Published in Nat Immunol on December 01, 2001
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity (2009) 2.51
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
TIM-1, a novel allergy and asthma susceptibility gene. Springer Semin Immunopathol (2003) 1.72
Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A (2009) 1.72
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood (2009) 1.54
Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J Exp Med (2003) 1.52
Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol (2007) 1.46
T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol (2010) 1.45
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest (2014) 1.38
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production. Blood (2009) 1.35
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev (2009) 1.32
The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev (2009) 1.25
Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol Cell Biol (2004) 1.24
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. J Immunol (2008) 1.11
Lipid signaling in T-cell development and function. Cold Spring Harb Perspect Biol (2010) 1.08
Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A (2008) 1.04
Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood (2005) 1.01
Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates. FEBS J (2011) 0.94
The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses. J Immunol (2008) 0.94
Itk: the rheostat of the T cell response. J Signal Transduct (2011) 0.91
Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol Pharmacol (2012) 0.89
The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells. J Immunol (2013) 0.88
Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration. J Immunol (2008) 0.87
Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk. PLoS One (2010) 0.87
Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects. J Clin Immunol (2014) 0.87
IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells. J Allergy Clin Immunol (2013) 0.86
Signals for the execution of Th2 effector function. Cytokine (2009) 0.86
In vivo significance of ITK-SLP-76 interaction in cytokine production. Mol Cell Biol (2010) 0.86
ITK inhibitors in inflammation and immune-mediated disorders. Curr Top Med Chem (2009) 0.86
Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways. J Immunol (2014) 0.85
A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice. J Immunol (2012) 0.84
A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation. BMC Immunol (2005) 0.83
ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner. J Leukoc Biol (2014) 0.83
The Tec family kinase Itk exists as a folded monomer in vivo. J Biol Chem (2009) 0.83
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun (2016) 0.83
Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk. J Immunol (2014) 0.82
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. Sci Signal (2014) 0.81
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J Biol Chem (2013) 0.78
IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I. Eur J Immunol (2009) 0.78
Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide. PLoS One (2013) 0.77
Targeting neoplastic B cells and harnessing microenvironment: the "double face" of ibrutinib and idelalisib. J Hematol Oncol (2015) 0.77
TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77
Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids. BMC Pharmacol Toxicol (2014) 0.77
Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. PLoS One (2014) 0.76
The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor. Int J Biochem Cell Biol (2013) 0.76
A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. J Immunol (2015) 0.75
The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection. Sci Rep (2015) 0.75
Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. PLoS One (2015) 0.75
Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases. Postdoc J (2014) 0.75
Functional diversity of helper T lymphocytes. Nature (1996) 18.09
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 14.74
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med (1988) 7.02
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A (1993) 6.12
Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence. Cell (1989) 6.04
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (1992) 5.94
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 5.48
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med (1991) 5.04
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol (1994) 4.86
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A (2001) 4.76
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol (1991) 4.69
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol (2001) 4.59
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell (1999) 4.55
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest (1999) 4.22
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol (1992) 4.02
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol (1992) 3.98
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun (1998) 3.80
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol (1991) 3.65
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med (2001) 3.64
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science (1994) 3.46
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J Immunol (1993) 3.34
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature (1994) 3.31
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity (2000) 3.27
Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev (1989) 3.21
Genomic mismatch scanning in pedigrees. IMA J Math Appl Med Biol (1994) 3.16
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol (1996) 3.15
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12
PATRIC: the VBI PathoSystems Resource Integration Center. Nucleic Acids Res (2006) 3.06
Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine. Eur J Immunol (1972) 3.04
IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol (2000) 3.03
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J Exp Med (1994) 2.99
The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur J Immunol (1992) 2.98
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry (2010) 2.95
Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature (1975) 2.92
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Proc Natl Acad Sci U S A (1992) 2.92
Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science (1992) 2.89
Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J Immunol (1985) 2.87
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A (2000) 2.80
IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol (1992) 2.78
Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci U S A (1993) 2.65
Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ (1968) 2.58
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 2.52
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature (1995) 2.52
Successful T cell priming in B cell-deficient mice. J Exp Med (1995) 2.52
CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Nat Immunol (2000) 2.49
Diversity of cytokine synthesis and function of mouse CD4+ T cells. Immunol Rev (1991) 2.49
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (1999) 2.45
Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes. J Immunol (1987) 2.43
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol (1999) 2.41
Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci U S A (1990) 2.37
Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A (2001) 2.29
Induction and regulation of IL-15 expression in murine macrophages. J Immunol (1996) 2.28
Meta-analysis of genome searches. Ann Hum Genet (1999) 2.27
Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol (1994) 2.25
Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J Exp Med (1994) 2.22
A quantitative post-mortem study of Schistosomiasis mansoni in man. Am J Trop Med Hyg (1968) 2.22
Outbreak of Brucella melitensis among microbiology laboratory workers in a community hospital. J Clin Microbiol (1991) 2.20
Coding of visual space by premotor neurons. Science (1994) 2.16
Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J Immunol (1992) 2.14
IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-gamma and TNF-alpha and occurs via a nitric oxide-dependent mechanism. J Immunol (1995) 2.12
Predicting treatment response in psoriasis using serum levels of adalimumab and etanercept: a single-centre, cohort study. Br J Dermatol (2013) 2.10
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development (2000) 2.10
IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. J Immunol (1997) 2.09
Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry (2008) 2.07
Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient mice. J Exp Med (1993) 2.07
Therapygenetics: the 5HTTLPR and response to psychological therapy. Mol Psychiatry (2011) 2.06
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06
Regulation of nitrate reductase in the basidiomycete Ustilago maydis. J Bacteriol (1970) 2.00
Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infect Immun (2001) 1.99
Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni. J Exp Med (1978) 1.98
Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol (2001) 1.97
Early history of lipoplasty in the United States. Aesthetic Plast Surg (1990) 1.96
Good worms or bad worms: do worm infections affect the epidemiological patterns of other diseases? Parasitol Today (2000) 1.96
Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol (2000) 1.94
IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma. J Immunol (1995) 1.94
Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors. J Clin Microbiol (2000) 1.92
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J Immunol (1999) 1.91
Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology (2001) 1.90
Fidelity of the ensemble code for visual motion in primate retina. J Neurophysiol (2004) 1.88
Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J Immunol (1990) 1.88
Regulation and biological function of helminth-induced cytokine responses. Immunol Today (1991) 1.87
Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function. Immunobiology (1999) 1.86