Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.

Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol (2009) 4.07

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol (2003) 2.58

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev (2004) 2.16

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev (2011) 2.06

Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength. J Cell Biol (2002) 1.83

p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J Cell Biol (1999) 1.70

Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64

Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation. Proc Natl Acad Sci U S A (2001) 1.63

Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol (2002) 1.48

A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J Cell Biol (2001) 1.43

Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A (2006) 1.39

Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol Cell Biol (2003) 1.33

E-cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol Biol Cell (2007) 1.33

Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms. Proc Natl Acad Sci U S A (2005) 1.29

H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J Cell Biol (1999) 1.26

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts. Mol Biol Cell (2000) 1.26

Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell (2005) 1.23

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol (2004) 1.20

Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19

Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol (2004) 1.17

Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype. EMBO Rep (2005) 1.11

Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation. J Biol Chem (2006) 1.09

The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. PLoS One (2008) 1.07

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet (2012) 1.04

Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab (2012) 1.03

p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cells. Mol Biol Cell (2003) 1.02

Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell (2010) 0.97

Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription. Biochem J (1999) 0.96

Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers. J Biol Chem (2009) 0.95

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS One (2012) 0.93

Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best Pract Res Clin Endocrinol Metab (2013) 0.93

Small GTPases and regulation of cadherin dependent cell-cell adhesion. Mol Pathol (1999) 0.92

Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS One (2010) 0.92

Regulation of adherens junction dynamics by phosphorylation switches. J Signal Transduct (2012) 0.92

The importance of keeping in touch: regulation of cell-cell contact in the exocrine pancreas. Gut (2005) 0.91

Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol (2005) 0.91

An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Mol Biol Cell (2015) 0.89

The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol (2011) 0.89

C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics. Adv Exp Med Biol (2012) 0.88

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane. Cell Adh Migr (2011) 0.88

Cell-cell contact preserves cell viability via plakoglobin. PLoS One (2011) 0.87

FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines. Br J Cancer (2001) 0.87

Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development. Dev Dyn (2013) 0.83

Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Histochem Cell Biol (2013) 0.81

Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget (2015) 0.79

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo. Mol Neurodegener (2016) 0.79

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators Inflamm (2015) 0.78

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. Sci Rep (2016) 0.78

Palmitoylation of plakophilin is required for desmosome assembly. J Cell Sci (2014) 0.78

Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes. J Dermatol Sci (2013) 0.77

Phosphorylation and isoform use in p120-catenin during development and tumorigenesis. Biochim Biophys Acta (2015) 0.77

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep (2015) 0.77

Expression of N-terminal truncated desmoglein 3 (deltaNDg3) in epidermis and its role in keratinocyte differentiation. Exp Mol Med (2009) 0.77

Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells. Med Mol Morphol (2015) 0.76

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin. Oncotarget (2016) 0.76

Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair. Mol Biol Cell (2016) 0.76

Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells. BMC Cell Biol (2013) 0.75

Characterization of partially lifted cell sheets. Tissue Eng Part A (2014) 0.75

Electroporation-mediated delivery of the FER gene in the resolution of trauma-related fatal pneumonia. Gene Ther (2016) 0.75

Characterisation of the cancer-associated glucocorticoid system: key role of 11β-hydroxysteroid dehydrogenase type 2. Br J Cancer (2017) 0.75

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

Cadherin cell adhesion receptors as a morphogenetic regulator. Science (1991) 13.78

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem (1996) 10.08

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J (1989) 10.05

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development (1988) 8.84

Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell (1980) 8.10

Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J (1988) 7.98

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A (1995) 5.54

The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell (1991) 5.27

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U S A (1990) 5.25

Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev (1996) 5.20

The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol (1997) 5.15

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol (1995) 4.60

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol (1994) 4.46

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J Cell Biol (1992) 4.12

Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J Cell Biol (1995) 3.86

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell (1992) 3.70

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol (1994) 3.66

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J (1993) 3.06

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99

Signal transduction of beta-catenin. Curr Opin Cell Biol (1995) 2.96

Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes Commun (1994) 2.87

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol (1995) 2.56

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene (1992) 2.49

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell (1997) 2.44

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell (1997) 2.33

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol (1995) 2.32

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev (1994) 2.28

A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated. Cell Adhes Commun (1994) 2.27

Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay. J Cell Biol (1996) 2.20

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene. Genes Dev (1989) 2.17

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Mol Cell Biol (1991) 2.12

Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin. J Biol Chem (1996) 2.07

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol (1994) 2.05

The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol (1995) 1.96

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift. J Cell Biol (1995) 1.92

Cytoskeleton-membrane interactions. Curr Opin Cell Biol (1996) 1.83

Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage. Cell (1993) 1.78

beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol (1996) 1.70

The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp Cell Res (1996) 1.64

Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res (1996) 1.57

fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev (1995) 1.51

Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation (1994) 1.51

Stepwise dissociation of yeast 60S ribosomal subunits by LiCl and identification of L25 as a primary 26S rRNA binding protein. Eur J Biochem (1984) 1.41

Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. J Biol Chem (1994) 1.37

Calcium-induced assembly of adherens junctions in keratinocytes. J Cell Biol (1987) 1.36

Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src. J Biol Chem (1997) 1.31

Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J Invest Dermatol (1994) 1.30

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J (1992) 1.27

Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol Cell Biol (1990) 1.07

Dispase, a neutral protease from Bacillus polymyxa, is a powerful fibronectinase and type IV collagenase. J Invest Dermatol (1989) 1.07

Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J Invest Dermatol (1995) 1.03

Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Mol Cell Biol (1992) 1.02

Identification of plakoglobin in oocytes and early embryos of Xenopus laevis: maternal expression of a gene encoding a junctional plaque protein. Differentiation (1992) 0.96

Functional evidence for an extracellular calcium receptor mechanism triggering tyrosine kinase activation associated with mouse keratinocyte differentiation. J Biol Chem (1994) 0.90

Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa. Oncogene (1995) 0.81

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science (1992) 4.58

TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J (2000) 4.41

The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Mol Cell (2000) 2.97

Pair formation and promiscuity of cytokeratins: formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides. J Cell Biol (1985) 2.37

Patterns of expression and organization of cytokeratin intermediate filaments. Ann N Y Acad Sci (1985) 2.21

The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. Proc Natl Acad Sci U S A (1995) 2.15

Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics. Proc Natl Acad Sci U S A (1983) 2.05

Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. J Virol (2002) 1.98

The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med (1999) 1.95

Amino acid sequence and gene organization of cytokeratin no. 19, an exceptional tail-less intermediate filament protein. EMBO J (1986) 1.81

Heterotypic tetramer (A2D2) complexes of non-epidermal keratins isolated from cytoskeletons of rat hepatocytes and hepatoma cells. J Mol Biol (1984) 1.75

Separation of cytokeratin polypeptides by gel electrophoretic and chromatographic techniques and their identification by immunoblotting. Methods Enzymol (1986) 1.60

fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev (1995) 1.51

A unique role for Fyn in CNS myelination. J Neurosci (2001) 1.51

Molecular map of the desmosomal plaque. J Cell Sci (1999) 1.39

Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. Cardiovasc Res (2000) 1.34

β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene (2011) 1.34

Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. Proc Natl Acad Sci U S A (1996) 1.25

The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J Biol Chem (1999) 1.21

Characterization of dimer subunits of intermediate filament proteins. J Mol Biol (1986) 1.20

Formation of antiviral cytoplasmic granules during orthopoxvirus infection. J Virol (2010) 1.18

Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders. J Cell Sci (2001) 1.13

p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. Oncogene (2010) 1.09

Analysis of cytokeratin domains by cloning and expression of intact and deleted polypeptides in Escherichia coli. EMBO J (1987) 1.05

The fate of desmosomal proteins in apoptotic cells. J Biol Chem (2001) 1.04

Unlocking vaults: organelles in search of a function. Trends Cell Biol (1991) 1.03

A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. Mol Cell (2000) 1.01

Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone. Differentiation (1986) 1.00

Cytokeratin No. 9, an epidermal type I keratin characteristic of a special program of keratinocyte differentiation displaying body site specificity. J Cell Biol (1986) 1.00

Phosphorylation in vitro of vimentin by protein kinases A and C is restricted to the head domain. Identification of the phosphoserine sites and their influence on filament formation. Eur J Biochem (1989) 0.99

Use of zolpidem in over 75-year-old patients with sleep disorders and comorbidities. Arch Gerontol Geriatr Suppl (2004) 0.90

Carbon-13 nuclear magnetic relaxation study on cobalt carbonic anhydrase: Evidence on the location of enzyme bound CO2 and HCO3. J Am Chem Soc (1977) 0.87

In vitro assembly properties of vimentin mutagenized at the beta-site tail motif. J Cell Sci (1993) 0.84

Effectiveness and safety of hypnotic drugs in the treatment of insomnia in over 70-year old people. Arch Gerontol Geriatr (2007) 0.83

Genetics of signal transduction: tales from the mouse. Curr Opin Genet Dev (1994) 0.82

Clonogenic cytotoxicity testing by microdrop encapsulation. Nature (1993) 0.82

Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun (1998) 0.81

Protein-protein interactions between keratin polypeptides expressed in the yeast two-hybrid system. Biochim Biophys Acta (1998) 0.79

Transcription of a gene cluster coding for two aminoacyl-tRNA synthetases and an initiation factor in Escherichia coli. J Mol Biol (1984) 0.79

Taste aversion learning in fyn mutant mice. Behav Neurosci (1996) 0.77

Golli-induced paralysis: a study in anergy and disease. J Immunol (1999) 0.76

p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle. J Muscle Res Cell Motil (2000) 0.75

[Epidemiologic data on the caloric balance and body weight of a group of nursing students]. Minerva Dietol Gastroenterol (1986) 0.75

Response. Science (1993) 0.75