Published in Proc Natl Acad Sci U S A on October 01, 1991
The A(2A)-adenosine receptor: a GPCR with unique features? Br J Pharmacol (2008) 1.29
Gsalpha-selective G protein antagonists. Proc Natl Acad Sci U S A (1998) 1.24
Expression of a rat neurotensin receptor in Escherichia coli. Biochem J (1993) 1.23
Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors. Br J Pharmacol (1995) 1.09
Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. J Biol Chem (2013) 0.96
Topological analysis of the human beta 2-adrenergic receptor expressed in Escherichia coli. Proc Natl Acad Sci U S A (1994) 0.90
Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C. Biochem J (1992) 0.88
Reengineering the collision coupling and diffusion mode of the A2A-adenosine receptor: palmitoylation in helix 8 relieves confinement. J Biol Chem (2012) 0.81
Binding and structure-activity-relation of benzo[f]isoquinoline- and norcodeinone-derivatives at mu-opioid receptors in the rat cerebral cortex. Br J Pharmacol (1993) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Diversity of G proteins in signal transduction. Science (1991) 7.41
Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 4.66
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61
Molecular characterization of the human beta 3-adrenergic receptor. Science (1989) 4.13
Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem (1980) 3.79
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
G proteins control diverse pathways of transmembrane signaling. FASEB J (1989) 2.21
Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem (1977) 2.20
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. J Biol Chem (1989) 1.75
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem (1989) 1.73
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J Biol Chem (1990) 1.69
Signal sorting and amplification through G protein-coupled receptors. Neuron (1989) 1.63
Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. Proc Natl Acad Sci U S A (1987) 1.62
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell. J Biol Chem (1979) 1.52
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science (1989) 1.39
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. Proc Natl Acad Sci U S A (1982) 1.39
Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. J Biol Chem (1990) 1.29
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem (1986) 1.27
Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors. J Pharmacol Exp Ther (1986) 1.06
The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols. J Biol Chem (1987) 1.06
Expression of three human beta-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells. Eur J Biochem (1991) 1.05
Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding. Biochem J (1991) 0.93
Differences in the GTP-regulation of membrane-bound and solubilized A1-adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol (1989) 0.91
Evidence for two specific affinity states of 3H-antagonist binding to cardiac beta-adrenergic receptors and influence of Gpp(NH)p. J Cyclic Nucleotide Protein Phosphor Res (1985) 0.90
Model testing in radioligand/receptor interaction by Monte Carlo simulation. J Recept Res (1983) 0.89
Localization and characterization of three different beta-adrenergic receptors expressed in Escherichia coli. Eur J Biochem (1990) 0.82
Molecular characterization of the human beta 3-adrenergic receptor. Science (1989) 4.13
A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet (1998) 2.68
Tissue distribution of beta 3-adrenergic receptor mRNA in man. J Clin Invest (1993) 2.16
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (1995) 1.99
Role of transforming growth factor beta type II receptor in hepatic fibrosis: studies of human chronic hepatitis C and experimental fibrosis in rats. Hepatology (1999) 1.90
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med (1995) 1.88
Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor. Nature (1982) 1.83
Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase. Proc Natl Acad Sci U S A (1980) 1.80
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet (2001) 1.79
A rabbit with the allotypic phenotype: ala2a3 b4b5b6. J Immunol (1974) 1.77
The human beta 3-adrenoceptor: the search for a physiological function. Trends Pharmacol Sci (1994) 1.76
Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol (2001) 1.75
Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles. Eur J Cell Biol (1989) 1.71
Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J (1991) 1.65
Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. Proc Natl Acad Sci U S A (1987) 1.62
ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J Immunol (1998) 1.56
Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol (1994) 1.55
Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J Biol Chem (1994) 1.46
Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest (1990) 1.44
[The basics of catecholamine therapy. 2. A guide to clinical use]. Anasthesiol Intensivmed Notfallmed Schmerzther (2000) 1.43
Different sites of adenosine formation in the heart. Am J Physiol (1981) 1.39
Evidence for reversible microclustering of lentil lectin membrane receptors on HeLa cells. FEBS Lett (1980) 1.34
The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization. Mol Pharmacol (1993) 1.31
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem (1997) 1.30
Evidence for a functional beta 3-adrenoceptor in man. Br J Pharmacol (1993) 1.27
The human carcinoma cell line A431 possesses large numbers of functional beta-adrenergic receptors. FEBS Lett (1984) 1.25
Comparison of the N-terminal sequences of aspartate and ornithine carbamoyltransferases of Escherichia coli. FEBS Lett (1977) 1.23
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. Biochem J (1997) 1.22
Nitric oxide and endothelin secretion by brain microvessel endothelial cells: regulation by cyclic nucleotides. J Cell Physiol (1993) 1.20
Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor. J Biol Chem (1991) 1.19
"Antibodies raised against beta-adrenergic receptors stimulate adenylate cyclase". Biochem Biophys Res Commun (1981) 1.18
Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity. Int J Obes Relat Metab Disord (2001) 1.17
Structural and conformational features determining selective signal transduction in the beta 3-adrenergic receptor. Mol Pharmacol (1993) 1.17
Extensive sequence homologies among lectins from leguminous plants. Biochem Biophys Res Commun (1977) 1.17
Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet (1997) 1.16
Mediation of most atypical effects by species homologues of the beta 3-adrenoceptor. Br J Pharmacol (1994) 1.15
Molecular characterization of salt-stress-associated protein in citrus: protein and cDNA sequence homology to mammalian glutathione peroxidases. Plant Mol Biol (1993) 1.15
Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart. Biochem J (1981) 1.14
Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines. J Pharmacol Exp Ther (1994) 1.14
Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms. Am J Respir Cell Mol Biol (1999) 1.13
Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography. Proc Natl Acad Sci U S A (1977) 1.13
Pelvic urine composition as a determinant of inner medullary solute concentration and urine osmolarity. Pflugers Arch (1972) 1.13
Characterization, serological specificity, and diagnostic possibilities of monoclonal antibodies against Legionella pneumophila. J Clin Microbiol (1983) 1.12
Substituting selenocysteine for catalytic cysteine 41 enhances enzymatic activity of plant phospholipid hydroperoxide glutathione peroxidase expressed in Escherichia coli. J Biol Chem (2000) 1.12
Expression of the target receptor CD33 in CD34+/CD38-/CD123+ AML stem cells. Eur J Clin Invest (2007) 1.11
beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody. Proc Natl Acad Sci U S A (1985) 1.11
Evidence for essential disulfide bonds in beta1-adrenergic receptors of turkey erythrocyte membranes. Inactivation by dithiothreitol. J Biol Chem (1979) 1.10
Impact of hemoglobin level and use of recombinant erythropoietin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx. Int J Radiat Oncol Biol Phys (2001) 1.10
Functional identification of adenylate cyclase-coupled adenosine receptors in rat brain microvessels. Eur J Pharmacol (1982) 1.09
The production and characterization of antibodies against beta-adrenergic antagonists. Biochem Pharmacol (1978) 1.09
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Mol Endocrinol (1999) 1.09
Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors. Br J Pharmacol (1995) 1.09
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Mol Cell Endocrinol (2006) 1.08
Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother Oncol (1999) 1.08
Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits. J Biol Chem (1992) 1.08
Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors. Clin Exp Immunol (1989) 1.07
Redistribution of muscarinic acetylcholine receptors on human fibroblasts induced by regulatory ligands. Biol Cell (1987) 1.06
Overexpression of transcription factor Ets-1 in rheumatoid arthritis synovial membrane: regulation of expression and activation by interleukin-1 and tumor necrosis factor alpha. Arthritis Rheum (2001) 1.06
Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3'-5'-monophosphate pathway. Biochem Pharmacol (1999) 1.06
Human beta 2-adrenergic receptors expressed in Escherichia coli membranes retain their pharmacological properties. Proc Natl Acad Sci U S A (1988) 1.05
Effector-dependent conformational changes in protein kinase C gamma through epitope mapping with inhibitory monoclonal antibodies. Eur J Biochem (1990) 1.05
Expression of three human beta-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells. Eur J Biochem (1991) 1.05
New molecular and structural determinants involved in beta 2-adrenergic receptor desensitization and sequestration. Delineation using chimeric beta 3/beta 2-adrenergic receptors. J Biol Chem (1996) 1.04
The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res (1997) 1.04
Localisation of three epitopes of the env protein of feline immunodeficiency virus. Mol Immunol (1992) 1.03
Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation. Mol Pharmacol (1999) 1.03
G protein antagonists. Trends Pharmacol Sci (1999) 1.03
Perioperative risk of bradyarrhythmias in patients with asymptomatic chronic bifascicular block or left bundle branch block: does an additional first-degree atrioventricular block make any difference? Anesthesiology (1998) 1.02
Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis. J Biol Chem (1999) 1.02
Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. J Immunol (2000) 1.02
Adenosine receptor agonists: binding and adenylate cyclase stimulation in rat liver plasma membranes. Naunyn Schmiedebergs Arch Pharmacol (1982) 1.00
Restricted rabbit antibodies: amino acid sequences of rabbit H chains of allotype a1, a2, and a3 in the region 80 to 94. J Immunol (1973) 0.99
Changes in intrinsic circular dichroism of several homogeneous anti-type 3 pneumococcal antibodies on binding of a small hapten. Proc Natl Acad Sci U S A (1972) 0.99
In vitro degradation of the C-terminal octapeptide of cholecystokinin by 'enkephalinase A'. FEBS Lett (1983) 0.99
Differential regulation of beta 1- and beta 2-adrenergic receptor protein and mRNA levels by glucocorticoids during 3T3-F442A adipose differentiation. J Biol Chem (1990) 0.99
Elevated procaspase levels in human melanoma. Melanoma Res (2001) 0.99
The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity. Eur J Biochem (1997) 0.98
Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an alpha 2-adrenergic receptor causes activation of both Gi2 and Gi3. Biochem J (1992) 0.98
Anti-idiotype and anti-hormone receptor antibodies. Springer Semin Immunopathol (1983) 0.98
The amino-terminal sequence of the 40,000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata. FEBS Lett (1979) 0.98
Common ancestor for concanavalin A and lentil lectin? Proc Natl Acad Sci U S A (1978) 0.98
Perioperative transcutaneous pacemaker in patients with chronic bifascicular block or left bundle branch block and additional first-degree atrioventricular block. Acta Anaesthesiol Scand (1999) 0.98
Serological diagnosis of feline immunodeficiency virus infection based on synthetic peptides from Env glycoproteins. Res Virol (1993) 0.97
Combined radiochemotherapy of locally advanced unresectable pancreatic adenocarcinoma with mitomycin C plus 24-hour continuous infusional gemcitabine. Int J Radiat Oncol Biol Phys (2001) 0.97
Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med (1998) 0.97
Purification of muscarinic acetylcholine receptors by affinity chromatography. EMBO J (1983) 0.97