Published in Nat Genet on June 01, 1999
Predicting the Response to Montelukast by Genetic Variation in Asthmatics | NCT00116324
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet (2001) 2.61
The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev (2011) 2.44
New insights into the role of cytokines in asthma. J Clin Pathol (2001) 2.09
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease. FASEB J (2007) 1.97
Hazardous air pollutants and asthma. Environ Health Perspect (2002) 1.67
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med (2005) 1.58
Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial. Lancet Respir Med (2014) 1.50
Anti-inflammatory therapeutics for the treatment of atherosclerosis. Nat Rev Drug Discov (2011) 1.48
Outcome measures in asthma. Thorax (2000) 1.48
Translating pharmacogenomics: challenges on the road to the clinic. PLoS Med (2007) 1.39
Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res (2003) 1.39
African Americans with asthma: genetic insights. Proc Am Thorac Soc (2007) 1.29
Candidate gene case-control association studies: advantages and potential pitfalls. Br J Clin Pharmacol (2001) 1.24
Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax (2000) 1.20
Asthma genetics and personalised medicine. Lancet Respir Med (2014) 1.17
An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol (2010) 1.16
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Hum Genet (2004) 1.12
Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med Genet (2008) 1.11
Interactions between genes and environmental factors in asthma and atopy: new developments. Respir Res (2001) 1.09
Rational or rationed medicine? The promise of genetics for improved clinical practice. BMJ (2000) 1.06
Genetics and pharmacogenetics of the leukotriene pathway. J Allergy Clin Immunol (2009) 1.03
5-Lipoxygenase: mechanisms of regulation. J Lipid Res (2008) 1.03
Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II). Br J Clin Pharmacol (2004) 1.02
Pharmacogenetics of asthma. Curr Opin Pulm Med (2009) 0.99
Pharmacogenomics: marshalling the human genome to individualise drug therapy. Gut (2003) 0.98
Asthma medications: basic pharmacology and use in the athlete. J Athl Train (2000) 0.95
Functional analysis of 5-lipoxygenase promoter repeat variants. Hum Mol Genet (2009) 0.94
5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. Pharmacogenet Genomics (2009) 0.94
Pharmacogenetics of asthma. Br J Clin Pharmacol (2002) 0.93
Pharmacogenetics and the future of medical practice. Br J Clin Pharmacol (2002) 0.93
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. Am J Respir Crit Care Med (2012) 0.93
Pharmacogenetics in drug regulation: promise, potential and pitfalls. Philos Trans R Soc Lond B Biol Sci (2005) 0.93
Pharmacogenetics in drug development. Philos Trans R Soc Lond B Biol Sci (2005) 0.91
Clinical utility of asthma biomarkers: from bench to bedside. Biologics (2013) 0.90
Emerging therapies for severe asthma. BMC Med (2011) 0.89
Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients (2014) 0.89
Genetic polymorphisms and associated susceptibility to asthma. Int J Gen Med (2013) 0.89
Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma. Respir Res (2001) 0.89
Asthma from a pharmacogenomic point of view. Br J Pharmacol (2008) 0.89
Leukotrienes and airway inflammation. Biochim Biophys Acta (2011) 0.88
Management of asthma in adults: current therapy and future directions. Postgrad Med J (2003) 0.88
Asthma phenotypes: the intriguing selective intervention with Montelukast. Asthma Res Pract (2016) 0.87
The role of pharmacogenomics in improving the management of asthma. J Allergy Clin Immunol (2010) 0.85
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. Clin Exp Allergy (2013) 0.84
The pharmacogenetics and pharmacogenomics of asthma therapy. Pharmacogenomics J (2011) 0.84
Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol (2006) 0.81
Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics (2012) 0.81
Pharmacogenetics, pharmacogenomics and airway disease. Respir Res (2001) 0.81
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics (2009) 0.80
Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells. Cell Immunol (2008) 0.80
Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J (2015) 0.80
Comparison of Glucocorticoid (Budesonide) and Antileukotriene (Montelukast) Effect in Patients with Bronchial Asthma Determined with Body Plethysmography. Acta Inform Med (2015) 0.80
Increased frequency of micronuclei in adults with a history of childhood sexual abuse: a discordant monozygotic twin study. PLoS One (2013) 0.80
Leukotriene receptor antagonist therapy. Postgrad Med J (2000) 0.79
Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance. Br J Clin Pharmacol (2002) 0.79
Pharmacogenomics of pediatric asthma. Indian J Hum Genet (2010) 0.78
The Use of SNPs in Pharmacogenomics Studies. Malays J Med Sci (2005) 0.78
Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay. Genet Test Mol Biomarkers (2009) 0.78
Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. Thorax (2005) 0.77
Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma. PLoS One (2015) 0.77
Pharmacogenomic approaches to asthma treatment. Allergy Asthma Immunol Res (2010) 0.77
Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials (2013) 0.77
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus (2014) 0.76
Role of biomarkers in understanding and treating children with asthma: towards personalized care. Pharmgenomics Pers Med (2013) 0.76
The Therapeutic Potential of Targeting Cytokine Alarmins to Treat Allergic Airway Inflammation. Front Physiol (2016) 0.76
Functional genomics in gastroenterology. Gut (2000) 0.76
Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia. Haematologica (2014) 0.75
The future of pharmacotherapy for schizophrenia. World Psychiatry (2003) 0.75
Role of genetic polymorphisms in therapeutic response to anti-asthma therapy. Allergy Asthma Clin Immunol (2007) 0.75
AAPS/RAPS/CAPRA collaborative program: exploring the challenges of drug regulation in a global environment: clinical concerns. AAPS PharmSci (2003) 0.75
Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med (2015) 0.75
In silico analysis of deleterious single nucleotide polymorphisms in human BUB1 mitotic checkpoint serine/threonine kinase B gene. Meta Gene (2016) 0.75
Emerging strategies and applications of pharmacogenomics. Hum Genomics (2004) 0.75
The role of pharmacogenetics and pharmacogenomics in improving translational medicine. Clin Cases Miner Bone Metab (2009) 0.75
Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. Br J Pharmacol (2007) 0.75
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. Front Pharmacol (2016) 0.75
Transcriptional regulation of the canine carbonyl reductase 1 gene (cbr1) by the specificity protein 1 (Sp1). Gene (2016) 0.75
Leukotrienes and sex: strange bedfellows? J Clin Invest (2017) 0.75
Human immunodeficiency virus infection among patients attending clinics for sexually transmitted diseases. N Engl J Med (1988) 4.81
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med (1996) 4.03
Physician knowledge, attitudes, and behavior related to reporting adverse drug events. Arch Intern Med (1988) 3.74
"White coat" versus "sustained" borderline hypertension in Tecumseh, Michigan. Hypertension (1990) 3.30
Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes. Proc Natl Acad Sci U S A (1990) 3.29
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA (2001) 3.21
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med (2000) 3.08
Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome. N Engl J Med (1991) 2.93
Environmental risk factors for Lyme disease identified with geographic information systems. Am J Public Health (1995) 2.78
Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection. Proc Natl Acad Sci U S A (1991) 2.54
Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med (1999) 2.53
Singleton deletions throughout the genome increase risk of bipolar disorder. Mol Psychiatry (2008) 2.50
Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med (1988) 2.32
Tumor cell autocrine motility factor. Proc Natl Acad Sci U S A (1986) 2.28
A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature (2000) 2.24
The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med (1994) 2.23
A 3-year-old boy's chronic diarrhea and unexplained death. J Am Acad Child Adolesc Psychiatry (1991) 2.19
Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax (2000) 2.10
Linkage of Bardet-Biedl syndrome to chromosome 16q and evidence for non-allelic genetic heterogeneity. Nat Genet (1993) 2.05
Childhood ataxia with diffuse central nervous system hypomyelination. Ann Neurol (1994) 1.98
OPTN policy regarding prioritization of patients with hepatopulmonary syndrome: does it provide equitable organ allocation? Am J Transplant (2008) 1.88
Investigation of an outbreak of Salmonella enteritidis gastroenteritis associated with consumption of eggs in a restaurant chain in Maryland. Am J Epidemiol (1988) 1.71
Predicting worsening asthma control following the common cold. Eur Respir J (2008) 1.70
High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest (2000) 1.67
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest (1997) 1.63
Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med (2001) 1.58
Salmeterol powder provides significantly better benefit than montelukast in asthmatic patients receiving concomitant inhaled corticosteroid therapy. Chest (2001) 1.57
Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. AJNR Am J Neuroradiol (1995) 1.56
Transcriptional synergy by the Epstein-Barr virus transactivator ZEBRA. J Virol (1992) 1.55
A geographic information systems application for disease surveillance. Am J Public Health (1998) 1.55
Tracheobronchopathia osteochondroplastica presenting as right middle lobe collapse. Diagnosis by bronchoscopy and computerized tomography. Chest (1988) 1.53
Measurement and interpretation of hand hygiene compliance rates: importance of monitoring entire care episodes. J Hosp Infect (2009) 1.49
Extrapituitary parasellar microadenoma in Cushing's disease. J Clin Endocrinol Metab (1999) 1.49
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA (1996) 1.47
CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. J Biol Chem (1999) 1.47
Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes. Proc Natl Acad Sci U S A (1988) 1.47
Persistence of cholera in the United States: isolation of Vibrio cholerae O1 from a patient with diarrhea in Maryland. J Clin Microbiol (1986) 1.44
Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies. AJR Am J Roentgenol (1988) 1.41
Two 21-kilodalton components of the Epstein-Barr virus capsid antigen complex and their relationship to ZEBRA-associated protein p21 (ZAP21). J Virol (1996) 1.41
Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. Am J Respir Crit Care Med (1999) 1.39
Should antileukotriene therapies be used instead of inhaled corticosteroids in asthma? Yes. Am J Respir Crit Care Med (1998) 1.39
Diagnostic yield of bronchoalveolar lavage and bronchoscopic lung biopsy for detection of Pneumocystis carinii. Mayo Clin Proc (1996) 1.38
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med (1999) 1.38
Comparison of phenotype between patients with Prader-Willi syndrome due to deletion 15q and uniparental disomy 15. Am J Med Genet (1997) 1.35
Cost-effectiveness of stroke prophylaxis for nonvalvular atrial fibrillation. JAMA (1996) 1.33
Epidemiology and spectrum of Vibrio infections in a Chesapeake Bay community. J Infect Dis (1989) 1.31
TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy (2010) 1.29
An outbreak of influenza A in a nursing home. Am J Public Health (1986) 1.28
Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis (1992) 1.26
Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. Am J Respir Crit Care Med (1996) 1.25
Molecular epidemiology of neonatal meningitis due to Citrobacter diversus: a study of isolates from hospitals in Maryland. J Infect Dis (1986) 1.23
Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med (1999) 1.23
Clinical predictors of health-related quality of life depend on asthma severity. Am J Respir Crit Care Med (2001) 1.23
Eotaxin expression after segmental allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med (2001) 1.22
Treating mild asthma--when are inhaled steroids indicated? N Engl J Med (1994) 1.22
Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma. Am J Respir Crit Care Med (1998) 1.22
Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med (2001) 1.20
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol (2001) 1.18
The public health impact of Lyme disease in Maryland. J Infect Dis (1996) 1.17
Chromosomal assignment of 2900 tri- and tetranucleotide repeat markers using NIGMS somatic cell hybrid panel 2. Genomics (1996) 1.16
Exhaled nitric oxide in patients with asthma: association with NOS1 genotype. Am J Respir Crit Care Med (2000) 1.16
Differential effects of ozone on airway and tissue mechanics in obese mice. J Appl Physiol (1985) (2004) 1.13
Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation. Proc Assoc Am Physicians (1996) 1.12
Epizootic of rabies in raccoons in Maryland from 1981 to 1987. J Am Vet Med Assoc (1992) 1.06
Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Transl Psychiatry (2011) 1.06
Blood pressure in genetically hypertensive rats. Influence of the Y chromosome. Hypertension (1995) 1.05
Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression. Mol Psychiatry (2008) 1.04
Restaurant-associated outbreak of typhoid fever in Maryland: identification of carrier facilitated by measurement of serum Vi antibodies. J Clin Microbiol (1988) 1.04
Eotaxin and impaired lung function in asthma. Am J Respir Crit Care Med (1999) 1.04
Antileukotrienes in the treatment of asthma. Ann Intern Med (1997) 1.04
Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. Lipids (1993) 1.04
Assessment of tobacco dependence in waterpipe smokers in Egypt. Int J Tuberc Lung Dis (2012) 1.03
Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet (1997) 1.03
Association of epidemic Kawasaki syndrome with the HLA-A2, B44, Cw5 antigen combination. Arthritis Rheum (1985) 1.03
The association of borderline hypertension with target organ changes and higher coronary risk. Tecumseh Blood Pressure study. JAMA (1990) 1.03
Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study. Radiology (1987) 1.03
Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle. Am J Respir Crit Care Med (2000) 1.02
Cefotaxime compared with nafcillin plus tobramycin for serious bacterial infections. A randomized, double-blind trial. Ann Intern Med (1984) 1.02
Mechanism of increased alpha adrenergic vasoconstriction in human essential hypertension. J Clin Invest (1987) 1.02
Plasminogen activator is an apparent lymphocyte mitogen. J Immunol (1981) 1.01
Comparison of positron emission tomography, cognition, and brain volume in Alzheimer's disease with and without severe abnormalities of white matter. J Neurol Neurosurg Psychiatry (1996) 1.01
Systemic histiocytosis presenting as multiple sclerosis. Ann Neurol (1993) 1.01
Viral inhibition of lymphocyte mitogenesis. I. Evidence for the nonspecificity of the effect. J Immunol (1980) 1.00
Outbreak of neonatal Citrobacter diversus meningitis in a suburban hospital. Pediatr Infect Dis J (1987) 0.99
Multi-state investigation of the actual disinfection/sterilization of endoscopes in health care facilities. Am J Med (1992) 0.98
Glove use by health care workers: results of a tristate investigation. Am J Infect Control (1991) 0.97
Sclerosing sweat duct (syringomatous) carcinoma. Am J Surg Pathol (1985) 0.97
Lyme disease in Maryland: 1987-1990. Md Med J (1992) 0.96
Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking. Am J Respir Crit Care Med (2001) 0.95
Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to-moderate asthma. J Allergy Clin Immunol (1995) 0.95
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol (1999) 0.95
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy (2012) 0.95
Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals. Am J Respir Crit Care Med (2000) 0.95