An internal polypyrimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3'-untranslated sequence.

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Published in Virology on February 15, 1999

Authors

T Ito1, M M Lai

Author Affiliations

1: Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, California, 90033-1054, USA.

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Evolution of the 5'-end of genomic RNA of murine coronaviruses during passages in vitro. Virology (1989) 1.43

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Immunophilins in the nervous system. Neuron (1998) 1.42

Requirement of the 5'-end genomic sequence as an upstream cis-acting element for coronavirus subgenomic mRNA transcription. J Virol (1994) 1.41

Heterogeneous nuclear ribonucleoprotein a1 binds to the 3'-untranslated region and mediates potential 5'-3'-end cross talks of mouse hepatitis virus RNA. J Virol (2001) 1.41

Heterogeneous nuclear ribonucleoprotein A1 regulates RNA synthesis of a cytoplasmic virus. EMBO J (2000) 1.38

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Heterogeneity of hepatitis delta antigen. Virology (1990) 1.23

The receptor for mouse hepatitis virus in the resistant mouse strain SJL is functional: implications for the requirement of a second factor for viral infection. J Virol (1992) 1.22

Unusual heterogeneity of leader-mRNA fusion in a murine coronavirus: implications for the mechanism of RNA transcription and recombination. J Virol (1994) 1.21

Recommendations of the Coronavirus Study Group for the nomenclature of the structural proteins, mRNAs, and genes of coronaviruses. Virology (1990) 1.21