Published in Proc Natl Acad Sci U S A on July 07, 1998
A habitat for psychrophiles in deep Antarctic ice. Proc Natl Acad Sci U S A (2000) 2.39
The effect of cytidine on the structure and function of an RNA ligase ribozyme. RNA (2001) 1.69
Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases. Proc Natl Acad Sci U S A (2011) 1.36
Prebiotic synthesis from CO atmospheres: implications for the origins of life. Proc Natl Acad Sci U S A (2002) 1.30
Ligation activity of fragmented ribozymes in frozen solution: implications for the RNA world. Nucleic Acids Res (2004) 1.19
Ice as a protocellular medium for RNA replication. Nat Commun (2010) 1.18
The algorithmic origins of life. J R Soc Interface (2012) 1.13
Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor. Nat Chem (2012) 1.06
Darwinian behavior in a cold, sporadically fed pool of ribonucleotides. Astrobiology (2012) 1.06
Prebiotic cytosine synthesis: a critical analysis and implications for the origin of life. Proc Natl Acad Sci U S A (1999) 1.02
The RNA world on ice: a new scenario for the emergence of RNA information. J Mol Evol (2005) 1.00
A content-centric organization of the genetic code. Genomics Proteomics Bioinformatics (2007) 0.96
Nonenzymatic RNA ligation in water. J Biol Chem (2008) 0.94
Differential adsorption of nucleic acid bases: Relevance to the origin of life. Proc Natl Acad Sci U S A (2001) 0.93
A scenario on the stepwise evolution of the genetic code. Genomics Proteomics Bioinformatics (2007) 0.93
Setting the stage: the history, chemistry, and geobiology behind RNA. Cold Spring Harb Perspect Biol (2012) 0.92
Catalytic improvement and evolution of atrazine chlorohydrolase. Appl Environ Microbiol (2009) 0.87
A new classification scheme of the genetic code. J Mol Evol (2004) 0.86
Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences. Nucleic Acids Res (2012) 0.85
On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution. Isr J Chem (2013) 0.82
Polymerization of Building Blocks of Life on Europa and Other Icy Moons. Astrobiology (2015) 0.81
Hydrolytic Fitness of N-glycosyl Bonds: Comparing the Deglycosylation Kinetics of Modified, Alternative and Native Nucleosides. J Phys Org Chem (2015) 0.79
Isolation and characterization of bacteria from ancient siberian permafrost sediment. Biology (Basel) (2013) 0.79
Primal eukaryogenesis: on the communal nature of precellular States, ancestral to modern life. Life (Basel) (2012) 0.78
Prebiotic chemistry: geochemical context and reaction screening. Life (Basel) (2013) 0.77
Refining the genetic alphabet: a late-period selection pressure? Astrobiology (2012) 0.77
DNA homoduplexes containing no pyrimidine nucleotide. Eur Biophys J (2003) 0.76
Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases. Front Genet (2016) 0.76
Impact synthesis of the RNA bases. Proc Natl Acad Sci U S A (2015) 0.75
Photophysical properties of pyrrolocytosine, a cytosine fluorescent base analogue. Phys Chem Chem Phys (2016) 0.75
Prediction of the maximum temperature for life based on the stability of metabolites to decomposition in water. Life (Basel) (2015) 0.75
Taming Prebiotic Chemistry: The Role of Heterogeneous and Interfacial Catalysis in the Emergence of a Prebiotic Catalytic/Information Polymer System. Life (Basel) (2016) 0.75
Ligation of RNA Oligomers by the Schistosoma mansoni Hammerhead Ribozyme in Frozen Solution. J Mol Evol (2016) 0.75
RNA catalysis in frozen solutions. Dokl Biochem Biophys (2005) 0.75
Cryosphere and Psychrophiles: Insights into a Cold Origin of Life? Life (Basel) (2017) 0.75
Bacterial evolution. Microbiol Rev (1987) 85.63
Instability and decay of the primary structure of DNA. Nature (1993) 25.58
The origin of the genetic code. J Mol Biol (1968) 9.44
Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry (1974) 5.70
Bisulfite modification of nucleic acids and their constituents. Prog Nucleic Acid Res Mol Biol (1976) 4.36
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet. Nature (1990) 3.82
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry (1990) 3.51
Earth's early atmosphere. Science (1993) 3.02
The emergence of life from iron monosulphide bubbles at a submarine hydrothermal redox and pH front. J Geol Soc London (1997) 2.46
The deamination of cytidine and cytosine by acidic buffer solutions. Mutagenic implications. Biochemistry (1966) 2.30
DNA cytosine methylation and heat-induced deamination. Biosci Rep (1986) 1.84
Origin of life--facing up to the physical setting. Cell (1991) 1.66
Energy yields for hydrogen cyanide and formaldehyde syntheses: the HCN and amino acid concentrations in the primitive ocean. Orig Life Evol Biosph (1987) 1.51
Annihilation of ecosystems by large asteroid impacts on the early Earth. Nature (1989) 1.42
Impact frustration of the origin of life. Nature (1988) 1.40
Rates of decomposition of ribose and other sugars: implications for chemical evolution. Proc Natl Acad Sci U S A (1995) 1.31
Climatic consequences of very high carbon dioxide levels in the earth's early atmosphere. Science (1986) 1.29
The origin of life--did it occur at high temperatures? J Mol Evol (1995) 1.21
Solvolysis of adenine nucleosides. II. Effects of sugars and adenine substituents on alkaline solvolyses. J Am Chem Soc (1972) 1.20
Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide. J Mol Biol (1967) 1.17
An all-purine precursor of nucleic acids. Proc Natl Acad Sci U S A (1988) 1.13
Impact melting of frozen oceans on the early Earth: implications for the origin of life. Proc Natl Acad Sci U S A (1994) 1.11
Solvolyses of cytosine and cytidine. J Pharm Sci (1972) 1.11
The effects of heavy meteorite bombardment on the early evolution--the emergence of the three domains of life. Orig Life Evol Biosph (1995) 1.10
Hydrolytic stability of biomolecules at high temperatures and its implication for life at 250 degrees C. Nature (1984) 1.09
Studies in prebiotic synthesis. 3. Synthesis of pyrimidines from cyanoacetylene and cyanate. J Mol Biol (1968) 1.03
Submarine hot springs and the origin of life. Nature (1988) 1.02
The prebiotic role of adenine: a critical analysis. Orig Life Evol Biosph (1995) 0.98
How long did it take for life to begin and evolve to cyanobacteria? J Mol Evol (1994) 0.97
Speculations on the origin of life and thermophily: review of available information on reverse gyrase suggests that hyperthermophilic procaryotes are not so primitive. Orig Life Evol Biosph (1995) 0.91
The stability of amino acids at submarine hydrothermal vent temperatures. Orig Life Evol Biosph (1995) 0.88
Of archae and eo: what's in a name? Proc Natl Acad Sci U S A (1995) 0.87
Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides. J Mol Evol (1994) 0.85
Conditions for purine synthesis: did prebiotic synthesis occur at low temperatures? Science (1966) 0.83
Prebiotic synthesis of diaminopyrimidine and thiocytosine. J Mol Evol (1996) 0.82
Did surface temperatures constrain microbial evolution? Bioscience (1993) 0.81
PURINE AND PYRIMIDINES IN SEDIMENTS FROM THE EXPERIMENTAL MOHOLE. Science (1964) 0.79
Language comprehension in language-learning impaired children improved with acoustically modified speech. Science (1996) 3.84
Temporal processing deficits of language-learning impaired children ameliorated by training. Science (1996) 3.80
Dental care for the mentally retarded; a challenge to the profession. J Public Health Dent (1965) 2.45
The case for an ancestral genetic system involving simple analogues of the nucleotides. Proc Natl Acad Sci U S A (1987) 2.12
An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J Appl Physiol (1985) (2000) 2.09
Sensitivity and specificity of the Papanicolaou-stained cervical smear in the diagnosis of Chlamydia trachomatis infection. Acta Cytol (1985) 1.77
Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab (2001) 1.67
Negative pressure in the interstitial fluid of animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital. Science (1968) 1.62
A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A. Nature (1995) 1.59
Concentration by evaporation and the prebiotic synthesis of cytosine. Orig Life Evol Biosph (2001) 1.54
Energy yields for hydrogen cyanide and formaldehyde syntheses: the HCN and amino acid concentrations in the primitive ocean. Orig Life Evol Biosph (1987) 1.51
Peptide nucleic acids and prebiotic chemistry. Nat Struct Biol (1997) 1.48
Prebiotic synthesis of 5-substituted uracils: a bridge between the RNA world and the DNA-protein world. Science (1995) 1.45
The origin and early evolution of life: prebiotic chemistry, the pre-RNA world, and time. Cell (1996) 1.44
Spinal cord hypothermia without systemic hypothermia. AJNR Am J Neuroradiol (2012) 1.42
Extraterrestrial synthesis. Nature (1991) 1.40
The Denver Aerosol Sources and Health (DASH) Study: Overview and Early Findings. Atmos Environ (1994) (2008) 1.35
Rates of decomposition of ribose and other sugars: implications for chemical evolution. Proc Natl Acad Sci U S A (1995) 1.31
Nonprotein amino acids from spark discharges and their comparison with the murchison meteorite amino acids. Proc Natl Acad Sci U S A (1972) 1.26
Reasons for the occurrence of the twenty coded protein amino acids. J Mol Evol (1981) 1.24
Hydrogen consumption by methanogens on the early Earth. Orig Life Evol Biosph (1998) 1.22
On the origin of metabolic pathways. J Mol Evol (1999) 1.21
Neural processes involved in directing attention. J Cogn Neurosci (1989) 1.20
Are polyphosphates or phosphate esters prebiotic reagents? J Mol Evol (1995) 1.17
Was ferrocyanide a prebiotic reagent? Orig Life Evol Biosph (1996) 1.16
Comparison of scrape, swab, and cytobrush samples for the diagnosis of cervical chlamydial infection by immunofluorescence. Diagn Microbiol Infect Dis (1987) 1.16
An efficient prebiotic synthesis of cytosine and uracil. Nature (1995) 1.15
The chemical conditions on the parent body of the Murchison meteorite: some conclusions based on amino, hydroxy and dicarboxylic acids. Adv Space Res (1984) 1.14
Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus (2007) 1.14
Clathrate hydrates of air in antarctic ice. Science (1969) 1.14
Peptide nucleic acids rather than RNA may have been the first genetic molecule. Proc Natl Acad Sci U S A (2000) 1.12
Prebiotic synthesis of adenine and amino acids under Europa-like conditions. Icarus (2000) 1.11
Effect of interferon on a primary conjunctival epithelial cell model of trachoma. Invest Ophthalmol Vis Sci (1991) 1.11
Home-based multisystemic therapy as an alternative to the hospitalization of youths in psychiatric crisis: clinical outcomes. J Am Acad Child Adolesc Psychiatry (1999) 1.11
Impact melting of frozen oceans on the early Earth: implications for the origin of life. Proc Natl Acad Sci U S A (1994) 1.11
A positron emission tomography (PET) study of autobiographical memory retrieval. Memory (2000) 1.07
The symmetry of self-complementary surfaces. J Mol Biol (1979) 1.06
A multi-zone model evaluation of the efficacy of upper-room air ultraviolet germicidal irradiation. Appl Occup Environ Hyg (1999) 1.04
Prebiotic synthesis in atmospheres containing CH4, CO, and CO2. I. Amino acids. J Mol Evol (1983) 1.03
Prebiotic synthesis of hydrophobic and protein amino acids. Proc Natl Acad Sci U S A (1972) 1.02
Clinical characteristics of women with chlamydial cervicitis. J Reprod Med (1988) 1.01
Simultaneous analysis of purines, pyrimidines, and amino acids. Anal Biochem (1969) 0.97
Supplementation of fibrin gels with sodium chloride enhances physical properties and ensuing osteogenic response. Acta Biomater (2010) 0.97
Origin of organic compounds on the primitive earth and in meteorites. J Mol Evol (1976) 0.97
Two-dimensional life? Proc Natl Acad Sci U S A (1991) 0.97
How long did it take for life to begin and evolve to cyanobacteria? J Mol Evol (1994) 0.97
Prebiotic synthesis in atmospheres containing CH4, CO, and CO2. II. Hydrogen cyanide, formaldehyde and ammonia. J Mol Evol (1983) 0.95
Ammonium ion concentration in the primitive ocean. Science (1968) 0.95
Mapping cerebral blood flow by xenon-enhanced computed tomography: clinical experience. Radiology (1984) 0.93
Equilibrium constants of several reactions involved in the fermentation of glutamate. Eur J Biochem (1987) 0.92
The origin and early evolution of life on Earth. Annu Rev Earth Planet Sci (1990) 0.92
Prebiotic synthesis of methionine. Science (1972) 0.91
Amino acid availability controls muscle protein metabolism. Diabetes Nutr Metab (1999) 0.91
Clinical rib fractures: are follow-up chest X-rays a waste of resources? Am Surg (2002) 0.91
Source apportionment of exposure to toxic volatile organic compounds using positive matrix factorization. J Expo Anal Environ Epidemiol (2001) 0.91
Oceanic protection of prebiotic organic compounds from UV radiation. Proc Natl Acad Sci U S A (1998) 0.90
Racemization and the origin of optically active organic compounds in living organisms. Biosystems (1987) 0.90
Infant speech-sound discrimination in noise. J Acoust Soc Am (1990) 0.90
Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep. BJOG (2006) 0.89
Enzymatic softening of connective tissue sheaths to aid microelectrode penetration. Comp Biochem Physiol (1967) 0.89
Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro. Blood (1987) 0.89
A kinetic estimate of the free aldehyde content of aldoses. Carbohydr Res (2000) 0.88
The stability of amino acids at submarine hydrothermal vent temperatures. Orig Life Evol Biosph (1995) 0.88
Potentially prebiotic syntheses of condensed phosphates. Orig Life Evol Biosph (1996) 0.87
Production of guanine from NH(4)CN polymerizations. J Mol Evol (1999) 0.86
Metabolic relationships between myelin subfractions: entry of galactolipids and phospholipids. J Neurochem (1976) 0.86
Preparation of large numbers of uniform tracheal organ cultures for long term studies. I. Effects of serum on establishment in culture. In Vitro (1976) 0.86
Identification of chlamydia in cervical smears by immunofluorescence: technic, sensitivity, and specificity. Am J Clin Pathol (1986) 0.86
Hydrolysis of dihydrouridine and related compounds. Biochemistry (1996) 0.86
Carbon dioxide clathrate in the martian ice cap. Science (1970) 0.85
Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides. J Mol Evol (1994) 0.85
Antibody to myelin-associated glycoprotein produces central nervous system demyelination. Neurology (1988) 0.84
CSF antibodies to myelin basic protein and oligodendrocytes in multiple sclerosis and other neurological diseases. Acta Neurol Scand (1983) 0.84
The cytologic features of chlamydial cervicitis. Acta Cytol (1985) 0.83
Use of tracheal organ cultures in toxicity testing. Environ Health Perspect (1976) 0.82
Origin of Life. Science (1959) 0.82
The kinetics and mechanism of the reversible nonenzymatic deamination of aspartic acid. J Am Chem Soc (1970) 0.82
Dosimetry of room-air germicidal (254 nm) radiation using spherical actinometry. Photochem Photobiol (1999) 0.82
Anesthetic potencies of sulfur hexafluoride, carbon tetrafluoride, chloroform and Ethrane in dogs: correlation with the hydrate and lipid theories of anesthetic action. Anesthesiology (1969) 0.82
Prebiotic synthesis of diaminopyrimidine and thiocytosine. J Mol Evol (1996) 0.82
Myelin synthesis during postnatal nutritional deprivation and subsequent rehabilitation. Brain Res (1976) 0.82
Production and characterization of monoclonal antibodies to peripheral and central nervous system myelin. J Neurochem (1984) 0.82
Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties. J Biol Chem (2001) 0.81
Expression of biochemical properties of oligodendrocytes in oligodendrocyte x glioma cell hybrids proliferating in vitro. Exp Cell Res (1981) 0.81
Template-directed synthesis of oligonucleotides under eutectic conditions. J Mol Evol (1991) 0.80
Reliability and validity of infant speech-sound discrimination-in-noise thresholds. J Speech Hear Res (1991) 0.80
Composition and analysis of the carotenoids in marigold petals. J Assoc Off Anal Chem (1972) 0.80
Comparative binding of murine and human monoclonal antibodies reacting with myelin-associated glycoprotein to myelin and human lymphocytes. J Neuroimmunol (1987) 0.80
The nicotinamide biosynthetic pathway is a by-product of the RNA world. J Mol Evol (2001) 0.80
The prebiotic synthesis of modified purines and their potential role in the RNA world. J Mol Evol (1999) 0.79
Prone positioning for acute respiratory distress syndrome in the surgical intensive care unit: who, when, and how long? Surgery (2000) 0.79
Occurrence and biological impacts of fishing gear and other marine debris in the Florida Keys. Mar Pollut Bull (2002) 0.79
Production of organic compounds in plasmas: a comparison among electric sparks, laser-induced plasmas, and UV light. Icarus (1989) 0.79
Histopathologic study of ocular changes in a syndrome of multiple congenital anomalies. Am J Ophthalmol (1987) 0.79
Myoglobinemia in severely burned patients: correlations with severity and survival. J Trauma (1982) 0.79
Particle size distributions and concentrations of airborne endotoxin using novel collection methods in homes during the winter and summer seasons. Indoor Air (2006) 0.79
The porous-surfaced electrode: a new concept in pacemaker lead design. J Thorac Cardiovasc Surg (1979) 0.79
Phenylalanine and tyrosine synthesis under primitive earth conditions. Science (1969) 0.78
Comparisons of packed cell volumes (PCVs) from so-called chicken anemia agent (CAA; a virus)-free broilers to PCVs from CAA-free specific-pathogen-free leghorns. Avian Dis (1993) 0.78
Case report. Multiple sclerosis: large plaque causing mass effect and ring sign. J Comput Assist Tomogr (1981) 0.78