Published in J Biol Chem on December 09, 1994
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A (1996) 5.53
Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62
Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science (2009) 2.60
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science (2009) 2.49
Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta (2006) 2.23
Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO J (1995) 1.76
Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta (2012) 1.74
Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc Natl Acad Sci U S A (1998) 1.66
Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci U S A (1999) 1.64
Dual regulation of the Arabidopsis high-affinity root iron uptake system by local and long-distance signals. Plant Physiol (2003) 1.58
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1. Proc Natl Acad Sci U S A (1998) 1.36
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect Immun (1999) 1.20
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways. Mol Cell Biol (1996) 1.20
Differences in the RNA binding sites of iron regulatory proteins and potential target diversity. Proc Natl Acad Sci U S A (1996) 1.17
Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). J Biol Chem (2012) 1.10
Coding elements in exons 2 and 3 target c-myc mRNA downregulation during myogenic differentiation. Mol Cell Biol (1997) 1.04
A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst (2009) 1.02
Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome. Curr Biol (2012) 1.01
Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex. EMBO J (1996) 1.00
Protein degradation and iron homeostasis. Biochim Biophys Acta (2012) 0.90
Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins. Trends Endocrinol Metab (2015) 0.88
Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein. Biochem J (2007) 0.87
Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol (2009) 0.84
Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. J Biol Chem (2009) 0.84
An emerging role for Cullin-3 mediated ubiquitination in sleep and circadian rhythm: insights from Drosophila. Fly (Austin) (2013) 0.81
A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris. RNA (2003) 0.81
Iron regulatory protein 2 turnover through a nonproteasomal pathway. J Biol Chem (2011) 0.80
Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways. J Biol Chem (2017) 0.79
Oxidative stress and the homeodynamics of iron metabolism. Biomolecules (2015) 0.79
Transferrin receptor induction in Toxoplasma gondii-infected HFF is associated with increased iron-responsive protein 1 activity and is mediated by secreted factors. Parasitol Res (2004) 0.79
Network analysis of endogenous gene expression profiles after polyethyleneimine-mediated DNA delivery. J Gene Med (2013) 0.77
Haem precursor delta-aminolaevulinic acid induces activation of the cytosolic iron regulatory protein 1. Biochem J (1997) 0.75
On the mechanism of iron sensing by IRP2: new players, new paradigms. Nat Chem Biol (2009) 0.75
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell (1989) 13.41
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway. Cell (1990) 9.19
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
The mammalian gene collection. Science (1999) 7.19
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79
Regulating the fate of mRNA: the control of cellular iron metabolism. Cell (1993) 6.47
Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proc Natl Acad Sci U S A (1988) 6.33
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell (1991) 6.30
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature (1992) 6.11
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment. Proc Natl Acad Sci U S A (1982) 5.74
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc Natl Acad Sci U S A (1990) 5.35
Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol (1969) 4.93
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science (1988) 4.86
A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome. Nat Genet (2000) 4.78
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68
A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science (1996) 4.60
Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins. Cell (1988) 4.42
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci U S A (2000) 4.41
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell (1992) 4.39
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science (1988) 4.35
Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science (1986) 4.30
The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol (1989) 4.30
Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (1995) 4.23
ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes. Proc Natl Acad Sci U S A (1992) 4.22
Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science (1987) 4.20
Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell (1991) 4.17
Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action. J Cell Biol (1990) 3.90
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci U S A (1996) 3.88
Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell (1994) 3.88
Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol (1995) 3.82
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75
Receptor-mediated endocytosis of transferrin in K562 cells. J Biol Chem (1983) 3.65
Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science (1989) 3.54
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43
Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein. Science (1991) 3.33
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27
Membrane protein association by potential intramembrane charge pairs. Nature (1991) 3.27
Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis. J Biol Chem (1980) 3.20
Infant botulism. Epidemiological, clinical, and laboratory aspects. JAMA (1977) 3.05
Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature (1989) 3.02
The cancer genome anatomy project: building an annotated gene index. Trends Genet (2000) 3.02
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94
A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron. Proc Natl Acad Sci U S A (1987) 2.89
Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci U S A (1992) 2.87
AIDS: an international perspective. Science (1988) 2.84
Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol Cell Biol (1990) 2.83
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci U S A (1989) 2.81
Development of a compact computed tomographic apparatus for dental use. Dentomaxillofac Radiol (1999) 2.79
AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J (1995) 2.76
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76
Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc Natl Acad Sci U S A (1989) 2.73
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J (1994) 2.70
Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science (1992) 2.67
Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol (1989) 2.65
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochim Biophys Acta (1996) 2.64
Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J (1996) 2.62
New opportunities for uncovering the molecular basis of cancer. Nat Genet (1997) 2.61
Intestinal infection and toxin production by Clostridium botulinum as one cause of sudden infant death syndrome. Lancet (1978) 2.60
Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58
Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58
The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J Biol Chem (1994) 2.57
Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA. EMBO J (1989) 2.54
Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes. Proc Natl Acad Sci U S A (1982) 2.54
The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake. Proc Natl Acad Sci U S A (1995) 2.50
T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50
Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell (1990) 2.49
Clinicopathological study of fatal myocardial sarcoidosis. Ann N Y Acad Sci (1976) 2.47
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47
Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci (1996) 2.46
A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules. Nature (1991) 2.45
Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event. J Biol Chem (1983) 2.45
Prevention of chronic hepatitis B virus infection from mothers to infants in the United States. Pediatrics (1983) 2.41
Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications. Cell (1991) 2.37
Selectivity of fluorescent lipid analogues for lipid domains. Biochemistry (1980) 2.35
Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus. J Cell Biol (1991) 2.33
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci U S A (1991) 2.32
A model for the structure and functions of iron-responsive elements. Gene (1988) 2.29
Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements. Mol Cell Biol (1989) 2.26
The concept of lipid domains in membranes. J Cell Biol (1982) 2.26
Global surveillance and forecasting of AIDS. Bull World Health Organ (1989) 2.17
A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum. Science (1990) 2.17
Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A (1992) 2.17
ARF: a key regulatory switch in membrane traffic and organelle structure. Curr Opin Cell Biol (1994) 2.15
Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature (1990) 2.14
Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci U S A (1986) 2.12
Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. EMBO J (1991) 2.08