PubRank

E S Lander

Author PubWeight™ 940.38‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999 83.27
2 A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001 42.18
3 Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996 39.80
4 Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A 1999 39.79
5 Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A 1987 35.83
6 Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 2002 28.79
7 Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A 2001 24.34
8 Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 1999 24.24
9 Dissecting the regulatory circuitry of a eukaryotic genome. Cell 1998 23.62
10 Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 1988 23.48
11 High-resolution haplotype structure in the human genome. Nat Genet 2001 20.51
12 Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A 2001 19.30
13 An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature 2000 19.19
14 Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 1998 18.23
15 An STS-based map of the human genome. Science 1995 17.72
16 Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics 1991 17.40
17 Linkage disequilibrium in the human genome. Nature 2001 17.24
18 On the allelic spectrum of human disease. Trends Genet 2001 16.26
19 The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000 15.19
20 A gene map of the human genome. Science 1996 14.32
21 Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A 1988 13.85
22 Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics 1992 13.63
23 A genetic linkage map of the human genome. Cell 1987 13.37
24 Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 1995 12.78
25 Positive natural selection in the human lineage. Science 2006 12.55
26 A physical map of 30,000 human genes. Science 1998 12.43
27 Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 1987 12.20
28 Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet 2001 11.12
29 Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000 10.11
30 Systematic detection of errors in genetic linkage data. Genomics 1992 10.06
31 Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991 9.99
32 Ploidy regulation of gene expression. Science 1999 9.98
33 Recognition of related proteins by iterative template refinement (ITR). Protein Sci 1994 9.67
34 Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell 2001 9.63
35 Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A 1986 9.51
36 A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 1992 8.53
37 Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res 2000 8.28
38 Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol 1986 8.22
39 Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A 2001 7.51
40 Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet 1995 6.51
41 Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A 2000 6.30
42 The plasticity of dendritic cell responses to pathogens and their components. Science 2001 5.58
43 Research on DNA typing catching up with courtroom application. Am J Hum Genet 1991 5.28
44 Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 1999 4.97
45 Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet 1999 4.79
46 Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature 1999 4.71
47 Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 1993 4.66
48 Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet 2000 4.66
49 A nonparametric approach for mapping quantitative trait loci. Genetics 1995 4.49
50 Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 2009 4.41
51 Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol 2000 4.10
52 Analysing complex genetic traits with chromosome substitution strains. Nat Genet 2000 3.92
53 Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. Genetics 1988 3.92
54 Faster multipoint linkage analysis using Fourier transforms. J Comput Biol 1998 3.87
55 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 2002 3.78
56 Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 2007 3.69
57 Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet 2000 3.52
58 ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet 2000 3.17
59 Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 1997 2.91
60 High-resolution genetic mapping of complex traits. Am J Hum Genet 1995 2.89
61 Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature 1996 2.58
62 Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet 1998 2.57
63 Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet 2001 2.50
64 Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 1996 2.48
65 Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet 2000 2.28
66 A radiation hybrid map of mouse genes. Nat Genet 2001 2.03
67 Effects of medical research on health care and economy. Science 1999 1.99
68 Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996 1.96
69 The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet 1998 1.96
70 Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet 2000 1.93
71 A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet 1988 1.92
72 Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc Natl Acad Sci U S A 1999 1.88
73 Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 1992 1.87
74 Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet 1997 1.82
75 Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet 2001 1.80
76 Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci 2001 1.77
77 SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proc Natl Acad Sci U S A 2000 1.74
78 The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. Genome Res 2001 1.72
79 Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 1995 1.70
80 Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 1996 1.61
81 Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet 1994 1.59
82 Construction of a large-insert yeast artificial chromosome library of the mouse genome. Mamm Genome 1993 1.58
83 CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis. Nat Genet 1998 1.58
84 Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 1997 1.57
85 Genomic mapping by anchoring random clones: a mathematical analysis. Genomics 1991 1.52
86 Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet 1999 1.47
87 Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma. Cancer Res 1995 1.47
88 Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 1996 1.45
89 Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene. Nat Genet 1996 1.44
90 Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 1997 1.40
91 Large human YACs constructed in a rad52 strain show a reduced rate of chimerism. Genomics 1994 1.40
92 Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics 1995 1.38
93 A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet 2001 1.36
94 The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene 2000 1.36
95 A magnetic attraction to high-throughput genomics. Science 1997 1.35
96 Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics 1995 1.33
97 Sequencing a genome by walking with clone-end sequences: a mathematical analysis. Genome Res 1999 1.32
98 The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron 1997 1.32
99 Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16. Gastroenterology 1998 1.32
100 Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. Am J Hum Genet 2002 1.31
101 A dictionary-based approach for gene annotation. J Comput Biol 1999 1.29
102 Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 1996 1.28
103 The recombinant congenic strains for analysis of multigenic traits: genetic composition. FASEB J 1992 1.26
104 The importance of being independent: sib pair analysis in diabetes. Nat Genet 1996 1.26
105 A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant. Nat Genet 1999 1.24
106 A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Res 1995 1.23
107 Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias. Am J Hum Genet 1996 1.22
108 A YAC-based physical map of the mouse genome. Nat Genet 1999 1.22
109 Identification of polymorphic simple sequence repeats in the genome of the zebrafish. Genomics 1992 1.21
110 Radiation hybrid map of the mouse genome. Nat Genet 1999 1.21
111 Progress in sequencing the mouse genome. Genesis 2001 1.20
112 Limits on fine mapping of complex traits. Am J Hum Genet 1996 1.17
113 Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A 2001 1.17
114 A locus for Fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet 1996 1.15
115 A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16. Am J Hum Genet 2001 1.12
116 A comprehensive large-insert yeast artificial chromosome library for physical mapping of the mouse genome. Mamm Genome 1996 1.11
117 Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J Biol Chem 2001 1.11
118 Forensic DNA tests and hardy-weinberg equilibrium. Science 1991 1.09
119 Splitting schizophrenia. Nature 1988 1.09
120 Mapping the mouse genome: current status and future prospects. Proc Natl Acad Sci U S A 1995 1.08
121 Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci U S A 1997 1.05
122 Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation. Cancer Res 1994 1.03
123 Protein secondary structure prediction using nearest-neighbor methods. J Mol Biol 1993 1.02
124 Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc Natl Acad Sci U S A 1994 1.02
125 Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Genomics 1996 1.01
126 Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mamm Genome 1998 1.01
127 Finding similarities and differences among genomes. Nat Genet 1993 0.99
128 Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia. Genomics 2001 0.97
129 Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol 1999 0.95
130 Sib-pair collection strategies for complex diseases. Genet Epidemiol 1998 0.95
131 cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. Biol Bull 2008 0.94
132 Diabetes, dependence, asymptotics, selection and significance. Nat Genet 1997 0.92
133 Consanguinity and heterogeneity: cystic fibrosis need not be homogeneous in Italy. Am J Hum Genet 1986 0.92
134 Identification of the Finnish founder mutation for diastrophic dysplasia (DTD). Eur J Hum Genet 1999 0.88
135 Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4. Proc Natl Acad Sci U S A 1997 0.88
136 An integrated genetic linkage map of the laboratory rat. Mamm Genome 1998 0.86
137 Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Cancer Res 1994 0.85
138 Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. Proc Natl Acad Sci U S A 1994 0.84
139 Assessing mapping progress in the Human Genome Project. Science 1994 0.82
140 Genome maps 7. The human transcript map. Wall chart. Science 1996 0.82
141 Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 2001 0.81
142 Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics 1993 0.81
143 Genomics: launching a revolution in medicine. J Law Med Ethics 2000 0.81
144 Sulfate transport in chondrodysplasia. Ann N Y Acad Sci 1996 0.80
145 Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mamm Genome 1998 0.80
146 DNA fingerprinting: the NRC report. Science 1993 0.80
147 Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. Int Immunol 1996 0.80
148 Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome 1995 0.79
149 Iterative template refinement: protein-fold prediction using iterative search and hybrid sequence/structure templates. Methods Enzymol 1996 0.79
150 A family of chondrodysplasias caused by mutations in the diastrophic dysplasia sulfate transporter gene and associated with impaired sulfation of proteoglycans. Ann N Y Acad Sci 1996 0.78
151 Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J Autoimmun 1995 0.78
152 Gene-based anchoring of the rat genetic linkage and cytogenetic maps. Transplant Proc 1999 0.77
153 Prospects for the genetic analysis of schizophrenia. Schizophr Bull 1989 0.76
154 Zebrafish genomic library in yeast artificial chromosomes. Genomics 1998 0.76
155 Construction of a large-insert yeast artificial chromosome library of the rat genome. Mamm Genome 1997 0.76
156 An automated method for DNA preparation from thousands of YAC clones. Nucleic Acids Res 1991 0.75
157 Founding father. Nature 1998 0.75
158 Transcript identification on the CLN5 region on chromosome 13q22. Hum Genet 1999 0.75
159 Software availability. Science 1995 0.75
160 Genetic mapping in hypertension. J Vasc Surg 1992 0.75