Published in J Exp Med on August 03, 1998
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest (2000) 4.79
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (2004) 4.16
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3. J Cell Biol (2000) 3.53
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21
Matrix metalloproteinases in lung biology. Respir Res (2000) 2.18
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest (1999) 1.64
Innate immune cell-produced IL-17 sustains inflammation in bullous pemphigoid. J Invest Dermatol (2014) 1.47
Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. J Exp Med (2001) 1.43
Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest (2001) 1.42
Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci (2009) 1.40
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem (2009) 1.37
Matrix metalloproteases in head and neck cancer. Head Neck (2006) 1.35
Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN. Clin Vaccine Immunol (2006) 1.34
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J (2004) 1.34
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.31
A critical role for neutrophil elastase in experimental bullous pemphigoid. J Clin Invest (2000) 1.30
Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol (2004) 1.29
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J Clin Invest (2005) 1.25
Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo. BMC Cancer (2006) 1.16
Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome. Am J Pathol (2000) 1.16
Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis. EMBO J (2000) 1.11
The pathophysiology of autoimmune blistering diseases. J Clin Invest (2005) 1.10
The role of metalloelastase in immune complex-induced acute lung injury. Am J Pathol (2001) 1.06
Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun (2005) 1.03
Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus. Clin Exp Immunol (2002) 1.02
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. J Clin Invest (1999) 0.98
Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen. Am J Pathol (2004) 0.96
Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Neoplasia (2007) 0.95
A shift in the collagen V antigenic epitope leads to T helper phenotype switch and immune response to self-antigen leading to chronic lung allograft rejection. Clin Exp Immunol (2012) 0.94
The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsone. Clin Exp Immunol (2001) 0.93
Gelatinase B deficiency impairs reproduction. J Clin Invest (2000) 0.92
Role of different pathways of the complement cascade in experimental bullous pemphigoid. J Clin Invest (2006) 0.90
MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction. Am J Pathol (2012) 0.89
Matrix metalloproteinase-9 is involved in the regulation of hair canal formation. J Invest Dermatol (2010) 0.88
Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood (2005) 0.87
Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem (2011) 0.86
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid. Matrix Biol (2011) 0.83
Soluble interleukin-2 receptor and metalloproteinase-9 expression in head and neck cancer: prognostic value and analysis of their relationships. Clin Exp Immunol (2007) 0.82
Elevated expression and release of tissue-type, but not urokinase-type, plasminogen activator after binding of autoantibodies to bullous pemphigoid antigen 180 in cultured human keratinocytes. Clin Exp Immunol (2004) 0.82
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid. Arch Dermatol Res (2007) 0.81
The imbalance between metalloproteinases and their tissue inhibitors is involved in the pathogenesis of dermatitis herpetiformis. Mediators Inflamm (2005) 0.79
Tissue destruction by neutrophils. N Engl J Med (1989) 13.81
Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol (1982) 10.99
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet (1990) 5.65
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase. J Biol Chem (1985) 3.15
Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med (1982) 3.09
Human 92- and 72-kilodalton type IV collagenases are elastases. J Biol Chem (1991) 2.71
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. J Clin Invest (1990) 2.56
A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest (1993) 2.19
Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol (1992) 1.99
Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane. Am J Respir Cell Mol Biol (1996) 1.96
Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. J Clin Invest (1990) 1.67
Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J Invest Dermatol (1985) 1.60
Human bullous pemphigoid antigen (BPAG1). Amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains. J Biol Chem (1991) 1.55
The role of complement in experimental bullous pemphigoid. J Clin Invest (1995) 1.55
A major role for neutrophils in experimental bullous pemphigoid. J Clin Invest (1997) 1.53
Cytoplasmic domain of the 180-kD bullous pemphigoid antigen, a hemidesmosomal component: molecular and cell biologic characterization. J Invest Dermatol (1992) 1.44
HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesmosome. J Biochem (1993) 1.40
Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient. J Invest Dermatol (1982) 1.35
Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins. J Biol Chem (1991) 1.35
92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. J Clin Invest (1994) 1.26
Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites. J Biol Chem (1993) 1.24
Mediators of inflammation in blister fluids from patients with pemphigus vulgaris and bullous pemphigoid. Arch Dermatol (1989) 1.19
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid. J Invest Dermatol (1983) 1.04
Immunopathologic mechanisms in pemphigus and bullous pemphigoid. J Invest Dermatol (1985) 0.99
Electron microscopic study of bullous pemphigoid. Arch Dermatol (1972) 0.99
Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida. J Invest Dermatol (1997) 0.99
Effect of vitamin A deficiency on the early response to experimental Pseudomonas keratitis. Invest Ophthalmol Vis Sci (1996) 0.98
Elevated levels of human collagenase inhibitor in blister fluids of diverse etiology. J Invest Dermatol (1986) 0.96
Enhanced association of plasminogen/plasmin with lesional epidermis of bullous pemphigoid. Br J Dermatol (1992) 0.93
The autoimmune blistering skin disease bullous pemphigoid. The presence of plasmin/alpha 2-antiplasmin complexes in skin blister fluid indicates plasmin generation in lesional skin. J Clin Invest (1993) 0.92
Cytotoxic proteases in blister fluid of pemphigus and pemphigoid patients. Int J Tissue React (1989) 0.89
Immune complex and complement-mediated leukocyte recruitment in bullous pemphigoid. Immunol Ser (1989) 0.83
Inactivation of alpha-1-proteinase inhibitor by neutrophil metalloproteinases. Crucial role of the myeloperoxidase system and effects of the anti-inflammatory drug nimesulide. Respiration (1993) 0.82
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med (1999) 9.18
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell (2000) 8.00
Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science (1988) 6.77
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (1995) 6.35
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell (1999) 6.08
Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev (2000) 5.33
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest (2000) 4.90
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest (2000) 4.79
Implantation and the placenta: key pieces of the development puzzle. Science (1994) 4.75
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71
Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med (1975) 4.60
Secretion of a specific collagenase by stimulated macrophages. J Exp Med (1975) 4.56
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature (1995) 4.56
Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. Proc Natl Acad Sci U S A (1982) 4.54
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol (1997) 4.22
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med (1977) 3.81
Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest (1982) 3.77
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. J Biol Chem (1985) 3.51
A massive binary black-hole system in OJ 287 and a test of general relativity. Nature (2008) 3.50
Chemotactic activity of elastin-derived peptides. J Clin Invest (1980) 3.33
Novel method for studying mRNA phenotypes in single or small numbers of cells. J Cell Biochem (1989) 3.30
Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol (1992) 3.29
Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem (1986) 3.24
The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol (2001) 3.22
Geminivirus strain demarcation and nomenclature. Arch Virol (2008) 3.21
Retracted Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study. Lancet (2005) 3.13
Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. J Biol Chem (1972) 3.10
Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture. Development (1991) 3.09
Chlamydia pneumoniae IgA titres and coronary heart disease; prospective study and meta-analysis. Eur Heart J (2002) 3.09
Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med (1982) 3.09
A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet (2004) 3.05
The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development (2001) 3.04
Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A (1981) 3.03
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science (1998) 2.95
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol (1992) 2.91
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med (2016) 2.89
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development (1996) 2.88
Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol (2000) 2.87
Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science (1983) 2.80
92-kD type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol (1991) 2.79
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes. Lancet (2001) 2.77
Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. Science (1988) 2.70
Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia (2006) 2.66
Matrix metalloproteinases and the development of cancer. Chem Biol (1996) 2.63
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. J Clin Invest (1990) 2.56
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res (1998) 2.54
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol (1989) 2.54
A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J (1974) 2.53
Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein. J Virol (1994) 2.52
Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol (1996) 2.51
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell (2000) 2.49
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol (1995) 2.45
Sexuality in a natural population of bacteria--Bacillus subtilis challenges the clonal paradigm. Mol Ecol (1992) 2.45
Case study of the effects of atmospheric aerosols and regional haze on agriculture: an opportunity to enhance crop yields in China through emission controls? Proc Natl Acad Sci U S A (1999) 2.44
Inflammatory cells and cancer: think different! J Exp Med (2001) 2.42
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance. Mol Cell Biol (1994) 2.42
RNA profiling of cell-free saliva using microarray technology. J Dent Res (2004) 2.40
Mouse macrophage elastase. Purification and characterization as a metalloproteinase. Biochem J (1981) 2.38
Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts. J Exp Med (1974) 2.36
ECM signalling: orchestrating cell behaviour and misbehaviour. Trends Cell Biol (1998) 2.30
Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol (1986) 2.30
Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity (1996) 2.29
Chemotactic activity of platelet alpha granule proteins for fibroblasts. J Cell Biol (1983) 2.28
Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity. J Biol Chem (1986) 2.26
Automatic segmentation of high-throughput RNAi fluorescent cellular images. IEEE Trans Inf Technol Biomed (2008) 2.25
Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin. J Cell Biol (1982) 2.25
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci U S A (1996) 2.24
Pemphigus: is there another half of the story? J Invest Dermatol (2001) 2.22
A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest (1993) 2.19
Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths. Development (1992) 2.19
Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev (1998) 2.19
Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions. J Exp Med (1978) 2.18
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J Biol Chem (1997) 2.15
Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell (1995) 2.15
The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. Biochem J (1974) 2.11
Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol Cell Biol (1994) 2.09
In vitro replication of adeno-associated virus DNA. J Virol (1994) 2.09
In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol (2005) 2.07
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia (2007) 2.04