Novel form of lipolysis induced by leptin.

PubWeight™: 1.67‹?› | Rank: Top 3%

🔗 View Article (PMID 10364187)

Published in J Biol Chem on June 18, 1999

Authors

M Y Wang1, Y Lee, R H Unger

Author Affiliations

1: Gifford Laboratories, Center for Diabetes Research and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.

Articles citing this

Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med (2008) 2.91

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest (2002) 2.38

Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab (2009) 2.27

Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep (2001) 2.04

Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci U S A (2004) 2.03

Hormone-sensitive lipase--new roles for an old enzyme. Biochem J (2004) 1.83

Functions of AMP-activated protein kinase in adipose tissue. J Physiol (2006) 1.70

Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci U S A (2004) 1.55

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad Sci U S A (2005) 1.50

Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol (2009) 1.47

Nonhomeostatic control of human appetite and physical activity in regulation of energy balance. Exerc Sport Sci Rev (2010) 1.42

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A (2002) 1.39

Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol (2010) 1.35

Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology (2007) 1.25

Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. Proc Natl Acad Sci U S A (2004) 1.21

Changes in neurohormonal gut peptides following bariatric surgery. Int J Obes (Lond) (2010) 1.13

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One (2012) 1.12

Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway. PLoS One (2009) 1.10

Circadian regulation of lipid mobilization in white adipose tissues. Diabetes (2013) 1.09

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism. Rev Endocr Metab Disord (2011) 1.07

The mitochondrial uncoupling proteins. Genome Biol (2002) 1.06

Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. Am J Physiol Endocrinol Metab (2006) 1.06

Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms. Endocrinology (2010) 0.98

Direct and indirect effects of leptin on adipocyte metabolism. Biochim Biophys Acta (2013) 0.95

Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis. Am J Physiol Regul Integr Comp Physiol (2009) 0.95

Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A (2009) 0.95

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia (2012) 0.94

Bilirubin Binding to PPARα Inhibits Lipid Accumulation. PLoS One (2016) 0.93

The role of leptin in glucose homeostasis. J Diabetes Investig (2012) 0.90

Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus. Neurosci Lett (2008) 0.86

The role of leptin in lipid metabolism in fatty degenerated hepatocytes of the grass carp Ctenopharyngodon idellus. Fish Physiol Biochem (2012) 0.85

Glucose-stimulated insulin response in pregnant sheep following acute suppression of plasma non-esterified fatty acid concentrations. Reprod Biol Endocrinol (2004) 0.83

α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression. Cytotechnology (2012) 0.83

Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Proc Natl Acad Sci U S A (1999) 0.83

Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot- and sex-related differential response. Genes Nutr (2009) 0.82

Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J Cell Physiol (2013) 0.81

Leptin administration enhances islet transplant performance in diabetic mice. Diabetes (2013) 0.80

Unique mode of lipogenic activation in rat preputial sebocytes. J Nutr Metab (2011) 0.78

Endurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet. Lipids (2013) 0.78

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation. Am J Pathol (2015) 0.78

Is leptin the parabiotic "satiety" factor? Past and present interpretations. Appetite (2012) 0.77

Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin. PLoS One (2013) 0.76

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice. Sci Rep (2017) 0.76

Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release. PLoS One (2012) 0.75

Evidence that leptin-induced weight loss requires activation of both forebrain and hindbrain receptors. Physiol Behav (2013) 0.75

A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice. PLoS One (2016) 0.75

Utility of transplantation in studying adipocyte biogenesis and function. Mol Cell Endocrinol (2009) 0.75

Assessing the Functional Role of Leptin in Energy Homeostasis and the Stress Response in Vertebrates. Front Endocrinol (Lausanne) (2017) 0.75

Articles by these authors

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A (2006) 6.33

Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A (2000) 5.65

RESOURCERER: a database for annotating and linking microarray resources within and across species. Genome Biol (2001) 4.79

Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest (1970) 4.74

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A (1998) 4.72

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A (1994) 4.01

Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci (1969) 3.42

Enrichment of gene-coding sequences in maize by genome filtration. Science (2003) 3.41

Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med (1970) 3.27

Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A (1997) 3.07

Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev (1998) 2.97

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol (1996) 2.90

Functional subdivision of islets of Langerhans and possible role of D cells. Lancet (1975) 2.83

Biomedical applications of collagen. Int J Pharm (2001) 2.76

Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. EMBO J (2001) 2.66

Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients. J Clin Invest (1968) 2.60

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem (1998) 2.59

Glucagon levels and metabolic effects in fasting man. J Clin Invest (1970) 2.58

The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet (1975) 2.54

The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs. J Clin Invest (1967) 2.53

Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest (1984) 2.52

Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia (1985) 2.48

Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose. J Clin Invest (1968) 2.46

Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest (1997) 2.45

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem (1995) 2.43

Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology (2009) 2.41

Oligogalacturonic acid and chitosan reduce stomatal aperture by inducing the evolution of reactive oxygen species from guard cells of tomato and Commelina communis. Plant Physiol (1999) 2.32

Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. Proc Natl Acad Sci U S A (1994) 2.16

The effect of experimental insulin deficiency on glucagon secretion. J Clin Invest (1971) 2.15

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci U S A (1996) 2.15

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci U S A (2000) 2.11

Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus. N Engl J Med (1990) 2.01

Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes (1982) 1.94

Reversing adipocyte differentiation: implications for treatment of obesity. Proc Natl Acad Sci U S A (1999) 1.92

Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation (2000) 1.91

Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Engl J Med (1979) 1.88

Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem (2001) 1.87

Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases. Arterioscler Thromb Vasc Biol (2001) 1.87

Effects of starvation on plasma pancreatic glucagon in normal man. Diabetes (1969) 1.86

Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses. Diabetes (1971) 1.85

Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science (1990) 1.85

Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study. Br J Anaesth (2012) 1.80

Physiology and pathophysiology of glucagon. Physiol Rev (1976) 1.79

A glucagon-secreting alpha-cell carcinoma of the pancreas. N Engl J Med (1966) 1.79

A prediction model for type 2 diabetes risk among Chinese people. Diabetologia (2008) 1.78

Entero-insular axis. Arch Intern Med (1969) 1.74

The use of the GlideScope for tracheal intubation in patients with ankylosing spondylitis. Br J Anaesth (2006) 1.74

Comparison of propofol deep sedation versus moderate sedation during endosonography. Dig Dis Sci (2010) 1.72

The role of aminogenic glucagon secretion in blood glucose homeostasis. J Clin Invest (1969) 1.71

Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids. J Clin Invest (1968) 1.71

Large glucagon immunoreactivity in extracts of pancreas. J Biol Chem (1970) 1.70

Control of pancreatic glucagon secretion by glucose. Diabetes (1969) 1.69

Glucagon physiology and pathophysiology in the light of new advances. Diabetologia (1985) 1.69

Evidence for subdivision within the M molecular form of Anopheles gambiae. Mol Ecol (2007) 1.67

Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif (2007) 1.67

Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes (1997) 1.66

Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance. Am J Med (1973) 1.66

Glucagon and the A cell: physiology and pathophysiology (first two parts). N Engl J Med (1981) 1.66

Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem (2000) 1.65

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci U S A (1998) 1.64

Abnormal pancreatic alpha-cell function in bacterial infections. N Engl J Med (1973) 1.62

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci U S A (1997) 1.59

Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Natl Acad Sci U S A (1976) 1.59

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci U S A (1999) 1.58

Hyperglucagonaemia after burns. Lancet (1974) 1.56

Recurrent cases of corticosteroid-induced mood disorder: clinical characteristics and treatment. J Clin Psychiatry (2000) 1.55

A new video intubating device: trachway intubating stylet. Anaesthesia (2009) 1.55

IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. Cell Death Differ (2009) 1.53

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A (1998) 1.53

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes. J Biol Chem (1996) 1.53

Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence. Diabetologia (1995) 1.52

The Banting Memorial Lecture 1975. Diabetes and the alpha cell. Diabetes (1976) 1.51

Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proc Natl Acad Sci U S A (1990) 1.51

Congestion of right liver graft in living donor liver transplantation. Transplantation (2001) 1.51

Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. J Clin Invest (1992) 1.50

Sequence analysis of a rainbow trout cDNA library and creation of a gene index. Cytogenet Genome Res (2003) 1.46

Long-term vitamin C supplement use and prevalence of early age-related lens opacities. Am J Clin Nutr (1997) 1.46

Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex. Philos Trans R Soc Lond B Biol Sci (1997) 1.46

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. Diabetes (1994) 1.45

Effects of secretin on insulin and glucagon in portal and peripheral blood in man. Lancet (1966) 1.44

Assessment of medical care by elderly people: general satisfaction and physician quality. Health Serv Res (1998) 1.43

Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man. J Clin Invest (1969) 1.42

Meticulous control of diabetes: benefits, risks, and precautions. Diabetes (1982) 1.41

Perceptions of the effectiveness of ethical guidelines: an international study of physicians. Med Health Care Philos (2009) 1.41

A novel leptin receptor isoform in rat. FEBS Lett (1996) 1.40

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia (2004) 1.40

Roles of the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex. Possible relevance to PTSD. Ann N Y Acad Sci (1997) 1.39

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A (2002) 1.39

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem (1998) 1.39

The effect of insulin on the alpha-cell response to hyperglycemia in long-standing alloxan diabetes. J Clin Invest (1974) 1.39