Published in Curr Biol on June 04, 1998
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell (2006) 2.85
Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol (2008) 1.82
Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron (2009) 1.45
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39
The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Genetics (2004) 1.36
Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. J Mol Biol (2006) 1.16
Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet (2013) 1.13
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J Mol Biol (2009) 1.04
A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling. PLoS One (2008) 0.96
Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons. Neuroscience (2009) 0.95
Novel Robinow syndrome causing mutations in the proximal region of the frizzled-like domain of ROR2 are retained in the endoplasmic reticulum. Hum Genet (2007) 0.92
A systematic survey of expression and function of zebrafish frizzled genes. PLoS One (2013) 0.82
Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation. Cell Mol Life Sci (2012) 0.81
HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform. Sci Rep (2014) 0.80
General aspects of colorectal cancer. ISRN Oncol (2012) 0.79
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem (2015) 0.78
Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling. Sci Rep (2015) 0.78
Structure, phylogeny, and expression of the frizzled-related gene family in the lophotrochozoan annelid Platynereis dumerilii. Evodevo (2015) 0.78
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. PLoS One (2014) 0.77
Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time. Curr Top Dev Biol (2015) 0.77
Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes Dev (2016) 0.76
Cardiac hormones are potent inhibitors of secreted frizzled-related protein-3 in human cancer cells. Exp Ther Med (2012) 0.75
Exploring Missense Mutations in Tyrosine Kinases Implicated with Neurodegeneration. Mol Neurobiol (2016) 0.75
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage. Oncogenesis (2017) 0.75
Molecular modeling of the complex between the xWNT8 protein and the CRD domain of the mFZD8 receptor. Dokl Biochem Biophys (2007) 0.75
Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Super-Family Protein RIG-3 in Caenorhabditis elegans. Genetics (2017) 0.75
Wnt signaling: a common theme in animal development. Genes Dev (1997) 12.94
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol (1998) 9.24
A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature (1984) 5.53
Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med (1988) 4.06
Information access. Building a "GenBank" of the published literature. Science (2001) 3.95
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell (1987) 3.78
Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev (1998) 3.65
A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature (1999) 3.22
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity (2000) 3.19
Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. Mol Cell Biol (1987) 2.96
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev (1999) 2.78
Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication. Cell (1989) 2.61
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev (1994) 2.50
The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev (1995) 2.46
Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell (1984) 2.44
dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature (1994) 2.29
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell (1998) 2.23
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature (1994) 2.20
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
WNT signaling in the control of hair growth and structure. Dev Biol (1999) 2.13
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J (1993) 2.12
Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J (1997) 1.97
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc Natl Acad Sci U S A (1990) 1.94
Wnts as ligands: processing, secretion and reception. Oncogene (2006) 1.90
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol (1994) 1.89
Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus. Cell (1981) 1.89
Correlation of ovarian function with galactose-1-phosphate uridyl transferase levels in galactosemia. J Pediatr (1988) 1.79
Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes Dev (1991) 1.69
Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J (1987) 1.69
A new nomenclature for int-1 and related genes: the Wnt gene family. Cell (1991) 1.67
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development (1999) 1.61
Structural analysis of a 1.7-kilobase mouse mammary tumor virus-specific RNA. J Virol (1983) 1.55
Signaling by wingless in Drosophila. Dev Biol (1994) 1.53
The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development (1992) 1.52
Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. Mol Cell (2000) 1.49
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene (2009) 1.48
The int genes in mammary tumorigenesis and in normal development. Trends Genet (1988) 1.43
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Nature (2001) 1.43
Translation of mouse mammary tumor virus RNA: precursor polypeptides are phosphorylated during processing. Virology (1978) 1.38
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Development (1999) 1.34
The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. EMBO J (1985) 1.34
Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice. J Virol (1987) 1.29
Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains. J Virol (1978) 1.26
Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain. J Exp Med (1980) 1.17
Impaired maturation of mouse mammary tumor virus precursor polypeptides in lymphoid leukemia cells, producing intracytoplasmic A particles and no extracellular B-type virions. J Virol (1979) 1.17
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci U S A (1997) 1.16
Deficit of uridine diphosphate galactose in galactosaemia. J Inherit Metab Dis (1989) 1.14
DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate. Genes Dev (1998) 1.14
The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS. Dev Biol (1995) 1.12
Biochemical and molecular studies of 132 patients with galactosemia. Hum Genet (1994) 1.12
Developmental biology. Making head or tail of Dickkopf. Nature (2001) 1.11
Translating insights from development into regenerative medicine: the function of Wnts in bone biology. Semin Cell Dev Biol (2008) 1.11
A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet (1997) 1.10
Immunologic, virologic, and genetic aspects of mammary tumor virus-induced cell-surface antigens: presence of these antigens and the Thy 1.2 antigen on murine mammary gland and tumor cells. J Natl Cancer Inst (1975) 1.08
Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development (1992) 1.07
wingless signaling in the Drosophila eye and embryonic epidermis. Development (1996) 1.06
Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA. Oncogene (1988) 1.05
Glucose-6-phosphate dehydrogenase variants and their frequency in Guangdong, China. Hum Genet (1988) 1.04
Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells. Mol Cell Biol (1989) 1.03
Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer. Semin Cancer Biol (1995) 1.02
Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells. Development (1994) 0.99
Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene (1992) 0.98
Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats. J Virol (1989) 0.97
Construction of a retroviral cDNA version of the int-1 mammary oncogene and its expression in vitro. Nucleic Acids Res (1986) 0.95
Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis. Mol Cell Biol (1984) 0.95
Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres. Mech Dev (1992) 0.94
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. Dev Suppl (1993) 0.94
The activation of cellular oncogenes by proviral insertion in murine mammary cancer. Cancer Treat Res (1988) 0.94
The effect of flexion-extension motion of the lumbar spine on the capacity of the spinal canal. An experimental study. Spine (Phila Pa 1976) (1989) 0.94
An ancient cluster of Wnt paralogues. Trends Genet (2001) 0.93
Surgical treatment of nonunited fractures of the odontoid process, with special reference to occipitocervical fusion for unreducible atlantoaxial subluxation or instability. Eur Spine J (2000) 0.93
Quantitation of virus-induced (MLr) and normal (Thy.1.2) cell surface antigens in isolated plasma membranes and the extracellular ascites fluid of mouse leukemia cells. Cancer Res (1975) 0.92
The molecular biology of breast cancer. Biochim Biophys Acta (1991) 0.92
Correlation of cognitive, neurologic, and ovarian outcome with the Q188R mutation of the galactose-1-phosphate uridyltransferase gene. J Pediatr (1994) 0.91
Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development (1998) 0.91
Analysis of secondary modifications of mouse mammary tumor virus proteins by two-dimensional gel electrophoresis. J Virol (1980) 0.89
Mouse mammary tumor virus expression and mammary tumor development. Curr Top Microbiol Immunol (1983) 0.88
Induction of mouse mammary tumor virus RNA in mammary tumors of BALB/c mice treated with urethane, X-irradiation, and hormones. J Virol (1979) 0.88
Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor. Oncogene (1990) 0.88
Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies. Oncogene (1990) 0.88
Amplification and over-expression of the neu oncogene in human breast carcinomas. Eur J Surg Oncol (1988) 0.86
Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. Genomics (1993) 0.85
Retroviral insertional mutagenesis in murine mammary cancer. Proc R Soc Lond B Biol Sci (1985) 0.85
Quantification of mouse mammary tumor virus structural proteins in hormone-induced mammary tumors of low mammary tumor mouse strains. Int J Cancer (1980) 0.84
Oncogene activation in human myeloid leukemia. Cancer Res (1985) 0.84
Distribution and antibody-induced redistribution of a mammary tumor virus-induced and a normal antigen on the surface of mouse leukemia cells. J Natl Cancer Inst (1975) 0.83
Patching up Hedgehog. Nature (1996) 0.82
Treatment of longitudinal injuries in avascular area of meniscus in dogs by trephination. Arthroscopy (1988) 0.82
Autogenous antibodies against the murine mammary tumor virus in strains of mice with low incidences of mammary tumors. J Natl Cancer Inst (1979) 0.81
Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL cell-surface antigens and THY1. Br J Cancer (1980) 0.80
Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats. Acta Pharmacol Sin (2001) 0.79
Wnt meeting 1996. Biochim Biophys Acta (1997) 0.79
Differential requirements for segment polarity genes in wingless signaling. Mech Dev (1995) 0.79
Molecular and biochemical basis of galactosemia. Mol Genet Metab (1998) 0.79
Gonadal function and ovarian galactose metabolism in classic galactosemia. Acta Endocrinol (Copenh) (1989) 0.77
Two adult galactosaemia females with normal ovarian function and identical GALT mutations (Q188R/R333G). J Inherit Metab Dis (2003) 0.76