Published in Proc Natl Acad Sci U S A on March 01, 1980
Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol (2005) 8.06
The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La. Proc Natl Acad Sci U S A (1981) 4.10
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J (2001) 3.42
Accelerating scientific publication in biology. Proc Natl Acad Sci U S A (2015) 2.65
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics. Nat Cell Biol (2005) 2.62
UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J (1991) 2.20
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol (2010) 1.94
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood (2007) 1.89
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A (1989) 1.82
The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol (1999) 1.74
The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73
Protease La from Escherichia coli hydrolyzes ATP and proteins in a linked fashion. Proc Natl Acad Sci U S A (1982) 1.57
Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation. Proc Natl Acad Sci U S A (1981) 1.53
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc Natl Acad Sci U S A (1981) 1.48
Isopeptidase: a novel eukaryotic enzyme that cleaves isopeptide bonds. Proc Natl Acad Sci U S A (1982) 1.47
Conjugation of ubiquitin to denatured hemoglobin is proportional to the rate of hemoglobin degradation in HeLa cells. Proc Natl Acad Sci U S A (1982) 1.44
Retracted Detection of ubiquityl-calmodulin conjugates with a novel high-molecular weight ubiquitylprotein-isopeptidase in rabbit tissues. Eur J Med Res (2010) 1.39
ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin. J Cell Biol (1983) 1.35
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. Mol Biol Cell (2006) 1.22
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
Ubiquitylation and the Fanconi anemia pathway. FEBS Lett (2011) 1.21
Cloning and characterization of a 20-kDa ubiquitin carrier protein from wheat that catalyzes multiubiquitin chain formation in vitro. Proc Natl Acad Sci U S A (1991) 1.20
Patented small molecule inhibitors in the ubiquitin proteasome system. BMC Biochem (2007) 1.19
The discovery of ubiquitin-dependent proteolysis. Proc Natl Acad Sci U S A (2005) 1.18
Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin. J Biol Chem (2009) 1.13
Regulation of cell death by the ubiquitin-proteasome system. Curr Opin Cell Biol (2009) 1.11
Intracellular distribution and degradation of immunoglobulin G and immunoglobulin G fragments injected into HeLa cells. J Cell Biol (1983) 1.07
A ubiquitin carrier protein from wheat germ is structurally and functionally similar to the yeast DNA repair enzyme encoded by RAD6. Proc Natl Acad Sci U S A (1989) 1.07
Targeting the UPS as therapy in multiple myeloma. BMC Biochem (2008) 1.05
In vitro proteolytic processing of a diubiquitin and a truncated diubiquitin formed from in vitro-generated mRNAs. Proc Natl Acad Sci U S A (1988) 1.05
Ubiquitin crosstalk connecting cellular processes. Cell Div (2006) 1.04
Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest (2015) 1.03
Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol (2012) 1.03
Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis. Biochem J (1995) 1.01
Quality control for unfolded proteins at the plasma membrane. J Cell Biol (2010) 0.96
Stimulation by glucocorticoids of protein degradation in hepatocyte monolayers. Biochem J (1981) 0.96
Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism. J Biol Chem (2013) 0.96
Correlation between recombinase activating gene 1 ubiquitin ligase activity and V(D)J recombination. Immunology (2009) 0.95
Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proc Natl Acad Sci U S A (2012) 0.93
UUCD: a family-based database of ubiquitin and ubiquitin-like conjugation. Nucleic Acids Res (2012) 0.93
The ubiquitination machinery of the ubiquitin system. Arabidopsis Book (2014) 0.93
Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets. Cancer Biol Ther (2010) 0.93
Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. Mol Immunol (2008) 0.92
Cellular content of ubiquitin and formation of ubiquitin conjugates during chicken spermatogenesis. Biochem J (1988) 0.92
Biochemical characterization of Caenorhabditis elegans UBC-1: self-association and auto-ubiquitination of a RAD6-like ubiquitin-conjugating enzyme in vitro. Biochem J (1997) 0.92
Deubiquitinating enzymes as oncotargets. Oncotarget (2015) 0.91
Purification and biochemical characterization of a vacuolar serine endopeptidase induced by glucose starvation in maize roots. Biochem J (1996) 0.88
Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer. Prostate (2013) 0.87
Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. Br J Haematol (2010) 0.87
An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex. Proc Natl Acad Sci U S A (1992) 0.87
Changes in the expression and the enzymic properties of the 20S proteasome in sugar-starved maize roots. evidence for an in vivo oxidation of the proteasome. Plant Physiol (2002) 0.86
The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions. Cell Host Microbe (2015) 0.86
Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1. J Biol Chem (2010) 0.84
Demonstration of ATP-Dependent, Ubiquitin-Conjugating Activities in Higher Plants. Plant Physiol (1987) 0.82
The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming. Stem Cells Int (2016) 0.82
Involvement of the ubiquitin-proteasome system in the formation of experimental postsurgical peritoneal adhesions. Mediators Inflamm (2012) 0.81
Conjugation of ubiquitin to proteins from green plant tissues. Plant Physiol (1991) 0.81
Ubiquitin-like polypeptide conjugates to acceptor proteins in concanavalin A- and interferon gamma-stimulated T-cells. Biochem J (1998) 0.80
Recombinant human phenylalanine hydroxylase is a substrate for the ubiquitin-conjugating enzyme system. Biochem J (1996) 0.79
Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3. FEBS Open Bio (2013) 0.79
Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting. Rambam Maimonides Med J (2012) 0.78
Nucleotide-stimulated proteolysis of histone H1. Proc Natl Acad Sci U S A (1983) 0.78
Ubiquitin-specific peptidase 22 functions and its involvement in disease. Oncotarget (2016) 0.77
Some lessons from my work on the biochemistry of the ubiquitin system. J Biol Chem (2008) 0.77
Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture. Front Genet (2016) 0.77
ATP-induced loss of Alz-50 immunoreactivity with the A68 proteins from Alzheimer brain is mediated by ubiquitin. Proc Natl Acad Sci U S A (1990) 0.76
Intraperitoneal oxygen/ozone treatment decreases the formation of experimental postsurgical peritoneal adhesions and the levels/activity of the local ubiquitin-proteasome system. Mediators Inflamm (2011) 0.75
Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites. Biomed Res Int (2015) 0.75
The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation. Int J Biol Macromol (2015) 0.75
Role of Linear Ubiquitination in Health and Disease. Am J Respir Cell Mol Biol (2016) 0.75
The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells (2016) 0.75
Regulation of pluripotency and differentiation by deubiquitinating enzymes. Cell Death Differ (2016) 0.75
Cell Adhesion Molecules and Ubiquitination-Functions and Significance. Biology (Basel) (2015) 0.75
Estrogen receptor negativity in breast cancer: A cause or consequence? Biosci Rep (2016) 0.75
2-DE Mapping of the Blue Mussel Gill Proteome: The Usual Suspects Revisited. Proteomes (2015) 0.75
AAA-ATPases in Protein Degradation. Front Mol Biosci (2017) 0.75
Activity-Based Probes for HECT E3 ubiquitin ligases. Chembiochem (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Escherichia coli recA gene product inactivates phage lambda repressor. Proc Natl Acad Sci U S A (1978) 5.42
Turnover of protein in growing and non-growing populations of Escherichia coli. Biochem J (1958) 5.25
A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. Proc Natl Acad Sci U S A (1977) 4.17
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun (1978) 3.92
Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction. Proc Natl Acad Sci U S A (1977) 3.47
The release of labeled amino acids from the proteins of rat liver slices. J Biol Chem (1953) 3.35
Turnover of intracellular proteins. Annu Rev Microbiol (1972) 3.16
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem (1971) 2.83
Intermediate steps in the degradation of a specific abnormal protein in Escherichia coli. J Biol Chem (1977) 2.46
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37
Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts. J Biol Chem (1973) 2.23
Protein degradation is stimulated by ATP in extracts of Escherichia coli. J Biol Chem (1979) 2.09
Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. Biochemistry (1975) 1.71
Observations on intracellular protein catabolism studied in vitro. Arch Biochem Biophys (1956) 1.49
Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli. Biochem Biophys Res Commun (1973) 1.12
The ubiquitin system. Annu Rev Biochem (1998) 43.36
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
The ubiquitin system for protein degradation. Annu Rev Biochem (1992) 8.84
pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1983) 8.41
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79
Studies concerning the alimentary absorption of water and tissue hydration in relation to diuresis. J Physiol (1932) 6.29
The mechanism of water diuresis in normal rats and rabbits as analysed by inulin and diodone clearances. J Physiol (1945) 6.29
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell (1995) 6.23
Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med (1967) 5.88
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell (1984) 5.70
Studies concerning the alimentary absorption of water and tissue hydration in relation to diuresis. J Physiol (1932) 5.36
The fate of the antidiuretic principle of postpituitary extracts in vivo and in vitro. J Physiol (1935) 5.04
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
"Pleiotypic response". Nat New Biol (1971) 4.85
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem (1983) 4.55
The renal function of newborn infants. J Physiol (1944) 4.14
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07
Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun (1978) 3.92
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. J Biol Chem (1982) 3.69
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol Cell Biol (1995) 3.56
The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. J Biol Chem (1992) 3.47
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin. J Biol Chem (1987) 3.41
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci U S A (1997) 3.31
The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates. J Biol Chem (1985) 3.29
Ubiquitin: roles in protein modification and breakdown. Cell (1983) 3.19
Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets. Antiviral Res (2002) 3.04
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem (1971) 2.83
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med (1999) 2.68
HLA and mate choice in humans. Am J Hum Genet (1997) 2.66
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J Biol Chem (1982) 2.65
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1995) 2.61
The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J (1996) 2.58
Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. Biochem Biophys Res Commun (1985) 2.56
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem (1982) 2.56
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. Proc Natl Acad Sci U S A (1987) 2.52
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci U S A (1995) 2.48
Immunoregulatory properties of ISG15, an interferon-induced cytokine. Proc Natl Acad Sci U S A (1996) 2.45
The significance of the pituitary in parturition. J Physiol (1932) 2.40
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37
A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J Biol Chem (1988) 2.33
The arthritis of familial Mediterranean fever (FMF). Arthritis Rheum (1966) 2.32
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J (1998) 2.31
Reference standards for flow cytometry and application in comparative studies of nuclear DNA content. Cytometry (1989) 2.26
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
The state in the blood and the excretion by the kidney of the antidiuretic principle of posterior pituitary extracts. J Physiol (1937) 2.21
"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15
Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J Biol Chem (1997) 2.14
Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus. J Infect Dis (2001) 2.11
Novel multiubiquitin chain linkages catalyzed by the conjugating enzymes E2EPF and RAD6 are recognized by 26 S proteasome subunit 5. J Biol Chem (1996) 2.10
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation. J Cell Biochem (1984) 2.10
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell (1983) 2.10
The politics of human-embryo research--avoiding ethical gridlock. N Engl J Med (1996) 2.09
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc Natl Acad Sci U S A (1997) 2.08
Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites. J Biol Chem (1988) 2.04
Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. J Biol Chem (1980) 1.99
The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol (1986) 1.98
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. Biochem Biophys Res Commun (1999) 1.93
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A (1998) 1.88
Isolating fetal cells from maternal blood. Advances in prenatal diagnosis through molecular technology. JAMA (1993) 1.84
The renal action of posterior pituitary extract and its fractions as analysed by clearance experiments on rats. J Physiol (1946) 1.83
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A (1989) 1.82
Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol (2000) 1.82
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. EMBO J (1997) 1.78
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death Differ (2008) 1.77
Spiral computerized tomography in the evaluation of acute flank pain: a replacement for excretory urography. J Urol (1997) 1.77
Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem Biophys Res Commun (2000) 1.74
Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. National Institute of Child Health and Development Fetal Cell Isolation Study. Prenat Diagn (2002) 1.74
The protein substrate binding site of the ubiquitin-protein ligase system. J Biol Chem (1986) 1.72
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. Proc Natl Acad Sci U S A (1994) 1.72
The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A (1998) 1.72
Role of arginine-tRNA in protein degradation by the ubiquitin pathway. Nature (1987) 1.71