Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

PubWeight™: 1.39‹?› | Rank: Top 10%

🔗 View Article (PMID 10329681)

Published in J Biol Chem on May 21, 1999

Authors

H Gonen1, B Bercovich, A Orian, A Carrano, C Takizawa, K Yamanaka, M Pagano, K Iwai, A Ciechanover

Author Affiliations

1: Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel.

Articles citing this

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol (2000) 3.51

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev (2001) 1.91

Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A (2002) 1.82

The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol Cell Biol (2000) 1.67

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. Mol Cell (2010) 1.61

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J (2000) 1.55

Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep (2013) 1.47

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2000) 1.43

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol (2010) 1.39

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis. Mol Cell Biol (2004) 1.33

Cell cycle-regulated proteolysis of mitotic target proteins. Mol Biol Cell (1999) 1.29

Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest (2000) 1.27

c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Mol Cell Biol (2001) 1.19

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev (2011) 1.17

Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress. Mol Biol Cell (2007) 1.14

SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem (2010) 1.05

The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells. Invest Ophthalmol Vis Sci (2008) 0.99

A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways. Sci Signal (2013) 0.99

Sustained oxidative stress inhibits NF-kappaB activation partially via inactivating the proteasome. Free Radic Biol Med (2008) 0.96

Quality control for unfolded proteins at the plasma membrane. J Cell Biol (2010) 0.96

Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Mol Cell Biol (2004) 0.93

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. J Lipid Res (2013) 0.92

Compensatory proteome adjustments imply tissue-specific structural and metabolic reorganization following episodic hypoxia or anoxia in the epaulette shark (Hemiscyllium ocellatum). Physiol Genomics (2010) 0.92

Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration. Mol Aspects Med (2012) 0.89

The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J (2014) 0.84

Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis. Virology (2009) 0.84

EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages. Oncol Lett (2011) 0.82

The effects of proteasomal inhibition on synaptic proteostasis. EMBO J (2016) 0.75

Network Cluster Analysis of Protein-Protein Interaction Network-Identified Biomarker for Type 2 Diabetes. Diabetes Technol Ther (2015) 0.75

Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. G3 (Bethesda) (2015) 0.75

Articles by these authors

The ubiquitin system. Annu Rev Biochem (1998) 43.36

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92

The ubiquitin system for protein degradation. Annu Rev Biochem (1992) 8.84

pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1983) 8.41

Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol (1995) 6.41

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell (1984) 5.70

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med (1997) 5.10

Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem (1983) 4.55

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (2000) 4.52

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci U S A (2000) 4.41

Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays (2000) 4.38

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07

Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03

Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. N Engl J Med (1989) 4.02

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01

The F-box protein family. Genome Biol (2000) 4.00

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75

Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med (1997) 3.71

Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol (2000) 3.65

Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network. Pediatrics (2000) 3.48

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene (1999) 3.36

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci U S A (1997) 3.31

Identification of a family of human F-box proteins. Curr Biol (1999) 3.31

Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma 32. EMBO J (1995) 3.18

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci U S A (1980) 2.96

NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94

Development of a compact computed tomographic apparatus for dental use. Dentomaxillofac Radiol (1999) 2.79

Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc Natl Acad Sci U S A (1991) 2.77

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71

The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med (1999) 2.68

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1995) 2.61

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J (1996) 2.58

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem (1982) 2.56

Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A (2001) 2.55

Clinicopathological study of fatal myocardial sarcoidosis. Ann N Y Acad Sci (1976) 2.47

Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol (2004) 2.46

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J (2001) 2.45

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J Biol Chem (1988) 2.33

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J (1998) 2.31

Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31

A likelihood-based method for real-time estimation of the serial interval and reproductive number of an epidemic. Stat Med (2008) 2.29

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression. J Bacteriol (1993) 2.19

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene (1994) 2.18

"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15

Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol (1998) 2.15

Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2000) 2.15

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J Biol Chem (1997) 2.14

E.coli MukB protein involved in chromosome partition forms a homodimer with a rod-and-hinge structure having DNA binding and ATP/GTP binding activities. EMBO J (1992) 2.12

The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation. J Cell Biochem (1984) 2.10

The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell (1983) 2.10

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene (1994) 2.10

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res (1997) 2.05

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem (1997) 2.05

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell (2000) 2.02

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res (1997) 2.00

Hunger in children in the United States: potential behavioral and emotional correlates. Pediatrics (1998) 1.99

The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol (1986) 1.98

White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. The Developmental Epidemiology Network. J Pediatr (1999) 1.93

Topology and subcellular localization of FtsH protein in Escherichia coli. J Bacteriol (1993) 1.93

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res (1998) 1.92

Purification, crystallization and properties of the D-xylose isomerase from Lactobacillus brevis. Biochim Biophys Acta (1968) 1.90

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A (1998) 1.88

Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Cancer Res (1994) 1.88

Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science (1989) 1.86

IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol (2000) 1.86

Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol (2000) 1.82

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J Biol Chem (1994) 1.79

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. EMBO J (1997) 1.78

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death Differ (2008) 1.77

Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. Proc Natl Acad Sci U S A (1994) 1.72

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report. Eur J Cancer Clin Oncol (1983) 1.72

Involvement of reactive oxygen intermediates in spontaneous and CD95 (Fas/APO-1)-mediated apoptosis of neutrophils. Blood (1997) 1.71

RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli. J Bacteriol (1996) 1.71

Role of arginine-tRNA in protein degradation by the ubiquitin pathway. Nature (1987) 1.71

Rescue of defective mitogenic signaling by D-type cyclins. Proc Natl Acad Sci U S A (1995) 1.71

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol (2001) 1.69

Magnetic resonance imaging in evaluation of the common bile duct. Br J Surg (1998) 1.67

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation. J Biol Chem (1995) 1.67

Corrected group prognostic curves and summary statistics. J Chronic Dis (1982) 1.67

Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene (2000) 1.67

How are substrates recognized by the ubiquitin-mediated proteolytic system? Trends Biochem Sci (1989) 1.66

Amino-acid sequence of slightly lysine-rich histone. Nature (1970) 1.65