A leptin missense mutation associated with hypogonadism and morbid obesity.

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🔗 View Article (PMID 9500540)

Published in Nat Genet on March 01, 1998

Authors

A Strobel, T Issad, L Camoin, M Ozata, A D Strosberg

Associated clinical trials:

Effects of Human Leptin Replacement | NCT00657605

Effects of Leptin Replacement in Children | NCT00659828

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Characterization, serological specificity, and diagnostic possibilities of monoclonal antibodies against Legionella pneumophila. J Clin Microbiol (1983) 1.12

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beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody. Proc Natl Acad Sci U S A (1985) 1.11

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Redistribution of muscarinic acetylcholine receptors on human fibroblasts induced by regulatory ligands. Biol Cell (1987) 1.06

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Effector-dependent conformational changes in protein kinase C gamma through epitope mapping with inhibitory monoclonal antibodies. Eur J Biochem (1990) 1.05

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Molecular basis of insulin action. Diabetes Metab (1998) 1.04

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Common ancestor for concanavalin A and lentil lectin? Proc Natl Acad Sci U S A (1978) 0.98

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Woodhouse and Sakati syndrome (MIM 241080): report of a new patient. Clin Dysmorphol (2000) 0.97

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Transformation by simian virus 40 of spleen cells from a hyperimmune rabbit: evidence for synthesis of immunoglobulin by the transformed cells. Proc Natl Acad Sci U S A (1974) 0.95

Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck. J Biol Chem (1993) 0.95

Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. J Gen Virol (2010) 0.94

Dopamine D4 receptor gene variation impacts self-reported altruism. Mol Psychiatry (2012) 0.94