Published in J Biol Chem on May 28, 1999
The role of the anaphylatoxins in health and disease. Mol Immunol (2009) 2.95
Function, structure and therapeutic potential of complement C5a receptors. Br J Pharmacol (2007) 2.25
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev (2010) 2.09
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.23
Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics. Pharmacol Ther (2008) 1.16
Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR. Proc Natl Acad Sci U S A (2004) 1.03
Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints. J Mol Biol (2009) 1.01
Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors. Am J Hum Genet (1999) 1.00
Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay. Proc Natl Acad Sci U S A (2000) 0.92
GPCR-I-TASSER: A Hybrid Approach to G Protein-Coupled Receptor Structure Modeling and the Application to the Human Genome. Structure (2015) 0.90
A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor. Mol Cell Biol (2004) 0.89
The use of evolutionary patterns in protein annotation. Curr Opin Struct Biol (2012) 0.87
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. Brain Res (2006) 0.86
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation. J Biol Chem (2012) 0.85
Cell wall trapping of autocrine peptides for human G-protein-coupled receptors on the yeast cell surface. PLoS One (2012) 0.82
Frizzled receptors signal through G proteins. Cell Signal (2013) 0.82
An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis. Biochem Pharmacol (2010) 0.80
Prediction and redesign of protein-protein interactions. Prog Biophys Mol Biol (2014) 0.80
Signaling of human frizzled receptors to the mating pathway in yeast. PLoS One (2007) 0.80
Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor. Proteins (2010) 0.79
E2F8 is a nonreceptor activator of heterotrimeric G proteins. J Mol Signal (2007) 0.77
Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence. FEBS J (2009) 0.77
Three "hotspots" important for adenosine A(2B) receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop. Purinergic Signal (2011) 0.77
The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins. Immunology (2004) 0.76
5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol (1987) 17.67
An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol (1996) 9.31
Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol (1987) 7.38
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
G proteins: a family of signal transducers. Annu Rev Cell Biol (1986) 5.38
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature (1989) 5.03
Two G protein oncogenes in human endocrine tumors. Science (1990) 4.46
Modulation of inflammation and immunity by cyclic AMP. Science (1974) 4.31
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature (1993) 3.57
The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. J Immunol (1972) 3.51
Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol (1999) 3.45
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21
A family of evolution-entropy hybrid methods for ranking protein residues by importance. J Mol Biol (2004) 3.00
Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3',5'-adenosine monophosphate in human leukocytes. J Immunol (1972) 2.70
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature (1992) 2.62
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell (1999) 2.61
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol (2000) 2.59
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature (1996) 2.55
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci (1995) 2.51
Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release. Science (1971) 2.47
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. J Biol Chem (1984) 2.39
Lipid modifications of trimeric G proteins. J Biol Chem (1995) 2.39
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature (1994) 2.36
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest (1971) 2.35
Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell (1993) 2.34
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. J Biol Chem (1983) 2.31
Activation and depalmitoylation of Gs alpha. Cell (1994) 2.29
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem (1984) 2.17
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol (1996) 2.17
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. J Biol Chem (1978) 2.12
Separate GTP binding and GTPase activating domains of a G alpha subunit. Science (1993) 2.08
Influence of mutation type and X chromosome inactivation on Rett syndrome phenotypes. Ann Neurol (2000) 2.03
Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A (1986) 2.03
Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors. J Pharmacol Exp Ther (1971) 2.02
Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. J Biol Chem (1993) 2.02
Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci U S A (1997) 1.99
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem (1994) 1.98
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. J Clin Invest (1974) 1.98
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J Biol Chem (1989) 1.95
Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. J Clin Invest (1973) 1.94
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. J Cell Biol (1992) 1.88
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature (1991) 1.87
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76
Selection of a variant lymphoma cell deficient in adenylate cyclase. Science (1975) 1.76
An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells. Proc Natl Acad Sci U S A (1976) 1.74
Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin. Science (1997) 1.71
Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. N Engl J Med (1980) 1.68
The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins (1972) 1.67
Identification of receptor contact site involved in receptor-G protein coupling. Nature (1988) 1.65
Influence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochem Biophys Res Commun (1977) 1.59
A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol (1992) 1.59
Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1985) 1.58
Cholera toxin induces cAMP-independent degradation of Gs. J Biol Chem (1989) 1.57
GTP-binding proteins. One molecular machine can transduce diverse signals. Nature (1986) 1.56
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med (1985) 1.54
G-protein diseases furnish a model for the turn-on switch. Nature (1998) 1.54
Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation. J Cell Biol (1995) 1.53
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin. J Biol Chem (1982) 1.53
Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (1975) 1.51
A mutation that prevents GTP-dependent activation of the alpha chain of Gs. Nature (1988) 1.50
Receptors for histamine can be detected on the surface of selected leukocytes. Science (1972) 1.46
Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants. J Cell Physiol (1975) 1.44
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. J Biol Chem (1992) 1.43
Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nat Struct Biol (2001) 1.42
The expanding spectrum of G protein diseases. N Engl J Med (1999) 1.41
A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proc Natl Acad Sci U S A (1991) 1.40
Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. Proc Natl Acad Sci U S A (1988) 1.40
Specific leukocyte receptors for small endogenous hormones. Detection by cell binding to insolubilized hormone preparations. J Clin Invest (1973) 1.39
An evolution based classifier for prediction of protein interfaces without using protein structures. Bioinformatics (2005) 1.38
Meeting review: the Second meeting on the Critical Assessment of Techniques for Protein Structure Prediction (CASP2), Asilomar, California, December 13-16, 1996. Fold Des (1997) 1.36
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem (1999) 1.36
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
Activation-induced subcellular redistribution of Gs alpha. Mol Biol Cell (1996) 1.36
Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science (1988) 1.35
Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. J Biol Chem (1990) 1.35
Genetic screens and selections for cell and nuclear fusion mutants. Methods Enzymol (1991) 1.34
Adenylyl cyclase in yeast. Hydrodynamic properties and activation by trypsin. J Biol Chem (1987) 1.34
Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? Proc Natl Acad Sci U S A (2001) 1.32
A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron (2000) 1.32
Evolutionary trace report_maker: a new type of service for comparative analysis of proteins. Bioinformatics (2006) 1.30
Galphai is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem (1999) 1.26
Some model experiments in hemodynamics: VI. Two-body collisions between blood cells. Biorheology (1981) 1.24
Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Mol Pharmacol (1996) 1.24
G alpha 13 stimulates Na-H exchange. J Biol Chem (1994) 1.24
Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene (1994) 1.22
Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J Biol Chem (1993) 1.20