Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMC 240792)

Published in J Virol on February 01, 1992

Authors

Y P Xia1, C T Yeh, J H Ou, M M Lai

Author Affiliations

1: Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033-1054.

Articles citing this

Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2. Plant Cell (1992) 3.55

Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res (1995) 2.52

Splinkerettes--improved vectorettes for greater efficiency in PCR walking. Nucleic Acids Res (1995) 2.51

Relating structure to function in the hepatitis delta virus antigen. J Virol (1993) 1.82

RNA-binding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication. J Virol (1993) 1.57

Assembly of viruslike particles by recombinant structural proteins of adeno-associated virus type 2 in insect cells. J Virol (1992) 1.52

Functional complementation of nuclear targeting-defective mutants of simian virus 40 structural proteins. J Virol (1994) 1.48

RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases. Mol Cell Biol (2000) 1.36

Domains required for assembly of adenovirus type 2 fiber trimers. J Virol (1996) 1.35

Replication of hepatitis delta virus RNA: effect of mutations of the autocatalytic cleavage sites. J Virol (1993) 1.34

Oligomerization of hepatitis delta antigen is required for both the trans-activating and trans-dominant inhibitory activities of the delta antigen. J Virol (1992) 1.32

Parameters of human hepatitis delta virus genome replication: the quantity, quality, and intracellular distribution of viral proteins and RNA. J Virol (2002) 1.29

Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus. J Virol (1993) 1.21

RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus. J Virol (2005) 1.21

Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen. J Virol (1998) 1.20

Hepatitis delta antigen mediates the nuclear import of hepatitis delta virus RNA. J Virol (1998) 1.12

Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol (2004) 1.08

Nuclear localization signals, but not putative leucine zipper motifs, are essential for nuclear transport of hepatitis delta antigen. J Virol (1992) 1.07

Self-association of a synthetic peptide from the N terminus of the hepatitis delta virus protein into an immunoreactive alpha-helical multimer. Proc Natl Acad Sci U S A (1995) 1.05

Hepatitis delta virus antigen forms dimers and multimeric complexes in vivo. J Virol (1993) 1.05

Baculovirus transregulator IE1 requires a dimeric nuclear localization element for nuclear import and promoter activation. J Virol (2002) 1.04

Isoprenylation masks a conformational epitope and enhances trans-dominant inhibitory function of the large hepatitis delta antigen. J Virol (1994) 1.03

Mutational analysis of delta antigen: effect on assembly and replication of hepatitis delta virus. J Virol (1994) 1.01

Expression of the hepatitis delta virus large and small antigens in transgenic mice. J Virol (1994) 0.99

Interactions between hepatitis delta virus proteins. J Virol (2000) 0.98

Mechanisms and signals for the nuclear import of proteins. Curr Genomics (2009) 0.96

Nucleic acid binding properties of the nucleic acid chaperone domain of hepatitis delta antigen. Nucleic Acids Res (2003) 0.95

Large hepatitis delta antigen in packaging and replication inhibition: role of the carboxyl-terminal 19 amino acids and amino-terminal sequences. J Virol (1995) 0.95

Functional domains of delta antigens and viral RNA required for RNA packaging of hepatitis delta virus. J Virol (1995) 0.95

Polyadenylation of the mRNA of hepatitis delta virus is dependent on the structure of the nascent RNA and regulated by the small or large delta antigen. Nucleic Acids Res (1994) 0.90

Interaction of host cellular proteins with components of the hepatitis delta virus. Viruses (2010) 0.89

Determination of the multimerization state of the hepatitis delta virus antigens in vivo. J Virol (2003) 0.88

Hepatitis delta virus RNA replication. Viruses (2009) 0.84

Protein-peptide arrays for detection of specific anti-hepatitis D virus (HDV) genotype 1, 6, and 8 antibodies among HDV-infected patients by surface plasmon resonance imaging. J Clin Microbiol (2015) 0.83

The C-terminal sequence of the large hepatitis delta antigen is variable but retains the ability to bind clathrin. Virol J (2009) 0.81

Local helix content and RNA-binding activity of the N-terminal leucine-repeat region of hepatitis delta antigen. J Biomol NMR (1998) 0.81

In Vivo Interaction of the Hepatitis Delta Virus Small Antigen with the ELAV-Like Protein HuR. Open Virol J (2011) 0.76

Animal models of chronic hepatitis delta virus infection host-virus immunologic interactions. Pathogens (2015) 0.76

Hepatitis D Virus: A Call to Screening. Gastroenterol Hepatol (N Y) (2014) 0.75

Hepatitis delta virus: A fascinating and neglected pathogen. World J Virol (2015) 0.75

Analyses of a whole-genome inter-clade recombination map of hepatitis delta virus suggest a host polymerase-driven and viral RNA structure-promoted template-switching mechanism for viral RNA recombination. Oncotarget (2017) 0.75

Articles cited by this

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

SV40-transformed simian cells support the replication of early SV40 mutants. Cell (1981) 34.67

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell (1991) 9.96

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature (1990) 9.31

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell (1986) 8.87

Structure, sequence and expression of the hepatitis delta (delta) viral genome. Nature (1986) 7.38

Protein import into the cell nucleus. Annu Rev Cell Biol (1986) 7.04

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J (1987) 5.76

Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut (1977) 5.12

Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA. Nature (1987) 4.52

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell (1989) 4.17

The hepatitis delta (delta) virus possesses a circular RNA. Nature (1986) 4.00

The delta agent. Hepatology (1983) 3.72

Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope. J Virol (1986) 3.63

Role of two forms of hepatitis delta virus antigen: evidence for a mechanism of self-limiting genome replication. J Virol (1990) 3.57

Amino acid sequences that determine the nuclear localization of yeast histone 2B. Mol Cell Biol (1987) 3.31

Human hepatitis delta antigen is a nuclear phosphoprotein with RNA-binding activity. J Virol (1988) 3.11

Antigens of hepatitis delta virus in the liver and serum of humans and animals. J Infect Dis (1986) 3.08

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function. Cell (1989) 2.85

Delta hepatitis agent: structural and antigenic properties of the delta-associated particle. Infect Immun (1984) 2.81

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol Cell Biol (1990) 2.73

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. J Biol Chem (1985) 2.52

Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA. J Virol (1990) 2.17

Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1). Mol Cell Biol (1990) 1.89

Type D (delta) hepatitis. JAMA (1989) 1.86

Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide. J Virol (1989) 1.85

Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein. Cell (1988) 1.81

The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport. J Virol (1990) 1.79

Fulminant B viral hepatitis: role of delta agent. Gastroenterology (1984) 1.74

Epidemiology and clinical impact of hepatitis D virus (delta) infection. Hepatology (1985) 1.60

Identification of domains involved in nuclear uptake and histone binding of protein N1 of Xenopus laevis. EMBO J (1988) 1.58

Sequence conservation and divergence of hepatitis delta virus RNA. Virology (1990) 1.56

Hepatitis delta virus RNA, protein synthesis and associated cytotoxicity in a stably transfected cell line. Virology (1990) 1.56

A human monoclonal antibody that recognizes viral polypeptides and in vitro translation products of the genome of the hepatitis D virus. J Infect Dis (1987) 1.32

Nuclear localization of the adenovirus DNA-binding protein: requirement for two signals and complementation during viral infection. Mol Cell Biol (1989) 1.23

Heterogeneity of hepatitis delta antigen. Virology (1990) 1.23

Clinical significance of antibody to the hepatitis delta virus in symptomless HBsAg carriers. Lancet (1985) 0.99

Articles by these authors

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell (1985) 7.45

Structure, sequence and expression of the hepatitis delta (delta) viral genome. Nature (1986) 7.38

Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail. Cell (1977) 7.23

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science (1999) 6.21

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci U S A (1986) 4.73

Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA. Nature (1987) 4.52

Adenylic acid-rich sequence in RNAs of Rous sarcoma virus and Rauscher mouse leukaemia virus. Nature (1972) 4.49

RNA of mouse hepatitis virus. J Virol (1978) 4.27

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology (1991) 4.07

Mouse hepatitis virus A59: mRNA structure and genetic localization of the sequence divergence from hepatotropic strain MHV-3. J Virol (1981) 4.00

Characterization of leader RNA sequences on the virion and mRNAs of mouse hepatitis virus, a cytoplasmic RNA virus. Proc Natl Acad Sci U S A (1984) 3.81

Human hepatitis delta virus RNA subfragments contain an autocleavage activity. Proc Natl Acad Sci U S A (1989) 3.51

Avian tumor virus RNA: a comparison of three sarcoma viruses and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridization. Proc Natl Acad Sci U S A (1973) 3.46

Ribonucleic acid components of murine sarcoma and leukemia viruses. Proc Natl Acad Sci U S A (1973) 3.42

Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Lett (1991) 3.35

Human hepatitis delta antigen is a nuclear phosphoprotein with RNA-binding activity. J Virol (1988) 3.11

Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. Hepatology (1999) 3.11

Presence of leader sequences in the mRNA of mouse hepatitis virus. J Virol (1983) 3.06

High-frequency RNA recombination of murine coronaviruses. J Virol (1986) 2.91

Replication of mouse hepatitis virus: negative-stranded RNA and replicative form RNA are of genome length. J Virol (1982) 2.86

A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 2.84

Characterization of replicative intermediate RNA of mouse hepatitis virus: presence of leader RNA sequences on nascent chains. J Virol (1983) 2.80

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci U S A (1988) 2.79

Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA. Proc Natl Acad Sci U S A (1982) 2.77

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol (1996) 2.68

Characterization of two RNA polymerase activities induced by mouse hepatitis virus. J Virol (1982) 2.46

Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol (1988) 2.41

The 3'-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site. J Virol (1998) 2.36

Further characterization of mRNA's of mouse hepatitis virus: presence of common 5'-end nucleotides. J Virol (1982) 2.34

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. Virology (1999) 2.33

Comparative analysis of RNA genomes of mouse hepatitis viruses. J Virol (1981) 2.30

Restriction enzyme sites on the avian RNA tumor virus genome. J Virol (1978) 2.29

Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome. J Virol (1997) 2.28

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. Proc Natl Acad Sci U S A (1986) 2.28

Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol (1998) 2.28

Occurrence of partial deletion and substitution of the src gene in the RNA genome of avian sarcoma virus. Proc Natl Acad Sci U S A (1977) 2.22

Recombination between nonsegmented RNA genomes of murine coronaviruses. J Virol (1985) 2.21

The 5'-end sequence of the murine coronavirus genome: implications for multiple fusion sites in leader-primed transcription. Virology (1987) 2.17

Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA. J Virol (1990) 2.17

A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J Virol (1999) 2.16

Leader sequences of murine coronavirus mRNAs can be freely reassorted: evidence for the role of free leader RNA in transcription. Proc Natl Acad Sci U S A (1986) 2.16

Comparative studies of the 3'-terminal sequences of several alpha virus RNAs. Virology (1981) 2.15

Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus. Virology (1983) 2.11

Phosphoproteins of murine hepatitis viruses. J Virol (1979) 2.07

Characterization of leader-related small RNAs in coronavirus-infected cells: further evidence for leader-primed mechanism of transcription. Virus Res (1985) 2.07

The 5'-terminal sequences of the genomic RNAs of several alphaviruses. J Mol Biol (1983) 2.05

Study of Dengue virus infection in SCID mice engrafted with human K562 cells. J Virol (1998) 2.03

Activation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis. Hepatology (2000) 1.96

High-frequency leader sequence switching during coronavirus defective interfering RNA replication. J Virol (1989) 1.95

The 3'-non-coding regions of alphavirus RNAs contain repeating sequences. J Mol Biol (1982) 1.92

An internal polypyrimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3'-untranslated sequence. Virology (1999) 1.90

Sequence and translation of the murine coronavirus 5'-end genomic RNA reveals the N-terminal structure of the putative RNA polymerase. J Virol (1987) 1.89

Analysis of efficiently packaged defective interfering RNAs of murine coronavirus: localization of a possible RNA-packaging signal. J Virol (1990) 1.88

Primary structure and translation of a defective interfering RNA of murine coronavirus. Virology (1988) 1.87

Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide. J Virol (1989) 1.85

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol (1997) 1.84

Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein. J Virol (1989) 1.82

The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport. J Virol (1990) 1.79

Identification of a new transcriptional initiation site and the corresponding functional gene 2b in the murine coronavirus RNA genome. J Virol (1989) 1.77

Discontinuous transcription generates heterogeneity at the leader fusion sites of coronavirus mRNAs. J Virol (1988) 1.76

Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro. Virology (1996) 1.76

Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B. Gastroenterology (1995) 1.75

Mouse hepatitis virus utilizes two carcinoembryonic antigens as alternative receptors. J Virol (1992) 1.75

Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus. J Virol (1993) 1.74

Differential subcellular localization of hepatitis C virus core gene products. Virology (1995) 1.73

Defective-interfering particles of murine coronavirus: mechanism of synthesis of defective viral RNAs. Virology (1988) 1.73

Deletion mapping of a mouse hepatitis virus defective interfering RNA reveals the requirement of an internal and discontiguous sequence for replication. J Virol (1993) 1.71

Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Proc Natl Acad Sci U S A (1997) 1.70

An in vitro system for the leader-primed transcription of coronavirus mRNAs. EMBO J (1990) 1.69

Genome of avian myelocytomatosis virus MC29: analysis by heteroduplex mapping. Proc Natl Acad Sci U S A (1979) 1.68

Phosphoproteins of Rous sarcoma viruses. Virology (1976) 1.67

Colocalization and membrane association of murine hepatitis virus gene 1 products and De novo-synthesized viral RNA in infected cells. J Virol (1999) 1.67

Differences between the envelope glycoproteins and glycopeptides of avian tumor viruses released from transformed and from nontransformed cells. Virology (1972) 1.67

Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol (1995) 1.66

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein. J Virol (1987) 1.64

Further characterization of mouse hepatitis virus RNA-dependent RNA polymerases. Virology (1984) 1.64

Three different cellular proteins bind to complementary sites on the 5'-end-positive and 3'-end-negative strands of mouse hepatitis virus RNA. J Virol (1993) 1.64

Identification of the cis-acting signal for minus-strand RNA synthesis of a murine coronavirus: implications for the role of minus-strand RNA in RNA replication and transcription. J Virol (1994) 1.64

Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain. J Gen Virol (1982) 1.62

Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B. Hepatology (2000) 1.62

Fulminant hepatic failure in acute hepatitis C: increased risk in chronic carriers of hepatitis B virus. Gut (1999) 1.60

Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses. Virology (1991) 1.60

Reversible cleavage and ligation of hepatitis delta virus RNA. Science (1989) 1.59

Sequence analysis of cDNA's derived from the RNA of Sindbis virions and of defective interfering particles. J Virol (1982) 1.59

Coronavirus leader RNA regulates and initiates subgenomic mRNA transcription both in trans and in cis. J Virol (1994) 1.58

Random nature of coronavirus RNA recombination in the absence of selection pressure. Virology (1991) 1.57

RNA-binding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication. J Virol (1993) 1.57

Sequence conservation and divergence of hepatitis delta virus RNA. Virology (1990) 1.56

Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci U S A (1993) 1.55

Analysis of intracellular small RNAs of mouse hepatitis virus: evidence for discontinuous transcription. Virology (1987) 1.52

Homotypic interaction and multimerization of hepatitis C virus core protein. Virology (1996) 1.51

Transcription of hepatitis delta antigen mRNA continues throughout hepatitis delta virus (HDV) replication: a new model of HDV RNA transcription and replication. J Virol (1998) 1.51

Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation. Mol Cell Biol (1993) 1.50

DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice. J Virol (1998) 1.49

Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity. Gastroenterology (1998) 1.47

Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation. J Virol (1999) 1.46

Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template. J Biol Chem (2000) 1.46

Sequence and structure of the catalytic RNA of hepatitis delta virus genomic RNA. J Mol Biol (1992) 1.44