Published in Mol Cell Biol on September 01, 1999
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest (2003) 2.97
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A (2001) 2.15
NF-kappaB and cancer: how intimate is this relationship. Mol Cell Biochem (2009) 2.03
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
The diverse roles of Rac signaling in tumorigenesis. Cell Cycle (2011) 1.38
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol (2006) 1.36
The role of FilGAP-filamin A interactions in mechanoprotection. Mol Biol Cell (2009) 1.28
Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation. Mol Biol Cell (2001) 1.16
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. Eukaryot Cell (2005) 1.11
Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6. Mol Cell Biol (2003) 1.07
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol (2001) 1.07
v-Src generates a p53-independent apoptotic signal. Mol Cell Biol (2000) 1.04
Death pathways triggered by activated Ras in cancer cells. Front Biosci (Landmark Ed) (2011) 1.00
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol (2012) 0.97
Fine tuning the transcriptional regulation of the CXCL1 chemokine. Prog Nucleic Acid Res Mol Biol (2003) 0.96
Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice. J Cancer Res Clin Oncol (2008) 0.94
A rac homolog is required for induction of hyphal growth in the dimorphic yeast Yarrowia lipolytica. J Bacteriol (2000) 0.93
Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75. Mol Cell Biol (2004) 0.93
Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways. Mol Cell Biol (2000) 0.92
Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells. Mol Cell Biol (2003) 0.90
Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. Neoplasia (2004) 0.90
Identification of a GTP-bound Rho specific scFv molecular sensor by phage display selection. BMC Biotechnol (2008) 0.88
Gene expression profiling of chemically induced rat bladder tumors. Neoplasia (2007) 0.87
Molecular interactions of human immunodeficiency virus type 1 with primary human oral keratinocytes. J Virol (2005) 0.84
Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras. Virchows Arch (2001) 0.84
Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer. Oncotarget (2015) 0.83
The insert region of Rac1 is essential for membrane ruffling but not cellular transformation. Mol Cell Biol (2001) 0.83
Ras and rheb signaling in survival and cell death. Cancers (Basel) (2013) 0.78
Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. Int J Oncol (2011) 0.77
Anoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists. Oncogene (2014) 0.77
Design and Characterization of Bioengineered Cancer-Like Stem Cells. PLoS One (2015) 0.75
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89
The stress-activated protein kinase subfamily of c-Jun kinases. Nature (1994) 11.45
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature (1997) 11.31
PI3K: downstream AKTion blocks apoptosis. Cell (1997) 7.73
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science (1997) 7.57
NF-kappa B: a lesson in family values. Cell (1995) 7.33
Identification and characterization of an IkappaB kinase. Cell (1997) 6.71
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell (1997) 6.55
Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature (1985) 6.41
Increasing complexity of Ras signaling. Oncogene (1998) 5.71
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature (1997) 5.43
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell (1996) 5.34
Multiple Ras functions can contribute to mammalian cell transformation. Cell (1995) 5.24
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol Cell Biol (1995) 4.78
The p21 ras C-terminus is required for transformation and membrane association. Nature (1984) 4.43
H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J (1993) 3.94
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci (1997) 3.68
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
Rho GTPases. J Biol Chem (1998) 3.35
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science (1997) 3.32
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science (1996) 3.30
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev (1997) 3.23
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (1996) 3.18
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Ras promotes cell survival in Drosophila by downregulating hid expression. Cell (1998) 2.75
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69
Ras signalling and apoptosis. Curr Opin Genet Dev (1998) 2.63
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci U S A (1994) 2.62
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J (1996) 2.59
Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature (1986) 2.48
Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development (1998) 2.43
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J Biol Chem (1996) 2.04
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr Biol (1994) 1.90
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol Cell Biol (1996) 1.86
Activate NF-kappa B or die? Curr Biol (1997) 1.85
The cat and mouse games that genes, viruses, and cells play. Cell (1997) 1.85
A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J (1998) 1.72
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J Biol Chem (1998) 1.40
Ras effectors and their role in mitogenesis and oncogenesis. J Mol Med (Berl) (1997) 1.40
A Rac1 effector site controlling mitogenesis through superoxide production. J Biol Chem (1998) 1.35
Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol Cell Biol (1997) 1.28
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J Biol Chem (1996) 1.27
Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B. Methods Enzymol (1994) 1.25
Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J Biol Chem (1997) 1.20
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J Biol Chem (1998) 1.13
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol Cell Biol (1998) 1.10
Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene (1995) 0.96
Overexpression of mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase. Oncogene (1995) 0.82
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev (1993) 7.41
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (1993) 6.38
Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol (1999) 5.78
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (1993) 5.02
Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science (1986) 4.99
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (1993) 4.54
The structural basis of the activation of Ras by Sos. Nature (1998) 4.50
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell (1997) 4.43
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell (1985) 3.73
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science (1996) 3.30
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol (1997) 3.22
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (1996) 3.18
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science (1998) 3.17
Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science (1995) 2.42
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature (1989) 2.14
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. EMBO J (1994) 2.10
Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J (1996) 2.00
Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell (1998) 1.77
Differential activation of the Rac pathway by Ha-Ras and K-Ras. J Biol Chem (2001) 1.72
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J Biol Chem (2001) 1.71
The Ras superfamily of GTPases. FASEB J (1996) 1.70
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell (2001) 1.68
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Mol Cell Biol (1996) 1.63
The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J (1997) 1.54
Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J Biol Chem (1998) 1.48
Regulation of Sos activity by intramolecular interactions. Mol Cell Biol (1998) 1.46
Rac1 mediates STAT3 activation by autocrine IL-6. Proc Natl Acad Sci U S A (2001) 1.46
Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science (1994) 1.40
Ras effectors and their role in mitogenesis and oncogenesis. J Mol Med (Berl) (1997) 1.40
A Rac1 effector site controlling mitogenesis through superoxide production. J Biol Chem (1998) 1.35
Effect of tunicamycin, an inhibitor of protein glycosylation, on the biological properties of acetylcholine receptor in cultured muscle cells. J Biol Chem (1983) 1.18
Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature (1990) 1.12
The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J Biol Chem (1997) 1.10
Differential interactions of human Sos1 and Sos2 with Grb2. J Biol Chem (1995) 1.10
Activation of Ras and other signaling pathways by receptor tyrosine kinases. Cold Spring Harb Symp Quant Biol (1994) 1.09
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int J Cancer (2001) 1.09
Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy. Gene Ther (2003) 1.08
Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event. J Cell Biol (1993) 0.97
Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion. J Cell Biol (1983) 0.95
SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene (1997) 0.94
Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein. J Virol (2000) 0.91
Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake. Anal Biochem (1991) 0.90
CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene (2012) 0.87
Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. Oncogene (1996) 0.87
Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP. Oncogene (1994) 0.87
Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. Am J Physiol (1992) 0.86
Tunicamycin inhibits the expression of surface Na+ channels in cultured muscle cells. J Cell Physiol (1983) 0.80
Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture. J Gen Physiol (1983) 0.78
Negative modulation of sodium channels in cultured chick muscle cells by the channel activator batrachotoxin. J Biol Chem (1985) 0.78
Single cell assays for Rac activity. Methods Enzymol (2000) 0.76
Phospholipase A2: microinjection and cell localization techniques. Methods Enzymol (1991) 0.75
Association of p21ras with cellular polypeptides. J Biol Chem (1991) 0.75
Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes. Cell Signal (1990) 0.75
SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway. Ann N Y Acad Sci (1999) 0.75
Purification of baculovirus-expressed human Sos1 protein. Methods Enzymol (1995) 0.75