Published in Science on November 06, 1998
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J (2007) 3.31
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Neonatal diabetes mellitus. Endocr Rev (2008) 2.64
Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci U S A (2002) 2.60
Molecular diversity and regulation of renal potassium channels. Physiol Rev (2005) 2.56
Central insulin action in energy and glucose homeostasis. J Clin Invest (2006) 2.51
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell (2013) 2.31
Hydrogen sulfide as a gasotransmitter. J Neurochem (2010) 2.30
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophys J (2000) 2.19
Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels. J Gen Physiol (2000) 2.11
Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev (2010) 2.06
Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc Natl Acad Sci U S A (2003) 2.04
A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO J (2004) 1.98
Cell physiology of cAMP sensor Epac. J Physiol (2006) 1.90
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. Proc Natl Acad Sci U S A (1999) 1.85
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels. J Physiol (2002) 1.80
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proc Natl Acad Sci U S A (2004) 1.72
Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels. J Physiol (1999) 1.56
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition. J Gen Physiol (1999) 1.51
ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch (2006) 1.47
Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells. EMBO J (2000) 1.46
Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel. J Gen Physiol (2001) 1.45
Channelopathies linked to plasma membrane phosphoinositides. Pflugers Arch (2010) 1.42
Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. EMBO J (2007) 1.41
Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J (2003) 1.40
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels. Proc Natl Acad Sci U S A (2000) 1.39
ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J Mol Cell Cardiol (2005) 1.38
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol (2006) 1.36
PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol (2005) 1.35
Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. J Gen Physiol (2000) 1.34
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. J Physiol (2005) 1.33
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. EMBO Rep (2005) 1.32
Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio. Nat Commun (2013) 1.29
Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels. J Gen Physiol (2002) 1.27
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides. J Physiol (2006) 1.26
Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits. J Gen Physiol (2003) 1.26
The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels. J Gen Physiol (2002) 1.25
Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits. J Gen Physiol (1999) 1.24
Nucleotides and phospholipids compete for binding to the C terminus of KATP channels. Proc Natl Acad Sci U S A (2002) 1.23
Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains. J Gen Physiol (2007) 1.23
Flexibility of the Kir6.2 inward rectifier K(+) channel pore. Proc Natl Acad Sci U S A (2001) 1.22
Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol (2006) 1.22
Molecular characteristics of phosphoinositide binding. Pflugers Arch (2007) 1.22
Identification of residues contributing to the ATP binding site of Kir6.2. EMBO J (2003) 1.22
Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore. J Gen Physiol (2003) 1.21
Leptin activation of ATP-sensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. J Physiol (2000) 1.19
Membrane stretch affects gating modes of a skeletal muscle sodium channel. Biophys J (1999) 1.18
Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale! J Mol Cell Cardiol (2009) 1.17
Gating mechanism of KATP channels: function fits form. J Gen Physiol (2003) 1.17
A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels. J Biol Chem (2005) 1.16
Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding. J Physiol (2007) 1.15
Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J Physiol (2001) 1.14
High glucose regulates the activity of cardiac sarcolemmal ATP-sensitive K+ channels via 1,3-bisphosphoglycerate: a novel link between cardiac membrane excitability and glucose metabolism. Diabetes (2005) 1.14
Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (1999) 1.13
Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Diabetes (2009) 1.13
Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivation. J Gen Physiol (2000) 1.11
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Hum Genet (2004) 1.10
Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculations. Pflugers Arch (2007) 1.10
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest (2010) 1.10
Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2010) 1.09
ATP interaction with the open state of the K(ATP) channel. Biophys J (2001) 1.07
How highly charged anionic lipids bind and regulate ion channels. J Gen Physiol (2008) 1.07
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol (2008) 1.06
Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity. Diabetes (2005) 1.06
Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ions. J Gen Physiol (1999) 1.06
Inactivation of P2X2 purinoceptors by divalent cations. J Physiol (2000) 1.05
Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action. Biochem J (2005) 1.04
Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism. J Physiol (2003) 1.03
Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism. J Biol Chem (2008) 1.03
Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2009) 1.02
Effect of phosphatidylserine on unitary conductance and Ba2+ block of the BK Ca2+-activated K+ channel: re-examination of the surface charge hypothesis. J Gen Physiol (2003) 1.02
Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C. J Physiol (2001) 1.02
Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure. J Biol Chem (2009) 1.01
Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase. Proc Natl Acad Sci U S A (2000) 1.01
Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci (2013) 0.99
Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels. Annu Rev Physiol (2014) 0.99
Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions. EMBO J (2005) 0.98
Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol (2009) 0.98
Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles. Proc Natl Acad Sci U S A (1999) 0.97
Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA). J Biol Chem (2013) 0.97
Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel. J Gen Physiol (2000) 0.97
Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K(+) channel. Pflugers Arch (2007) 0.97
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current. J Physiol (2002) 0.97
The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP. Biophys J (2000) 0.97
KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines. J Physiol (2010) 0.95
Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. Br J Pharmacol (2001) 0.95
The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol (2014) 0.94
Modulation of rat atrial G protein-coupled K+ channel function by phospholipids. J Physiol (1999) 0.94
Regulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2. J Gen Physiol (2001) 0.94
Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium. Exp Eye Res (2008) 0.94
The calcium-activated slow AHP: cutting through the Gordian knot. Front Cell Neurosci (2012) 0.93
Molecular biology of K(ATP) channels and implications for health and disease. IUBMB Life (2009) 0.93
Plasma membrane phosphatidylinositol 4,5-bisphosphate levels decrease with time in culture. Plant Physiol (2001) 0.92
Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1. J Gen Physiol (2010) 0.92
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science (1995) 6.91
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature (1994) 6.45
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature (1993) 5.69
Octameric stoichiometry of the KATP channel complex. J Gen Physiol (1997) 3.48
Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. J Gen Physiol (1997) 3.02
The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. J Physiol (1989) 2.86
Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patches. J Physiol (1989) 2.78
Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. J Gen Physiol (1997) 2.32
The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines. J Gen Physiol (1995) 2.29
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophys J (2000) 2.19
Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels. J Gen Physiol (2000) 2.11
Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell (2000) 1.96
A novel method for measurement of submembrane ATP concentration. J Biol Chem (2000) 1.92
Inward rectifiers in the heart: an update on I(K1). J Mol Cell Cardiol (2001) 1.84
Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here? Circ Res (2001) 1.66
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. Diabetes (1998) 1.59
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels. J Biol Chem (2000) 1.56
ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. J Physiol (1999) 1.53
Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential. Proc Natl Acad Sci U S A (1988) 1.47
[K+] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1). J Gen Physiol (1996) 1.42
Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver. J Physiol (1999) 1.39
K(ATP) channels and insulin secretion disorders. Am J Physiol Endocrinol Metab (2002) 1.33
Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines. J Gen Physiol (1998) 1.30
The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels. J Gen Physiol (2002) 1.25
Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits. J Gen Physiol (1999) 1.24
Cloning and expression of a novel human brain inward rectifier potassium channel. J Biol Chem (1994) 1.23
Flexibility of the Kir6.2 inward rectifier K(+) channel pore. Proc Natl Acad Sci U S A (2001) 1.22
Hyperinsulinism in mice with heterozygous loss of K(ATP) channels. Diabetologia (2006) 1.22
The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. J Physiol (1989) 1.19
Gating mechanism of KATP channels: function fits form. J Gen Physiol (2003) 1.17
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol (2000) 1.16
Depletion of intracellular polyamines relieves inward rectification of potassium channels. Proc Natl Acad Sci U S A (1996) 1.15
Hyperinsulinism induced by targeted suppression of beta cell KATP channels. Proc Natl Acad Sci U S A (2002) 1.12
Genetic heterogeneity in familial hyperinsulinism. Hum Mol Genet (1998) 1.12
Protein kinase C inhibition of cloned inward rectifier (HRK1/KIR2.3) K+ channels expressed in Xenopus oocytes. J Physiol (1996) 1.09
ATP interaction with the open state of the K(ATP) channel. Biophys J (2001) 1.07
Effects of pipette geometry on the time course of solution change in patch clamp experiments. Biophys J (1991) 1.06
[K+] dependence of open-channel conductance in cloned inward rectifier potassium channels (IRK1, Kir2.1). Biophys J (1996) 1.06
Tolerance for ATP-insensitive K(ATP) channels in transgenic mice. Circ Res (2001) 1.05
Independent trafficking of KATP channel subunits to the plasma membrane. J Biol Chem (1998) 1.05
Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase. Proc Natl Acad Sci U S A (2000) 1.01
Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. J Biol Chem (2001) 1.00
Modulation of ATP-sensitive K+ channel activity and contractile behavior in mammalian ventricle by the potassium channel openers cromakalim and RP49356. J Pharmacol Exp Ther (1990) 0.99
The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle. J Physiol (1988) 0.99
Structural basis of inward rectifying potassium channel gating. Trends Cardiovasc Med (2002) 0.97
Internal Na+ and Mg2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. Inward rectification of a delayed rectifier. J Gen Physiol (1994) 0.97
The gamma subunit of the Na,K-ATPase induces cation channel activity. Proc Natl Acad Sci U S A (1998) 0.97
Contractility and ischemic response of hearts from transgenic mice with altered sarcolemmal K(ATP) channels. Am J Physiol Heart Circ Physiol (2002) 0.97
On the mechanism of inhibition of KATP channels by glibenclamide in rat ventricular myocytes. J Cardiovasc Electrophysiol (1993) 0.94
Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. J Biol Chem (1995) 0.93
MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. J Biol Chem (2001) 0.91
Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. Diabetologia (2011) 0.91
The mechanism of KATP channel inhibition by ATP. J Gen Physiol (1991) 0.91
Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel. J Biol Chem (1992) 0.90
Evaluation of cervicothoracic junction injury. Ann Emerg Med (1987) 0.90
Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. J Biol Chem (1996) 0.89
Spermidine release from xenopus oocytes. Electrodiffusion through a membrane channel. J Biol Chem (1996) 0.89
The influence of 'diastolic' length on the contractility of isolated cat papillary muscle. J Physiol (1985) 0.89
Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs. Mol Pharmacol (2005) 0.88
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. J Physiol (2001) 0.87
Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice. J Mol Cell Cardiol (2006) 0.87
Assembly of ROMK1 (Kir 1.1a) inward rectifier K+ channel subunits involves multiple interaction sites. Biophys J (1998) 0.85
Sarcolemmal K(ATP) channels in the heart: molecular mechanisms brought to light, but physiologic consequences still in the dark. J Cardiovasc Electrophysiol (2001) 0.84
2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. J Pharmacol Exp Ther (1993) 0.83
Polyamine flux in Xenopus oocytes through hemi-gap junctional channels. J Physiol (2003) 0.82
Toxic shock syndrome associated with use of latex nasal packing. Arch Intern Med (1990) 0.80
Novel tools for localizing ion channels in living cells. Trends Pharmacol Sci (1998) 0.79
Sulfonylurea receptors and ATP-sensitive K+ channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors. J Biol Chem (1993) 0.78
The mitochondria and insulin release: Nnt just a passing relationship. Cell Metab (2006) 0.77
Block of delayed rectifier (DRK1) K+ channels by internal 2,3-butanedione monoxime in Xenopus oocytes. Receptors Channels (1993) 0.76
K(ATP) channel regulators: balanced diets include carbohydrates, proteins, and fats. Circ Res (2001) 0.75
A novel crystallization method for visualizing the membrane localization of potassium channels. Biophys J (1998) 0.75
Chopped-meat medium tube filler. Am J Clin Pathol (1972) 0.75
Nucleotides and insulin secretion. Nutrition (1999) 0.75
Selection for increased weaning or yearling weight in Hereford cattle. II. Direct and correlated responses. J Anim Sci (1985) 0.75
Selection for increased weaning or yearling weight in Hereford cattle. I. Measurement of selection applied. J Anim Sci (1985) 0.75