| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
51
|
Full-length transcriptome assembly from RNA-Seq data without a reference genome.
|
Nat Biotechnol
|
2011
|
53.86
|
|
52
|
Global cancer statistics, 2012.
|
CA Cancer J Clin
|
2015
|
53.52
|
|
53
|
New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.
|
Syst Biol
|
2010
|
53.37
|
|
54
|
MolProbity: all-atom structure validation for macromolecular crystallography.
|
Acta Crystallogr D Biol Crystallogr
|
2009
|
53.36
|
|
55
|
BEDTools: a flexible suite of utilities for comparing genomic features.
|
Bioinformatics
|
2010
|
53.23
|
|
56
|
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
|
N Engl J Med
|
2012
|
52.99
|
|
57
|
Fast and accurate long-read alignment with Burrows-Wheeler transform.
|
Bioinformatics
|
2010
|
52.01
|
|
58
|
Search and clustering orders of magnitude faster than BLAST.
|
Bioinformatics
|
2010
|
51.97
|
|
59
|
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
50.94
|
|
60
|
Prevalence and trends in obesity among US adults, 1999-2008.
|
JAMA
|
2010
|
50.58
|
|
61
|
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
|
N Engl J Med
|
2010
|
50.17
|
|
62
|
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
|
Science
|
2009
|
49.82
|
|
63
|
RNA-guided human genome engineering via Cas9.
|
Science
|
2013
|
48.29
|
|
64
|
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
|
Science
|
2012
|
48.17
|
|
65
|
Integrated genomic analyses of ovarian carcinoma.
|
Nature
|
2011
|
47.72
|
|
66
|
Comprehensive molecular portraits of human breast tumours.
|
Nature
|
2012
|
47.39
|
|
67
|
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
|
N Engl J Med
|
2009
|
46.35
|
|
68
|
De novo assembly of human genomes with massively parallel short read sequencing.
|
Genome Res
|
2009
|
45.91
|
|
69
|
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
|
N Engl J Med
|
2011
|
45.46
|
|
70
|
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
|
N Engl J Med
|
2012
|
44.56
|
|
71
|
DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.
|
Bioinformatics
|
2009
|
44.48
|
|
72
|
Trimmomatic: a flexible trimmer for Illumina sequence data.
|
Bioinformatics
|
2014
|
44.23
|
|
73
|
A human gut microbial gene catalogue established by metagenomic sequencing.
|
Nature
|
2010
|
43.63
|
|
74
|
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.
|
Nucleic Acids Res
|
2010
|
43.51
|
|
75
|
ABySS: a parallel assembler for short read sequence data.
|
Genome Res
|
2009
|
43.20
|
|
76
|
Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.
|
Mol Ecol Resour
|
2010
|
42.87
|
|
77
|
Integrative genomics viewer.
|
Nat Biotechnol
|
2011
|
42.83
|
|
78
|
Prodigal: prokaryotic gene recognition and translation initiation site identification.
|
BMC Bioinformatics
|
2010
|
42.80
|
|
79
|
Emergence of a novel swine-origin influenza A (H1N1) virus in humans.
|
N Engl J Med
|
2009
|
42.75
|
|
80
|
Health professionals for a new century: transforming education to strengthen health systems in an interdependent world.
|
Lancet
|
2010
|
42.10
|
|
81
|
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
41.47
|
|
82
|
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.
|
Clin Chem
|
2009
|
40.90
|
|
83
|
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.
|
Lancet Infect Dis
|
2015
|
40.89
|
|
84
|
Sequencing technologies - the next generation.
|
Nat Rev Genet
|
2009
|
40.57
|
|
85
|
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
|
Int J Cancer
|
2014
|
40.30
|
|
86
|
MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space.
|
Syst Biol
|
2012
|
40.23
|
|
87
|
Circos: an information aesthetic for comparative genomics.
|
Genome Res
|
2009
|
40.02
|
|
88
|
Dabigatran versus warfarin in patients with atrial fibrillation.
|
N Engl J Med
|
2009
|
39.97
|
|
89
|
Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences.
|
Genome Biol
|
2010
|
39.63
|
|
90
|
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
|
Crit Care Med
|
2013
|
39.56
|
|
91
|
SOAP2: an improved ultrafast tool for short read alignment.
|
Bioinformatics
|
2009
|
39.47
|
|
92
|
REFMAC5 for the refinement of macromolecular crystal structures.
|
Acta Crystallogr D Biol Crystallogr
|
2011
|
39.32
|
|
93
|
Epithelial-mesenchymal transitions in development and disease.
|
Cell
|
2009
|
39.17
|
|
94
|
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
|
Cancer Cell
|
2010
|
39.09
|
|
95
|
Regularization Paths for Generalized Linear Models via Coordinate Descent.
|
J Stat Softw
|
2010
|
38.65
|
|
96
|
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
|
Nat Protoc
|
2009
|
38.62
|
|
97
|
Reduced lung-cancer mortality with low-dose computed tomographic screening.
|
N Engl J Med
|
2011
|
38.61
|
|
98
|
The Pfam protein families database.
|
Nucleic Acids Res
|
2009
|
37.98
|
|
99
|
Prevalence of childhood and adult obesity in the United States, 2011-2012.
|
JAMA
|
2014
|
36.94
|
|
100
|
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
|
N Engl J Med
|
2010
|
36.78
|