Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice.

PubWeight™: 2.20‹?› | Rank: Top 2%

🔗 View Article (PMID 10357944)

Published in Development on July 01, 1999

Authors

G H Fong1, L Zhang, D M Bryce, J Peng

Author Affiliations

1: Lawson Research Institute, St Joseph's Health Centre, Departments of Paediatrics and Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 4V2. gfong@lri.stjosephs.london.on.ca

Articles citing this

Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell (2009) 4.52

Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest (2002) 4.38

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med (2002) 4.00

Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25

Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol (2006) 3.15

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

Preparing the "soil": the premetastatic niche. Cancer Res (2006) 2.92

Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol (2006) 1.86

VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J (2003) 1.84

Modeling the early stages of vascular network assembly. EMBO J (2003) 1.78

Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. Am J Pathol (2001) 1.69

VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci (2006) 1.65

The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am J Pathol (2004) 1.61

MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res (2012) 1.56

Roles for VEGF in the adult. Microvasc Res (2007) 1.48

Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood (2008) 1.40

Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood (2007) 1.39

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J (2010) 1.37

Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest (2006) 1.36

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited. Acta Neuropathol (2012) 1.30

A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network. Proc Natl Acad Sci U S A (2006) 1.29

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. EMBO J (2000) 1.28

Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax (2006) 1.26

Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer Res (2009) 1.22

Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20

Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol (2000) 1.16

Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res (2006) 1.14

Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac. Development (2013) 1.13

r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction. PLoS One (2010) 1.13

Regulation of vascular endothelial growth factor receptors by Rb and E2F1: role of acetylation. Cancer Res (2010) 1.12

Perlecan and tumor angiogenesis. J Histochem Cytochem (2003) 1.09

A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study. J Matern Fetal Neonatal Med (2009) 1.09

A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1. J Biol Chem (2005) 1.07

HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells. Mol Cell Biol (2003) 1.07

Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation. Oncogene (2004) 1.05

The opening act: vasculogenesis and the origins of circulation. Arterioscler Thromb Vasc Biol (2008) 1.03

Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. Am J Pathol (2001) 1.01

Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta. Proc Natl Acad Sci U S A (2003) 1.01

Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol (2013) 1.01

Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice. Circulation (2012) 1.01

Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol (2005) 1.00

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99

Angiogenesis and chronic kidney disease. Fibrogenesis Tissue Repair (2010) 0.99

Role of VEGF in organogenesis. Organogenesis (2008) 0.96

Vascular endothelial growth factor (VEGF) pathway as a therapeutic target in gynecologic malignancies. Gynecol Oncol (2007) 0.93

Therapeutic potential of manipulating VEGF splice isoforms in oncology. Future Oncol (2009) 0.93

Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway. Blood (2011) 0.93

Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors. Ann N Y Acad Sci (2010) 0.93

Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood (2013) 0.90

Embryonic vasculogenesis and hematopoietic specification. Organogenesis (2008) 0.89

Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice. Hum Mol Genet (2010) 0.88

The murine allantois: a model system for the study of blood vessel formation. Blood (2012) 0.87

VEGF receptor signaling in vertebrate development. Organogenesis (2010) 0.87

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest (2012) 0.87

Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis. Am J Pathol (2006) 0.87

Life is a pattern: vascular assembly within the embryo. Front Biosci (Elite Ed) (2012) 0.86

Pathophysiology of tumor neovascularization. Vasc Health Risk Manag (2005) 0.86

Genetic and epigenetic mechanisms in the early development of the vascular system. J Anat (2006) 0.84

Soluble flt-1 and the angiopoietins in the development and regulation of placental vasculature. J Anat (2002) 0.84

The balance of proangiogenic and antiangiogenic VEGFA isoforms regulate follicle development. Cell Tissue Res (2012) 0.83

Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy. J Ophthalmol (2015) 0.83

Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice. Cardiovasc Diabetol (2014) 0.80

Fine-tuning the angiogenic response to vascular endothelial growth factor. Circ Res (2008) 0.80

Vascular-targeted therapies for Duchenne muscular dystrophy. Skelet Muscle (2013) 0.80

Brain homeostasis: VEGF receptor 1 and 2-two unequal brothers in mind. Cell Mol Life Sci (2013) 0.80

Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. Am J Pathol (2000) 0.79

Comparative Analysis of Glycogene Expression in Different Mouse Tissues Using RNA-Seq Data. Int J Genomics (2014) 0.76

Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy. HSOA J Ophthalmol Clin Res (2014) 0.75

Vasculogenesis and Angiogenesis in VEGF Receptor-1 Deficient Mice. Methods Mol Biol (2015) 0.75

Articles by these authors

Serial analysis of gene expression. Science (1995) 60.15

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30

Characterization of the yeast transcriptome. Cell (1997) 11.33

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

Phytochrome A null mutants of Arabidopsis display a wild-type phenotype in white light. Plant Cell (1993) 7.51

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev (1997) 6.88

Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem (1996) 6.78

Analysis of human transcriptomes. Nat Genet (1999) 6.14

The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev (1997) 5.13

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09

Ligand binding to integrins. J Biol Chem (2000) 4.94

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36

Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature (2000) 4.31

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28

Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17

The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08

P-TEFb kinase recruitment and function at heat shock loci. Genes Dev (2000) 4.07

Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07

A quantum dot single-photon turnstile device. Science (2000) 3.89

DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81

The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63

TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49

HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron (2000) 3.45

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34

Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16

Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

PUMA, a potent killer with or without p53. Oncogene (2008) 3.09

TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08

Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98

Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol (2000) 2.92

Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. J Virol (1996) 2.77

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

In vivo pharmacodynamics of a new oxazolidinone (linezolid). Antimicrob Agents Chemother (2002) 2.66

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61

Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol Cell Biol (2000) 2.58

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55

The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. J Virol (1998) 2.51

Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol (2001) 2.51

Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol (1998) 2.48

HIV-1 subtype and second-receptor use. Nature (1996) 2.46

Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest (1999) 2.42

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics (2006) 2.38

Meta-analysis: prevalence of HIV infection and syphilis among MSM in China. Sex Transm Infect (2009) 2.36

Ultrasonic hydrophone based on short in-fiber bragg gratings. Appl Opt (1998) 2.35

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet (2004) 2.33

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31

Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26

Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci (1999) 2.26

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol (2000) 2.26

Cancer incidence and mortality in France over the period 1978-2000. Rev Epidemiol Sante Publique (2003) 2.25

Accurate control of contrast on microcomputer displays. Vision Res (1991) 2.21

New structural picture of the Ge2Sb2Te5 phase-change alloy. Phys Rev Lett (2011) 2.21

Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys. J Virol (1997) 2.16

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A (1995) 2.14

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther (2010) 2.13

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol (1989) 2.12

Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry (1999) 2.10

Purification, primary structure, and immunological characterization of the 26-kDa calsequestrin binding protein (junctin) from cardiac junctional sarcoplasmic reticulum. J Biol Chem (1995) 2.08

The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003. Occup Environ Med (2008) 2.06

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem (1999) 2.05

Viability and functional activity of cryopreserved mononuclear cells. Clin Diagn Lab Immunol (2000) 2.05

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med (2000) 2.04

Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS). Neurology (2005) 2.04

Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol (1998) 2.04

Can clinical and radiological features predict recurrence in solitary keratocystic odontogenic tumors? Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 2.01

Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I. J Virol (1995) 1.98

Gibberellin: inhibitor of an inhibitor of...? Bioessays (1998) 1.97

Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1998) 1.96

Virulence characteristics of Escherichia coli causing first urinary tract infection predict risk of second infection. J Infect Dis (1995) 1.96

Intracellular trafficking of adeno-associated viral vectors. Gene Ther (2005) 1.95

Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol (1995) 1.95