Published in J Clin Invest on December 01, 1976
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest (1980) 2.15
Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci U S A (1986) 1.94
Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action. J Clin Invest (1977) 1.85
Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J Exp Med (1982) 1.64
Neurocytotoxic antibodies in serum of patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1978) 1.57
Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen. Proc Natl Acad Sci U S A (1986) 1.43
Accelerated degradation of acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins. Proc Natl Acad Sci U S A (1977) 1.39
Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies. J Clin Endocrinol Metab (2010) 1.29
Selective modification of a private I-A allo-stimulating determinant(s) upon association of antigen with an antigen-presenting cell. J Exp Med (1984) 1.25
Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor. Biochem J (1987) 1.09
Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats. J Clin Invest (1983) 1.05
Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci U S A (1987) 1.04
Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. Proc Natl Acad Sci U S A (1979) 1.01
Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest (1992) 0.99
Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts. J Clin Invest (1980) 0.99
Antireceptor antibodies as probes of insulinlike growth factor receptor structure. J Clin Invest (1983) 0.98
Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. Proc Natl Acad Sci U S A (1981) 0.96
A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies. Proc Natl Acad Sci U S A (1991) 0.94
Polyglandular autoimmune syndrome: current concepts. CMAJ (1988) 0.89
Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. J Clin Invest (1983) 0.88
Specific pancreatic beta-cell surface antigens recognized by a xenogenic antiserum. J Cell Biol (1982) 0.85
Using Drosophila to discover mechanisms underlying type 2 diabetes. Dis Model Mech (2016) 0.80
Clinical evaluation of insulin resistance and beta-cell function by the homeostasis model assessment in patients with systemic lupus erythematosus. Clin Rheumatol (2004) 0.80
Genetics in endocrinology: genetic forms of severe insulin resistance: what endocrinologists should know. Eur J Endocrinol (2013) 0.80
Systemic lupus erythematosus presenting as hypoglycemia with insulin receptor antibodies. West J Med (1989) 0.75
Insulin receptor antibodies in diabetes mellitus. Clin Exp Immunol (1988) 0.75
Peripheral metabolism of hormones: clinical implications. J R Soc Med (1979) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun (1971) 3.74
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Thyroid-stimulating immunoglobulins in Graves' disease. Lancet (1974) 2.84
Serum globulin in myasthenia gravis: inhibition of alpha-bungarotoxin binding to acetylcholine receptors. Science (1974) 2.69
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
Relation of thyroid-stimulating immunoglobulins to thyroid function and effects of surgery, radioiodine, and antithyroid drugs. Lancet (1975) 2.57
The bioassay of thyrotropin in serum. Endocrinology (1958) 2.53
Myasthenia gravis: a serum factor blocking acetylcholine receptors of the human neuromuscular junction. Lancet (1975) 1.84
Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man. Proc Natl Acad Sci U S A (1975) 1.83
Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet (1975) 1.66
The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells. Diabetologia (1974) 1.42
Insulin-resistant diabetes associated with increased endogenous plasma insulin followed by complete remission. J Clin Invest (1961) 1.29
Immunopharmacological disease: a break in tolerance to receptor sites. Lancet (1971) 1.23
Effects of long-acting thyroid stimulator (LATS) and LATS protector on human thyroid adenyl cyclase activity. Br Med J (1973) 1.10
Insulin resistance, skin changes, and virilization: a recessively inherited syndrome possibly due to pineal gland dysfunction. Diabetologia (1974) 1.01
Effects of long-acting thyroid stimulator on thyrotropin stimulation of adenyl cyclase activity in thyroid plasma membranes. J Clin Invest (1972) 0.94
Stimulation of the human thyroid by infusions of plasma containing LATS protector. J Clin Endocrinol Metab (1974) 0.86
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. J Clin Endocrinol Metab (1974) 0.86
Activation of thyroid adenyl cyclase by long-acting thyroid stimulator. Life Sci I (1970) 0.85
INSULIN RESISTANCE AND ACANTHOSIS NIGRICANS. Diabetes (1965) 0.81
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
Insulin signalling and the regulation of glucose and lipid metabolism. Nature (2001) 16.41
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72
Obesity and insulin resistance. J Clin Invest (2000) 10.47
Obesity and the regulation of energy balance. Cell (2001) 9.48
Procedure for identifying nonsense mutations. J Bacteriol (1968) 8.16
Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 8.14
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
Role of leptin in the neuroendocrine response to fasting. Nature (1996) 8.02
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature (1994) 7.86
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem (1978) 7.15
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol (1982) 6.67
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell (1999) 6.53
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (1992) 6.28
A transgenic model of visceral obesity and the metabolic syndrome. Science (2001) 6.22
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med (1995) 5.45
The insulin signaling system. J Biol Chem (1994) 5.25
Adipogenesis and obesity: rounding out the big picture. Cell (1996) 5.15
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol (1994) 5.13
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science (1982) 5.01
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med (1990) 4.87
Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proc Natl Acad Sci U S A (1981) 4.85
Leptin. Annu Rev Physiol (2000) 4.78
Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue. J Histochem Cytochem (1981) 4.62
Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol (1998) 4.30
Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol (1987) 4.27
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Adipose tissue as an endocrine organ. Trends Endocrinol Metab (2000) 4.07
Cluster of genes controlling proline degradation in Salmonella typhimurium. J Bacteriol (1978) 4.04
PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products. Nucleic Acids Res (1990) 3.93
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature (1982) 3.90
Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell (1998) 3.84
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun (1971) 3.74
Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Proc Natl Acad Sci U S A (1971) 3.65
Insulin resistance--mechanisms, syndromes, and implications. N Engl J Med (1991) 3.58
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell (1985) 3.54
Membrane receptors for hormones and neurotransmitters. J Cell Biol (1976) 3.54
Hybrid DNA artifact from PCR of closely related target sequences. Nucleic Acids Res (1989) 3.54
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med (2000) 3.53
The changing natural history of nephropathy in type I diabetes. Am J Med (1985) 3.50
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest (2000) 3.50
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science (1987) 3.44
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 3.38
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron (1999) 3.37
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest (1999) 3.36
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest (1995) 3.18
The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. J Bacteriol (1999) 3.17
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet (2002) 3.12
Insulin receptors are widely distributed in the central nervous system of the rat. Nature (1978) 3.07
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J Biol Chem (1988) 3.05
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem (1997) 3.01
Site-site interactions among insulin receptors. Characterization of the negative cooperativity. J Biol Chem (1976) 3.01
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest (1996) 2.98
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Bidirectional modulation of insulin action by amino acids. J Clin Invest (1998) 2.92
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem (1988) 2.90
Insulin action and the insulin signaling network. Endocr Rev (1995) 2.89
Regulation of the major proline permease gene of Salmonella typhimurium. J Bacteriol (1978) 2.87
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation. J Biol Chem (1972) 2.78
Influence of left ventricular function on outcome of patients treated with implantable defibrillators. Circulation (1992) 2.77
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest (2000) 2.75
Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med (1997) 2.73
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest (1997) 2.73
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Three-year outcomes for maintenance therapies in recurrent depression. Arch Gen Psychiatry (1990) 2.66
The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem (1999) 2.63
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem (1997) 2.57
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science (1993) 2.57
Plasma insulin and growth hormone levels in obesity and diabetes. Ann N Y Acad Sci (1965) 2.56
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest (1999) 2.48
Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med (1997) 2.48
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47
Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A (2001) 2.44
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J (1997) 2.44