Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12.

PubWeight™: 2.31‹?› | Rank: Top 2%

🔗 View Article (PMID 9461216)

Published in Nature on January 29, 1998

Authors

W Shou1, B Aghdasi, D L Armstrong, Q Guo, S Bao, M J Charng, L M Mathews, M D Schneider, S L Hamilton, M M Matzuk

Author Affiliations

1: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.

Articles citing this

mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci (2009) 5.04

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88

Calreticulin is essential for cardiac development. J Cell Biol (1999) 2.88

Calcium and arrhythmogenesis. Physiol Rev (2007) 2.76

A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A (2002) 2.53

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50

Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A (1998) 2.49

Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol (2004) 2.01

Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev (2003) 1.84

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron (2008) 1.80

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol (2003) 1.78

Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. EMBO J (2000) 1.54

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 1.49

Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis. Plant Physiol (2004) 1.47

Protein-protein interactions in intracellular Ca2+-release channel function. Biochem J (1999) 1.43

Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii. Plant Physiol (2005) 1.40

TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med (2007) 1.30

Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest (2008) 1.24

SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell (2009) 1.23

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle. Proc Natl Acad Sci U S A (2001) 1.19

Paradoxical SR Ca2+ release in guinea-pig cardiac myocytes after beta-adrenergic stimulation revealed by two-photon photolysis of caged Ca2+. J Physiol (2005) 1.19

A chloroplast FKBP interacts with and affects the accumulation of Rieske subunit of cytochrome bf complex. Proc Natl Acad Sci U S A (2002) 1.19

Smad7 is required for the development and function of the heart. J Biol Chem (2008) 1.18

Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell (2004) 1.08

The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Plant Physiol (2004) 1.07

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor. Biochem J (2001) 1.05

FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor. Biophys J (2002) 1.05

Analysis of ventricular hypertrabeculation and noncompaction using genetically engineered mouse models. Pediatr Cardiol (2009) 1.04

TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol (2003) 1.02

FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res (2011) 0.99

Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. J Am Heart Assoc (2012) 0.98

Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Comp Funct Genomics (2005) 0.97

Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC). Am J Med Genet C Semin Med Genet (2013) 0.96

Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem (2011) 0.96

Frontier of epilepsy research - mTOR signaling pathway. Exp Mol Med (2011) 0.95

Expression and functional characterization of the cardiac muscle ryanodine receptor Ca(2+) release channel in Chinese hamster ovary cells. Biophys J (1999) 0.92

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res (2009) 0.92

Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family. Proc Natl Acad Sci U S A (2003) 0.92

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells. Proc Natl Acad Sci U S A (2003) 0.91

Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics (1999) 0.90

A new syndrome with noncompaction cardiomyopathy, bradycardia, pulmonary stenosis, atrial septal defect and heterotaxy with suggestive linkage to chromosome 6p. Hum Genet (2007) 0.88

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6. PLoS One (2012) 0.87

Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires. BMC Genomics (2006) 0.87

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development (2013) 0.86

Analysing the visible conformational substates of the FK506-binding protein FKBP12. Biochem J (2013) 0.86

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol (2000) 0.85

Systolic-diastolic coupling of myocardial deformation of the left ventricle in children with left ventricular noncompaction. Heart Vessels (2010) 0.85

Cell cycle regulation to repair the infarcted myocardium. Heart Fail Rev (2003) 0.84

Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis. Cardiovasc Res (2014) 0.84

14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol (2012) 0.83

FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury. J Appl Physiol (1985) (2008) 0.83

Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells. Invest Ophthalmol Vis Sci (2008) 0.82

Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. J Am Soc Nephrol (2015) 0.81

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochem J (2003) 0.81

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev Dyn (2011) 0.80

Structural basis of conformational transitions in the active site and 80's loop in the FK506-binding protein FKBP12. Biochem J (2014) 0.80

Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype. Int J Biol Sci (2015) 0.79

Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem (2014) 0.78

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol (2016) 0.78

Statistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain. Biophys Chem (2014) 0.77

Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system. Biol Open (2013) 0.77

Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency. BMB Rep (2013) 0.77

Probing early heart development to instruct stem cell differentiation strategies. Dev Dyn (2016) 0.76

The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function. Pediatr Cardiol (2012) 0.76

Compacting the heart with Notch. Nat Med (2013) 0.75

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. MBio (2016) 0.75

Myosin heavy chain 15 is associated with bovine pulmonary arterial pressure. Pulm Circ (2014) 0.75

Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. World J Stem Cells (2015) 0.75

FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation. Biophys J (2014) 0.75

A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy. J Negat Results Biomed (2012) 0.75

A simple and efficient route to the FKBP-binding domain from rapamycin. Tetrahedron Lett (2011) 0.75

FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: insights from new functional and structural knowledge. Channels (Austin) (2017) 0.75

Murine Electrophysiological Models of Cardiac Arrhythmogenesis. Physiol Rev (2017) 0.75

Articles by these authors

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science (2001) 5.93

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest (1997) 5.19

Social amnesia in mice lacking the oxytocin gene. Nat Genet (2000) 4.52

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38

Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature (1996) 4.34

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20

Math1 is essential for genesis of cerebellar granule neurons. Nature (1997) 4.16

Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69

Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol (2001) 2.91

Persistent and specific influences of early acoustic environments on primary auditory cortex. Nat Neurosci (2001) 2.75

The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science (1994) 2.53

Genetic dissection of cardiac growth control pathways. Annu Rev Physiol (2000) 2.41

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development (1999) 2.35

Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc Natl Acad Sci U S A (1996) 2.31

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate. Nature (1991) 2.30

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med (2000) 2.29

Anti-Müllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology (2001) 2.28

Cyclin A1 is required for meiosis in the male mouse. Nat Genet (1998) 2.28

Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes. J Clin Invest (1990) 2.25

Escherichia coli type-1 topoisomerases: identification, mechanism, and role in recombination. Cold Spring Harb Symp Quant Biol (1983) 2.22

Hypoxia inducible factors in cancer stem cells. Br J Cancer (2010) 2.21

A tyrosyl-tRNA synthetase can function similarly to an RNA structure in the Tetrahymena ribozyme. Nature (1994) 2.16

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol (2000) 2.14

Paracrine actions of growth differentiation factor-9 in the mammalian ovary. Mol Endocrinol (1999) 2.08

Functional anatomy of macaque striate cortex. II. Retinotopic organization. J Neurosci (1988) 2.00

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. Proc Natl Acad Sci U S A (1996) 1.96

Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein. Circ Res (2001) 1.93

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev (1994) 1.91

Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Nat Struct Biol (1995) 1.90

Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation. J Biol Chem (2001) 1.89

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia (2011) 1.87

Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol (1996) 1.83

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Natl Acad Sci U S A (2001) 1.83

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res (1998) 1.82

Optimized single-slab three-dimensional spin-echo MR imaging of the brain. Radiology (2000) 1.82

Identification of calcium release-triggering and blocking regions of the II-III loop of the skeletal muscle dihydropyridine receptor. J Biol Chem (1995) 1.78

Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel. Mol Pharmacol (1990) 1.77

A topographic gradient of molecules in retina can be used to identify neuron position. Proc Natl Acad Sci U S A (1981) 1.77

Death by design. Programmed cell death in cardiovascular biology and disease. Circ Res (1997) 1.76

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev (1996) 1.75

The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol (1998) 1.72

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist. J Biol Chem (1988) 1.72

The "atheroprotective" mediators apolipoprotein A-I and Foxp3 are over-abundant in unstable carotid plaques. Int J Cardiol (2009) 1.69

Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes. J Mol Endocrinol (2001) 1.69

Somatostatin stimulates Ca(2+)-activated K+ channels through protein dephosphorylation. Nature (1991) 1.68

Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Neuron (1996) 1.67

Evidence of increasing coronary heart disease mortality among black men of lower social class. Ann Epidemiol (1999) 1.67

Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol Endocrinol (1999) 1.64

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain. J Biol Chem (1993) 1.63

Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod (2004) 1.63

Symptomatic hyponatremia in rats: effect of treatment on mortality and brain lesions. Am J Physiol (1989) 1.63

Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel. J Biol Chem (1994) 1.62

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest (1997) 1.62

Determinants for calmodulin binding on voltage-dependent Ca2+ channels. J Biol Chem (2000) 1.61

Functional anatomy of macaque striate cortex. V. Spatial frequency. J Neurosci (1988) 1.61

Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse. Horm Behav (2000) 1.59

Percutaneous hot saline injection therapy for hepatic tumors: an alternative to percutaneous ethanol injection therapy. Radiology (1994) 1.56

Matching glass-forming ability with the density of the amorphous phase. Science (2008) 1.55

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med (2001) 1.55

Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A (2000) 1.54

Autonomous expression of c-myc in BC3H1 cells partially inhibits but does not prevent myogenic differentiation. Mol Cell Biol (1987) 1.52

Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology (1998) 1.52

Regulation of RYR1 activity by Ca(2+) and calmodulin. Biochemistry (2000) 1.52

Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell (1995) 1.51

Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. J Clin Invest (1993) 1.51

Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. Mol Cell Biol (2005) 1.48

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. J Biol Chem (1994) 1.46

Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. J Neurosci (1996) 1.46

Recombination site selection by Tn3 resolvase: topological tests of a tracking mechanism. Cell (1985) 1.46

Gonadotropin beta subunits determine the rate of assembly and the oligosaccharide processing of hormone dimer in transfected cells. J Cell Biol (1987) 1.46

Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutions. J Biol Chem (2001) 1.46

Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation. J Neurosci (1998) 1.46

p21 Ras as a governor of global gene expression. J Biol Chem (1994) 1.43

Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J (1999) 1.43

Disulfide bond cross-linked dimer in acetylcholine receptor from Torpedo californica. Biochem Biophys Res Commun (1977) 1.41

A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol (2000) 1.40

Reversible encephalopathy and seizures as a result of conventional vincristine administration. Med Pediatr Oncol (1988) 1.40

Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Mol Endocrinol (1998) 1.40

Spontaneous mesangiocapillary glomerulonephritis in Finn cross lambs from Alberta. Can J Comp Med (1984) 1.39

Role of the inositol 1,4,5-trisphosphate receptor in Ca(2+) feedback inhibition of calcium release-activated calcium current (I(crac)). J Biol Chem (1999) 1.39

Thermodynamics of G-tetraplex formation by telomeric DNAs. Biochemistry (1993) 1.38

Calcium binding to calmodulin leads to an N-terminal shift in its binding site on the ryanodine Receptor. J Biol Chem (2000) 1.38

Structure and stability of sodium and potassium complexes of dT4G4 and dT4G4T. Biochemistry (1992) 1.37

Large tunable Rashba spin splitting of a two-dimensional electron gas in Bi2Se3. Phys Rev Lett (2011) 1.37

Artificial airways. Resuscitation guidelines you can follow. Nursing (1992) 1.37

Smad5 is required for mouse primordial germ cell development. Mech Dev (2001) 1.34

Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo. Peptides (2004) 1.34

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proc Natl Acad Sci U S A (1997) 1.33

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet (2000) 1.33

Functional anatomy of macaque striate cortex. I. Ocular dominance, binocular interactions, and baseline conditions. J Neurosci (1988) 1.32

Characterization of oocyte and follicle development in growth differentiation factor-9-deficient mice. Dev Biol (1998) 1.31

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. Nature (1993) 1.31

Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases. Oncogene (2007) 1.30

Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev (1998) 1.30