Published in Mol Cell Biol on April 01, 1996
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res (1999) 3.68
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev (1997) 3.33
The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. EMBO J (1998) 3.06
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A (1997) 2.55
Messenger RNA translation state: the second dimension of high-throughput expression screening. Proc Natl Acad Sci U S A (1999) 2.42
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34
A global role for EKLF in definitive and primitive erythropoiesis. Blood (2005) 2.24
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci U S A (1998) 2.02
Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. J Biol Chem (1997) 1.91
Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res (2000) 1.85
The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J (2005) 1.83
A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem (2008) 1.72
Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene (2004) 1.70
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev (2000) 1.64
Hemoglobin induction in mouse macrophages. Proc Natl Acad Sci U S A (1999) 1.64
FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes. Mol Cell Biol (1999) 1.57
Role of Kruppel-like factors in leukocyte development, function, and disease. Blood (2010) 1.54
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes Dev (1998) 1.48
Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells. Mol Cell Biol (2007) 1.45
Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol (2008) 1.36
Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A (2006) 1.35
Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics (2007) 1.34
Role for SUMO modification in facilitating transcriptional repression by BKLF. Mol Cell Biol (2005) 1.31
Pentaprobe: a comprehensive sequence for the one-step detection of DNA-binding activities. Nucleic Acids Res (2003) 1.28
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol (2006) 1.26
Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol (2013) 1.18
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor. Genome Biol (2014) 1.17
Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. Mol Cell Biol (2000) 1.17
Mechanisms directing the nuclear localization of the CtBP family proteins. Mol Cell Biol (2006) 1.13
Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. Dev Biol (2006) 1.13
EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood (2007) 1.11
The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proc Natl Acad Sci U S A (2005) 0.97
Induction of KLF4 in response to heat stress. Cell Stress Chaperones (2006) 0.97
Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci (2011) 0.94
Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene. Nucleic Acids Res (2000) 0.94
The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cell Biol (2012) 0.93
Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol (2012) 0.93
Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. J Biol Chem (2004) 0.92
Krüppel-like factor KLF8 plays a critical role in adipocyte differentiation. PLoS One (2012) 0.91
Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor. Proc Natl Acad Sci U S A (2001) 0.91
KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites. Mol Cell Biol (2010) 0.90
A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression. Mol Cell Biol (2013) 0.90
The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain. J Biol Chem (2011) 0.89
ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet (2013) 0.87
Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor. Nucleic Acids Res (2013) 0.86
Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2). Diabetes (2013) 0.86
A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. Am J Hum Genet (2013) 0.84
Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis. Mol Biol Cell (2010) 0.81
Transcriptome profiling of genes involved in neural tube closure during human embryonic development using long serial analysis of gene expression (long-SAGE). Birth Defects Res A Clin Mol Teratol (2012) 0.80
Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity. J Biol Chem (2015) 0.78
KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes. Genome Biol Evol (2015) 0.78
Differential effects of Sp cellular transcription factors on viral promoter activation by varicella-zoster virus (VZV) IE62 protein. Virology (2015) 0.76
Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3). J Biol Chem (2016) 0.76
Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells. BMC Mol Biol (2014) 0.76
Analysis of KLF transcription factor family gene variants in type 2 diabetes. BMC Med Genet (2007) 0.76
Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain. Nucleic Acids Res (2015) 0.75
RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer. Oncotarget (2017) 0.75
Molecular Modeling and Phylogeny of the Krüppel-like Factor 4 (cKLF4) Protein from the Arabian Camel, Camelus dromedarius. Bioinform Biol Insights (2016) 0.75
Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system. Gene Expr Patterns (2016) 0.75
Krüppel-like factors in mammalian stem cells and development. Development (2017) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res (1991) 13.54
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol (1993) 5.70
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (1995) 4.80
Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev (1991) 4.54
The beta-globin dominant control region: hypersensitive site 2. EMBO J (1990) 3.75
Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature (1988) 3.69
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev (1991) 3.61
Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene. Proc Natl Acad Sci U S A (1989) 3.53
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (1987) 3.39
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol (1995) 3.39
Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J (1988) 3.34
Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells. Cell (1989) 3.00
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J (1992) 2.65
Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem (1995) 2.51
In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer. Genes Dev (1987) 2.27
Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem (1994) 2.22
cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res (1993) 2.08
Cell-specific activity of the constituent elements of the simian virus 40 enhancer. Proc Natl Acad Sci U S A (1987) 1.97
In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. Proc Natl Acad Sci U S A (1992) 1.87
Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. EMBO J (1987) 1.87
Regulation of globin gene expression in erythroid cells. Eur J Biochem (1995) 1.86
Regulation of the beta-globin locus. Curr Opin Genet Dev (1993) 1.71
The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter. Mol Cell Biol (1995) 1.61
Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties. Mol Cell Biol (1993) 1.43
Genomic footprinting and sequencing of human beta-globin locus. Tissue specificity and cell line artifact. J Biol Chem (1994) 1.41
Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene. Mol Cell Biol (1990) 1.28
Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference. J Biol Chem (1993) 1.20
The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression. Mol Cell Biol (1993) 1.11
The regulation of human globin gene expression. Baillieres Clin Haematol (1993) 1.06
Comparative analysis of the locus control region of the rabbit beta-like gene cluster: HS3 increases transient expression of an embryonic epsilon-globin gene. Nucleic Acids Res (1993) 1.05
Understanding erythroid differentiation. Curr Biol (1993) 0.96
In vitro and in vivo protein--DNA interactions on the rat erythroid-specific L' pyruvate kinase gene promoter. Nucleic Acids Res (1992) 0.92
Transcriptional regulation of the pyruvate kinase erythroid-specific promoter. J Biol Chem (1993) 0.85
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Nature (1982) 9.47
Epigenetic inheritance at the agouti locus in the mouse. Nat Genet (1999) 9.14
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (1989) 9.08
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature (1995) 8.12
Emergence of vancomycin-resistant enterococci in New York City. Lancet (1993) 7.37
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet (1995) 7.34
Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12
Rationale and standards for the systematic review of qualitative literature in health services research. Qual Health Res (1998) 6.95
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A (1999) 6.29
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell (1997) 5.78
Estimating the burden of musculoskeletal disorders in the community: the comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation. Ann Rheum Dis (1998) 5.76
The mutation and polymorphism of the human beta-globin gene and its surrounding DNA. Annu Rev Genet (1984) 5.74
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature (1995) 5.42
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev (1990) 5.25
Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science (1985) 5.23
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev (1994) 5.22
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A (1996) 5.20
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature (1990) 5.13
Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet (1987) 4.97
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events. Proc Natl Acad Sci U S A (1987) 4.91
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Repeat-induced gene silencing in mammals. Nat Genet (1998) 4.74
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J (1997) 4.61
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell (1996) 4.35
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev (1990) 4.35
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med (1978) 4.34
DNA-binding specificity of GATA family transcription factors. Mol Cell Biol (1993) 4.34
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell (1995) 4.32
Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res (1987) 4.25
An essential role in liver development for transcription factor XBP-1. Genes Dev (2000) 4.17
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol (1993) 4.13
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol (1997) 4.12
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology (2001) 4.10
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature (1990) 3.96
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood (2001) 3.93
Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet (1999) 3.92
A community training scheme in cardiopulmonary resuscitation. Br Med J (Clin Res Ed) (1984) 3.83
A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J (1974) 3.80
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature (1989) 3.76
The transcriptional control of hematopoiesis. Blood (1996) 3.72
Public health research and lay knowledge. Soc Sci Med (1996) 3.72
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev (1991) 3.61
Structural and functional characterization of human immunodeficiency virus tat protein. J Virol (1989) 3.57
Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature (1986) 3.50
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet (2000) 3.50
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol (1995) 3.39
Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase. Proc Natl Acad Sci U S A (1983) 3.33
The duplicated human alpha globin genes lie close together in cellular DNA. Proc Natl Acad Sci U S A (1978) 3.33
Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin gene. EMBO J (1986) 3.25
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A (1998) 3.22
GATA transcription factors: key regulators of hematopoiesis. Exp Hematol (1995) 3.09
Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A (1975) 3.05
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet (1999) 3.00
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev (1998) 3.00
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. EMBO J (1991) 3.00
Development of homozygosity for chromosome 11p markers in Wilms' tumour. Nature (1984) 2.97
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A (2000) 2.91
A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. Science (1990) 2.91
The genesis of chronic illness: narrative re-construction. Sociol Health Illn (1984) 2.87
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature (1985) 2.87
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell (2000) 2.86
Development of hematopoietic cells lacking transcription factor GATA-1. Development (1995) 2.78
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A (1995) 2.78
Vascular endothelial cell lineage-specific promoter in transgenic mice. Development (1995) 2.76
Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proc Natl Acad Sci U S A (1986) 2.69
The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc Natl Acad Sci U S A (1990) 2.68
Ultrasound-guided transversus abdominis plane (TAP) block. Anaesth Intensive Care (2007) 2.67
Prevalence of cognitive impairment: data from the Indianapolis Study of Health and Aging. Neurology (2001) 2.67
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet (1992) 2.66
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell (1999) 2.66
Improved detection of the sickle mutation by DNA analysis: application to prenatal diagnosis. N Engl J Med (1982) 2.64
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A (1993) 2.63
Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. J Virol (1990) 2.63
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood (1999) 2.62
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J (2001) 2.62
Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood (1999) 2.61
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A (1997) 2.55
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature (1995) 2.50
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest (1984) 2.43
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell (1979) 2.41