Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster.

PubWeight™: 3.49‹?› | Rank: Top 1%

🔗 View Article (PMC 1166852)

Published in EMBO J on April 01, 1986

Authors

S Schneuwly1, A Kuroiwa, P Baumgartner, W J Gehring

Author Affiliations

1: Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstr. 70, CH-4056 Basel, Switzerland.

Articles citing this

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Res (1987) 9.63

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J (1988) 3.77

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res (1994) 3.52

A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res (1991) 3.44

Characterization and localization of the even-skipped protein of Drosophila. EMBO J (1987) 3.29

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J (1990) 2.97

DNA binding properties of the purified Antennapedia homeodomain. Proc Natl Acad Sci U S A (1990) 2.60

Structure and sequence of the Drosophila zeste gene. EMBO J (1987) 2.55

Alternative RNA products from the Ultrabithorax domain of the bithorax complex. EMBO J (1988) 2.30

Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development. EMBO J (1987) 2.10

Drosophila NK-homeobox genes. Proc Natl Acad Sci U S A (1989) 2.04

Structure of transcripts from the homeotic Antennapedia gene of Drosophila melanogaster: two promoters control the major protein-coding region. Mol Cell Biol (1986) 2.00

Characterization of two RNAs transcribed from the cis-regulatory region of the abd-A domain within the Drosophila bithorax complex. Proc Natl Acad Sci U S A (1990) 1.86

The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation. EMBO J (1988) 1.85

Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na channel. EMBO J (1987) 1.74

Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J (1988) 1.72

Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J (1991) 1.72

Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. EMBO J (1992) 1.70

Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions. EMBO J (1988) 1.70

Effects of transposable elements on the expression of the forked gene of Drosophila melanogaster. Genetics (1993) 1.68

Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J (1989) 1.67

The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor. Proc Natl Acad Sci U S A (1990) 1.63

Multiple transcripts from the Antennapedia gene of Drosophila melanogaster. Mol Cell Biol (1986) 1.63

Primary structure and nuclear localization of a murine homeodomain protein. Proc Natl Acad Sci U S A (1987) 1.63

The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene. Proc Natl Acad Sci U S A (1999) 1.62

Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J (1987) 1.61

Molecular analysis of the dominant homeotic Antennapedia phenotype. EMBO J (1987) 1.53

The yeast ADR6 gene encodes homopolymeric amino acid sequences and a potential metal-binding domain. Nucleic Acids Res (1988) 1.53

Polar zippers: their role in human disease. Protein Sci (1994) 1.53

Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. EMBO J (1988) 1.46

A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts. EMBO J (1987) 1.42

The product of the Drosophila zeste gene binds to specific DNA sequences in white and Ubx. EMBO J (1987) 1.42

Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit. EMBO J (1987) 1.38

LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A (1993) 1.36

Developmentally regulated alternative splicing of transcripts from the Drosophila homeotic gene Antennapedia can produce four different proteins. EMBO J (1988) 1.35

Localization of the Antennapedia protein in Drosophila embryos and imaginal discs. EMBO J (1986) 1.35

The Abdominal-B gene of Drosophila melanogaster: overlapping transcripts exhibit two different spatial distributions. EMBO J (1988) 1.33

NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci U S A (1992) 1.27

Multiple, compensatory regulatory elements specify spermatocyte-specific expression of the Drosophila melanogaster hsp26 gene. Mol Cell Biol (1990) 1.27

cDNA clone encoding Drosophila transcription factor TFIID. Proc Natl Acad Sci U S A (1990) 1.24

Molecular analysis of ref(2)P, a Drosophila gene implicated in sigma rhabdovirus multiplication and necessary for male fertility. EMBO J (1989) 1.24

Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia. EMBO J (1992) 1.23

A novel, tissue-specific, Drosophila homeobox gene. EMBO J (1988) 1.23

Alternative RNA splicing that is spatially regulated: generation of transcripts from the Antennapedia gene of Drosophila melanogaster with different protein-coding regions. Mol Cell Biol (1988) 1.21

The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster. Mol Cell Biol (1996) 1.12

The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box. Nucleic Acids Res (1995) 1.09

Conserved DNA binding and self-association domains of the Drosophila zeste protein. Mol Cell Biol (1992) 1.08

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Mol Cell Biol (1992) 1.08

Modulo, a new maternally expressed Drosophila gene encodes a DNA-binding protein with distinct acidic and basic regions. Nucleic Acids Res (1989) 1.07

Rapid appearance and asymmetric distribution of glucose transporter SGTP4 at the apical surface of intramammalian-stage Schistosoma mansoni. Proc Natl Acad Sci U S A (1996) 1.06

Xenopus homeobox-containing cDNAs expressed in early development. Nucleic Acids Res (1988) 1.04

The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences. J Biol Chem (2006) 1.03

Splice site consensus sequences are preferentially accessible to nucleases in isolated adenovirus RNA. Nucleic Acids Res (1986) 1.02

Comparative studies of Drosophila Antennapedia genes. Genetics (1992) 1.01

Genetic and molecular characterization of the optomotor-blind gene locus in Drosophila melanogaster. Genetics (1990) 0.98

Structure and expression of Hox-2.2, a murine homeobox-containing gene. Proc Natl Acad Sci U S A (1988) 0.98

Promoter region of the human platelet-derived growth factor A-chain gene. Proc Natl Acad Sci U S A (1991) 0.96

My what big eyes you have: how the Drosophila retina grows. Dev Neurobiol (2011) 0.94

DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol (1987) 0.94

A functional splice site in the 5' untranslated region of a zein gene. Nucleic Acids Res (1990) 0.93

Sequence of the Tribolium castaneum homeotic complex: the region corresponding to the Drosophila melanogaster antennapedia complex. Genetics (2002) 0.92

Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J (1992) 0.91

Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. Nucleic Acids Res (1991) 0.89

Homology modeling using simulated annealing of restrained molecular dynamics and conformational search calculations with CONGEN: application in predicting the three-dimensional structure of murine homeodomain Msx-1. Protein Sci (1997) 0.88

The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion. Genetics (1994) 0.83

Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects. Genetics (1992) 0.83

In situ hybridization with oligonucleotides: a simplified method to detect Drosophila transcripts. Nucleic Acids Res (1991) 0.81

Mass spectrometric amino acid sequencing of a mixture of seed storage proteins (napin) from Brassica napus, products of a multigene family. Proc Natl Acad Sci U S A (1996) 0.78

Articles cited by this

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

New M13 vectors for cloning. Methods Enzymol (1983) 90.74

Organization and expression of eucaryotic split genes coding for proteins. Annu Rev Biochem (1981) 49.46

Sequence data handling by computer. Nucleic Acids Res (1977) 45.33

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res (1984) 39.52

A catalogue of splice junction sequences. Nucleic Acids Res (1982) 39.41

3' non-coding region sequences in eukaryotic messenger RNA. Nature (1976) 39.12

A gene complex controlling segmentation in Drosophila. Nature (1978) 23.75

Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72

The engrailed locus of Drosophila: structural analysis of an embryonic transcript. Cell (1985) 11.03

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences. Cell (1985) 10.00

Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science (1983) 7.94

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5' end in different developmental stages. Cell (1983) 6.84

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (1984) 6.62

A repressor (MAT alpha 2 Product) and its operator control expression of a set of cell type specific genes in yeast. Cell (1985) 5.77

opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell (1985) 5.71

Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22. Cell (1986) 5.00

A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell (1984) 4.95

An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex. EMBO J (1983) 4.77

Segmental distribution of bithorax complex proteins during Drosophila development. Nature (1985) 4.55

The molecular organization of the Antennapedia locus of Drosophila. Cell (1983) 4.50

Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature (1984) 4.33

High-sensitivity S1 mapping with single-stranded [32P]DNA probes synthesized from bacteriophage M13mp templates. Gene (1984) 3.81

Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47

Protein products of the bithorax complex in Drosophila. Cell (1984) 3.40

Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster. Dev Biol (1981) 3.25

An improved DNA sequencing strategy. Anal Biochem (1985) 3.22

A homoeotic mutation transforming leg to antenna in Drosophila. Nature (1981) 3.19

Localization of the fushi tarazu protein during Drosophila embryogenesis. Cell (1985) 3.00

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors. Cell (1985) 2.73

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell (1985) 2.70

Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50

Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts. EMBO J (1985) 1.77

Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila. Cell (1984) 1.55

Articles by these authors

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science (1995) 7.35

Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A (1987) 7.02

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature (1984) 6.62

Homeo boxes in the study of development. Science (1987) 6.21

P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev (1989) 5.76

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science (1994) 5.75

Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22. Cell (1986) 5.00

A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell (1984) 4.95

The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res (1987) 4.92

Control elements of the Drosophila segmentation gene fushi tarazu. Cell (1985) 4.83

An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex. EMBO J (1983) 4.77

Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature (1984) 4.33

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell (1989) 4.13

Regulation and function of the Drosophila segmentation gene fushi tarazu. Cell (1987) 3.91

Homeotic genes and the homeobox. Annu Rev Genet (1986) 3.60

Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J (1990) 3.50

Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47

P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev (1989) 3.45

The interaction with DNA of wild-type and mutant fushi tarazu homeodomains. EMBO J (1990) 2.97

Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell (1984) 2.89

Position effects on eukaryotic gene expression. Annu Rev Cell Biol (1990) 2.82

Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia. Nature (1987) 2.81

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature (1994) 2.76

Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development. Cell (1984) 2.72

PAX-6 in development and evolution. Annu Rev Neurosci (1997) 2.68

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature (1990) 2.67

DNA binding properties of the purified Antennapedia homeodomain. Proc Natl Acad Sci U S A (1990) 2.60

Isolation and sequence-specific DNA binding of the Antennapedia homeodomain. EMBO J (1988) 2.57

Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development (1998) 2.56

Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A (1983) 2.52

Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A (2001) 2.51

Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell (1987) 2.50

Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50

Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain. J Mol Biol (1994) 2.43

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun (1998) 2.31

Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leader. EMBO J (1985) 2.30

The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev (1992) 2.24

Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis. Science (1988) 2.23

Isolation of a hybrid plasmid with homologous sequences to a transposing element of Drosophila melanogaster. Cell (1980) 2.23

Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature (1984) 2.16

Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell (1978) 2.10

Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. Cell (1984) 2.08

RNA binding and translational suppression by bicoid. Nature (1996) 2.08

Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J (1985) 2.07

Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J (1985) 2.06

twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol Cell (1999) 2.06

Two mouse piwi-related genes: miwi and mili. Mech Dev (2001) 2.05

Molecular cloning of the white locus region of Drosophila melanogaster using a large transposable element. EMBO J (1982) 2.04

spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J (1994) 1.99

The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell (1990) 1.99

The 5S genes of Drosophila melanogaster. Cell (1977) 1.94

Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science (1994) 1.91

Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature (1992) 1.84

Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell (1979) 1.80

Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts. EMBO J (1985) 1.77

Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated. Genes Dev (1990) 1.75

Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J (1988) 1.72

Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J (1991) 1.72

Germ line dependence of the deep orange maternal effect in Drosophila. Dev Biol (1977) 1.69

Homeodomain proteins and the regulation of gene expression. Curr Opin Cell Biol (1990) 1.65

Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system. Development (1998) 1.62

Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development (2000) 1.59

Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos. Genes Dev (1988) 1.57

The homeo box: a key to the understanding of development? Cell (1985) 1.55

Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila. Cell (1984) 1.55

Deletions of two heat-activated loci in Drosophila melanogaster and their effects on heat-induced protein synthesis. Cell (1977) 1.54

Developmentally regulated Drosophila gene family encoding the fork head domain. Proc Natl Acad Sci U S A (1992) 1.54

Molecular analysis of the dominant homeotic Antennapedia phenotype. EMBO J (1987) 1.53

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development (2001) 1.51

A dialysis patient with systemic calciphylaxis exhibiting rapidly progressive visceral ischemia and acral gangrene. Intern Med (1995) 1.49

Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. Development (1999) 1.49

Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy. J Mol Biol (1990) 1.47

The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development (1996) 1.46

Heparin-releasable platelet factor 4 in patients with coronary artery disease. Clin Cardiol (1991) 1.46

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Proc Natl Acad Sci U S A (1989) 1.44

Sequence requirement for expression of the Drosophila melanogaster heat shock protein hsp22 gene during heat shock and normal development. Mol Cell Biol (1986) 1.43

Does coronary flow reserve assessed by blood flow velocity analysis reflect absolute coronary flow reserve? Cathet Cardiovasc Diagn (1996) 1.42

New perspectives on eye evolution. Curr Opin Genet Dev (1995) 1.42

Comparison of serum lipid values in variant angina pectoris and fixed coronary artery disease with normal subjects. Am J Cardiol (1989) 1.40

The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Development (2000) 1.40

Excision of copia element in a revertant of the white-apricot mutation of Drosophila melanogaster leaves behind one long-terminal repeat. Mol Gen Genet (1985) 1.39

Protein component from Drosophila larval nuclei showing sequence specificity for a short region near a major heat-shock protein gene. Cell (1981) 1.39

Functional specificity of the Antennapedia homeodomain. Proc Natl Acad Sci U S A (1993) 1.39

Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent. Dig Dis Sci (1995) 1.39

The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells. Proc Natl Acad Sci U S A (1991) 1.38

Are cross-regulatory interactions between homoeotic genes functionally significant? Nature (1990) 1.38

Developmental expression of the white locus of Drosophila melanogaster. EMBO J (1984) 1.38

Comparative effects of dobutamine and amrinone on coronary blood flow in patients with idiopathic dilated cardiomyopathy. Cathet Cardiovasc Diagn (1997) 1.38

Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc Natl Acad Sci U S A (1999) 1.37

BMP-2/-4 mediate programmed cell death in chicken limb buds. Development (1996) 1.36

Localization of the Antennapedia protein in Drosophila embryos and imaginal discs. EMBO J (1986) 1.35

P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development (1989) 1.34