Published in Annu Rev Cell Dev Biol on January 01, 1998
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol (2003) 4.31
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04
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Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev (2003) 3.46
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A (2002) 2.93
The Wnts. Genome Biol (2001) 2.90
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev (1999) 2.78
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity (2007) 2.71
The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nat Rev Genet (2000) 2.51
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development (2006) 2.50
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J (2000) 2.40
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Lung organogenesis. Curr Top Dev Biol (2010) 2.30
Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone. Proc Natl Acad Sci U S A (2015) 2.25
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res (2008) 2.18
CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol (2006) 2.15
Wnt signal transduction pathways. Organogenesis (2008) 2.14
Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol (2007) 2.09
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol (2001) 2.09
The links between axin and carcinogenesis. J Clin Pathol (2005) 2.07
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol (2003) 2.07
Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J Biol (2005) 2.06
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev (2002) 2.01
Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol (2002) 2.00
Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet (2004) 1.97
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol (2000) 1.93
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes Dev (2001) 1.90
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci U S A (2004) 1.89
Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One (2008) 1.86
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol (2006) 1.82
A mutant Arabidopsis heterotrimeric G-protein beta subunit affects leaf, flower, and fruit development. Plant Cell (2001) 1.82
Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet (2007) 1.82
Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A (2000) 1.81
Development and differentiation of the intestinal epithelium. Cell Mol Life Sci (2003) 1.80
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev (2003) 1.78
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77
Control of bone formation by the serpentine receptor Frizzled-9. J Cell Biol (2011) 1.77
Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol Endocrinol (2004) 1.76
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 1.76
Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet (2004) 1.72
Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol Cell Biol (2001) 1.69
PTH and PTHrP signaling in osteoblasts. Cell Signal (2009) 1.69
Roles of Wnt proteins in neural development and maintenance. Curr Opin Neurobiol (2000) 1.68
Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol (2011) 1.68
A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. EMBO J (2009) 1.68
Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol (2007) 1.68
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol Cell Biol (2003) 1.67
Wnts: up-and-coming at the synapse. Trends Neurosci (2007) 1.67
The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Genes Dev (2000) 1.63
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63
Mitotic and mitogenic Wnt signalling. EMBO J (2012) 1.62
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J (2003) 1.61
Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn (2006) 1.61
The role of secondary heart field in cardiac development. Dev Biol (2009) 1.60
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol (2011) 1.59
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol (2001) 1.59
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev (2003) 1.55
The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. J Cell Sci (2006) 1.55
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med (2008) 1.54
Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol (2003) 1.54
WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol (2004) 1.53
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50
Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev (2002) 1.50
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. J Clin Invest (2010) 1.50
Intrinsic disorder in scaffold proteins: getting more from less. Prog Biophys Mol Biol (2008) 1.49
Wingful, an extracellular feedback inhibitor of Wingless. Genes Dev (2002) 1.48
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci U S A (2010) 1.47
Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip. J Anat (2007) 1.46
Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron (2009) 1.45
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn (2006) 1.44
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Proc Natl Acad Sci U S A (1999) 1.42
β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol (2011) 1.41
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Mol Cell Biol (2006) 1.41
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41
Wnt signaling: a common theme in animal development. Genes Dev (1997) 12.94
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature (1984) 5.53
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Information access. Building a "GenBank" of the published literature. Science (2001) 3.95
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell (1987) 3.78
Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev (1998) 3.65
A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature (1999) 3.22
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity (2000) 3.19
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The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev (1994) 2.50
The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev (1995) 2.46
Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell (1984) 2.44
dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature (1994) 2.29
Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell (1998) 2.23
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature (1994) 2.20
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
WNT signaling in the control of hair growth and structure. Dev Biol (1999) 2.13
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J (1993) 2.12
Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J (1997) 1.97
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Wnts as ligands: processing, secretion and reception. Oncogene (2006) 1.90
Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus. Cell (1981) 1.89
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol (1994) 1.89
Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes Dev (1991) 1.69
Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. EMBO J (1987) 1.69
A new nomenclature for int-1 and related genes: the Wnt gene family. Cell (1991) 1.67
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development (1999) 1.61
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The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development (1992) 1.52
Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. Mol Cell (2000) 1.49
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene (2009) 1.48
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Nature (2001) 1.43
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Translation of mouse mammary tumor virus RNA: precursor polypeptides are phosphorylated during processing. Virology (1978) 1.38
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Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Development (1999) 1.34
The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. EMBO J (1985) 1.34
Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice. J Virol (1987) 1.29
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Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain. J Exp Med (1980) 1.17
Impaired maturation of mouse mammary tumor virus precursor polypeptides in lymphoid leukemia cells, producing intracytoplasmic A particles and no extracellular B-type virions. J Virol (1979) 1.17
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci U S A (1997) 1.16
DWnt-2, a Drosophila Wnt gene required for the development of the male reproductive tract, specifies a sexually dimorphic cell fate. Genes Dev (1998) 1.14
The Drosophila Wnt protein DWnt-3 is a secreted glycoprotein localized on the axon tracts of the embryonic CNS. Dev Biol (1995) 1.12
Developmental biology. Making head or tail of Dickkopf. Nature (2001) 1.11
Translating insights from development into regenerative medicine: the function of Wnts in bone biology. Semin Cell Dev Biol (2008) 1.11
A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet (1997) 1.10
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Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila. Development (1992) 1.07
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Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer. Semin Cancer Biol (1995) 1.02
Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells. Development (1994) 0.99
Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene (1992) 0.98
Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats. J Virol (1989) 0.97
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