Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii.

PubWeight™: 2.92‹?› | Rank: Top 1%

🔗 View Article (PMC 58851)

Published in Plant Physiol on January 01, 2000

Authors

A Melis1, L Zhang, M Forestier, M L Ghirardi, M Seibert

Author Affiliations

1: Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, California 94720-3102, USA. melis@nature.berkeley.edu

Articles citing this

(truncated to the top 100)

Assembling the marine metagenome, one cell at a time. PLoS One (2009) 4.10

Genetic engineering of algae for enhanced biofuel production. Eukaryot Cell (2010) 2.97

Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev (2012) 2.65

Exploiting diversity and synthetic biology for the production of algal biofuels. Nature (2012) 1.80

Increased lipid accumulation in the Chlamydomonas reinhardtii sta7-10 starchless isoamylase mutant and increased carbohydrate synthesis in complemented strains. Eukaryot Cell (2010) 1.76

Nitrogen-Sparing Mechanisms in Chlamydomonas Affect the Transcriptome, the Proteome, and Photosynthetic Metabolism. Plant Cell (2014) 1.42

Transcriptome for photobiological hydrogen production induced by sulfur deprivation in the green alga Chlamydomonas reinhardtii. Eukaryot Cell (2008) 1.37

Hydrogen photoproduction is attenuated by disruption of an isoamylase gene in Chlamydomonas reinhardtii. Plant Cell (2004) 1.34

A type II NAD(P)H dehydrogenase mediates light-independent plastoquinone reduction in the chloroplast of Chlamydomonas. Proc Natl Acad Sci U S A (2008) 1.33

Application of synthetic biology in cyanobacteria and algae. Front Microbiol (2012) 1.28

Hydrogen production by Chlamydomonas reinhardtii: an elaborate interplay of electron sources and sinks. Planta (2007) 1.26

Photosynthetic H2 metabolism in Chlamydomonas reinhardtii (unicellular green algae). Planta (2007) 1.25

The metabolome of Chlamydomonas reinhardtii following induction of anaerobic H2 production by sulfur depletion. J Biol Chem (2009) 1.25

Control of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii. Plant Cell (2011) 1.22

Oxygen deficiency responsive gene expression in Chlamydomonas reinhardtii through a copper-sensing signal transduction pathway. Plant Physiol (2002) 1.19

Flexibility in anaerobic metabolism as revealed in a mutant of Chlamydomonas reinhardtii lacking hydrogenase activity. J Biol Chem (2008) 1.18

Analytical approaches to photobiological hydrogen production in unicellular green algae. Photosynth Res (2011) 1.18

Potential for hydrogen production with inducible chloroplast gene expression in Chlamydomonas. Proc Natl Acad Sci U S A (2007) 1.17

Microalgae as bioreactors. Plant Cell Rep (2005) 1.16

Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng (2010) 1.15

Autotrophic and mixotrophic hydrogen photoproduction in sulfur-deprived chlamydomonas cells. Appl Environ Microbiol (2005) 1.15

Potential for green microalgae to produce hydrogen, pharmaceuticals and other high value products in a combined process. Crit Rev Biotechnol (2012) 1.08

Rewiring hydrogenase-dependent redox circuits in cyanobacteria. Proc Natl Acad Sci U S A (2011) 1.06

The chloroplast proteome: a survey from the Chlamydomonas reinhardtii perspective with a focus on distinctive features. Curr Genet (2011) 1.05

Phylogenetic and molecular analysis of hydrogen-producing green algae. J Exp Bot (2009) 1.05

Fermentation metabolism and its evolution in algae. Front Plant Sci (2013) 1.04

Hydrogen production in Chlamydomonas: photosystem II-dependent and -independent pathways differ in their requirement for starch metabolism. Plant Physiol (2009) 1.03

Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP+-oxidoreductase (FNR) enzymes in vitro. Proc Natl Acad Sci U S A (2011) 1.02

Gene expression patterns of sulfur starvation in Synechocystis sp. PCC 6803. BMC Genomics (2008) 1.01

Biochemical and physiological characterization of the pyruvate formate-lyase Pfl1 of Chlamydomonas reinhardtii, a typically bacterial enzyme in a eukaryotic alga. Eukaryot Cell (2008) 0.98

LHCBM1 and LHCBM2/7 polypeptides, components of major LHCII complex, have distinct functional roles in photosynthetic antenna system of Chlamydomonas reinhardtii. J Biol Chem (2012) 0.98

Nitrogen deprivation results in photosynthetic hydrogen production in Chlamydomonas reinhardtii. Planta (2011) 0.98

Promoting R & D in photobiological hydrogen production utilizing mariculture-raised cyanobacteria. Mar Biotechnol (NY) (2007) 0.96

Characterization of the key step for light-driven hydrogen evolution in green algae. J Biol Chem (2009) 0.96

Characterization and differential expression of microRNAs elicited by sulfur deprivation in Chlamydomonas reinhardtii. BMC Genomics (2012) 0.95

Altered fermentative metabolism in Chlamydomonas reinhardtii mutants lacking pyruvate formate lyase and both pyruvate formate lyase and alcohol dehydrogenase. Plant Cell (2012) 0.94

Heterologous expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] hydrogenases in Synechococcus elongatus. PLoS One (2011) 0.94

Copper response regulator1-dependent and -independent responses of the Chlamydomonas reinhardtii transcriptome to dark anoxia. Plant Cell (2013) 0.94

Molecular dynamics and experimental investigation of H(2) and O(2) diffusion in [Fe]-hydrogenase. Biochem Soc Trans (2005) 0.94

Metabolic modeling of Chlamydomonas reinhardtii: energy requirements for photoautotrophic growth and maintenance. J Appl Phycol (2011) 0.93

Gas exchange in the filamentous cyanobacterium Nostoc punctiforme strain ATCC 29133 and Its hydrogenase-deficient mutant strain NHM5. Appl Environ Microbiol (2004) 0.92

Pyruvate:ferredoxin oxidoreductase is coupled to light-independent hydrogen production in Chlamydomonas reinhardtii. J Biol Chem (2012) 0.90

Low oxygen response mechanisms in green organisms. Int J Mol Sci (2013) 0.90

Increased photosystem II stability promotes H2 production in sulfur-deprived Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (2013) 0.90

Time-course global expression profiles of Chlamydomonas reinhardtii during photo-biological H₂ production. PLoS One (2011) 0.89

Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii. BMC Genomics (2011) 0.88

Trails of green alga hydrogen research - from hans gaffron to new frontiers. Photosynth Res (2004) 0.87

RNAi knock-down of LHCBM1, 2 and 3 increases photosynthetic H2 production efficiency of the green alga Chlamydomonas reinhardtii. PLoS One (2013) 0.87

Atomic resolution modeling of the ferredoxin:[FeFe] hydrogenase complex from Chlamydomonas reinhardtii. Biophys J (2007) 0.86

Differential expression of the Chlamydomonas [FeFe]-hydrogenase-encoding HYDA1 gene is regulated by the copper response regulator1. Plant Physiol (2012) 0.86

Probing green algal hydrogen production. Philos Trans R Soc Lond B Biol Sci (2002) 0.86

Evolutionary significance of an algal gene encoding an [FeFe]-hydrogenase with F-domain homology and hydrogenase activity in Chlorella variabilis NC64A. Planta (2011) 0.85

The interplay of proton, electron, and metabolite supply for photosynthetic H2 production in Chlamydomonas reinhardtii. J Biol Chem (2010) 0.84

Anaerobic expression of the ferredoxin-encoding FDX5 gene of Chlamydomonas reinhardtii is regulated by the Crr1 transcription factor. Eukaryot Cell (2010) 0.84

The involvement of hydrogen-producing and ATP-dependent NADPH-consuming pathways in setting the redox poise in the chloroplast of Chlamydomonas reinhardtii in anoxia. J Biol Chem (2015) 0.83

Structure prediction and molecular simulation of gases diffusion pathways in hydrogenase. Bioinformation (2010) 0.83

Light-Harvesting Complex Protein LHCBM9 Is Critical for Photosystem II Activity and Hydrogen Production in Chlamydomonas reinhardtii. Plant Cell (2014) 0.82

Auto-flotation of heterocyst enables the efficient production of renewable energy in cyanobacteria. Sci Rep (2014) 0.82

High yields of hydrogen production induced by meta-substituted dichlorophenols biodegradation from the green alga Scenedesmus obliquus. PLoS One (2012) 0.82

Accumulation of ferrous iron in Chlamydomonas reinhardtii. Influence of CO2 and anaerobic induction of the reversible hydrogenase. Plant Physiol (2003) 0.82

Plastidial Expression of Type II NAD(P)H Dehydrogenase Increases the Reducing State of Plastoquinones and Hydrogen Photoproduction Rate by the Indirect Pathway in Chlamydomonas reinhardtii1. Plant Physiol (2014) 0.82

The growth of Chlamydomonas reinhardtii as influenced by high CO2 and low O2 in flue gas from a silicomanganese smelter. J Appl Phycol (2014) 0.81

Engineering photosynthetic organisms for the production of biohydrogen. Photosynth Res (2014) 0.81

Inactivation of [Fe-Fe]-Hydrogenase by O(2). Thermodynamics and Frontier Molecular Orbitals Analyses. Int J Quantum Chem (2009) 0.81

A novel screening protocol for the isolation of hydrogen producing Chlamydomonas reinhardtii strains. BMC Plant Biol (2008) 0.81

Brownian dynamics and molecular dynamics study of the association between hydrogenase and ferredoxin from Chlamydomonas reinhardtii. Biophys J (2008) 0.81

Genomics of green algal hydrogen research. Photosynth Res (2004) 0.81

Rationales and approaches for studying metabolism in eukaryotic microalgae. Metabolites (2014) 0.80

Biohydrogen production: strategies to improve process efficiency through microbial routes. Int J Mol Sci (2015) 0.80

Function of the chloroplast hydrogenase in the microalga Chlamydomonas: the role of hydrogenase and state transitions during photosynthetic activation in anaerobiosis. PLoS One (2013) 0.80

Evolutionary and biotechnological implications of robust hydrogenase activity in halophilic strains of Tetraselmis. PLoS One (2014) 0.79

Chlamydomonas Flavodiiron Proteins Facilitate Acclimation to Anoxia During Sulfur Deprivation. Plant Cell Physiol (2015) 0.79

Genome-wide long non-coding RNA screening, identification and characterization in a model microorganism Chlamydomonas reinhardtii. Sci Rep (2016) 0.78

Synthetic antisense oligodeoxynucleotides to transiently suppress different nucleus- and chloroplast-encoded proteins of higher plant chloroplasts. Plant Physiol (2011) 0.78

Multi-Omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-Mediated H2 Production in Cyanothece sp. ATCC 51142. Sci Rep (2015) 0.78

Induction of Photosynthetic Carbon Fixation in Anoxia Relies on Hydrogenase Activity and Proton-Gradient Regulation-Like1-Mediated Cyclic Electron Flow in Chlamydomonas reinhardtii. Plant Physiol (2015) 0.78

Mechanistic modeling of sulfur-deprived photosynthesis and hydrogen production in suspensions of Chlamydomonas reinhardtii. Biotechnol Bioeng (2013) 0.77

Localization and function of SulP, a nuclear-encoded chloroplast sulfate permease in Chlamydomonas reinhardtii. Planta (2004) 0.77

Residue Mutations in [Fe-Fe]-hydrogenase Impedes O(2) Binding: A QM/MM Investigation. Int J Quantum Chem (2009) 0.77

Identification of the Elusive Pyruvate Reductase of Chlamydomonas reinhardtii Chloroplasts. Plant Cell Physiol (2015) 0.77

Challenges and opportunities for hydrogen production from microalgae. Plant Biotechnol J (2016) 0.76

Antimycin A effect on the electron transport in chloroplasts of two Chlamydomonas reinhardtii strains. Planta (2013) 0.76

The tide turns towards microalgae. Current research aims to produce traditional biofuels from algae, but their potential to generate sustainable energy might be even greater and more 'natural'. EMBO Rep (2010) 0.76

Distinct mechanisms regulating gene expression coexist within the fermentative pathways in Chlamydomonas reinhardtii. ScientificWorldJournal (2012) 0.76

Exploitation of algal-bacterial associations in a two-stage biohydrogen and biogas generation process. Biotechnol Biofuels (2015) 0.76

Overproduction of the membrane-bound [NiFe]-hydrogenase in Thermococcus kodakarensis and its effect on hydrogen production. Front Microbiol (2015) 0.76

Deletion of Proton Gradient Regulation 5 (PGR5) and PGR5-Like 1 (PGRL1) proteins promote sustainable light-driven hydrogen production in Chlamydomonas reinhardtii due to increased PSII activity under sulfur deprivation. Front Plant Sci (2015) 0.75

[Fe-Fe]-hydrogenase Reactivated by Residue Mutations as Bridging Carbonyl Rearranges: A QM/MM Study. Int J Quantum Chem (2010) 0.75

Distribution of Hydrogenases in Cyanobacteria: A Phylum-Wide Genomic Survey. Front Genet (2016) 0.75

Hydrogen overproducing nitrogenases obtained by random mutagenesis and high-throughput screening. Sci Rep (2016) 0.75

Dynamic modelling of high biomass density cultivation and biohydrogen production in different scales of flat plate photobioreactors. Biotechnol Bioeng (2015) 0.75

Design and construction of a photobioreactor for hydrogen production, including status in the field. J Appl Phycol (2016) 0.75

Temperature-sensitive PSII: a novel approach for sustained photosynthetic hydrogen production. Photosynth Res (2016) 0.75

Designed surface residue substitutions in [NiFe] hydrogenase that improve electron transfer characteristics. Int J Mol Sci (2015) 0.75

Low oxygen levels contribute to improve photohydrogen production in mixotrophic non-stressed Chlamydomonas cultures. Biotechnol Biofuels (2015) 0.75

Reversible oxygen-tolerant hydrogenase carried by free-living N2-fixing bacteria isolated from the rhizospheres of rice, maize, and wheat. Microbiologyopen (2012) 0.75

A Holistic Approach to Managing Microalgae for Biofuel Applications. Int J Mol Sci (2017) 0.75

The Involvement of hybrid cluster protein 4, HCP4, in Anaerobic Metabolism in Chlamydomonas reinhardtii. PLoS One (2016) 0.75

Hydrogen Production by a Chlamydomonas reinhardtii Strain with Inducible Expression of Photosystem II. Int J Mol Sci (2017) 0.75

The dual effect of a ferredoxin-hydrogenase fusion protein in vivo: successful divergence of the photosynthetic electron flux towards hydrogen production and elevated oxygen tolerance. Biotechnol Biofuels (2016) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS. Plant Physiol (1949) 174.11

X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution. Science (1998) 6.07

The structure and mechanism of iron-hydrogenases. Biochim Biophys Acta (1990) 2.25

The regulation of photosynthetic electron transport during nutrient deprivation in Chlamydomonas reinhardtii. Plant Physiol (1998) 2.24

Hydrogen Evolution by Nitrogen-Fixing Anabaena cylindrica Cultures. Science (1974) 2.19

Fermentative Metabolism of Chlamydomonas reinhardtii: I. Analysis of Fermentative Products from Starch in Dark and Light. Plant Physiol (1984) 2.16

Nucleotide sequence of the gene encoding the hydrogenase from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem (1985) 2.05

Hydrogen evolution by a chloroplast-ferredoxin-hydrogenase system. Proc Natl Acad Sci U S A (1973) 2.02

Organization of the genes encoding [Fe] hydrogenase in Desulfovibrio vulgaris subsp. oxamicus Monticello. J Bacteriol (1989) 1.88

Nickel hydrogenases: in search of the active site. Biochim Biophys Acta (1994) 1.81

Mutants of Chlamydomonas with Aberrant Responses to Sulfur Deprivation. Plant Cell (1994) 1.67

FERMENTATIVE AND PHOTOCHEMICAL PRODUCTION OF HYDROGEN IN ALGAE. J Gen Physiol (1942) 1.65

Characterization of Sulfate Transport in Chlamydomonas reinhardtii during Sulfur-Limited and Sulfur-Sufficient Growth. Plant Physiol (1994) 1.48

Oxygen sensitivity of algal H2- production. Appl Biochem Biotechnol (1997) 1.44

Induction, localization and metal content of hydrogenase in the green alga Chlamydomonas reinhardtii. Eur J Biochem (1994) 1.38

Hydrogen biotechnology: progress and prospects. Nat Biotechnol (1996) 1.30

Fermentative Metabolism of Chlamydomonas reinhardii: III. Photoassimilation of Acetate. Plant Physiol (1986) 1.28

Photosynthetic hydrogen and oxygen production: kinetic studies. Science (1982) 1.20

Hydrogenase-Mediated Activities in Isolated Chloroplasts of Chlamydomonas reinhardii. Plant Physiol (1986) 1.18

Photosystem I is indispensable for photoautotrophic growth, CO2 fixation, and H2 photoproduction in Chlamydomonas reinhardtii. J Biol Chem (1999) 1.13

Primary structure of hydrogenase I from Clostridium pasteurianum. Biochemistry (1991) 1.09

Activation and de novo synthesis of hydrogenase in chlamydomonas. Plant Physiol (1984) 1.08

Chromatic regulation inChlamydomonas reinhardtii alters photosystem stoichiometry and improves the quantum efficiency of photosynthesis. Photosynth Res (1996) 1.01

Energetic efficiency of hydrogen photoevolution by algal water splitting. Biophys J (1988) 0.93

The potential applications of cyanobacterial photosynthesis for clean technologies. Photosynth Res (1995) 0.92

Effect of anaerobiosis on photosynthetic reactions and nitrogen metabolism of algae with and without hydrogenase. Arch Mikrobiol (1973) 0.91

Articles by these authors

Serial analysis of gene expression. Science (1995) 60.15

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30

Characterization of the yeast transcriptome. Cell (1997) 11.33

The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23

PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20

Analysis of human transcriptomes. Nat Genet (1999) 6.14

The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09

Ligand binding to integrins. J Biol Chem (2000) 4.94

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28

Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17

The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08

Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07

A quantum dot single-photon turnstile device. Science (2000) 3.89

DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81

The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63

TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49

HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34

Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16

Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12

PUMA, a potent killer with or without p53. Oncogene (2008) 3.09

TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08

Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98

Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93

Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol (2013) 2.92

Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78

Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. J Virol (1996) 2.77

NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature (2005) 2.74

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58

Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55

Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol (2001) 2.51

Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol (1998) 2.48

HIV-1 subtype and second-receptor use. Nature (1996) 2.46

Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44

HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest (1999) 2.42

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics (2006) 2.38

Meta-analysis: prevalence of HIV infection and syphilis among MSM in China. Sex Transm Infect (2009) 2.36

Ultrasonic hydrophone based on short in-fiber bragg gratings. Appl Opt (1998) 2.35

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. Am J Hum Genet (2004) 2.33

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med (2000) 2.31

Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26

Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci (1999) 2.26

Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol (2000) 2.26

Accurate control of contrast on microcomputer displays. Vision Res (1991) 2.21

New structural picture of the Ge2Sb2Te5 phase-change alloy. Phys Rev Lett (2011) 2.21

Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development (1999) 2.20

Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 2.16

Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys. J Virol (1997) 2.16

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A (1995) 2.14

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review. Clin Pharmacol Ther (2010) 2.13

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol (1989) 2.12

Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry (1999) 2.10

Purification, primary structure, and immunological characterization of the 26-kDa calsequestrin binding protein (junctin) from cardiac junctional sarcoplasmic reticulum. J Biol Chem (1995) 2.08

The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003. Occup Environ Med (2008) 2.06

Viability and functional activity of cryopreserved mononuclear cells. Clin Diagn Lab Immunol (2000) 2.05

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med (2000) 2.04

Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS). Neurology (2005) 2.04

Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol (1998) 2.04

Can clinical and radiological features predict recurrence in solitary keratocystic odontogenic tumors? Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 2.01

Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I. J Virol (1995) 1.98

Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa. Antimicrob Agents Chemother (1998) 1.96

Virulence characteristics of Escherichia coli causing first urinary tract infection predict risk of second infection. J Infect Dis (1995) 1.96

Intracellular trafficking of adeno-associated viral vectors. Gene Ther (2005) 1.95

Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol (1995) 1.95

Molecular identification of the ryanodine receptor pore-forming segment. J Biol Chem (1999) 1.95

The "hukou" system and rural-urban migration in China: processes and changes. China Q (1999) 1.95

Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci U S A (1993) 1.94

Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience (2006) 1.93

Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res (2000) 1.93

Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (1999) 1.93

Meiotic recombination break points resolve at high rates at the 5' end of a maize coding sequence. Plant Cell (1995) 1.89

Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. Genes Immun (2003) 1.88

Risk factors for second urinary tract infection among college women. Am J Epidemiol (2000) 1.88

Bacterial virulence characteristics of Escherichia coli isolates from first-time urinary tract infection. J Infect Dis (1995) 1.86

Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation. J Biol Chem (1997) 1.86

Mu opioid receptor phosphorylation, desensitization, and ligand efficacy. J Biol Chem (1997) 1.86

Diversity of the vaccine candidate AMA-1 of Plasmodium falciparum. Mol Biochem Parasitol (1996) 1.86