Published in Proc Natl Acad Sci U S A on August 01, 1978
Structure and nucleotide sequence of the heavy chain gene of HLA-DR. Proc Natl Acad Sci U S A (1983) 3.21
Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules. J Exp Med (1982) 2.15
Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons. J Clin Invest (1984) 2.00
Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens. Immunology (1983) 1.85
Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease. J Exp Med (1984) 1.75
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain. Proc Natl Acad Sci U S A (1982) 1.75
DR (Ia-like) antigens on human melanoma cells. Serological detection and immunochemical characterization. J Exp Med (1979) 1.63
Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility. Proc Natl Acad Sci U S A (1983) 1.55
The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules. J Exp Med (1984) 1.51
Analysis of HLA-DR polymorphism by two-dimensional peptide mapping. Proc Natl Acad Sci U S A (1981) 1.49
Translation and assembly of HLA-DR antigens in Xenopus oocytes injected with mRNA from a human B-cell line. EMBO J (1982) 1.46
Monoclonal antibodies against HLA-DR antigens replace T helper cells in activation of B lymphocytes. Proc Natl Acad Sci U S A (1983) 1.28
Cell surface properties of HLA antigens on Epstein-Barr virus-transformed cell lines. Proc Natl Acad Sci U S A (1982) 1.18
Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. II. A hybridoma secreting antibody against an antigen expressed by human B and null lymphocytes. Clin Exp Immunol (1980) 1.11
Identification of cells expressing T and p28,33 (Ia-like) antigens in sections of human lymphoid tissue. Clin Exp Immunol (1980) 0.97
Antigen presentation by murine and human cells to a murine T-cell hybridoma: demonstration of a restriction element associated with a major histocompatibility complex class II determinant(s) shared by both species. Proc Natl Acad Sci U S A (1984) 0.94
An HLA-DR5 homozygous cell line expresses two DS (I-A-like) molecules. J Exp Med (1983) 0.93
Multiple HLA-DR antigens: detection with monoclonal antibodies and translation in vitro. Proc Natl Acad Sci U S A (1982) 0.91
Identification of two cis-encoded HLA-DQ molecules that carry distinct alloantigenic specificities. J Exp Med (1984) 0.78
Disease susceptibility genes and the Ia system. Rheumatol Int (1984) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. J Immunol (1975) 47.77
The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol (1975) 9.19
The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens. J Exp Med (1975) 5.48
Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes. J Exp Med (1975) 4.96
Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A (1971) 4.14
Structural and serological properties of murine Ia alloantigens. Transplant Rev (1976) 2.35
Cellular distrubtion, purification, and molecular nature of human Ia antigens. Scand J Immunol (1977) 2.04
Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex. Cold Spring Harb Symp Quant Biol (1977) 1.91
Purification and structural characterisation of human HLA-linked B-cell antigens. Nature (1977) 1.83
Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4). Proc Natl Acad Sci U S A (1977) 1.79
Isolation and immunologic characterization of a human. B-lymphocyte-specific, cell surface antigen. J Exp Med (1976) 1.74
Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture. Nature (1975) 1.64
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion. Proc Natl Acad Sci U S A (1977) 1.56
Guinea-pig Ia antigens: functional significance and chemical characterization. Transplant Rev (1976) 1.44
Chemical characterization of products of the H-2 complex. Cold Spring Harb Symp Quant Biol (1977) 1.11
Graft survival in unrelated donor--recipient pairs matched for MLC and HL-A. Transplant Proc (1973) 1.09
Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex. Proc Natl Acad Sci U S A (1977) 1.09
Mixed leukocyte cultures and immune response region disparity. Transplant Proc (1973) 1.08
Immunogenicity of human B cell antigens solubilized from cultured human lymphoid cells. J Immunol (1977) 0.90
Isolation and structure of HLA antigens. Birth Defects Orig Artic Ser (1978) 0.89
A new alloantigenic system on human lymphocytes. Tissue Antigens (1975) 0.84
Partial amino acid sequences of Ia alloantigens. Transplant Proc (1977) 0.84
Enhancement of antitumor immunity by CTLA-4 blockade. Science (1996) 17.94
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 14.21
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell (1994) 9.51
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med (1995) 8.31
A procedure for rapid and sensitive staining of protein fractionated by polyacrylamide gel electrophoresis. Anal Biochem (1967) 7.96
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature (1992) 7.15
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med (1996) 6.13
Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. J Immunol (1982) 5.92
The emerging role of CTLA-4 as an immune attenuator. Immunity (1997) 5.35
ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature (2001) 5.32
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science (1993) 5.30
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol (2001) 5.17
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Protein iodination with solid state lactoperoxidase. Biochemistry (1974) 4.52
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex. Proc Natl Acad Sci U S A (1973) 4.45
Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol (2000) 4.23
Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell (1988) 3.88
Electrophoretic heterogeneity of polypeptide chains of specific antibodies. Science (1966) 3.88
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med (1998) 3.70
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. J Hered (1986) 3.68
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes. J Exp Med (1974) 3.56
CTLA-4-Mediated inhibition of early events of T cell proliferation. J Immunol (1999) 3.49
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature (1988) 3.48
Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol (1992) 3.37
Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity (1996) 3.33
A simple, rapid method for the purification of poly A+ RNA. Biotechniques (1988) 3.22
Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide. Clin Immunol Immunopathol (1975) 3.11
LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science (1992) 2.98
Regeneration of adult axons in white matter tracts of the central nervous system. Nature (1998) 2.94
Tumor antigens induced by nontransforming mutants of polyoma virus. Cell (1978) 2.92
Positive selection of natural autoreactive B cells. Science (1999) 2.91
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res (2000) 2.89
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci U S A (1998) 2.78
Further Studies on Convergent Improvement in Corn. Genetics (1959) 2.76
Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J Immunol (1993) 2.73
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci (1991) 2.73
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity (1997) 2.72
Costimulatory regulation of T cell function. Curr Opin Cell Biol (1999) 2.69
Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci (1999) 2.64
Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses. Proc Natl Acad Sci U S A (1986) 2.60
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci U S A (1997) 2.53
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J Exp Med (1987) 2.52
Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors. Science (1991) 2.49
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci (1999) 2.43
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer (2009) 2.39
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature (1987) 2.38
Co-stimulation in T cell responses. Curr Opin Immunol (1997) 2.35
Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci U S A (1994) 2.30
Isolation of human T and B lymphocytes by rosette formation with 2-aminoethylisothiquronium bromide (AET) -treated sheep red blood cells with monkey red blood cells. J Immunol Methods (1976) 2.30
Expression of Ia-like antigens in normal human nonlymphoid tissues. Transplantation (1981) 2.29
Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR. J Immunol (1983) 2.25
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. Proc Natl Acad Sci U S A (1988) 2.21
Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells. Proc Natl Acad Sci U S A (1982) 2.21
Characterization of responding cells in oxidative mitogen stimulation. II. Identification of an Ia-bearing adherent accessory cell. J Immunol (1980) 2.19
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol (1990) 2.19
The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol Rev (1996) 2.18
Salt extraction of soluble HL-A antigens. Science (1971) 2.18
Structure, function, and serology of the T-cell antigen receptor complex. Annu Rev Immunol (1987) 2.17
HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology (1991) 2.16
Mutations Affecting Quantitative Traits in the Selfed Progeny of Doubled Monoploid Maize Stocks. Genetics (1960) 2.16
Force-velocity properties of human skeletal muscle fibres: myosin heavy chain isoform and temperature dependence. J Physiol (1996) 2.16
Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules. J Exp Med (1982) 2.15
Anticipation in Crohn's disease may be influenced by gender and ethnicity of the transmitting parent. Am J Gastroenterol (1998) 2.14
Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells. J Exp Med (1976) 2.12
Nanoliter scale PCR with TaqMan detection. Nucleic Acids Res (1997) 2.11
Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus. Virology (1983) 2.11
Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. J Virol (2000) 2.09
Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression. J Clin Invest (1991) 2.08
Separation of 7S gamma-1-globulin, 7S gamma-2-globulin and macroglobulin guinea pig antibodies. Proc Soc Exp Biol Med (1966) 2.08
Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest (1986) 2.07
Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci U S A (1992) 2.07
The mouse T cell receptor: structural heterogeneity of molecules of normal T cells defined by xenoantiserum. Cell (1983) 2.04
Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res (1984) 2.01
Regulation of T-cell receptor gamma-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature (1987) 2.00
The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents. Virology (1991) 1.97
Serologic evidence for antigens controlled by the Ir region in mice. J Exp Med (1973) 1.94
CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J Exp Med (1993) 1.93
Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex. Cold Spring Harb Symp Quant Biol (1977) 1.91
Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci U S A (1985) 1.86
Antigen-processing machinery breakdown and tumor growth. Immunol Today (2000) 1.82
Ear oximetry to detect apnea and differentiate rapid eye movement (REM) and non-REM (NREM) sleep. Screening for the sleep apnea syndrome. Chest (1986) 1.81
Identification of antigen receptor-associated structures on murine T cells. Nature (1985) 1.79
Structural studies of murine I-E and human DR antigens. Mol Immunol (1979) 1.79
A syncytia assay for human immunodeficiency virus type I (HIV-I) envelope protein and its use in studying HIV-I mutations. Virology (1989) 1.78
The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J Immunol (1990) 1.74
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development (2000) 1.74