Published in Nature on May 10, 2001
A haplotype map of the human genome. Nature (2005) 105.70
A map of recent positive selection in the human genome. PLoS Biol (2006) 29.19
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
Calibrating a coalescent simulation of human genome sequence variation. Genome Res (2005) 15.04
Linkage disequilibrium in humans: models and data. Am J Hum Genet (2001) 14.97
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet (2001) 10.48
Inference of human population history from individual whole-genome sequences. Nature (2011) 8.05
Structure of linkage disequilibrium and phenotypic associations in the maize genome. Proc Natl Acad Sci U S A (2001) 7.57
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations. Genetics (2004) 7.00
Recent human effective population size estimated from linkage disequilibrium. Genome Res (2007) 6.79
Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Nat Genet (2007) 6.63
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06
Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels. Am J Hum Genet (2001) 5.84
Runs of homozygosity in European populations. Am J Hum Genet (2008) 5.34
European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci U S A (2005) 5.21
Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers. Am J Hum Genet (2003) 5.14
A dynamic programming algorithm for haplotype block partitioning. Proc Natl Acad Sci U S A (2002) 5.12
Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet (2004) 5.02
Fast and flexible simulation of DNA sequence data. Genome Res (2008) 4.45
Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet (2002) 4.29
Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am J Hum Genet (2004) 4.15
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet (2002) 4.03
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Novel multilocus measure of linkage disequilibrium to estimate past effective population size. Genome Res (2003) 3.83
Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet (2004) 3.83
Global landscape of recent inferred Darwinian selection for Homo sapiens. Proc Natl Acad Sci U S A (2005) 3.77
Single-nucleotide polymorphisms in soybean. Genetics (2003) 3.73
The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci U S A (2001) 3.38
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nat Genet (2010) 3.33
ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet (2003) 3.12
The landscape of recombination in African Americans. Nature (2011) 3.06
Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations. Am J Hum Genet (2001) 3.04
Homozygosity and linkage disequilibrium. Genetics (2002) 3.04
Perspectives on human genetic variation from the HapMap Project. PLoS Genet (2005) 2.91
Haplotype block structure and its applications to association studies: power and study designs. Am J Hum Genet (2002) 2.88
Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res (2004) 2.85
Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh. Proc Natl Acad Sci U S A (2004) 2.83
The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc Natl Acad Sci U S A (2002) 2.80
Association testing by DNA pooling: an effective initial screen. Proc Natl Acad Sci U S A (2002) 2.79
Genome association studies of complex diseases by case-control designs. Am J Hum Genet (2003) 2.74
High-resolution patterns of meiotic recombination across the human major histocompatibility complex. Am J Hum Genet (2002) 2.71
Sequence variations in the public human genome data reflect a bottlenecked population history. Proc Natl Acad Sci U S A (2002) 2.70
Survey of allelic expression using EST mining. Genome Res (2005) 2.67
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Assessing the performance of the haplotype block model of linkage disequilibrium. Am J Hum Genet (2003) 2.59
Genomic signatures of positive selection in humans and the limits of outlier approaches. Genome Res (2006) 2.56
Inferring admixture histories of human populations using linkage disequilibrium. Genetics (2013) 2.51
Caution on pedigree haplotype inference with software that assumes linkage equilibrium. Am J Hum Genet (2002) 2.51
Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet (2010) 2.48
Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci U S A (2001) 2.48
Multiple sclerosis. J Clin Invest (2004) 2.48
Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms. Genome Res (2003) 2.47
Population genetic analysis of ascertained SNP data. Hum Genomics (2004) 2.41
Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect (2003) 2.36
Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping. PLoS Genet (2011) 2.34
Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet (2002) 2.29
Linkage disequilibrium in domestic sheep. Genetics (2002) 2.29
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Biases and reconciliation in estimates of linkage disequilibrium in the human genome. Am J Hum Genet (2006) 2.26
Geography is a better determinant of human genetic differentiation than ethnicity. Hum Genet (2005) 2.20
Genetic and haplotypic structure in 14 European and African cattle breeds. Genetics (2007) 2.18
Extreme population-dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare. Genetics (2005) 2.13
Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol (2013) 2.08
A linkage map of the Atlantic salmon (Salmo salar) based on EST-derived SNP markers. BMC Genomics (2008) 2.07
Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet (2003) 2.05
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. Cell (2014) 2.04
Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data. Genetics (2007) 2.00
Molecular genetic studies of complex phenotypes. Transl Res (2011) 1.95
Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets. Hum Genet (2011) 1.93
Population genetic structure of the people of Qatar. Am J Hum Genet (2010) 1.91
Length distributions of identity by descent reveal fine-scale demographic history. Am J Hum Genet (2012) 1.91
Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestors. Am J Hum Genet (2002) 1.89
Understanding the accuracy of statistical haplotype inference with sequence data of known phase. Genet Epidemiol (2007) 1.87
A comprehensive literature review of haplotyping software and methods for use with unrelated individuals. Hum Genomics (2005) 1.84
MHC haplotype matching for unrelated hematopoietic cell transplantation. PLoS Med (2007) 1.83
GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol (2003) 1.83
Linkage disequilibrium and demographic history of wild and domestic canids. Genetics (2009) 1.79
Evidence for positive selection and population structure at the human MAO-A gene. Proc Natl Acad Sci U S A (2002) 1.79
Detecting ancient admixture and estimating demographic parameters in multiple human populations. Mol Biol Evol (2009) 1.78
CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup. Am J Hum Genet (2009) 1.78
Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica. Hum Genet (2003) 1.76
Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet (2009) 1.75
A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations. Am J Hum Genet (2005) 1.75
Patterns of linkage disequilibrium in the MHC region on human chromosome 6p. Hum Genet (2004) 1.73
The recombination landscape of the zebra finch Taeniopygia guttata genome. Genome Res (2010) 1.72
Genomic BLUP decoded: a look into the black box of genomic prediction. Genetics (2013) 1.71
Finding haplotype block boundaries by using the minimum-description-length principle. Am J Hum Genet (2003) 1.71
Linkage disequilibrium decay and haplotype block structure in the pig. Genetics (2008) 1.71
Inbreeding and the genetic complexity of human hypertension. Genetics (2003) 1.67
A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies. PLoS Genet (2012) 1.66
Deep haplotype divergence and long-range linkage disequilibrium at xp21.1 provide evidence that humans descend from a structured ancestral population. Genetics (2005) 1.66
High nucleotide polymorphism and rapid decay of linkage disequilibrium in wild populations of Caenorhabditis remanei. Genetics (2006) 1.66
Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet (2006) 1.66
Using population mixtures to optimize the utility of genomic databases: linkage disequilibrium and association study design in India. Ann Hum Genet (2007) 1.65
The sequence of the human genome. Science (2001) 101.55
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79
Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A (1987) 35.83
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34
Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24
Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62
Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature (1988) 23.48
High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30
An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature (2000) 19.19
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23
An STS-based map of the human genome. Science (1995) 17.72
Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics (1991) 17.40
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19
A gene map of the human genome. Science (1996) 14.32
Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A (1988) 13.85
Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics (1992) 13.63
A genetic linkage map of the human genome. Cell (1987) 13.37
Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78
Positive natural selection in the human lineage. Science (2006) 12.55
A physical map of 30,000 human genes. Science (1998) 12.43
Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12
Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11
Systematic detection of errors in genetic linkage data. Genomics (1992) 10.06
Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell (1991) 9.99
Ploidy regulation of gene expression. Science (1999) 9.98
Recognition of related proteins by iterative template refinement (ITR). Protein Sci (1994) 9.67
Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell (2001) 9.63
Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res (2000) 8.28
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet (1995) 6.51
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
The plasticity of dendritic cell responses to pathogens and their components. Science (2001) 5.58
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Research on DNA typing catching up with courtroom application. Am J Hum Genet (1991) 5.28
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature (1999) 4.71
Improved detection of coronary artery disease by exercise electrocardiography with the use of right precordial leads. N Engl J Med (1999) 4.67
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell (1993) 4.66
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66
A nonparametric approach for mapping quantitative trait loci. Genetics (1995) 4.49
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet (2001) 4.17
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol (2000) 4.10
Analysing complex genetic traits with chromosome substitution strains. Nat Genet (2000) 3.92
Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. Genetics (1988) 3.92
THE ISOLATION OF POLIOMYELITIS VIRUS FROM HUMAN EXTRA-NEURAL SOURCES. III. PERSISTENCE OF VIRUS IN STOOLS AFTER ACUTE INFECTION. J Clin Invest (1946) 3.88
Faster multipoint linkage analysis using Fourier transforms. J Comput Biol (1998) 3.87
Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med (1999) 3.84
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry (2002) 3.78
Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69
Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet (2000) 3.63
INSECTS AND EPIDEMIOLOGY OF POLIOMYELITIS. Science (1942) 3.59
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
FLIES AS CARRIERS OF POLIOMYELITIS VIRUS IN URBAN EPIDEMICS. Science (1941) 3.48
Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet (2001) 3.22
ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet (2000) 3.17
Complete mitochondrial genome sequences of two extinct moas clarify ratite evolution. Nature (2001) 3.12
POLIOMYELITIS VIRUS IN FLY-CONTAMINATED FOOD COLLECTED AT AN EPIDEMIC. Science (1945) 3.04
Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat Med (1996) 2.96
The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum (1999) 2.92
Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet (1997) 2.91
High-resolution genetic mapping of complex traits. Am J Hum Genet (1995) 2.89
Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. Hum Mol Genet (1994) 2.83
THE NATURAL HISTORY OF HUMAN POLIOMYELITIS : I. DISTRIBUTION OF VIRUS IN NERVOUS AND NON-NERVOUS TISSUES. J Exp Med (1941) 2.68
Occupational asthma due to porcine pancreatic amylase. Occup Environ Med (1997) 2.62
Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature (1996) 2.58
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet (1998) 2.57
NATURE OF NON-PARALYTIC AND TRANSITORY PARALYTIC POLIOMYELITIS IN RHESUS MONKEYS INOCULATED WITH HUMAN VIRUS. J Exp Med (1941) 2.54
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48
The effectiveness of exercise for the prevention and treatment of antenatal depression: systematic review with meta-analysis. BJOG (2014) 2.45
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet (2000) 2.28
Development and mapping of microsatellite (SSR) markers in wheat. Theor Appl Genet (2005) 2.27
Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis (2001) 2.23
mtDNA and the origin of the Icelanders: deciphering signals of recent population history. Am J Hum Genet (2000) 2.23
Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. Am J Hum Genet (2000) 2.22
Submillimetre galaxies reside in dark matter haloes with masses greater than 3 × 10(11) solar masses. Nature (2011) 2.21
The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study. Eur J Clin Nutr (2007) 2.21
Direct measurement of attentional dwell time in human vision. Nature (1994) 2.15
Metastatic malignant mesothelioma presenting as colonic polyps. Hum Pathol (1997) 2.09
Efficacy and safety of high-dose rhesus-human reassortant rotavirus vaccine in Native American populations. J Pediatr (1997) 2.07
A radiation hybrid map of mouse genes. Nat Genet (2001) 2.03
Effects of medical research on health care and economy. Science (1999) 1.99
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet (1996) 1.96
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
Restricted attentional capacity within but not between sensory modalities. Nature (1997) 1.96