Published in FEBS Lett on October 09, 1998
The caveolin proteins. Genome Biol (2004) 2.23
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00
Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res (2006) 1.73
Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol (2001) 1.67
Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Am J Pathol (2002) 1.62
Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am J Pathol (2003) 1.60
Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype. Br J Cancer (2008) 1.55
Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell (2003) 1.53
Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet (1998) 1.46
Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer (2012) 1.44
Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am J Pathol (2001) 1.43
Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res (2009) 1.36
Are all n-3 polyunsaturated fatty acids created equal? Lipids Health Dis (2009) 1.29
The effect of the intra-S-phase checkpoint on origins of replication in human cells. Genes Dev (2011) 1.21
The role of caveolin-1 in prostate cancer: clinical implications. Prostate Cancer Prostatic Dis (2009) 1.20
Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem (2008) 1.17
Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status. Am J Pathol (2006) 1.16
Integrin regulation of caveolin function. J Cell Mol Med (2007) 1.10
Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. Br J Cancer (2003) 1.05
Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol (2009) 1.05
The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism. Mol Cell Biol (2009) 1.05
Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolution. Chromosome Res (2002) 0.97
Lipid rafts and caveolae in signaling by growth factor receptors. Open Biochem J (2007) 0.96
Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconj J (2001) 0.95
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis. Int J Cancer (2013) 0.92
Novel insights into the role of caveolin-2 in cell- and tissue-specific signaling and function. Biochem Res Int (2011) 0.92
Increased PEA3/E1AF and decreased Net/Elk-3, both ETS proteins, characterize human NSCLC progression and regulate caveolin-1 transcription in Calu-1 and NCI-H23 NSCLC cell lines. Carcinogenesis (2009) 0.91
Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. Mol Carcinog (2008) 0.90
Fragile sites-cytogenetic similarity with molecular diversity. Am J Hum Genet (1999) 0.89
Identification of a novel prostate cancer biomarker, caveolin-1: Implications and potential clinical benefit. Cancer Manag Res (2010) 0.88
Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. Br J Cancer (2002) 0.86
Caveola-forming proteins caveolin-1 and PTRF in prostate cancer. Nat Rev Urol (2013) 0.86
Caveolin-1, caveolae, and glioblastoma. Neuro Oncol (2012) 0.86
Caveolin 1 protein expression in renal cell carcinoma predicts survival. BMC Urol (2011) 0.85
Caveolin-1 as a promoter of tumour spreading: when, how, where and why. J Cell Mol Med (2013) 0.84
Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS One (2010) 0.83
Association of caveolin-1 and -2 genetic variants and post-treatment serum caveolin-1 with prostate cancer risk and outcomes. Prostate (2010) 0.82
Expression of caveolin-1 in gastrointestinal and extraintestinal cancers. J Cancer Res Clin Oncol (2003) 0.81
Isolation and characterization of renal cancer stem cells from patient-derived xenografts. Oncotarget (2016) 0.81
In vitro evolution of ligands to the membrane protein caveolin. J Am Chem Soc (2011) 0.81
Phosphocaveolin-1 enforces tumor growth and chemoresistance in rhabdomyosarcoma. PLoS One (2014) 0.81
Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract. J Korean Med Sci (2008) 0.79
Immunolocalization of caveolin-1 in rat and human mesothelium. J Histochem Cytochem (2004) 0.79
Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation. Am J Transl Res (2013) 0.79
Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation. Am J Pathol (2012) 0.78
Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model. Oncotarget (2014) 0.76
Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites. J Gynecol Res (2015) 0.75
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem (2001) 7.03
Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol (1993) 6.62
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem (1998) 6.26
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem (1996) 4.50
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem (1997) 4.12
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem (1997) 3.80
Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem (1996) 3.62
Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem (1995) 3.45
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem (1997) 3.14
Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci U S A (1995) 3.13
Emerging themes in lipid rafts and caveolae. Cell (2001) 3.09
Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem (1996) 3.05
Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci U S A (1995) 3.03
Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem (1996) 2.95
Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem (2000) 2.86
Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem (1997) 2.74
Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy. Nat Genet (1998) 2.72
Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol (1994) 2.69
Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A (1996) 2.68
Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J Biol Chem (1997) 2.63
Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem (2001) 2.62
Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem (2000) 2.56
Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem (1997) 2.52
Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett (1998) 2.40
Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J Biol Chem (1997) 2.34
Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31
Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J Biol Chem (1995) 2.25
Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J (1998) 2.23
Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J Biol Chem (2001) 2.16
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol (2000) 2.04
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00
Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J Biol Chem (1999) 2.00
Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo. J Biol Chem (1996) 1.93
Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin. Proc Natl Acad Sci U S A (1994) 1.88
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87
Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo. J Biol Chem (2001) 1.82
A new species of yunnanozoan with implications for deuterostome evolution. Science (2003) 1.82
Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J Biol Chem (1999) 1.79
Glycosylphosphatidylinositol-anchored proteins are preferentially targeted to the basolateral surface in Fischer rat thyroid epithelial cells. J Cell Biol (1993) 1.78
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem (1998) 1.77
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem (2000) 1.77
Caveolin-deficient mice: insights into caveolar function human disease. J Clin Invest (2001) 1.71
Caveolin is an activator of insulin receptor signaling. J Biol Chem (1998) 1.66
Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide. J Biol Chem (1997) 1.66
Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J Biol Chem (1998) 1.61
Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol (1998) 1.59
Caveolin-3 in muscular dystrophy. Hum Mol Genet (1998) 1.55
Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J Biol Chem (2000) 1.51
Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions. J Biol Chem (1997) 1.51
A molecular dissection of caveolin-1 membrane attachment and oligomerization. Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivo. J Biol Chem (2000) 1.50
Crowded little caves: structure and function of caveolae. Cell Signal (1998) 1.49
Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes. J Biol Chem (1996) 1.47
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46
Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Mol Cell Biol (2001) 1.46
Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet (1998) 1.46
Demonstration of a neutral atom controlled-NOT quantum gate. Phys Rev Lett (2010) 1.45
Isolation and preliminary characterization of clathrin-associated proteins. Eur J Biochem (1982) 1.44
Phenotypic behavior of caveolin-3 mutations that cause autosomal dominant limb girdle muscular dystrophy (LGMD-1C). Retention of LGMD-1C caveolin-3 mutants within the golgi complex. J Biol Chem (1999) 1.43
Regulation of G protein-coupled receptor kinases by caveolin. J Biol Chem (1999) 1.42
Correctly sorted molecules of a GPI-anchored protein are clustered and immobile when they arrive at the apical surface of MDCK cells. J Cell Biol (1993) 1.41
Elevated expression of caveolin-1 in adenocarcinoma of the colon. Am J Clin Pathol (2001) 1.41
Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem (2000) 1.39
Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis. J Biol Chem (1998) 1.36
Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J Biol Chem (1999) 1.34
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol Endocrinol (2000) 1.32
Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype. Proc Natl Acad Sci U S A (2000) 1.31
Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. FEBS Lett (1998) 1.31
Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem (1998) 1.30
Minimally invasive total hip arthroplasty: a systematic review. Int Orthop (2009) 1.28
The cyclin D1 gene is transcriptionally repressed by caveolin-1. J Biol Chem (2000) 1.28
Caveolae and caveolin-3 in muscular dystrophy. Trends Mol Med (2001) 1.27
Baculovirus-based expression of mammalian caveolin in Sf21 insect cells. A model system for the biochemical and morphological study of caveolae biogenesis. J Biol Chem (1996) 1.27
Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. Am J Physiol Heart Circ Physiol (2000) 1.26
Caveolinopathies: mutations in caveolin-3 cause four distinct autosomal dominant muscle diseases. Neurology (2004) 1.26
Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase. J Biol Chem (1998) 1.25
Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. J Biol Chem (1999) 1.21
An Early Cambrian tunicate from China. Nature (2001) 1.21
Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury. Proc Natl Acad Sci U S A (1998) 1.21
The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J Biol Chem (1999) 1.20
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS Lett (1998) 1.20
Molecular and cellular biology of caveolae paradoxes and plasticities. Trends Cardiovasc Med (1997) 1.18
Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy. J Cell Sci (2000) 1.18