Published in Lancet Respir Med on May 02, 2014
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med (2016) 4.09
Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol (2015) 0.86
Epigenetics in allergic diseases. Curr Opin Pediatr (2015) 0.79
Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. Am J Physiol Lung Cell Mol Physiol (2015) 0.79
Toward precision medicine and health: Opportunities and challenges in allergic diseases. J Allergy Clin Immunol (2016) 0.79
Epigenome-wide Analysis Links SMAD3 Methylation at Birth to Asthma in Children of Asthmatic Mothers. J Allergy Clin Immunol (2016) 0.79
Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO. Allergy Asthma Immunol Res (2017) 0.77
Genome-Wide Gene by Environment Interaction Analysis Identifies Common SNPs at 17q21.2 that Are Associated with Increased Body Mass Index Only among Asthmatics. PLoS One (2015) 0.76
Asthma heterogeneity and severity. World Allergy Organ J (2016) 0.76
Genetic basis of asthma. Indian J Med Res (2015) 0.75
TRPA1 gene polymorphisms and childhood asthma. Pediatr Allergy Immunol (2016) 0.75
What Does "Precision Medicine" Have to Say About Prevention? Epidemiology (2017) 0.75
Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine? Front Immunol (2017) 0.75
IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod). J Immunol (2016) 0.75
Implications of population structure and ancestry on asthma genetic studies. Curr Opin Allergy Clin Immunol (2014) 0.75
Genes and Cardiovascular Disease: Where do we go from here? Sultan Qaboos Univ Med J (2015) 0.75
Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy. Allergy Asthma Immunol Res (2017) 0.75
Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med (2015) 0.75
Interleukin-13 increases pendrin abundance to the cell surface in bronchial NCI-H292 cells via Rho/actin signaling. Pflugers Arch (2017) 0.75
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Cumulative association of five genetic variants with prostate cancer. N Engl J Med (2008) 15.34
Genetic mapping in human disease. Science (2008) 15.12
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
A large-scale, consortium-based genomewide association study of asthma. N Engl J Med (2010) 9.17
Asthma. N Engl J Med (2001) 8.73
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. Am J Respir Crit Care Med (2000) 8.09
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med (2008) 5.80
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Glucocorticoid resistance in inflammatory diseases. Lancet (2009) 3.57
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet (2011) 3.03
Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med (2013) 2.53
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol (2010) 2.51
Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet (2007) 2.41
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet (1999) 2.37
Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate. Am J Respir Crit Care Med (2009) 2.27
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol (2012) 2.12
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax (2000) 2.10
Molecular mechanisms of corticosteroid resistance. Chest (2008) 2.06
Communicating new knowledge on previously reported genetic variants. Genet Med (2012) 2.02
Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med (2010) 1.82
A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study. Circ Cardiovasc Genet (2012) 1.81
Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol (2011) 1.58
Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet (2011) 1.38
Asthma genetics and genomics 2009. Curr Opin Genet Dev (2009) 1.37
Challenges and approaches for the development of safer immunomodulatory biologics. Nat Rev Drug Discov (2013) 1.35
Genetics of allergic disease. J Allergy Clin Immunol (2010) 1.31
Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J Allergy Clin Immunol (2011) 1.30
Genome-wide association study to identify genetic determinants of severe asthma. Thorax (2012) 1.27
The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years. Clin Epigenetics (2013) 1.22
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem (2013) 1.22
The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol (2009) 1.21
Polymorphism of the beta2-adrenoceptor and the response to long-term beta2-agonist therapy in asthma. Eur Respir J (1998) 1.16
Gene-environment interactions in asthma and allergic diseases: challenges and perspectives. J Allergy Clin Immunol (2012) 1.14
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol (2012) 1.11
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet (2012) 1.09
Predicting who will have asthma at school age among preschool children. J Allergy Clin Immunol (2012) 1.06
Epigenetic mechanisms and models in the origins of asthma. Curr Opin Allergy Clin Immunol (2013) 1.02
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One (2012) 0.99
Pharmacogenetics of asthma. Curr Opin Pulm Med (2009) 0.99
Regulating leukotriene synthesis: the role of nuclear 5-lipoxygenase. J Cell Biochem (2005) 0.99
Stratified approaches to the treatment of asthma. Br J Clin Pharmacol (2013) 0.98
The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol (2012) 0.98
IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. J Allergy Clin Immunol (2012) 0.96
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy (2012) 0.95
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. Am J Respir Crit Care Med (2012) 0.93
The cysteinyl leukotrienes: where do they come from? What are they? Where are they going? Nat Immunol (2008) 0.93
Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr (2013) 0.92
Genome-wide association studies in asthma; perhaps, the end of the beginning. Curr Opin Allergy Clin Immunol (2013) 0.92
Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data. PLoS One (2013) 0.92
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One (2013) 0.91
Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med (2009) 0.89
I have taken my umbrella, so of course it does not rain. Thorax (2011) 0.88
Genome-wide association study of aspirin-exacerbated respiratory disease in a Korean population. Hum Genet (2012) 0.87
Identification of ATPAF1 as a novel candidate gene for asthma in children. J Allergy Clin Immunol (2011) 0.86
Pharmacogenetics of asthma. Curr Opin Pharmacol (2010) 0.86
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. Clin Exp Allergy (2013) 0.84
Leukotriene biosynthesis. Ann N Y Acad Sci (1991) 0.82
[Genome-wide association study of bronchial asthma in the Volga-Ural region of Russia]. Mol Biol (Mosk) (2012) 0.81
5-Lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents. Curr Med Chem (2006) 0.81
Molecular tools for companion diagnostics. N Biotechnol (2012) 0.79
Pathway analysis of genome-wide association study on asthma. Hum Immunol (2012) 0.77
From functional genomics to personalised medicine: ten years of an ESF Research Networking Programme. N Biotechnol (2013) 0.77