Published in J Cell Biol on June 12, 2000
How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (2004) 4.16
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol (2013) 3.77
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol (2001) 3.32
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development (2001) 3.04
A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev (2006) 2.78
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol (2006) 2.50
MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol (2004) 2.45
Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am J Pathol (2002) 2.27
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J (2001) 2.23
Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol Biol Cell (2003) 2.19
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J (2002) 2.05
Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Blood (2009) 2.04
Regulation and function of miRNA-21 in health and disease. RNA Biol (2011) 1.99
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell (2000) 1.90
Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells. Nat Mater (2009) 1.87
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc Natl Acad Sci U S A (2009) 1.84
Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis (2008) 1.83
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis. Proc Natl Acad Sci U S A (2001) 1.83
Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes. J Exp Med (2002) 1.81
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity. J Cell Biol (2001) 1.71
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest (2002) 1.55
MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. J Exp Med (2005) 1.55
Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase. Mol Biol Cell (2008) 1.54
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol (2007) 1.50
Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. J Cell Sci (2008) 1.49
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res (2006) 1.49
An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature. Genes Dev (2005) 1.47
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev Cell (2009) 1.46
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene (2005) 1.45
Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One (2015) 1.43
A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype. J Theor Biol (2007) 1.37
Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem (2009) 1.37
Fibroblasts and the ground they walk on. Physiology (Bethesda) (2013) 1.34
MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. J Cell Sci (2009) 1.33
Breast cancer progression: insights into multifaceted matrix metalloproteinases. Clin Exp Metastasis (2007) 1.32
Matrix metalloproteinase control of capillary morphogenesis. Crit Rev Eukaryot Gene Expr (2008) 1.32
Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26
Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP. Mol Biol Cell (2006) 1.26
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. Mol Cancer (2006) 1.22
Porcine collagen crosslinking, degradation and its capability for fibroblast adhesion and proliferation. J Mater Sci Mater Med (2004) 1.19
A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis. Mol Biol Cell (2006) 1.18
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains. Biochem J (2001) 1.17
MT1-MMP controls human mesenchymal stem cell trafficking and differentiation. Blood (2009) 1.17
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin. Biochem J (2001) 1.16
Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol (2009) 1.13
Interstitial collagen catabolism. J Biol Chem (2013) 1.13
Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Am J Pathol (2001) 1.12
Contribution of MT1-MMP and of human laminin-5 gamma2 chain degradation to mammary epithelial cell migration. J Cell Sci (2001) 1.12
Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes (2010) 1.11
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis. Arthritis Rheum (2009) 1.11
A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism. J Biol Chem (2010) 1.10
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination. Cancer Res (2009) 1.10
Probing cellular microenvironments and tissue remodeling by atomic force microscopy. Pflugers Arch (2007) 1.10
Membrane associated proteases and their inhibitors in tumour angiogenesis. J Clin Pathol (2004) 1.10
Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell (2009) 1.09
Matrilysin-dependent elastolysis by human macrophages. J Exp Med (2003) 1.08
Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices. J Biol Chem (2009) 1.08
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins. Br J Pharmacol (2003) 1.08
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res (2012) 1.08
The aortic ring model of angiogenesis: a quarter century of search and discovery. J Cell Mol Med (2009) 1.07
Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase. J Biol Chem (2011) 1.05
Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences. Biochemistry (2007) 1.05
Localizing matrix metalloproteinase activities in the pericellular environment. FEBS J (2010) 1.03
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. J Cell Sci (2011) 1.02
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases define the migratory characteristics of human monocyte-derived dendritic cells. Immunology (2002) 1.01
Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. Br J Cancer (2008) 1.01
PtdIns(3,4)P2 instigates focal adhesions to generate podosomes. Cell Adh Migr (2009) 1.00
Caught in the act: revealing the metastatic process by live imaging. Dis Model Mech (2013) 0.99
Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography. Biomaterials (2010) 0.99
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. Dev Biol (2011) 0.99
Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization. Int J Biochem Cell Biol (2008) 0.96
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci U S A (2010) 0.94
Development of a solid-phase assay for analysis of matrix metalloproteinase activity. J Biomol Tech (2004) 0.94
Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy. Neuro Oncol (2005) 0.93
Cell migration through extracellular matrix: membrane-type metalloproteinases make the way. J Cell Biol (2000) 0.93
MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer. Int J Clin Exp Pathol (2014) 0.92
Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices. J Thromb Haemost (2010) 0.92
Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion. PLoS One (2011) 0.91
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. Mol Cancer (2006) 0.91
Collagen extracts derived from young and aged mice demonstrate different structural properties and cellular effects in three-dimensional gels. J Gerontol A Biol Sci Med Sci (2010) 0.91
Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. Angiogenesis (2012) 0.91
Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. J Biol Chem (2011) 0.91
Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers. Am J Physiol Lung Cell Mol Physiol (2011) 0.91
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen. Mol Cancer Res (2009) 0.89
MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction. Am J Pathol (2012) 0.89
URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. J Cell Mol Med (2008) 0.89
Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). J Biol Chem (2012) 0.88
EGF-receptor regulation of matrix metalloproteinases in epithelial ovarian carcinoma. Future Oncol (2009) 0.88
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem (2013) 0.87
Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia. Front Cell Infect Microbiol (2013) 0.87
Regulation of MT1-MMP activity by β-catenin in MDCK non-cancer and HT1080 cancer cells. J Cell Physiol (2010) 0.87
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase. Biochem J (2005) 0.87
Maspin is not required for embryonic development or tumour suppression. Nat Commun (2014) 0.87
Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen. J Biol Chem (2012) 0.87
Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells. BMC Dev Biol (2007) 0.86
Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin. J Biol Chem (2009) 0.85
Tissue destruction by neutrophils. N Engl J Med (1989) 13.81
Matrix metalloproteinases. J Biol Chem (1999) 12.08
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70
A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (1994) 9.31
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev (2000) 8.24
Collagen substrata for studies on cell behavior. J Cell Biol (1972) 7.00
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell (1996) 6.52
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell (1999) 6.40
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell (1999) 6.08
ECM and cell surface proteolysis: regulating cellular ecology. Cell (1997) 6.00
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res (1998) 4.39
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol (1997) 4.22
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem (1997) 3.74
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell (1998) 3.72
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem (1995) 3.52
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem (1996) 3.00
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol (2000) 2.94
Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell (1991) 2.78
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases. Eur J Biochem (1997) 2.63
Epithelial morphogenesis. Cell (1992) 2.43
Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature (1995) 2.40
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol (1995) 2.30
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol (1997) 2.29
Proteolysis and cell migration: creating a path? Curr Opin Cell Biol (1999) 2.19
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J Biol Chem (1997) 2.15
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum (1998) 2.00
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J Biol Chem (1996) 1.98
Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J Exp Med (1998) 1.96
Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Mol Biol Cell (1995) 1.96
In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J Cell Biol (1998) 1.95
Matrilysin expression and function in airway epithelium. J Clin Invest (1998) 1.94
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell (2000) 1.90
Molecular aspects of mesenchymal-epithelial interactions. Annu Rev Cell Biol (1993) 1.63
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. FEBS Lett (1996) 1.63
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Res (1997) 1.60
Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem (1999) 1.52
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface. Biochem J (1998) 1.48
Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. J Cell Biol (1997) 1.48
Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery. Circ Res (2000) 1.46
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci U S A (1999) 1.46
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter. J Cell Biol (1999) 1.45
Catabolism and turnover of collagens: collagenases. Methods Enzymol (1987) 1.44
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors. Am J Pathol (1999) 1.42
Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. Cell Res (1999) 1.34
Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3. J Biol Chem (1994) 1.34
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells. Cancer Res (1998) 1.30
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res (1999) 1.29
The role of interstitial collagens in cleft formation of mouse embryonic submandibular gland during initial branching. Development (1988) 1.27
Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis. Mol Cell Biol (1995) 1.25
Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells. Cancer Res (1997) 1.25
A novel host/tumor cell interaction activates matrix metalloproteinase 1 and mediates invasion through type I collagen. J Biol Chem (1999) 1.22
High affinity binding of latent matrix metalloproteinase-9 to the alpha2(IV) chain of collagen IV. J Biol Chem (1998) 1.15
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cells. Biochem Biophys Res Commun (1998) 1.10
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. Cancer Res (2000) 1.08
Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells. Cell Growth Differ (1999) 1.04
The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-(alpha) and membrane type matrix metalloprotease (MT1-MMP). J Cell Sci (1999) 1.02
Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility. Mol Biol Cell (1998) 0.99
Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase. Eur J Biochem (1999) 0.99
Membrane-type metalloproteinases in tumor invasion. Int J Biochem Cell Biol (1998) 0.96
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases. Biochem J (1996) 0.95
Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis. Dev Dyn (1998) 0.86
Native type I collagen is not a substrate for MMP2 (gelatinase A) J Invest Dermatol (1999) 0.84
Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor. Kidney Int (1998) 0.83
THE SYNTHESIS OF HEMOGLOBIN IN A CELL-FREE SYSTEM. Proc Natl Acad Sci U S A (1958) 4.92
Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. BMJ (1999) 4.66
Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science (1991) 3.96
Pupil-led sex education in England (RIPPLE study): cluster-randomised intervention trial. Lancet (2004) 3.86
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell (1998) 3.72
Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest (1982) 3.33
Application of operant conditioning procedures to the behavior problems of an autistic child: a follow-up and extension. Behav Res Ther (1967) 3.23
Evaluation of a serologic marker, CA19-9, in the diagnosis of pancreatic cancer. Ann Intern Med (1989) 3.02
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest (1981) 2.97
Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc Natl Acad Sci U S A (1995) 2.84
Human granulocyte generation of hydroxyl radical. J Exp Med (1978) 2.54
Craniopagus parasiticus. Everard Home's Two-Headed Boy of Bengal and some other cases. Surg Neurol (1989) 2.50
Increasing the completion of the durable power of attorney for health care. A randomized, controlled trial. JAMA (1994) 2.48
Recovery of human ova from the uterine tubes. J Am Med Assoc (1928) 2.43
Phagocyte-generated oxygen metabolites and cellular injury. Lab Invest (1982) 2.43
Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature (1995) 2.40
Oxidative autoactivation of latent collagenase by human neutrophils. Science (1985) 2.40
BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group's disease activity index for patients with systemic lupus erythematosus. Rheumatology (Oxford) (2005) 2.37
Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients. J Neurosurg (1989) 2.32
Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells. Biochem J (1982) 2.27
Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. Diabetes Obes Metab (2009) 2.19
Very short patch mismatch repair in phage lambda: repair sites and length of repair tracts. Genetics (1986) 2.17
Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. Cell (1987) 1.99
Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France. J Virol (1995) 1.99
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J Biol Chem (1996) 1.98
Long-lived oxidants generated by human neutrophils: characterization and bioactivity. Science (1983) 1.96
Tuberculosis in young adults and the elderly. A prospective comparison study. Chest (1994) 1.94
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell (2000) 1.90
Free-operant compounding of variable-interval and low-rate discriminative stimuli. J Exp Anal Behav (1967) 1.90
Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells. Nat Mater (2009) 1.87
Brominating oxidants generated by human eosinophils. Science (1986) 1.86
Evidence for hydroxyl radical generation by human Monocytes. J Clin Invest (1977) 1.85
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis. Proc Natl Acad Sci U S A (2001) 1.83
An effective and economical sound-attenuation chamber. J Exp Anal Behav (1970) 1.82
Parents explain more often to boys than to girls during shared scientific thinking. Psychol Sci (2001) 1.81
Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes. Am J Respir Cell Mol Biol (2001) 1.78
The influence of John Hunter's inoculation practice on Edward Jenner's discovery of vaccination against smallpox. J R Soc Med (1990) 1.76
THE INCORPORATION OF AMINO ACIDS INTO RIBONUCLEIC ACID. Proc Natl Acad Sci U S A (1958) 1.75
Attainment of glycaemic goals in type 2 diabetes with once-, twice-, or thrice-daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study). Diabetes Obes Metab (2006) 1.71
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity. J Cell Biol (2001) 1.71
Iodide transport in a continuous line of cultured cells from rat thyroid. Endocrinology (1984) 1.71
International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease. Rheumatology (Oxford) (2003) 1.71
Deep hypothermic circulatory arrest: I. Effects of cooling on electroencephalogram and evoked potentials. Ann Thorac Surg (2001) 1.70
Is phosphatidic acid a calcium ionophore under neurohumoral control? Nature (1980) 1.70
Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J Exp Med (2000) 1.70
Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites. J Clin Invest (1984) 1.67
Oxygen, ischemia and inflammation. Acta Physiol Scand Suppl (1986) 1.63
Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall. J Clin Invest (1989) 1.62
Malignant and Non-malignant Uterine and Vaginal Lesions in Mice Receiving Estrogens and Estrogens and Androgens Simultaneously. Yale J Biol Med (1939) 1.61
A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity. Blood (1980) 1.59
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Nature (1997) 1.58
Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology (1991) 1.57
Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc Natl Acad Sci U S A (1986) 1.57
Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system. J Clin Invest (1982) 1.56
Bleeding and cupping. Ann R Coll Surg Engl (1983) 1.53
The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Nature (1997) 1.53
Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. J Biol Chem (1994) 1.53
Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils. J Biol Chem (1984) 1.53
Discrimination training and stimulus compounding: consideration of non-reinforcement and response differentiation consequences of S. J Exp Anal Behav (1971) 1.52
Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science (1990) 1.43
Stimulus compounding in free-operant and classical conditioning. A review and analysis. Psychol Bull (1972) 1.43
Structure and function of a cap-independent translation element that functions in either the 3' or the 5' untranslated region. RNA (2000) 1.42
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. FEBS Lett (1995) 1.42
Effect of dental treatment on the lung function of children with asthma. J Am Dent Assoc (1998) 1.42
Serum levels of pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG), a glycosylated beta-lactoglobulin homologue, in successful and unsuccessful assisted conception. Hum Reprod (1990) 1.39
Single pump mechanically aspirated venous drainage (SPMAVD) for cardiac reoperation. Perfusion (1995) 1.38
Cocaine self-administration increased by compounding discriminative stimuli. Psychopharmacology (Berl) (1996) 1.38
The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. Cell (1988) 1.36
Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am J Respir Cell Mol Biol (1999) 1.36
Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environ Health Perspect (2001) 1.35
Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy. Thorax (2006) 1.35
The effect of dislike of school on risk of teenage pregnancy: testing of hypotheses using longitudinal data from a randomised trial of sex education. J Epidemiol Community Health (2005) 1.35
An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity. Blood (1980) 1.34
Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3. J Biol Chem (1994) 1.34
Oxidative mechanisms of monocyte-mediated cytotoxicity. Proc Natl Acad Sci U S A (1980) 1.33
Generation of nitrogen-chlorine oxidants by human phagocytes. J Clin Invest (1984) 1.32
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells. Cancer Res (1998) 1.30
Receptor regulation of calcium release and calcium permeability in parotid gland cells. Philos Trans R Soc Lond B Biol Sci (1981) 1.30
Domestic violence in an inner-city ED. Ann Emerg Med (1997) 1.30
The role of superoxide in the destruction of erythrocyte targets by human neutrophils. J Biol Chem (1980) 1.27
Discriminated response and incentive processes in operant conditioning: a two-factor model of stimulus control. J Exp Anal Behav (1978) 1.27
Does calcium mediate the increase in potassium permeability due to phenylephrine or angiotensin II in the liver? J Pharmacol Exp Ther (1978) 1.26
The relationship of phosphatidylinositol turnover to receptors and calcium-ion channels in rat parotid acinar cells. Biochem J (1981) 1.26
Deficient in vitro and in vivo phagocytosis of apoptotic T cells by resident murine alveolar macrophages. J Immunol (2000) 1.25
Role of stromelysin 1 and gelatinase B in experimental acute lung injury. Am J Respir Cell Mol Biol (2001) 1.25
Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. J Clin Invest (1991) 1.25
Immune complex induced generation of oxygen metabolites by human neutrophils. J Immunol (1982) 1.23
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions. J Clin Invest (1986) 1.22
Treatment of Brucella canis and Brucella abortus in vitro and in vivo by stable plurilamellar vesicle-encapsulated aminoglycosides. J Infect Dis (1985) 1.19
Neutrophil-mediated methemoglobin formation in the erythrocyte. The role of superoxide and hydrogen peroxide. J Biol Chem (1982) 1.18
Deep hypothermic circulatory arrest: II. Changes in electroencephalogram and evoked potentials during rewarming. Ann Thorac Surg (2001) 1.16
Superoxide generation by human monocytes and macrophages. Am J Hematol (1978) 1.16
Compounding discriminative stimuli controlling free-operant avoidance. J Exp Anal Behav (1972) 1.16
Regulation of phosphatidate synthesis by secretagogues in parotid acinar cells. Biochem J (1982) 1.15
Thyrotropin-stimulated iodide transport mediated by adenosine 3',5'-monophosphate and dependent on protein synthesis. Endocrinology (1984) 1.15
Pituitary growth hormone suppression with low-dosage, long-acting corticoid administration. J Pediatr (1968) 1.15