Published in J Biol Chem on July 23, 1999
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci (2003) 2.43
Geometry and intrinsic tilt of a tryptophan-anchored transmembrane alpha-helix determined by (2)H NMR. Biophys J (2002) 2.01
Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR. Biophys J (2004) 1.98
Sequence-function analysis of the K+-selective family of ion channels using a comprehensive alignment and the KcsA channel structure. Biophys J (2003) 1.79
Molecular dynamics simulations of model trans-membrane peptides in lipid bilayers: a systematic investigation of hydrophobic mismatch. Biophys J (2006) 1.65
Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes. Proc Natl Acad Sci U S A (2011) 1.50
Changes in transmembrane helix alignment by arginine residues revealed by solid-state NMR experiments and coarse-grained MD simulations. J Am Chem Soc (2010) 1.41
Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. Biophys J (2003) 1.39
The dynamic orientation of membrane-bound peptides: bridging simulations and experiments. Biophys J (2007) 1.31
Energetics of hydrophobic matching in lipid-protein interactions. Biophys J (2008) 1.30
Hydrophobic mismatch between helices and lipid bilayers. Biophys J (2003) 1.28
Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity. J Virol (2009) 1.27
Comparison of "Polarization inversion with spin exchange at magic angle" and "geometric analysis of labeled alanines" methods for transmembrane helix alignment. J Am Chem Soc (2008) 1.24
Conformation of the synaptobrevin transmembrane domain. Proc Natl Acad Sci U S A (2006) 1.22
Orientation and motion of tryptophan interfacial anchors in membrane-spanning peptides. Biochemistry (2007) 1.20
Charged or aromatic anchor residue dependence of transmembrane peptide tilt. J Biol Chem (2010) 1.20
Orientation and dynamics of transmembrane peptides: the power of simple models. Eur Biophys J (2009) 1.18
Electrospray ionization mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics of transmembrane peptides in lipid bilayers. Proc Natl Acad Sci U S A (2000) 1.18
Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. PLoS Pathog (2013) 1.16
De novo design of conformationally flexible transmembrane peptides driving membrane fusion. Proc Natl Acad Sci U S A (2004) 1.14
Lipid-protein interactions of integral membrane proteins: a comparative simulation study. Biophys J (2004) 1.12
Interfacial tryptophan residues: a role for the cation-pi effect? Biophys J (2005) 1.11
Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class. Biophys J (2011) 1.06
Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. Biophys J (2009) 1.05
Boosting antimicrobial peptides by hydrophobic oligopeptide end tags. J Biol Chem (2009) 1.03
Order parameters of a transmembrane helix in a fluid bilayer: case study of a WALP peptide. Biophys J (2010) 1.02
Transmembrane helix dynamics of bacterial chemoreceptors supports a piston model of signalling. PLoS Comput Biol (2011) 1.02
The effect of peptide/lipid hydrophobic mismatch on the phase behavior of model membranes mimicking the lipid composition in Escherichia coli membranes. Biophys J (2000) 1.02
Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: implications for protein-induced membrane fusion. Biophys J (2005) 1.00
Tyrosine replacing tryptophan as an anchor in GWALP peptides. Biochemistry (2012) 0.99
Buried lysine, but not arginine, titrates and alters transmembrane helix tilt. Proc Natl Acad Sci U S A (2013) 0.99
Influence of hydrophobic mismatch and amino acid composition on the lateral diffusion of transmembrane peptides. Biophys J (2010) 0.98
Solid-state NMR ensemble dynamics as a mediator between experiment and simulation. Biophys J (2011) 0.98
The topology of lysine-containing amphipathic peptides in bilayers by circular dichroism, solid-state NMR, and molecular modeling. Biophys J (2000) 0.96
Membrane insertion and orientation of polyalanine peptides: a (15)N solid-state NMR spectroscopy investigation. Biophys J (2001) 0.95
Evaluating tilt angles of membrane-associated helices: comparison of computational and NMR techniques. Biophys J (2005) 0.94
Unfolding and extraction of a transmembrane alpha-helical peptide: dynamic force spectroscopy and molecular dynamics simulations. Biophys J (2005) 0.94
Backbone structure of a small helical integral membrane protein: A unique structural characterization. Protein Sci (2009) 0.94
Single amino acid insertions at the junction of the sindbis virus E2 transmembrane domain and endodomain disrupt virus envelopment and alter infectivity. J Virol (2005) 0.93
Conformation and environment of channel-forming peptides: a simulation study. Biophys J (2005) 0.93
Mutational analysis of mesentericin y105, an anti-Listeria bacteriocin, for determination of impact on bactericidal activity, in vitro secondary structure, and membrane interaction. Appl Environ Microbiol (2004) 0.93
Molecular dynamics simulation of transmembrane polypeptide orientational fluctuations. Biophys J (2004) 0.92
In silico vaccine design based on molecular simulations of rhinovirus chimeras presenting HIV-1 gp41 epitopes. J Mol Biol (2008) 0.91
Invariance of single-file water mobility in gramicidin-like peptidic pores as function of pore length. Biophys J (2007) 0.90
Response of GWALP transmembrane peptides to changes in the tryptophan anchor positions. Biochemistry (2011) 0.90
Activity of synthetic ion channels is influenced by cation-pi interactions with phospholipid headgroups. Org Biomol Chem (2005) 0.89
Exploring peptide-membrane interactions with coarse-grained MD simulations. Biophys J (2011) 0.88
Stoichiometry of lipid interactions with transmembrane proteins--Deduced from the 3D structures. Protein Sci (2006) 0.87
Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim Biophys Acta (2010) 0.87
Comparisons of interfacial Phe, Tyr, and Trp residues as determinants of orientation and dynamics for GWALP transmembrane peptides. Biochemistry (2014) 0.86
Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins? Biochemistry (2008) 0.86
Transmembrane peptides influence the affinity of sterols for phospholipid bilayers. Biophys J (2010) 0.84
Channel and nonchannel forms of spin-labeled gramicidin in membranes and their equilibria. J Phys Chem B (2010) 0.84
Three-dimensional stress field around a membrane protein: atomistic and coarse-grained simulation analysis of gramicidin A. Biophys J (2013) 0.82
Membrane binding of an acyl-lactoferricin B antimicrobial peptide from solid-state NMR experiments and molecular dynamics simulations. Biochim Biophys Acta (2011) 0.82
Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides. Biophys J (2007) 0.81
Phospholipid flip-flop modulated by transmembrane peptides WALP and melittin. J Struct Biol (2009) 0.81
Single tryptophan and tyrosine comparisons in the N-terminal and C-terminal interface regions of transmembrane GWALP peptides. J Phys Chem B (2013) 0.80
Canonical azimuthal rotations and flanking residues constrain the orientation of transmembrane helices. Biophys J (2013) 0.80
Distribution of hydrophobic residues is crucial for the fusogenic properties of the Ebola virus GP2 fusion peptide. J Virol (2004) 0.80
Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers. Biochemistry (2009) 0.79
Comparative membrane interaction study of viscotoxins A3, A2 and B from mistletoe (Viscum album) and connections with their structures. Biochem J (2003) 0.79
Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore. Biochim Biophys Acta (2011) 0.79
Peptide nanopores and lipid bilayers: interactions by coarse-grained molecular-dynamics simulations. Biophys J (2009) 0.79
Influence of High pH and Cholesterol on Single Arginine-Containing Transmembrane Peptide Helices. Biochemistry (2016) 0.78
Properties of membrane-incorporated WALP peptides that are anchored on only one end. Biochemistry (2012) 0.78
Structure and dynamics of a fusion peptide helical hairpin on the membrane surface: comparison of molecular simulations and NMR. J Phys Chem B (2014) 0.78
Indole and other aromatic compounds activate the yeast TRPY1 channel. FEBS Lett (2008) 0.78
Delivery of oligonucleotides into mammalian cells by anionic peptides: comparison between monomeric and dimeric peptides. Biochem J (2001) 0.78
Cytotoxic potency of cardiotoxin from Naja sputatrix: development of a new cytolytic assay. Biochem J (2002) 0.78
Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophys J (2011) 0.78
Effect of cholesterol on bilayer location of the class A peptide Ac-18A-NH2 as revealed by fluorescence resonance energy transfer. Eur Biophys J (2003) 0.77
Effect of phospholipids and a transmembrane peptide on the stability of the cubic phase of monoolein: implication for protein crystallization from a cubic phase. Biophys J (2003) 0.77
Transmembrane T-cell receptor peptides inhibit B- and natural killer-cell function. Immunology (2003) 0.77
New user-friendly approach to obtain an Eisenberg plot and its use as a practical tool in protein sequence analysis. Int J Mol Sci (2011) 0.77
Structure of the pore-helix of the hERG K(+) channel. Eur Biophys J (2009) 0.77
Evidence for Surface Recognition by a Cholesterol-Recognition Peptide. Biophys J (2016) 0.77
Distinct second extracellular loop structures of the brain cannabinoid CB(1) receptor: implication in ligand binding and receptor function. Proteins (2011) 0.76
Aromaticity at the water-hydrocarbon core interface of the membrane: consequences on the nicotinic acetylcholine receptor. Channels (Austin) (2008) 0.75
Structure-Function Analysis of the Two-Peptide Bacteriocin Plantaricin EF. Biochemistry (2016) 0.75
Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor. Biophys J (2015) 0.75
Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data. BMC Biophys (2011) 0.75
Do guanidinium and tetrapropylammonium ions specifically interact with aromatic amino acid side chains? Proc Natl Acad Sci U S A (2017) 0.75
The Transmembrane Helix Tilt May Be Determined by the Balance between Precession Entropy and Lipid Perturbation. J Chem Theory Comput (2012) 0.75
Transmembrane helices containing a charged arginine are thermodynamically stable. Eur Biophys J (2017) 0.75
Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am (2002) 5.95
Lipid polymorphism and the functional roles of lipids in biological membranes. Biochim Biophys Acta (1979) 5.39
Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science (1999) 5.30
Racial disparities in access to renal transplantation--clinically appropriate or due to underuse or overuse? N Engl J Med (2000) 4.67
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J Biol Chem (2000) 3.65
Molecular determinants of channel function. Physiol Rev (1992) 2.84
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes. Biochim Biophys Acta (1974) 2.79
Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas (2009) 2.74
Gramicidin A crystals contain two cation binding sites per channel. Nature (1979) 2.53
X-ray diffraction study of the polymorphism of hydrated diacyl- and dialkylphosphatidylethanolamines. Biochemistry (1984) 2.45
Calorimetric studies of the gel-fluid (L beta-L alpha) and lamellar-inverted hexagonal (L alpha-HII) phase transitions in dialkyl- and diacylphosphatidylethanolamines. Biochemistry (1983) 2.33
Induction of nonbilayer structures in diacylphosphatidylcholine model membranes by transmembrane alpha-helical peptides: importance of hydrophobic mismatch and proposed role of tryptophans. Biochemistry (1996) 2.31
Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association. Science (1990) 2.31
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. I. Specificity of the membrane permeability changes induced by the polyene antibiotics. Biochim Biophys Acta (1974) 2.25
Clinical significance of tolerant strains of Staphylococcus aureus in patients with endocarditis. Ann Intern Med (1980) 2.16
Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane. Biochim Biophys Acta (1990) 2.10
Amino acid sequence modulation of gramicidin channel function: effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration. Biochemistry (1991) 2.09
Influence of lipid/peptide hydrophobic mismatch on the thickness of diacylphosphatidylcholine bilayers. A 2H NMR and ESR study using designed transmembrane alpha-helical peptides and gramicidin A. Biochemistry (1998) 2.07
Single-channel studies on linear gramicidins with altered amino acid sequences. A comparison of phenylalanine, tryptophane, and tyrosine substitutions at positions 1 and 11. Biophys J (1984) 2.04
Helical channels in crystals of gramicidin A and of a cesium--gramicidin A complex: an x-ray diffraction study. J Mol Biol (1978) 2.01
Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A. Biophys J (1986) 1.97
Visualizing detergent resistant domains in model membranes with atomic force microscopy. FEBS Lett (2001) 1.92
Titration of the phase transition of phosphatidylserine bilayer membranes. Effects of pH, surface electrostatics, ion binding, and head-group hydration. Biochemistry (1981) 1.90
Molecular motion in phospholipid bilayers in the gel phase: long axis rotation. Biochemistry (1980) 1.86
Determination of fluid and gel domain sizes in two-component, two-phase lipid bilayers. An electron spin resonance spin label study. Biophys J (1992) 1.85
Comparative studies on the effects of pH and Ca2+ on bilayers of various negatively charged phospholipids and their mixtures with phosphatidylcholine. Biochim Biophys Acta (1978) 1.83
Rhodopsin-lipid associations in bovine rod outer segment membranes. Identification of immobilized lipid by spin-labels. Biochemistry (1979) 1.81
Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence. J Mol Biol (1990) 1.80
Anionic phospholipids are determinants of membrane protein topology. EMBO J (1997) 1.77
Protein surface-distribution and protein-protein interactions in the binding of peripheral proteins to charged lipid membranes. Biophys J (1995) 1.77
The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study. Biochim Biophys Acta (1978) 1.73
Pheromone-regulated anemotaxis in flying moths. Science (1974) 1.71
Phosphatidylglycerol is involved in protein translocation across Escherichia coli inner membranes. Nature (1988) 1.71
Negatively charged phospholipids restore prePhoE translocation across phosphatidylglycerol-depleted Escherichia coli inner membranes. J Biol Chem (1991) 1.70
Freeze-etch electron microscopy of erythrocytes, Acholeplasma laidlawii cells and liposomal membranes after the action of filipin and amphotericin B. Biochim Biophys Acta (1973) 1.68
The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane. Biochemistry (1997) 1.66
Comparative Chemical Studies of the Ocular Fluids, of Cerebrospinal Fluid, and of the Blood. Trans Am Ophthalmol Soc (1927) 1.65
Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry (2001) 1.64
Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle. Osteoporos Int (2013) 1.60
Induction of conductance heterogeneity in gramicidin channels. Biochemistry (1989) 1.58
Biomembranes. Lipids beyond the bilayer. Nature (1997) 1.58
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J Biol Chem (1993) 1.58
Predicting survival after treatment for fracture of the proximal femur and the effect of delays to surgery. J Clin Epidemiol (2003) 1.57
Anionic phospholipids are involved in membrane association of FtsY and stimulate its GTPase activity. EMBO J (2000) 1.56
Inhibition of protein kinase C by tamoxifen. Cancer Res (1985) 1.56
Electron spin resonance: spin labels. Mol Biol Biochem Biophys (1981) 1.53
Orientations of the tryptophan 9 and 11 side chains of the gramicidin channel based on deuterium nuclear magnetic resonance spectroscopy. Biophys J (1994) 1.52
SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study. Biochemistry (1992) 1.52
The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes. J Biol Chem (1985) 1.52
Hydration of noncharged lipid bilayer membranes. Theory and experiments with phosphatidylethanolamines. Biophys J (1985) 1.51
Cytochrome c specifically induces non-bilayer structures in cardiolipin-containing model membranes. Biochim Biophys Acta (1980) 1.47
Amino acid substitutions and ion channel function. Model-dependent conclusions. Biophys J (1992) 1.45
Interaction of cholesterol with sphingomyelin in mixed membranes containing phosphatidylcholine, studied by spin-label ESR and IR spectroscopies. A possible stabilization of gel-phase sphingolipid domains by cholesterol. Biochemistry (2001) 1.43
Metastability and polymorphism in the gel and fluid bilayer phases of dilauroylphosphatidylethanolamine. Two crystalline forms in excess water. J Biol Chem (1983) 1.43
Specificity and function of the individual amino acids of an important determinant of human immunodeficiency virus type 1 that induces neutralizing activity. J Gen Virol (1989) 1.41
Lipid membrane expansion and micelle formation by polymer-grafted lipids: scaling with polymer length studied by spin-label electron spin resonance. Biophys J (2001) 1.40
Phospholipid Motional Characteristics in a Dry Biological System : A P-Nuclear Magnetic Resonance Study of Hydrating Typha latifolia Pollen. Plant Physiol (1982) 1.40
Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata. Proc Natl Acad Sci U S A (1978) 1.40
Polyene antibiotic-sterol interactions in membranes of Acholesplasma laidlawii cells and lecithin liposomes. II. Temperature dependence of the polyene antibiotic-sterol complex formation. Biochim Biophys Acta (1974) 1.39
The C terminus of SecA is involved in both lipid binding and SecB binding. J Biol Chem (1995) 1.38
Interactions of hydrophobic lung surfactant proteins SP-B and SP-C with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol bilayers studied by electron spin resonance spectroscopy. Biochemistry (1995) 1.38
Orientation of the valine-1 side chain of the gramicidin transmembrane channel and implications for channel functioning. A 2H NMR study. Biochemistry (1992) 1.38
Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular force transducers. Methods Enzymol (1999) 1.38
An interacting spin label study of the fluidizing and condensing effects of cholesterol on lecithin bilayers. Biochim Biophys Acta (1973) 1.36
Non-bilayer lipids are required for efficient protein transport across the plasma membrane of Escherichia coli. EMBO J (1995) 1.36
Design and characterization of gramicidin channels. Methods Enzymol (1999) 1.35
Control of the structure and fluidity of phosphatidylglycerol bilayers by pH titration. Biochim Biophys Acta (1978) 1.34
Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas (2013) 1.34
On the supramolecular organization of gramicidin channels. The elementary conducting unit is a dimer. Biophys J (1992) 1.34
Evidence for phase boundary lipid. Permeability of Tempo-choline into dimyristoylphosphatidylcholine vesicles at the phase transition. Biochemistry (1976) 1.34
Spin-label studies of lipid immobilization in dimyristoylphosphatidylcholine-substituted cytochrome oxidase. Biochemistry (1979) 1.32
Dynamin is membrane-active: lipid insertion is induced by phosphoinositides and phosphatidic acid. Biochemistry (2000) 1.31
Molecular ordering of interfacially localized tryptophan analogs in ester- and ether-lipid bilayers studied by 2H-NMR. Biophys J (1998) 1.30
Precursors in vivo of glutamate, aspartate and their derivatives of rat brain. J Neurochem (1966) 1.30
Investigation of secondary and tertiary structural changes of cytochrome c in complexes with anionic lipids using amide hydrogen exchange measurements: an FTIR study. Biophys J (1993) 1.29
Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane? Biochim Biophys Acta (1997) 1.28
Electron spin resonance study of phospholipid membranes employing a comprehensive line-shape model. Biochemistry (1985) 1.28
Molecular basis of glycoalkaloid induced membrane disruption. Biochim Biophys Acta (1995) 1.28
Membrane fusion and the lamellar-to-inverted-hexagonal phase transition in cardiolipin vesicle systems induced by divalent cations. Biophys J (1999) 1.26
Visualization of highly ordered striated domains induced by transmembrane peptides in supported phosphatidylcholine bilayers. Biochemistry (2000) 1.24
Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids. Biochem J (1966) 1.24
Binding of peripheral proteins to mixed lipid membranes: effect of lipid demixing upon binding. Biophys J (1999) 1.24
The orientation of nisin in membranes. Biochemistry (1998) 1.23
Characterisation of new intracellular membranes in Escherichia coli accompanying large scale over-production of the b subunit of F(1)F(o) ATP synthase. FEBS Lett (2000) 1.23
The lantibiotic nisin, a special case or not? Biochim Biophys Acta (1999) 1.23
Functional domains of the ferredoxin transit sequence involved in chloroplast import. J Biol Chem (1995) 1.23
Pneumonia perceptions and management: an ethnographic study in urban squatter settlements of Karachi, Pakistan. Soc Sci Med (1997) 1.22