Heterodimerization is required for the formation of a functional GABA(B) receptor.

PubWeight™: 5.59‹?› | Rank: Top 1%

🔗 View Article (PMID 9872316)

Published in Nature on December 17, 1998

Authors

J H White1, A Wise, M J Main, A Green, N J Fraser, G H Disney, A A Barnes, P Emson, S M Foord, F H Marshall

Author Affiliations

1: Receptor Systems, Molecular Pharmacology Unit, GlaxoWellcome, Medicines Research Centre, Stevenage, Hertfordshire, UK.

Articles citing this

(truncated to the top 100)

Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J (1999) 6.25

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04

Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A (2002) 5.91

G-protein-coupled receptor heterodimerization modulates receptor function. Nature (1999) 4.73

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A (2000) 4.46

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res (2008) 3.76

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev (2010) 3.27

Synaptic control of motoneuronal excitability. Physiol Rev (2000) 2.93

Anatomical profiling of G protein-coupled receptor expression. Cell (2008) 2.88

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol (2009) 2.60

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem (2007) 2.59

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J (2001) 2.28

The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett (2004) 2.19

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J (2001) 2.17

Analysis of receptor oligomerization by FRAP microscopy. Nat Methods (2009) 2.06

Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry (2004) 2.03

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol (2009) 1.97

GPCR monomers and oligomers: it takes all kinds. Trends Neurosci (2008) 1.97

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J (2001) 1.94

mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol (2006) 1.93

Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol (2011) 1.91

Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol Rev (2010) 1.89

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature (2010) 1.86

Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A (2001) 1.82

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization. Proc Natl Acad Sci U S A (2012) 1.82

Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. EMBO J (2006) 1.66

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J (2006) 1.64

Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface. Proc Natl Acad Sci U S A (2006) 1.57

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci U S A (2000) 1.53

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem (2001) 1.49

The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors. AAPS PharmSci (1999) 1.47

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization. Br J Pharmacol (2007) 1.47

Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. Reprod Biol Endocrinol (2003) 1.46

Heteromeric association creates a P2Y-like adenosine receptor. Proc Natl Acad Sci U S A (2001) 1.46

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. J Biol Chem (2004) 1.45

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol (2006) 1.45

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J (2008) 1.40

The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci U S A (2000) 1.36

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A (2001) 1.36

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction. J Biol Chem (2008) 1.34

Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? Proc Natl Acad Sci U S A (2001) 1.32

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep (2006) 1.31

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J Biol Chem (2008) 1.30

Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+. Biochem J (2003) 1.30

GABAB receptor modulation of synaptic function. Curr Opin Neurobiol (2011) 1.28

G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding. Mol Pharmacol (2011) 1.27

Molecular basis for amino acid sensing by family C G-protein-coupled receptors. Br J Pharmacol (2009) 1.25

Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J (2005) 1.24

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc Natl Acad Sci U S A (2002) 1.21

Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers. J Am Chem Soc (2012) 1.20

Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci (2010) 1.18

Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A (2001) 1.15

Modulation of chemokine receptor activity through dimerization and crosstalk. Cell Mol Life Sci (2009) 1.15

Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev (2008) 1.14

Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J (2008) 1.14

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A (2009) 1.14

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor. Mol Pharmacol (2009) 1.12

Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol (2009) 1.11

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J Biol Chem (2010) 1.10

The systematic annotation of the three main GPCR families in Reactome. Database (Oxford) (2010) 1.09

Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J (2013) 1.08

Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc Natl Acad Sci U S A (1999) 1.07

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal (2013) 1.06

The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proc Natl Acad Sci U S A (2000) 1.06

Gamma-aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling. Endocrinology (2009) 1.05

Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 1.05

The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05

Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharmacol (2011) 1.05

Functional expression of GABAB receptors in airway epithelium. Am J Respir Cell Mol Biol (2008) 1.04

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics (2007) 1.04

Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers. J Biol Chem (2012) 1.03

Subcellular distribution of GABA(B) receptor homo- and hetero-dimers. Biochem J (2005) 1.03

Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing. Endocrinology (2007) 1.02

Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering. J Physiol (2003) 1.01

Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cell Mol Neurobiol (2002) 1.01

Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophys J (2008) 1.01

Apoptosis. Death deceiver. Nature (1998) 1.00

G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes. Biochem J (2002) 1.00

REEP2 enhances sweet receptor function by recruitment to lipid rafts. J Neurosci (2010) 1.00

Structure and function of G protein-coupled receptors using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc (2010) 1.00

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition. Br J Pharmacol (2013) 0.98

Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective. Curr Neuropharmacol (2007) 0.98

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chem Rev (2016) 0.97

Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance. Neuropsychopharmacology (2013) 0.96

Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. Cell Mol Neurobiol (2007) 0.96

Genomic organization and characterization of splice variants of the human histamine H3 receptor. Biochem J (2001) 0.95

ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging. Proc Natl Acad Sci U S A (2013) 0.95

Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding. J Pharmacol Exp Ther (2009) 0.93

Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection. Br J Pharmacol (2009) 0.92

Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment. J Neurosci (2014) 0.92

A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry (2012) 0.92

Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Sci (2005) 0.92

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy. EMBO J (2006) 0.91

GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates. J Anat (2000) 0.91

GPR80/99, proposed to be the P2Y(15) receptor activated by adenosine and AMP, is not a P2Y receptor. Purinergic Signal (2004) 0.91

Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors. Adv Pharmacol (2011) 0.91

Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocr Rev (2014) 0.91

Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. Pflugers Arch (2004) 0.91

GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation. Neurosci Lett (2009) 0.91

Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae. Eukaryot Cell (2005) 0.90

Articles by these authors

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature (1998) 5.98

The influence of the ovary on pituitary secretion; a probable factor in parturition. J Physiol (1924) 5.73

Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst (1989) 3.48

AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem (2001) 3.32

Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood (2001) 2.99

Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med (1987) 2.98

On the ovarian factor concerned in the recurrence of the oestrous cycle. J Physiol (1914) 2.95

The occurrence of ovulation and pseudo-pregnancy in the rabbit as a result of central nervous stimulation. J Physiol (1936) 2.86

Gestational diabetes mellitus in India. J Assoc Physicians India (2004) 2.86

Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase. Diabetologia (2012) 2.85

Liver disease and bile duct abnormalities in adults with cystic fibrosis. Lancet (1989) 2.76

Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science (1990) 2.56

Familiarity with and social distance from people who have serious mental illness. Psychiatr Serv (2001) 2.47

Cystic fibrosis in adolescents and adults. Thorax (1987) 2.47

Buteyko breathing techniques in asthma: a blinded randomised controlled trial. Med J Aust (1999) 2.42

Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins. BMJ (1995) 2.40

Fecal calprotectin: validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2001) 2.33

Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med (2001) 2.26

Neonatal screening for inborn errors of metabolism: cost, yield and outcome. Health Technol Assess (1997) 2.20

Hereditary haemorrhagic telangiectasia: a population-based study of prevalence and mortality in Danish patients. J Intern Med (1999) 2.19

CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology (2006) 2.19

N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest (2000) 2.13

Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. J Clin Endocrinol Metab (1999) 2.13

Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities. Obes Rev (2008) 2.11

The importance of genes and environment for ocular refraction and its determiners: a population based study among 20-45 year old twins. Br J Ophthalmol (2001) 2.09

The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab (1995) 2.07

Cause of death and correlation with autopsy findings in burns patients. Burns (2012) 2.07

Epidemiological studies of diabetes mellitus in Denmark. II. A prevalence study based on insulin prescriptions. Diabetologia (1981) 2.06

Tolerance of nicotinamide and carbogen with radiation therapy for glioblastoma. Radiother Oncol (1996) 2.03

Health sector reform and the interpretation of policy context. Health Policy (1999) 2.00

Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand (1980) 1.98

Further evidence for an association between genetic variation in transforming growth factor alpha and cleft lip and palate. Am J Hum Genet (1991) 1.98

Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease. Gut (2002) 1.96

Prejudice, social distance, and familiarity with mental illness. Schizophr Bull (2001) 1.95

Nail patella syndrome: a review of the phenotype aided by developmental biology. J Med Genet (2003) 1.95

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol Pharmacol (1999) 1.89

How much residual plasma may cause TRALI? Transfus Med (2008) 1.85

Beyond ovulation: oral contraceptives and epithelial ovarian cancer. Epidemiology (2000) 1.82

Review of the epidemiologic literature on EMF and Health. Environ Health Perspect (2001) 1.80

Risk analysis in the development of pterygia. Ophthalmology (1992) 1.79

Idiopathic adhesive capsulitis. A prospective functional outcome study of nonoperative treatment. J Bone Joint Surg Am (2000) 1.78

Common acquired naevi and the risk of malignant melanoma. Int J Cancer (1985) 1.76

The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation (1996) 1.75

Decentralization and primary health care: some negative implications in developing countries. Int J Health Serv (1994) 1.75

Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE). Int J Cancer (1995) 1.68

Melanocytic lesions excised from the skin: what percentage are malignant? Aust J Public Health (1994) 1.67

Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. Science (1998) 1.67

Biopterin derivatives in normal and phenylketonuric patients after oral loads of L-phenylalanine, L-tyrosine, and L-tryptophan. Arch Dis Child (1976) 1.66

Prevalence of K329E mutation in medium-chain acyl-CoA dehydrogenase gene determined from Guthrie cards. Lancet (1991) 1.66

Is childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates. Diabetologia (2001) 1.66

Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer (2007) 1.66

Studies of the HLA system and insulin-dependent diabetes mellitus. Diabetes Care (1980) 1.63

Agonist control of G-protein levels. Trends Pharmacol Sci (1991) 1.63

On the occurrence of compensatory hypertrophy in the ovary. J Physiol (1908) 1.63

Population based study of prevalence of islet cell autoantibodies in monozygotic and dizygotic Danish twin pairs with insulin dependent diabetes mellitus. BMJ (1997) 1.61

Comparative pupil dilation using phenylephrine alone or in combination with tropicamide. Ophthalmology (1998) 1.61

A study of patient satisfaction and adherence to preventive care practice guidelines. Am J Med (1995) 1.60

A study of sweat sodium and chloride; criteria for the diagnosis of cystic fibrosis. Ann Clin Biochem (1985) 1.60

Monitoring the international use of unrelated donors for transplantation: the WMDA annual reports. Bone Marrow Transplant (2010) 1.60

Evaluation of eight and a half years of neonatal screening for haemoglobinopathies in Birmingham. Br Med J (Clin Res Ed) (1988) 1.59

CDKN2A variants in a population-based sample of Queensland families with melanoma. J Natl Cancer Inst (1999) 1.59

Methylation patterns at the hypervariable X-chromosome locus DXS255 (M27 beta): correlation with X-inactivation status. Genomics (1990) 1.57

A novel candidate region for ALS on chromosome 14q11.2. Neurology (2004) 1.56

Fecal shedding of Campylobacter and Arcobacter spp. in dairy cattle. Appl Environ Microbiol (2000) 1.56

Meta-analyses of studies of ventricular enlargement and cortical sulcal prominence in mood disorders. Comparisons with controls or patients with schizophrenia. Arch Gen Psychiatry (1995) 1.55

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain (2002) 1.55

Regional variations in medium-chain acyl-CoA dehydrogenase deficiency. Lancet (1995) 1.52

Sunburn and malignant melanoma. Br J Cancer (1985) 1.51

The new Danish Twin Register: establishment and analysis of twinning rates. Int J Epidemiol (1995) 1.50

Declining prevalence of STI in the London sex industry, 1985 to 2002. Sex Transm Infect (2004) 1.50

Fecal shedding of Salmonella spp. by dairy cows on farm and at cull cow markets. J Food Prot (2001) 1.50

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time. Aliment Pharmacol Ther (2013) 1.50

Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2001) 1.49

Neuroblastoma--when are urinary catecholamines and their metabolites 'normal'? Ann Clin Biochem (1988) 1.48

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal Biochem (1997) 1.47

Meta-analysis of brain and cranial size in schizophrenia. Schizophr Res (1996) 1.45

The occurrence of ovulation in the rabbit as a result of stimulation of the central nervous system by drugs. J Physiol (1939) 1.44

Control of expression of the varicella-zoster virus major immediate early gene. J Gen Virol (1990) 1.43

HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus. Diabetologia (1981) 1.43

Long-term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study. Br J Ophthalmol (1997) 1.42

Differential methylation of the hypervariable locus DXS255 on active and inactive X chromosomes correlates with the expression of a human X-linked gene. Genomics (1990) 1.41

A study of infertility treatment and melanoma. Melanoma Res (2001) 1.41

Successful pregnancy in a patient with type III glycogen storage disease managed with cornstarch supplements. Br J Obstet Gynaecol (1998) 1.40

Peripheral primitive neuroectodermal tumor (peripheral neuroepithelioma) in children. A review of the St. Jude experience and controversies in diagnosis and management. Cancer (1989) 1.40

Health issues associated with increasing use of "crack" cocaine among female sex workers in London. Sex Transm Infect (2000) 1.39

Information technology in nutrition and dietetic education. Br J Nutr (1998) 1.39

Evidence for recycling of insulin receptors in isolated rat adipocytes. J Biol Chem (1981) 1.38

Risk of cutaneous melanoma associated with a family history of the disease. The International Melanoma Analysis Group (IMAGE). Int J Cancer (1995) 1.38

Has sexuality anything to do with psychoanalysis? Int J Psychoanal (1995) 1.38

The role of the subthalamic nucleus in response inhibition: evidence from deep brain stimulation for Parkinson's disease. Neuropsychologia (2009) 1.38

Smoking and prostate cancer. Epidemiol Rev (2001) 1.38

Congenital hemolytic anemia with high-sodium, low-potassium red cells. Studies of three generations of a family with a new variant. N Engl J Med (1969) 1.37

Opening the debate on DALYs (disability-adjusted life years). Health Policy Plan (1996) 1.37

The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci U S A (2000) 1.36