Published in J Muscle Res Cell Motil on November 01, 1998
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest (2001) 5.05
Virus entry by macropinocytosis. Nat Cell Biol (2009) 3.87
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. J Cell Biol (2006) 3.15
Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol (2004) 3.03
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol (1999) 2.84
Caspases and kinases in a death grip. Cell (2009) 2.47
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II. Mol Biol Cell (2003) 2.17
Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
PAK signaling in oncogenesis. Oncogene (2009) 2.13
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol (2000) 1.82
Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase. Arch Biochem Biophys (2006) 1.76
Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol (2008) 1.57
A fluorescent resonant energy transfer-based biosensor reveals transient and regional myosin light chain kinase activation in lamella and cleavage furrows. J Cell Biol (2002) 1.53
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Am J Physiol Cell Physiol (2010) 1.44
Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem J (2005) 1.42
Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle. Circ Res (2013) 1.42
Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology (2005) 1.42
Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle. Am J Physiol Cell Physiol (2000) 1.32
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
PAK signaling in cancer. Cell Logist (2012) 1.27
Myosin IIA drives neurite retraction. Mol Biol Cell (2003) 1.24
Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Mol Biol Cell (2004) 1.24
Intracellular signalling involved in modulating human endothelial barrier function. J Anat (2002) 1.22
Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK. Mol Biol Cell (2007) 1.20
Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol (2005) 1.18
Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study. J Cell Sci (2010) 1.15
Identification of a new form of death-associated protein kinase that promotes cell survival. J Biol Chem (2001) 1.14
Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1. J Physiol (2003) 1.14
220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns. Am J Physiol Cell Physiol (2002) 1.12
Nonmuscle myosin II is responsible for maintaining endothelial cell basal tone and stress fiber integrity. Am J Physiol Cell Physiol (2008) 1.07
Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol Biol Cell (2009) 1.07
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. J Cell Biol (2013) 1.06
Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives. Cytoskeleton (Hoboken) (2012) 1.03
Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1. J Biol Chem (2001) 1.00
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochem J (2007) 1.00
Migration of airway smooth muscle cells. Proc Am Thorac Soc (2008) 0.99
Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge. Biochem J (2003) 0.99
Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts. Am J Physiol Cell Physiol (2003) 0.96
Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Mol Cell Biol (2009) 0.95
Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. Mol Biol Cell (2012) 0.94
Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics. PLoS One (2012) 0.90
Temperature effects on morphological integrity and Ca²⁺ signaling in freshly isolated murine feed artery endothelial cell tubes. Am J Physiol Heart Circ Physiol (2011) 0.90
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol (2011) 0.89
VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. Histochem Cell Biol (2005) 0.87
Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis. J Cell Biol (2008) 0.87
Untangling the complexity of PAK1 dynamics: The future challenge. Cell Logist (2012) 0.85
Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen. J Cell Sci (2013) 0.84
Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines. Korean J Physiol Pharmacol (2012) 0.84
Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife (2014) 0.84
Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics (2010) 0.83
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol (2015) 0.83
The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton. Int J Alzheimers Dis (2013) 0.82
The role of p21-activated kinases in hepatocellular carcinoma metastasis. J Mol Signal (2014) 0.81
Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells. PLoS One (2013) 0.79
Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility. J Biol Chem (2012) 0.79
Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification. J Biol Chem (2010) 0.79
cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing. Stem Cells Dev (2015) 0.78
P21-activated kinase in inflammatory and cardiovascular disease. Cell Signal (2014) 0.78
Autophagy and the Cell Cycle: A Complex Landscape. Front Oncol (2017) 0.77
The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. Exp Cell Res (2014) 0.77
Motility of select ovarian cancer cell lines: effect of extra-cellular matrix proteins and the involvement of PAK2. Int J Oncol (2014) 0.77
The fate of the primary cilium during myofibroblast transition. Mol Biol Cell (2014) 0.77
Non-muscle myosin II in disease: mechanisms and therapeutic opportunities. Dis Model Mech (2015) 0.76
p21-Activated kinase (Pak) regulates airway smooth muscle contraction by regulating paxillin complexes that mediate actin polymerization. J Physiol (2016) 0.75
Conventional myosins - unconventional functions. Biophys Rev (2010) 0.75
Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa. Biol Open (2013) 0.75
Dual regulation of tumor necrosis factor-α on myosin light chain phosphorylation in vascular smooth muscle. Am J Physiol Heart Circ Physiol (2014) 0.75
Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation. J Cell Sci (2017) 0.75
Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study. J Cell Biol (1992) 2.61
Isolation of phosphorylated peptides and proteins on ion exchange papers. Anal Biochem (1978) 2.33
Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J Cell Biol (1995) 1.98
Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem (2000) 1.45
Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells. Am J Physiol (1997) 1.21
Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation. J Biol Chem (1995) 1.17
Identification of a new form of death-associated protein kinase that promotes cell survival. J Biol Chem (2001) 1.14
Phosphorylation of ribosomal protein S6 at multiple sites by a cyclic AMP-independent protein kinase from lymphoid cells. J Biol Chem (1984) 1.10
Myosin phosphorylation by human cdc42-dependent S6/H4 kinase/gammaPAK from placenta and lymphoid cells. Recept Signal Transduct (1997) 1.07
Differential localization of myosin II isoforms in resting and activated osteoclasts. Calcif Tissue Int (2002) 1.02
Ca2+-dependent and Ca2+-independent pathways for release of arachidonic acid from phosphatidylinositol in endothelial cells. J Biol Chem (1987) 1.01
Enhancement of human polymorphonuclear leukocyte adherence to plastic and endothelium by phorbol myristate acetate. Comparison with human C5a. Am J Pathol (1986) 0.84
Primary substrate specificity determinants for the H4-specific protease-activated protein phosphotransferase. Eur J Biochem (1983) 0.84
Inhibitor of the factor VIIa-tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease. J Clin Invest (1987) 0.84
Phosphatidylcholine metabolism in endothelial cells: evidence for phospholipase A and a novel Ca2+-independent phospholipase C. Biochim Biophys Acta (1987) 0.83
Histone 1 phosphotransferase activities during the maturation of oocytes of Xenopus laevis. Arch Biochem Biophys (1979) 0.83
Activation of an S6 kinase from human placenta by autophosphorylation. J Biol Chem (1993) 0.82
Nonmuscle myosin phosphorylation sites for calcium-dependent and calcium-independent protein kinases. Biochem Biophys Res Commun (1986) 0.82
Standardization of the assay for the catalytic subunit of cyclic AMP-dependent protein kinase using a synthetic peptide substrate. Anal Biochem (1983) 0.81
Structural analysis of the calcium-binding protein calmodulin from Ascaris suum obliquely striated muscle. J Parasitol (1986) 0.79
Histone 4 phosphotransferase activities in proliferating lymphocytes. Partial purification and characterization of an enzyme specific for Ser-47. J Biol Chem (1977) 0.77
Comparative purification and characterization of invertebrate muscle glycogen synthase from the porcine parasite Ascaris suum. J Biol Chem (1985) 0.77
Calcium/phospholipid-dependent protein kinase and its relationship to antidiuretic hormone in toad urinary bladder epithelium. Biochem Biophys Res Commun (1985) 0.77
Amblyomma americanum (L.): protein kinase C-independent fluid secretion by isolated salivary glands. Exp Parasitol (1992) 0.77
Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C. Biochim Biophys Acta (1988) 0.77
Calcium-dependent muscle contraction in obliquely striated Ascaris suum muscle. Comp Biochem Physiol B (1985) 0.76
Resolution and characterization of calcium/phospholipid-dependent protein kinase and H4 protease-activated protein kinase activities in lymphoid cells. Biochem Biophys Res Commun (1983) 0.76
Ascaris suum: regulation of myosin light chain phosphorylation from adult skeletal muscle. Exp Parasitol (1986) 0.75
Diethylstilbestrol effect on the in vitro synthesis of progesterone in the bovine corpus luteum. Endocrinology (1969) 0.75
Glycogen synthesis in the obliquely striated muscle of Ascaris suum. Eur J Biochem (1989) 0.75
Glycogen metabolizing enzymes during starvation and feeding of Ascaris suum maintained in a perfusion chamber. J Parasitol (1981) 0.75
Protein phosphotransferase activities and cyclic nucleotide action in proliferating lymphocytes. Cancer Res (1976) 0.75
Site-specific phosphorylation of a synthetic peptide derived from ribosomal protein S6 by human placenta protein kinases. Biochem Biophys Res Commun (1990) 0.75
A method for quantitative elution of microgram quantities of steroids from silica gel layers. Steroids (1968) 0.75
Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6. J Biol Chem (1991) 0.75
Protein phosphatase assay using a modification of the P81 paper protein kinase assay procedure. J Biochem Biophys Methods (1993) 0.75
Serotonin (5-hydroxytryptamine): a possible regulator of glycogenolysis in perfused muscle segments of Ascaris suum. Biochem Biophys Res Commun (1981) 0.75
The role of cyclic AMP-mediated regulation of glycogen metabolism in levamisole-perfused Ascaris suum muscle. Mol Pharmacol (1983) 0.75
Activation of a cyclic AMP-independent protein kinase by an endogenous ATP-requiring protease from lymphosarcoma cells. J Biol Chem (1983) 0.75
Purification and characterization of phosphorylase B from Ascaris suum. Mol Biochem Parasitol (1983) 0.75
Kinetics of adenosine 3':5'-monophosphate-dependent protein kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells. Cancer Res (1983) 0.75
Activation of cyclic AMP-dependent protein kinase by epinephrine in proliferating lymphoid cells. Arch Biochem Biophys (1982) 0.75