Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects.

PubWeight™: 1.83‹?› | Rank: Top 3%

🔗 View Article (PMC 2377392)

Published in Kidney Int on May 01, 2006

Authors

H Yasuda1, P S T Yuen, X Hu, H Zhou, R A Star

Author Affiliations

1: Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, Bethesda, Maryland, USA.

Associated clinical trials:

Statins for the Early Treatment of Sepsis (SETS) | NCT00528580

Articles citing this

Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med (2008) 8.79

Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest (2009) 2.71

Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol (2009) 2.61

Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int (2008) 2.37

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. J Immunol (2012) 1.61

Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2008) 1.59

AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int (2008) 1.54

The role of Toll-like receptors in renal diseases. Nat Rev Nephrol (2010) 1.42

Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care (2010) 1.34

Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int (2011) 1.33

Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol (2014) 1.28

Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. Am J Pathol (2011) 1.27

Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis (2008) 1.26

Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol (2014) 1.25

Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2011) 1.19

Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol (2008) 1.17

Association between statins given in hospital and mortality in pneumonia patients. J Gen Intern Med (2011) 1.08

Alteration of microvascular permeability in acute kidney injury. Microvasc Res (2008) 1.06

Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis. Shock (2011) 1.05

TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. PLoS One (2012) 1.03

A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes (2014) 1.03

Immune mechanisms and novel pharmacological therapies of acute kidney injury. Curr Drug Targets (2009) 1.02

Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI. J Am Soc Nephrol (2013) 0.94

Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther (2012) 0.93

Hydrogel-embedded endothelial progenitor cells evade LPS and mitigate endotoxemia. Am J Physiol Renal Physiol (2011) 0.91

Role of surfactant proteins A and D in sepsis-induced acute kidney injury. Shock (2015) 0.91

Increased expression of CD14 in macrophages after inhibition of the cholesterol biosynthetic pathway by lovastatin. Mol Med (2007) 0.90

Rolipram improves renal perfusion and function during sepsis in the mouse. J Pharmacol Exp Ther (2013) 0.89

Oxidative stress and modification of renal vascular permeability are associated with acute kidney injury during P. berghei ANKA infection. PLoS One (2012) 0.89

Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance. J Pharmacol Exp Ther (2011) 0.87

Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther (2014) 0.86

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9. J Am Soc Nephrol (2015) 0.85

Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury. J Pharmacol Exp Ther (2011) 0.82

Renoprotective approaches and strategies in acute kidney injury. Pharmacol Ther (2016) 0.82

Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infect Immun (2010) 0.82

The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis. ScientificWorldJournal (2013) 0.80

Therapeutic and predictive targets of AKI. Clin Nephrol (2008) 0.79

Ischemic preconditioning attenuates lipid peroxidation and apoptosis in the cecal ligation and puncture model of sepsis. Exp Ther Med (2013) 0.78

Approaches to the Management of Acute Kidney Injury in Children. Recent Pat Biomark (2011) 0.78

Statins decrease mortality in Lebanese patients with sepsis: A multicenter study. Pharm Pract (Granada) (2013) 0.78

Simvastatin inhibits apoptosis of endothelial cells induced by sepsis through upregulating the expression of Bcl-2 and downregulating Bax. World J Emerg Med (2014) 0.78

Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia. Clin J Am Soc Nephrol (2012) 0.78

Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy. Int J Mol Sci (2015) 0.78

A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial. Trials (2011) 0.77

Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats. Int J Mol Sci (2015) 0.77

Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice. Front Microbiol (2015) 0.75

Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway. Mol Med (2015) 0.75

Sesamol ameliorates hypotension by modulating cytokines and PPAR-gamma in systemic inflammatory response. EXCLI J (2015) 0.75

The role of statins in the setting of HIV infection. Curr HIV/AIDS Rep (2015) 0.75

Effect of simvastatin on mitochondrial enzyme activities, ghrelin, hypoxia-inducible factor 1α in hepatic tissue during early phase of sepsis. Int J Clin Exp Med (2015) 0.75

Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target? Intensive Care Med Exp (2014) 0.75

Pediatric Statin Administration: Navigating a Frontier with Limited Data. J Pediatr Pharmacol Ther (2016) 0.75

Pleiotropic effects of statins on acute kidney injury: involvement of Krüppel-like factor 4. Clin Exp Nephrol (2016) 0.75

Articles cited by this

Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99

Intensive insulin therapy in critically ill patients. N Engl J Med (2001) 40.00

Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70

Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA (2005) 19.57

The immunopathogenesis of sepsis. Nature (2002) 11.83

The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA (1995) 9.54

C-reactive protein levels and outcomes after statin therapy. N Engl J Med (2005) 9.47

Acute renal failure and sepsis. N Engl J Med (2004) 7.18

The effect of acute renal failure on mortality. A cohort analysis. JAMA (1996) 6.09

Acute renal failure. Lancet (2005) 5.60

Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58

Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med (2005) 4.64

Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol (2003) 3.99

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med (2004) 3.59

TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest (2002) 3.48

Diagnosis and treatment of acute tubular necrosis. Ann Intern Med (2002) 3.33

Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock (2000) 3.12

The effect of statins on mortality in patients with bacteremia. Clin Infect Dis (2001) 3.02

Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int (2002) 2.94

Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation (2004) 2.82

Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet (2004) 2.52

HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation (2004) 2.30

Injury of the renal microvascular endothelium alters barrier function after ischemia. Am J Physiol Renal Physiol (2003) 2.19

A simplified method for HPLC determination of creatinine in mouse serum. Am J Physiol Renal Physiol (2004) 2.17

Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int (2003) 2.15

Statin treatment after onset of sepsis in a murine model improves survival. Circulation (2005) 2.08

Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol (2002) 1.96

Statin therapy reduces contrast-induced nephropathy: an analysis of contemporary percutaneous interventions. Am J Med (2005) 1.92

Statin effects beyond lipid lowering--are they clinically relevant? Eur Heart J (2003) 1.90

Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol (1994) 1.75

INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med (1996) 1.73

Prognostic factors in acute renal failure due to sepsis. Results of a prospective multicentre study. The French Study Group on Acute Renal Failure. Nephrol Dial Transplant (1996) 1.68

FDA adverse event reports on statin-associated rhabdomyolysis. Ann Pharmacother (2002) 1.67

Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation. Am J Pathol (2001) 1.67

Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol (2005) 1.65

Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine. J Lab Clin Med (1988) 1.55

Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis. Am J Respir Crit Care Med (2002) 1.52

Evidence of tubular hypoxia in the early phase in the remnant kidney model. J Am Soc Nephrol (2004) 1.52

Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest (1997) 1.48

Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int (2001) 1.41

Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med (2003) 1.32

Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect Immun (2001) 1.31

Angiostatin and matrix metalloprotease expression following ischemic acute renal failure. Am J Physiol Renal Physiol (2004) 1.22

Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury. Am J Physiol Renal Physiol (2004) 1.21

Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice. Kidney Int (2005) 1.21

Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion. J Thorac Cardiovasc Surg (2003) 1.16

HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. Circ Res (2005) 1.14

Cancer therapy and renal injury. J Clin Invest (2002) 1.14

Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse. Shock (2002) 1.11

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis. J Am Soc Nephrol (2004) 1.09

Protective effect of HMG-CoA reductase inhibitor on experimental renal ischemia-reperfusion injury. Am J Nephrol (2002) 1.09

Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury. Kidney Int (2005) 1.03

Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs. Am J Physiol Heart Circ Physiol (2000) 1.03

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function. Am J Kidney Dis (2005) 1.01

Binding of 14C-misonidazole to hypoxic cells in V79 spheroids. Br J Cancer (1982) 1.00

Differential alterations in microvascular perfusion in various organs during early and late sepsis. Am J Physiol (1992) 0.96

The mevalonate pathway during acute tubular injury: selected determinants and consequences. Am J Pathol (2002) 0.92

Reduction in vascular responsiveness to adrenomedullin during sepsis. J Surg Res (1999) 0.90

Prevention and treatment of acute renal failure in sepsis. J Am Soc Nephrol (2003) 0.87

Sepsis syndrome stimulates proximal tubule cholesterol synthesis and suppresses the SR-B1 cholesterol transporter. Kidney Int (2003) 0.86

The statins--therapeutic diversity in renal disease? Curr Opin Nephrol Hypertens (2005) 0.86

Simvastatin acts synergistically with ACE inhibitors or amlodipine to decrease oxygen consumption in rat hearts. J Cardiovasc Pharmacol (2000) 0.85

Renal ischemia-induced increase in vascular permeability is limited by hypothermia. Immunopharmacology (1999) 0.84

Helicobacter pylori lipopolysaccharide provokes iNOS-mediated acute systemic microvascular inflammatory responses in rat cardiac, hepatic, renal and pulmonary tissues. J Physiol Paris (2001) 0.83

Noncholesterol-lowering effects of statins. Vasc Endovascular Surg (2003) 0.82

Morphometric studies on acute renal failure in humans during the oligoanuric and polyuric phases. Clin Nephrol (1983) 0.79

Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats. Virchows Arch (2004) 0.77

Articles by these authors

An STS-based map of the human genome. Science (1995) 17.72

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10

Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51

Climate change. Recent reductions in China's greenhouse gas emissions. Science (2001) 5.77

Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol (2001) 5.69

Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58

A tool for analyzing and annotating genomic sequences. Genomics (1997) 5.33

The crystal structure of the light-harvesting complex II (B800-850) from Rhodospirillum molischianum. Structure (1996) 4.34

Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet (2001) 4.19

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell (1994) 4.15

Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in the People's Republic of China. Infect Immun (1992) 4.02

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature (1997) 3.74

Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67

Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis (2009) 3.11

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene (1997) 3.08

CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell (1995) 3.00

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int (2006) 3.00

Imaging brain function in humans at 7 Tesla. Magn Reson Med (2001) 2.98

Frequent Hemodialysis Network (FHN) randomized trials: study design. Kidney Int (2006) 2.85

Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology (2004) 2.81

Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation (1997) 2.80

Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J Bone Miner Res (2001) 2.65

Longitudinal studies of Aedes aegypti (Diptera: Culicidae) in Thailand and Puerto Rico: population dynamics. J Med Entomol (2000) 2.58

Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med (1998) 2.58

A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol (1998) 2.57

A cDNA clone from the Duchenne/Becker muscular dystrophy gene. Nature (1987) 2.55

Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules. Proc Natl Acad Sci U S A (1998) 2.50

Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. Kidney Int (2006) 2.44

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci U S A (1999) 2.41

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol (1998) 2.28

Major bleeding after hospitalization for deep-venous thrombosis. Am J Med (1999) 2.25

Seven novel methylation guide small nucleolar RNAs are processed from a common polycistronic transcript by Rat1p and RNase III in yeast. Mol Cell Biol (1999) 2.20

Imaging at high magnetic fields: initial experiences at 4 T. Magn Reson Q (1993) 2.14

The use of Medpor coated tear drainage tube in conjunctivodacryocystorhinostomy. Eye (Lond) (2007) 2.13

A suppressor of TBP mutations encodes an RNA polymerase III transcription factor with homology to TFIIB. Cell (1992) 2.12

Effects of increased solar ultraviolet radiation on materials. J Photochem Photobiol B (1998) 2.12

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol (2002) 2.10

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator. Mol Cell (1999) 2.09

Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int (2001) 2.06

Context sequences of translation initiation codon in plants. Plant Mol Biol (1997) 2.05

Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron (2000) 2.04

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Mol Cell (2000) 2.02

Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo. Virology (2000) 1.98

Prospective comparison treatment of 595-nm pulsed-dye lasers for virgin port-wine stain. Br J Dermatol (2015) 1.96

The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging. Magn Reson Med (1997) 1.94

Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science (2013) 1.91

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. Am J Physiol (1997) 1.88

Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol (2001) 1.86

Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med (1998) 1.86

Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent. J Biol Inorg Chem (2004) 1.85

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A (1999) 1.84

Nosocomial pneumonia caused by carbapenem-resistant Raoultella planticola: a case report and literature review. Infection (2015) 1.82

Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. Mol Cell Biol (2001) 1.80

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene (2010) 1.80

Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76

RYR1 mutations are a common cause of congenital myopathies with central nuclei. Ann Neurol (2010) 1.75

Functional domains of transcription factor TFIIB. Proc Natl Acad Sci U S A (1993) 1.75

Renin expression in renal proximal tubule. J Clin Invest (1993) 1.74

Intercommunity differences in acid aerosol (H+)/sulfate (SO4(2-) ratios. J Expo Anal Environ Epidemiol (1996) 1.74

Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections. J Virol (2000) 1.73

Association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces. J Virol (1997) 1.71

BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med (1995) 1.71

Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology (2003) 1.69

Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem (2001) 1.68

Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol (2010) 1.67

Radiological factors influencing femoral and acetabular failure in cemented Charnley total hip arthroplasties. J Bone Joint Surg Br (1999) 1.67

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum Gene Ther (1998) 1.67

Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone (1999) 1.66

Modification of seed oil content and acyl composition in the brassicaceae by expression of a yeast sn-2 acyltransferase gene. Plant Cell (1997) 1.66

Risk factors for severe injuries associated with falls from playground equipment. Accid Anal Prev (2000) 1.64

Improved survival with plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Am J Med (1999) 1.63

4 T-fMRI study of nonspatial shifting of selective attention: cerebellar and parietal contributions. J Neurophysiol (1998) 1.60

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell (1997) 1.60

Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem (2000) 1.59

Stretching single-stranded DNA: interplay of electrostatic, base-pairing, and base-pair stacking interactions. Biophys J (2001) 1.58

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol (2006) 1.58

Evaluation of a promotional strategy to increase bicycle helmet use by children. Pediatrics (1993) 1.57

Retrospective estimation and correction of physiological artifacts in fMRI by direct extraction of physiological activity from MR data. Magn Reson Med (1996) 1.57

Patellar complications (total knee arthroplasty). Effect of lateral release and thickness. Clin Orthop Relat Res (1999) 1.56

Migraine prevalence by age and sex in the United States: a life-span study. Cephalalgia (2010) 1.56

The incidence of venous thromboembolism among patients with primary lung cancer. J Thromb Haemost (2008) 1.55

AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int (2008) 1.54

Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. Genomics (2000) 1.53

The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem (2000) 1.53

The Drosophila dCREB2 gene affects the circadian clock. Neuron (1999) 1.53

Representation of stereoscopic edges in monkey visual cortex. Vision Res (2000) 1.52

Membrane localization of H+ and HCO3- transporters in the rat pancreatic duct. J Gen Physiol (1994) 1.52

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene (2011) 1.52

Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy. Osteoporos Int (2009) 1.52

Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene (2009) 1.51

Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx. J Biol Chem (1994) 1.48