Published in Mol Cell Biol on September 01, 1998
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol (2008) 8.43
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes (2006) 4.95
Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91
Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res (2008) 2.88
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest (2007) 2.85
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol (2008) 2.08
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J (2004) 1.88
Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest (2011) 1.88
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol (2003) 1.81
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J (2006) 1.75
Adipocyte metabolism and obesity. J Lipid Res (2008) 1.62
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56
Reactive oxygen species in health and disease. J Biomed Biotechnol (2012) 1.52
Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell Immunol (2008) 1.42
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39
The cell biology of fat expansion. J Cell Biol (2015) 1.37
Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am J Physiol Endocrinol Metab (2008) 1.29
Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol (2000) 1.27
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J Appl Physiol (1985) (2010) 1.26
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes (2009) 1.18
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes (2009) 1.17
Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. Biochem J (2001) 1.16
DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle. J Lipid Res (2011) 1.09
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Rep (2014) 1.06
Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling. Diabetes (2009) 1.05
The role of skeletal muscle sphingolipids in the development of insulin resistance. Rev Diabet Stud (2008) 1.03
Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Diabetologia (2011) 1.03
"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action. Curr Diabetes Rev (2007) 1.02
Cardiac lipotoxicity: molecular pathways and therapeutic implications. Curr Heart Fail Rep (2013) 1.01
PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes (2012) 0.99
Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. Alcohol Clin Exp Res (2011) 0.98
Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells. Endocrinology (2006) 0.98
Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids Health Dis (2013) 0.95
Targeting the PI3-kinase/Akt/mTOR signaling pathway. Surg Oncol Clin N Am (2013) 0.94
Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. Mol Cell Biol (2013) 0.93
Ceramides and glucosylceramides are independent antagonists of insulin signaling. J Biol Chem (2013) 0.92
Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin. Biochem J (2000) 0.92
TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep (2012) 0.89
Differences in muscle transcriptome among pigs phenotypically extreme for fatty acid composition. PLoS One (2014) 0.89
Defect of insulin signal in peripheral tissues: Important role of ceramide. World J Diabetes (2014) 0.87
Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes. Am J Physiol Endocrinol Metab (2007) 0.87
Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects. J Physiol (2013) 0.87
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells. Proc Natl Acad Sci U S A (2014) 0.86
Palmitate alters neuregulin signaling and biology in cardiac myocytes. Biochem Biophys Res Commun (2008) 0.86
Sphingolipid metabolic pathway: an overview of major roles played in human diseases. J Lipids (2013) 0.85
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. J Biol Chem (2013) 0.85
Glut4 storage vesicles without Glut4: transcriptional regulation of insulin-dependent vesicular traffic. Mol Cell Biol (2004) 0.85
Sphingolipid metabolism and obesity-induced inflammation. Front Endocrinol (Lausanne) (2013) 0.84
Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro. Free Radic Biol Med (2010) 0.84
GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. J Mol Endocrinol (2015) 0.82
Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. World J Cardiol (2013) 0.82
The adipokine/ceramide axis: key aspects of insulin sensitization. Biochimie (2013) 0.82
Hip circumference and the risk of type 2 diabetes in middle-aged and elderly men and women: the Shanghai women and Shanghai men's health studies. Ann Epidemiol (2011) 0.81
Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle. BMC Biochem (2014) 0.80
Dihydroceramides: From Bit Players to Lead Actors. J Biol Chem (2015) 0.80
Lipid Use and Misuse by the Heart. Circ Res (2016) 0.79
Stimulation of GLUT4 (glucose transporter isoform 4) storage vesicle formation by sphingolipid depletion. Biochem J (2010) 0.79
Bioreactors addressing diabetes mellitus. J Diabetes Sci Technol (2014) 0.79
Effects of 4 weeks recombinant human growth hormone administration on insulin resistance of skeletal muscle in rats. Yonsei Med J (2008) 0.79
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase. Biochem J (2000) 0.79
CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance. J Physiol (2016) 0.78
The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. Biochem Biophys Res Commun (2009) 0.78
Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial. Circulation (2017) 0.77
Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide. Biol Open (2014) 0.77
Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate. Endocrinology (2009) 0.77
Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells. J Nutr Biochem (2013) 0.77
Metabolic Conversion of Ceramides in HeLa Cells - A Cholesteryl Phosphocholine Delivery Approach. PLoS One (2015) 0.76
Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture. PLoS One (2013) 0.76
Sphingolipids and Lipoproteins in Health and Metabolic Disorders. Trends Endocrinol Metab (2017) 0.75
De Novo Lipogenesis Products and Endogenous Lipokines. Diabetes (2016) 0.75
Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway. Biochem J (2001) 0.75
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders. Nat Rev Endocrinol (2016) 0.75
Calcitriol concomitantly enhances insulin sensitivity and alters myocellular lipid partitioning in high fat-treated skeletal muscle cells. J Physiol Biochem (2017) 0.75
Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol (2017) 0.75
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature (1995) 11.61
PI3K: downstream AKTion blocks apoptosis. Cell (1997) 7.73
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (1991) 6.54
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem (1996) 6.35
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes (1997) 5.61
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol (1994) 5.13
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem (1994) 4.90
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A (1998) 4.72
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A (1991) 4.66
Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes (1994) 4.66
The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem (1994) 4.21
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci U S A (1996) 3.50
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem (1991) 3.17
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem (1998) 2.93
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J (1995) 2.92
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem (1998) 2.51
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J (1994) 2.30
Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci (1995) 2.28
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem (1996) 1.85
1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J Biol Chem (1990) 1.74
Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology (1997) 1.73
Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem (1992) 1.72
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem (1996) 1.71
The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J Biol Chem (1995) 1.62
Lipid-regulated kinases: some common themes at last. Science (1998) 1.53
Characterization of the insulin-regulated membrane aminopeptidase in 3T3-L1 adipocytes. J Biol Chem (1996) 1.53
Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol (1997) 1.44
Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes. J Biol Chem (1996) 1.39
Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form. J Biol Chem (1997) 1.35
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem (1995) 1.30
Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner. Biochem Biophys Res Commun (1998) 1.28
Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane. J Biol Chem (1994) 1.24
The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity. J Biol Chem (1994) 1.23
Early events in TNF signaling: a story of associations and dissociations. J Leukoc Biol (1997) 1.23
Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. Biochem Biophys Res Commun (1995) 1.23
Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Biochem Biophys Res Commun (1994) 1.18
Stress-induced apoptosis and the sphingomyelin pathway. Biochem Pharmacol (1997) 1.17
Ceramide and the induction of apoptosis. Clin Cancer Res (1996) 1.12
Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1. J Biol Chem (1996) 1.11
A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake. Biochem Soc Trans (1997) 1.02
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes. Diabetes (1998) 0.97
Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells. FEBS Lett (1997) 0.89
Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes. FEBS Lett (1997) 0.84
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem (1996) 6.35
Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol (2001) 5.69
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell (2001) 5.57
A tool for analyzing and annotating genomic sequences. Genomics (1997) 5.33
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol (1999) 5.00
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci U S A (1986) 4.40
Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet (2001) 4.19
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell (1994) 4.15
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature (1997) 3.74
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis (2009) 3.11
The role of FoxO in the regulation of metabolism. Oncogene (2008) 3.09
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene (1997) 3.08
CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell (1995) 3.00
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet (1997) 2.97
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem (1998) 2.93
Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology (2004) 2.81
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73
Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J Bone Miner Res (2001) 2.65
Longitudinal studies of Aedes aegypti (Diptera: Culicidae) in Thailand and Puerto Rico: population dynamics. J Med Entomol (2000) 2.58
Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med (1998) 2.58
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci U S A (1999) 2.41
Major bleeding after hospitalization for deep-venous thrombosis. Am J Med (1999) 2.25
Seven novel methylation guide small nucleolar RNAs are processed from a common polycistronic transcript by Rat1p and RNase III in yeast. Mol Cell Biol (1999) 2.20
The use of Medpor coated tear drainage tube in conjunctivodacryocystorhinostomy. Eye (Lond) (2007) 2.13
A suppressor of TBP mutations encodes an RNA polymerase III transcription factor with homology to TFIIB. Cell (1992) 2.12
Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol (2000) 2.11
Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol (2002) 2.10
Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator. Mol Cell (1999) 2.09
Context sequences of translation initiation codon in plants. Plant Mol Biol (1997) 2.05
Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron (2000) 2.04
Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo. Virology (2000) 1.98
Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus. Science (1989) 1.97
A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol (1999) 1.95
Insulin increases the association of Akt-2 with Glut4-containing vesicles. J Biol Chem (1998) 1.95
A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. Am J Physiol (1997) 1.88
Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol (2001) 1.86
Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med (1998) 1.86
Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle. Biochem Biophys Res Commun (2000) 1.85
The regulation of AMP-activated protein kinase by H(2)O(2). Biochem Biophys Res Commun (2001) 1.84
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A (1999) 1.84
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int (2006) 1.83
Nosocomial pneumonia caused by carbapenem-resistant Raoultella planticola: a case report and literature review. Infection (2015) 1.82
Glucose deprivation and hexose transporter polypeptides of murine fibroblasts. J Biol Chem (1986) 1.81
Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. Mol Cell Biol (2001) 1.80
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest (1991) 1.76
Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76
RYR1 mutations are a common cause of congenital myopathies with central nuclei. Ann Neurol (2010) 1.75
Functional domains of transcription factor TFIIB. Proc Natl Acad Sci U S A (1993) 1.75
Intercommunity differences in acid aerosol (H+)/sulfate (SO4(2-) ratios. J Expo Anal Environ Epidemiol (1996) 1.74
Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections. J Virol (2000) 1.73
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science (1987) 1.70
Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology (2003) 1.69
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J Biol Chem (1998) 1.68
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem (2000) 1.68
Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem (2001) 1.68
Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol (2010) 1.67
High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum Gene Ther (1998) 1.67
Radiological factors influencing femoral and acetabular failure in cemented Charnley total hip arthroplasties. J Bone Joint Surg Br (1999) 1.67
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone (1999) 1.66
Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. J Biol Chem (1993) 1.64
Improved survival with plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Am J Med (1999) 1.63
The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J Biol Chem (1995) 1.62
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell (1997) 1.60
Stretching single-stranded DNA: interplay of electrostatic, base-pairing, and base-pair stacking interactions. Biophys J (2001) 1.58
Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol (2006) 1.58
Patellar complications (total knee arthroplasty). Effect of lateral release and thickness. Clin Orthop Relat Res (1999) 1.56
The incidence of venous thromboembolism among patients with primary lung cancer. J Thromb Haemost (2008) 1.55
The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem (2000) 1.53
Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. Genomics (2000) 1.53
Growth factors rapidly induce expression of the glucose transporter gene. J Biol Chem (1988) 1.53
The Drosophila dCREB2 gene affects the circadian clock. Neuron (1999) 1.53
Representation of stereoscopic edges in monkey visual cortex. Vision Res (2000) 1.52
Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy. Osteoporos Int (2009) 1.52
Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene (2009) 1.51
GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Nat Genet (1998) 1.49
Transcription factor IID mutants defective for interaction with transcription factor IIA. Science (1992) 1.48
The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc Natl Acad Sci U S A (1997) 1.44
Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism. Bone (2007) 1.43
Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson's disease in southern China. Eur J Neurol (2011) 1.42
Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nat Med (2000) 1.41
Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes. J Biol Chem (2000) 1.40
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ (2010) 1.39
Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum Gene Ther (1997) 1.39
Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer (2000) 1.39
Safety profile of a divided dose of propranolol for heart rate in children with infantile haemangioma during 16 weeks of treatment. Br J Dermatol (2014) 1.38
Preimplantation urinary hormone profiles and the probability of conception in healthy women. Fertil Steril (1999) 1.37
The acquisition of increased insulin-responsive hexose transport in 3T3-L1 adipocytes correlates with expression of a novel transporter gene. J Biol Chem (1989) 1.36
MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene (2011) 1.35
Clinic-based evaluation of Clearview Chlamydia MF for detection of Chlamydia trachomatis in vaginal and cervical specimens from women at high risk in China. Sex Transm Infect (2006) 1.34
Heritable Q-T prolongation without deafness. Circulation (1970) 1.34
Multiplexed immunobead-based assay for detection of oral cancer protein biomarkers in saliva. Oral Dis (2008) 1.33