Published in Proc Natl Acad Sci U S A on September 29, 2004
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem (2008) 2.34
Interaction and conformational dynamics of membrane-spanning protein helices. Protein Sci (2009) 1.19
HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of beta strand conformation with membrane cholesterol, and proximity to lipid headgroups. Biochemistry (2009) 1.17
Conformational flexibility and strand arrangements of the membrane-associated HIV fusion peptide trimer probed by solid-state NMR spectroscopy. Biochemistry (2006) 1.13
The Gaussian curvature elastic energy of intermediates in membrane fusion. Biophys J (2008) 1.05
Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: implications for protein-induced membrane fusion. Biophys J (2005) 1.00
Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange. Biophys J (2008) 0.94
Secondary structure and distribution of fusogenic LV-peptides in lipid membranes. Eur Biophys J (2007) 0.93
Direct visualization of large and protein-free hemifusion diaphragms. Biophys J (2010) 0.90
Helix packing and orientation in the transmembrane dimer of gp55-P of the spleen focus forming virus. Biophys J (2005) 0.87
Determining the ratio of the Gaussian curvature and bending elastic moduli of phospholipids from Q(II) phase unit cell dimensions. Biophys J (2006) 0.85
The measles virus fusion protein transmembrane region modulates availability of an active glycoprotein complex and fusion efficiency. J Virol (2008) 0.84
Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices. Biophys J (2010) 0.84
Vacuolar SNARE protein transmembrane domains serve as nonspecific membrane anchors with unequal roles in lipid mixing. J Biol Chem (2015) 0.82
Helix-destabilizing, beta-branched, and polar residues in the baboon reovirus p15 transmembrane domain influence the modularity of FAST proteins. J Virol (2011) 0.82
pH-Dependent lytic peptides discovered by phage display. Biochemistry (2006) 0.82
A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis. PLoS One (2009) 0.81
Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing. J Virol (2006) 0.80
Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus-cell fusion. Proc Natl Acad Sci U S A (2015) 0.79
Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophys J (2011) 0.78
Stabilization of conformationally dynamic helices by covalently attached acyl chains. Protein Sci (2009) 0.78
The Multifaceted Role of SNARE Proteins in Membrane Fusion. Front Physiol (2017) 0.77
Intrinsic flexibility and structural adaptability of Plasticins membrane-damaging peptides as a strategy for functional versatility. Eur Biophys J (2007) 0.77
Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix. Protein Sci (2012) 0.77
Synaptobrevin Transmembrane Domain Dimerization Studied by Multiscale Molecular Dynamics Simulations. Biophys J (2015) 0.76
Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A (2015) 0.76
SNAREpins: minimal machinery for membrane fusion. Cell (1998) 16.97
Membrane fusion. Cell (2003) 7.68
Use of resonance energy transfer to monitor membrane fusion. Biochemistry (1981) 6.38
Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion. Cell (1994) 5.65
Measurement of the beta-sheet-forming propensities of amino acids. Nature (1994) 3.36
Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. Science (2004) 3.24
Proline-induced distortions of transmembrane helices. J Mol Biol (2002) 2.76
Quaternary structure of influenza virus hemagglutinin after acid treatment. J Virol (1986) 2.54
Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides. J Biol Chem (1999) 2.44
Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A (2004) 2.28
Attenuated total reflection infrared spectroscopy of proteins and lipids in biological membranes. Biochim Biophys Acta (1999) 2.17
Intrinsic beta-sheet propensities result from van der Waals interactions between side chains and the local backbone. Proc Natl Acad Sci U S A (1999) 2.06
The transmembrane domain in viral fusion: essential role for a conserved glycine residue in vesicular stomatitis virus G protein. Proc Natl Acad Sci U S A (1998) 1.99
Mutations in the membrane-spanning domain of the human immunodeficiency virus envelope glycoprotein that affect fusion activity. J Virol (1994) 1.93
A conserved membrane-spanning amino acid motif drives homomeric and supports heteromeric assembly of presynaptic SNARE proteins. J Biol Chem (2000) 1.67
Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol (2000) 1.66
Determination of soluble and membrane protein structure by Fourier transform infrared spectroscopy. I. Assignments and model compounds. Subcell Biochem (1994) 1.63
Membrane fusion: a structural perspective on the interplay of lipids and proteins. Curr Opin Struct Biol (2003) 1.52
A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion. Mol Biol Cell (2000) 1.43
A set of constructed type spectra for the practical estimation of peptide secondary structure from circular dichroism. Anal Biochem (1997) 1.40
A turn propensity scale for transmembrane helices. J Mol Biol (1999) 1.37
Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity. J Mol Biol (2001) 1.34
A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains. FEBS Lett (1999) 1.29
Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. Biochemistry (1998) 1.28
Uncoupling hydrophobicity and helicity in transmembrane segments. Alpha-helical propensities of the amino acids in non-polar environments. J Biol Chem (1998) 1.24
Secondary structure, orientation, oligomerization, and lipid interactions of the transmembrane domain of influenza hemagglutinin. Biochemistry (2000) 1.23
The role of the membrane-spanning domain sequence in glycoprotein-mediated membrane fusion. Mol Biol Cell (1999) 1.19
Glycine and beta-branched residues support and modulate peptide helicity in membrane environments. FEBS Lett (1992) 1.13
VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. Biochemistry (2002) 1.07
Palmitoylation, membrane-proximal basic residues, and transmembrane glycine residues in the reovirus p10 protein are essential for syncytium formation. J Virol (2003) 1.04
The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion. J Biol Chem (2002) 1.03
Microscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusion. Proc Natl Acad Sci U S A (2004) 1.03
Proteins and peptides in water-restricted environments. Proteins (1986) 1.01
Peptide mimics of the vesicular stomatitis virus G-protein transmembrane segment drive membrane fusion in vitro. J Biol Chem (2001) 0.99
Synaptobrevin transmembrane domain dimerization-revisited. Biochemistry (2004) 0.98
The role of the transmembrane and of the intraviral domain of glycoproteins in membrane fusion of enveloped viruses. Biosci Rep (2000) 0.91
Micellar solubilization of biopolymers in organic solvents. Activity and conformation of lysozyme in isooctane reverse micelles. J Biol Chem (1981) 0.91
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol (2007) 6.94
A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med (2007) 6.02
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem (2008) 2.34
Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy. Nature (2005) 2.31
Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A (2009) 1.97
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol (2008) 1.78
Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction. BMC Syst Biol (2009) 1.62
Pediatric emergency health care providers' knowledge, attitudes, and experiences regarding emergency contraception. Acad Emerg Med (2011) 1.49
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A (2010) 1.47
Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment. Biophys J (2004) 1.41
Proton binding within a membrane protein by a protonated water cluster. Proc Natl Acad Sci U S A (2005) 1.36
Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum (2002) 1.30
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci U S A (2008) 1.30
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. Eur J Pharm Biopharm (2008) 1.23
Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition. J Mol Biol (2006) 1.15
Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc Natl Acad Sci U S A (2011) 1.15
N-Ras forms dimers at POPC membranes. Biophys J (2012) 1.13
Phenylalanine promotes interaction of transmembrane domains via GxxxG motifs. J Mol Biol (2007) 1.12
Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J Immunol (2007) 1.12
Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem (2011) 1.11
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A (2012) 1.09
The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper. J Biol Chem (2003) 1.08
Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl (2010) 1.07
In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle. J Biol Chem (2012) 1.06
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Proteins in action monitored by time-resolved FTIR spectroscopy. Chemphyschem (2005) 1.06
The assignment of the different infrared continuum absorbance changes observed in the 3000-1800-cm(-1) region during the bacteriorhodopsin photocycle. Biophys J (2004) 1.06
Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing. J Cell Sci (2005) 1.05
Stepwise diagnosis of Trichomonas vaginalis infection in adolescent women. J Clin Microbiol (2008) 1.05
Urinary symptoms in adolescent females: STI or UTI? J Adolesc Health (2007) 1.04
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies. J Biol Chem (2003) 1.04
The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion. J Biol Chem (2002) 1.03
A unique sequence motif in the 54-kDa subunit of the chloroplast signal recognition particle mediates binding to the 43-kDa subunit. J Biol Chem (2005) 1.03
Coupling of light-induced electron transfer to proton uptake in photosynthesis. Nat Struct Biol (2003) 1.02
Elucidating the mechanism of lipid membrane-induced IAPP fibrillogenesis and its inhibition by the red wine compound resveratrol: a synchrotron X-ray reflectivity study. J Am Chem Soc (2009) 1.02
Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger. J Biol Chem (2004) 1.02
Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein. Biophys J (2005) 1.02
Surface change of Ras enabling effector binding monitored in real time at atomic resolution. Chembiochem (2007) 1.01
Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc Natl Acad Sci U S A (2012) 0.99
Synaptobrevin transmembrane domain dimerization-revisited. Biochemistry (2004) 0.98
Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl (2011) 0.98
15N MAS NMR studies of cph1 phytochrome: Chromophore dynamics and intramolecular signal transduction. J Phys Chem B (2006) 0.98
Tryptophan supports interaction of transmembrane helices. J Mol Biol (2005) 0.97
Unravelling the mechanism of dual-specificity GAPs. EMBO J (2010) 0.96
Structural changes of membrane-anchored native PrP(C). Proc Natl Acad Sci U S A (2008) 0.96
Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange. Biophys J (2008) 0.94
Directional proton transfer in membrane proteins achieved through protonated protein-bound water molecules: a proton diode. Angew Chem Int Ed Engl (2010) 0.94
Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections. J Biophotonics (2012) 0.93
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. J Am Chem Soc (2013) 0.93
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations. FEBS Lett (2007) 0.93
Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy. FEBS J (2005) 0.92
The interface of a membrane-spanning leucine zipper mapped by asparagine-scanning mutagenesis. Protein Sci (2004) 0.92
Cross-amyloid interaction of Aβ and IAPP at lipid membranes. Angew Chem Int Ed Engl (2011) 0.90
The lipid modifications of Ras that sense membrane environments and induce local enrichment. Angew Chem Int Ed Engl (2009) 0.90
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. Eur Biophys J (2012) 0.90
Direct visualization of large and protein-free hemifusion diaphragms. Biophys J (2010) 0.90
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. J Mol Biol (2006) 0.89
Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging. Analyst (2015) 0.89
Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents. Biomaterials (2010) 0.89
The specific vibrational modes of GTP in solution and bound to Ras: a detailed theoretical analysis by QM/MM simulations. Phys Chem Chem Phys (2011) 0.89
Prion protein alpha-to-beta transition monitored by time-resolved Fourier transform infrared spectroscopy. Appl Spectrosc (2007) 0.89
How does a membrane protein achieve a vectorial proton transfer via water molecules? Chemphyschem (2008) 0.89
Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy. Analyst (2014) 0.89
Manipulating actin dynamics affects human in vitro decidualization. Biol Reprod (2009) 0.88
Water dynamics simulation as a tool for probing proton transfer pathways in a heptahelical membrane protein. Proteins (2005) 0.88
Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site. FEBS Lett (2008) 0.87
An automated application for deconvolution of circular dichroism spectra of small peptides. Anal Biochem (2007) 0.87
Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function. J Mol Biol (2009) 0.87
FTIR spectroscopy of biofluids revisited: an automated approach to spectral biomarker identification. Analyst (2013) 0.87
Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease. J Immunol (2009) 0.87
The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations. Biophys J (2012) 0.87
Early formation of the ion-conducting pore in channelrhodopsin-2. Angew Chem Int Ed Engl (2014) 0.86
Secondary structure of lipidated Ras bound to a lipid bilayer. FEBS J (2008) 0.86
Tyr39 of ran preserves the Ran.GTP gradient by inhibiting GTP hydrolysis. J Mol Biol (2010) 0.85
Understanding the energetics of helical peptide orientation in membranes. Proteins (2005) 0.85
The effect of Aβ on IAPP aggregation in the presence of an isolated β-cell membrane. J Mol Biol (2012) 0.85
Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices. Biophys J (2010) 0.84
Does different orientation of the methoxy groups of ubiquinone-10 in the reaction centre of Rhodobacter sphaeroides cause different binding at QA and QB? Eur J Biochem (2003) 0.83
The dynamics of the catalytic site in small GTPases, variations on a common motif. FEBS Lett (2013) 0.83
A ToxR-based dominant-negative system to investigate heterotypic transmembrane domain interactions. Proteins (2006) 0.83
The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays. FEBS Lett (2011) 0.82
Evidence for a copper-binding superfamily of the amyloid precursor protein. Biochemistry (2002) 0.82
Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion. Mol Membr Biol (2010) 0.82
Modelling of the human papillomavirus type 16 E5 protein. Biochim Biophys Acta (2002) 0.82
Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy. Biochim Biophys Acta (2008) 0.82
Assistive technology and computer adaptations for individuals with spinal cord injury. NeuroRehabilitation (2004) 0.82
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein. Proc Natl Acad Sci U S A (2009) 0.82
Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle. J Biol Chem (2012) 0.81
Ionic interactions promote transmembrane helix-helix association depending on sequence context. J Mol Biol (2009) 0.81
Solid state NMR investigation of the interaction between biomimetic lipid bilayers and de novo designed fusogenic peptides. Chembiochem (2007) 0.81
Influence of chelate conjugation on a newly identified tumor-targeting peptide. J Nucl Med (2007) 0.81