 0.80
Potentiation of specific association of insulin with HepG2 cells by phorbol esters. Biochem J (1986) 0.79
The role of the phosphatidylinositol turnover in 12-hydroxyeicosatetraenoic acid generation from human platelets by Escherichia coli alpha-haemolysin, thrombin and fluoride. Immunology (1993) 0.79
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J (1991) 0.79
Induction of the 47 kDa platelet substrate of protein kinase C during differentiation of HL-60 cells. Biochem J (1987) 0.78
Effect of gastric secretagogues on the formation of inositol phosphates in isolated gastric cells of the rat. Br J Pharmacol (1987) 0.78
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. Br J Pharmacol (1984) 0.77
The effects of 1-oleoyl-2-acetylglycerol on platelet protein phosphorylation and platelet ultrastructure. Am J Pathol (1985) 0.77
The inhibition of human platelet function by ganodermic acids. Biochem J (1991) 0.75
Effect of hexadecane on protein kinase C of pig epidermis. Arch Dermatol Res (1987) 0.75
Aggregation and/or oxygenated products of arachidonic acid are not required for collagen-induced deacylation of phosphatidylcholine in human platelets. Biochem J (1989) 0.75
Calcium- and cyclic AMP-regulated protein kinases of bovine central-nervous-system myelin. Biochem J (1984) 0.75
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Studies and perspectives of protein kinase C. Science (1986) 14.73
Turnover of inositol phospholipids and signal transduction. Science (1984) 5.76
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem (1980) 5.08
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Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med (1989) 4.20
The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem (1988) 4.15
Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem (1979) 4.12
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Binding of neuroligins to PSD-95. Science (1997) 3.88
Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J Cell Biol (1993) 3.87
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J Biol Chem (1968) 3.81
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem (1982) 3.64
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem (1983) 3.60
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Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci U S A (1989) 3.21
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem (1997) 3.08
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Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun (1979) 2.96
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Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
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Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
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Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.77
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci U S A (1989) 2.72
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol (1993) 2.71
The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem (1989) 2.70
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Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med (1982) 2.52
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Randomized comparison of ultrasonic vs clamp transection of the liver. Arch Surg (2001) 2.25
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Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A (1999) 2.04
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