IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs.

PubWeight™: 1.91‹?› | Rank: Top 3%

🔗 View Article (PMID 9916716)

Published in J Immunol on January 15, 1999

Authors

M G Chiaramonte1, L R Schopf, T Y Neben, A W Cheever, D D Donaldson, T A Wynn

Author Affiliations

1: Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0425, USA.

Articles citing this

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest (1999) 4.22

Integrating mechanisms of pulmonary fibrosis. J Exp Med (2011) 3.57

Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med (2003) 2.71

Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med (2003) 2.54

Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog (2009) 2.07

Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect Immun (2006) 1.76

NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. Am J Pathol (2000) 1.67

IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J Clin Invest (2000) 1.66

Immunology of parasitic helminth infections. Infect Immun (2002) 1.62

Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med (1999) 1.47

Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immun (2003) 1.45

Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol (2010) 1.35

Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med (2012) 1.28

Immune interactions in hepatic fibrosis. Clin Liver Dis (2008) 1.23

Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens. Infect Immun (2004) 1.22

Macrophage heterogeneity in respiratory diseases. Mediators Inflamm (2013) 1.20

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A (2013) 1.16

Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol (2009) 1.11

Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans. Infect Immun (2006) 1.05

Cytokines and STATs in Liver Fibrosis. Front Physiol (2012) 1.02

Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis. Invest Ophthalmol Vis Sci (2010) 1.02

Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment. Infect Immun (1999) 0.99

The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells. Mucosal Immunol (2013) 0.99

Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum. J Infect Dis (2008) 0.98

IL-4 and IL-13 signaling in allergic airway disease. Cytokine (2015) 0.96

The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani. Am J Pathol (2006) 0.95

Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment. Infect Immun (1999) 0.95

Chemokines and chemokine receptors: their role in allergic airway disease. J Clin Immunol (1999) 0.95

TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis. Am J Pathol (2006) 0.94

Granulocytes in helminth infection -- who is calling the shots? Curr Med Chem (2012) 0.92

Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa. Int J Obes (Lond) (2009) 0.91

Chronic schistosome infection leads to modulation of granuloma formation and systemic immune suppression. Front Immunol (2013) 0.91

Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody. Infect Immun (1999) 0.89

Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients. BMC Immunol (2002) 0.88

IL-13 Signaling in Liver Fibrogenesis. Front Immunol (2012) 0.88

Investigation of the change in CD4⁺ T cell subset in children with Henoch-Schonlein purpura. Rheumatol Int (2011) 0.87

The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. BMC Immunol (2010) 0.87

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med (2015) 0.86

Interleukin-13 fusion cytotoxin arrests Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Am J Pathol (2002) 0.86

Gender-related cytokine patterns in sera of schistosomiasis patients with Symmers' fibrosis. Clin Diagn Lab Immunol (2004) 0.85

Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes. Infect Immun (2000) 0.85

HTLV-1 modifies the clinical and immunological response to schistosomiasis. Clin Exp Immunol (2004) 0.84

Gene Therapy against Murine Melanoma B16F10-Nex2 Using IL-13Ralpha2-Fc Chimera and Interleukin 12 in Association with a Cyclopalladated Drug. Transl Oncol (2008) 0.83

Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation. Infect Immun (2011) 0.81

Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol (2015) 0.80

FOXO1 regulates dendritic cell activity through ICAM-1 and CCR7. J Immunol (2015) 0.80

Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni. Parasitol Res (2004) 0.79

Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ (2014) 0.79

IL-13 induces YY1 through the AKT pathway in lung fibroblasts. PLoS One (2015) 0.78

IL-13 is a therapeutic target in radiation lung injury. Sci Rep (2016) 0.78

Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ. J Pathol (2016) 0.77

Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections. Biomed Res Int (2016) 0.77

Urinary cytokines in Schistosoma haematobium-infected schoolchildren from Tana Delta District of Kenya. BMC Infect Dis (2014) 0.76

Schistosomiasis-associated pulmonary hypertension. Pulm Circ (2014) 0.76

Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-related Osteonecrosis of the Jaw. J Biol Chem (2016) 0.76

Enhanced interleukin-12 and CD40 ligand activities but reduced Staphylococcus aureus Cowan 1-induced responses suggest a generalized and progressively impaired type 1 cytokine pattern for human schistosomiasis. Infect Immun (2002) 0.76

Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016. Radiat Res (2017) 0.75

Articles by these authors

Interleukin-13: central mediator of allergic asthma. Science (1998) 14.05

Requirement for IL-13 independently of IL-4 in experimental asthma. Science (1998) 10.76

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 7.61

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75

IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity (1998) 4.65

Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol (2001) 4.59

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest (1999) 4.22

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med (2001) 3.63

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J Immunol (1993) 3.34

Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol (2001) 3.25

Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev (1989) 3.21

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest (1993) 3.19

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol (1996) 3.15

Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J Immunol (1993) 3.14

Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12

IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol (2000) 3.03

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J Exp Med (1994) 2.99

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Proc Natl Acad Sci U S A (1992) 2.92

Characterization of two Phaseolus vulgaris phytohemagglutinin genes closely linked on the chromosome. EMBO J (1985) 2.88

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest (1993) 2.84

Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med (1997) 2.79

Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol (2001) 2.63

Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ (1968) 2.58

The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol (1998) 2.57

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature (1995) 2.52

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci U S A (1990) 2.37

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science (1993) 2.35

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol (1994) 2.25

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22

A quantitative post-mortem study of Schistosomiasis mansoni in man. Am J Trop Med Hyg (1968) 2.22

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science (2014) 2.20

IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. J Immunol (1997) 2.09

Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infect Immun (2001) 1.99

Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology (2001) 1.90

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J Immunol (1990) 1.88

Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J Immunol (1999) 1.78

Il-13 and IFN-gamma: interactions in lung inflammation. J Immunol (2001) 1.75

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med (1996) 1.68

NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. Am J Pathol (2000) 1.67

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunol (2010) 1.65

Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol (2001) 1.63

Pathological lesions associated with Schistosoma mansoni infection in man. Trans R Soc Trop Med Hyg (1967) 1.61

Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells. J Immunol (1996) 1.60

CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling. J Exp Med (1998) 1.56

Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol (2001) 1.55

Pathogenesis of post-thymectomy autoimmunity. Role of syngeneic MLR-reactive T cells. J Immunol (1995) 1.55

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. J Immunol (1998) 1.54

Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol (1999) 1.53

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci U S A (1994) 1.53

Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol (2000) 1.52

Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature (1988) 1.51

The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man. Clin Exp Immunol (1978) 1.40

Schistosoma mansoni and S. haematobium infections in Egypt. II. Quantitative parasitological findings at necropsy. Am J Trop Med Hyg (1977) 1.37

Cytokine regulation of granuloma formation in schistosomiasis. Curr Opin Immunol (1995) 1.36

Counting of Schistosoma mansoni eggs in feces. Comparison of a filtration technique and a dilution technique. J Parasitol (1968) 1.36

IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. J Immunol (1993) 1.36

Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J Infect Dis (1996) 1.36

Immunopathology of schistosomiasis mansoni in mice and men. Immunol Today (2000) 1.34

Synthesis and protein body deposition of maize 15-kd zein in transgenic tobacco seeds. EMBO J (1987) 1.32

Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. FASEB J (2001) 1.30

Schistosome infections in humans: perspectives and recent findings. NIH conference. Ann Intern Med (1982) 1.25

Characterization of T helper cell responses to the trypanosome variant surface glycoprotein. J Immunol (1993) 1.25

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms. J Immunol (1999) 1.24

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol (1997) 1.23

Quantitative comparison of the intensity of Schistosoma mansoni infections in man and experimental animals. Trans R Soc Trop Med Hyg (1969) 1.22

The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections. Curr Opin Immunol (1999) 1.22

Microcystic dystrophy of the cornea. A partial explanation for its pathogenesis. Arch Ophthalmol (1974) 1.20

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma. J Immunol (1995) 1.19

Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol (1995) 1.18

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J Immunol (1995) 1.18

Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni. Am J Trop Med Hyg (1987) 1.18

A new instrument for the measurement of corneal thickness. Arch Ophthalmol (1966) 1.16

Fibroblast stimulation in schistosomiasis. I. Stimulation in vitro of fibroblasts by soluble products of egg granulomas. J Infect Dis (1981) 1.16

Immunopathology of Schistosoma japonicum and S. mansoni infection in B cell depleted mice. Parasite Immunol (1985) 1.12

Cytokine production in acute versus chronic human Schistosomiasis mansoni: the cross-regulatory role of interferon-gamma and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. J Infect Dis (1999) 1.11

Comparison of geographical strains of Schistosoma mansoni in the mouse. Bull World Health Organ (1972) 1.11

Diagnosis of pathologically confirmed Symmers' periportal fibrosis by ultrasonography: a prospective blinded study. Am J Trop Med Hyg (1988) 1.11

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J Immunol (1996) 1.11

Testing time-, ignorance-, and danger-based models of tolerance. J Immunol (2001) 1.08

IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12. J Immunol (1998) 1.08